Clinical trials: Subarachnoid Hemorrhage
Traumatic Brain Injury, Ischemic Stroke
Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor
The goals of the project are to evaluate a noninvasive monitor of brain metabolism and blood flow in critically ill humans. If validated, such a reliable noninvasive brain blood flow and metabolism monitor, by allowing…
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NNOM (NCT02983786)
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Pennsylvania
Subarachnoid Hemorrhage
Preconditioning for Aneurismal Subarachnoid Hemorrhage
In remote preconditioning, ischemia in one organ protects distant organs from ischemic insults. e.g. brief induced limb ischemia protects the brain from an otherwise more severe stroke.
- Trial name
- NCT01110239
- Testing
- remote limb preconditioning
- Volunteers
- 34 people
- Sponsor
- University of Miami
Partial Corticotrope Insufficiency
Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency
The purpose of this study is to evaluate the efficacy of hydrocortisone replacement therapy in patients with partial cortisol deficiency after traumatic brain injury or subarachnoid hemorrhage on cognitive function.
- Trial name
- CSMünchen01 (NCT01089075)
- Testing
- Hydrocortisone
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Endocrine Dysfunction, Cerebral Infarctions
Endocrine Dysfunction and Quality of Life After Subarachnoid Hemorrhage
Investigation of the incidence of endocrine dysfunction following subarachnoid hemorrhage (SAH), and to see if this has a relation to CNS lesions as evaluated by MRI and to common symptoms after SAH such as general exhaustion…
- Conditions
- Endocrine Dysfunction, Cerebral Infarctions, Quality of Life
- Trial name
- NCT01101711
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Lund University Hospital
Cerebral Vasospasm
Safety Study of Nicardipine to Treat Cerebral Vasospasm
The purpose of this study is to determine if intrathecal nicardipine is safe for the treatment of cerebral vasospasm.
- Trial name
- NCT01810302
- Testing
- Nicardipine hydrochloride, Preservative-free normal saline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Subarachnoid Hemorrhage
MicroRNA Diagnostics in Subarachnoid Hemorrhage
The purpose of this study is to compare the profile of microRNA in cerebrospinal fluid from patients suffering subarachnoid hemorrhage with and without delayed cerebral ischemia.
- Trial name
- NCT01791257
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Subarachnoid Hemorrhage
Intravenous Magnesium Sulfate in Aneurysmal Subarachnoid Haemorrhage (IMASH)
The IMASH trial is a simple, randomized, double-blinded, placebo-controlled, multi-center trial to answer the question: "Does intravenous magnesium sulfate improve clinical outcome after aneurysmal subarachnoid hemorrhage?"
- Trial name
- NCT00124150
- Testing
- Intravenous magnesium sulfate infusion
- Where
- China
- Volunteers
- 327 people
- Sponsor
- Chinese University of Hong Kong
Cerebral Vasospasm, Subarachnoid Hemorrhage
Safety of Intravenous Milrinone for the Treatment of Subarachnoid Hemorrhage-induced Vasospasm
The aim of this study is to evaluate the tolerance of intravenous milrinone combined to the current standard treatment for cerebral vasospasm following subarachnoid hemorrhage.
- Trial name
- MilriSpasm (NCT03517670)
- Testing
- Rhythmic tolerance, Hematological tolerance, Milrinone efficiency on cerebral vasospasm
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Vasospasm
Cerebrospinal Fluid Hemoglobin to Monitor for Aneurysmal Subarachnoid Hemorrhage Related Secondary Brain Injury
The primary objective of this study is to evaluate the association between hemoglobin levels in the cerebrospinal fluid (CSF-Hb) and the occurrence of secondary brain injury in patients after aneurysmal subarachnoid hemorrhage…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Delayed Cerebral Ischemia, Delayed Ischemic Neurological Deficit
- Trial name
- HeMoVal (NCT04998370)
- Where
- 8 sites in Austria, Germany and 1 more
- Volunteers
- 366 people
- Sponsor
- University of Zurich
Hyperventilation, Aneurysmal Subarachnoid Hemorrhage
Drug Intervention of Spontaneous Hyperventilation in Patients With Aneurysmal Subarachnoid Hemorrhage
Although spontaneous hyperventilation patients with aneurysmal subarachnoid hemorrhage closely associated with poor outcomes, the standard therapy remains unavailable.
- Conditions
- Hyperventilation, Aneurysmal Subarachnoid Hemorrhage, Cerebral Blood Flow
- Trial name
- NCT04940273
- Testing
- Remifentanil Injection [Ultiva]
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Subarachnoid Hemorrhage
Treatment of Subarachnoid Hemorrhage With Human Albumin
The proposed study was set up to evaluate the tolerability and safety of 25% human albumin (HA) therapy in patients with subarachnoid hemorrhage (SAH). It is estimated that 37,500 people in the USA have SAH every year.
- Trial name
- ALISAH (NCT01747408)
- Testing
- Human Albumin
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Baylor College of Medicine
Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic
Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients
This is a prospective observational cohort study of adult patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic, Cerebral Hemorrhage, Ischemic Stroke
- Trial name
- NCT07577713
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Aneurysmal Subarachnoid Hemorrhage
The Role of Statins in Preventing Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage
Delayed ischemia caused by cerebral vasospasm remains a common cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage. A great deal of drugs has been tested in the last years.
- Trial name
- NCT01346748
- Testing
- statin
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo General Hospital
Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome
Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage
Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure
- Trial name
- NCT06906432
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage
Impact of Nimodipine on Sublingual Microcirculation in Patients With Hemorrhage - a Prospective Monocentric Observational Study
Nimodipine can increase Functional Capillary Density (FCD) as a parameter of the sublingual microcirculation in patients with subarachnoid hemorrhage (SAH) compared to patients without nimodipine.
- Trial name
- NCT04311840
- Where
- Czechia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Hradec Kralove
Aneurysmal Subarachnoid Haemorrhage
CytoSorb SAH Trial
In aSAH high levels of IL-6 (a pro-inflammatory cytokine) in the cerebrospinal fluid, as well as systemically have been linked to the severity grade and the occurrence of vasospasm and delayed cerebral ischemia caused by…
- Trial name
- NCT05259514
- Testing
- CytoSorb
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Emanuela Keller
Acute, Non-traumatic Subarachnoid Hemorrhage, Intraparenchymal Hemorrhage
Normoglycemia and Neurological Outcome
Brain injury patients who meet defined criteria will be assigned to intensive insulin treatment (target blood glucose levels of 10-110 mg/dl) or conventional IV insulin treatment (target glucose of 150-170 mg/dl).
- Conditions
- Acute, Non-traumatic Subarachnoid Hemorrhage, Intraparenchymal Hemorrhage, Brain Injuries
- Trial name
- NCT01137773
- Testing
- Insulin, Conventional insulin treatment
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Louisville
Subarachnoid Haemorrhage (SAH)
Evaluation of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm After Subarachnoid Haemorrhage
Subarachnoid haemorrhage (SAH) secondary to ruptured aneurysm represents 5 to 15% of all cases of stroke. The mortality rate of SAH is 40% and the risk of serious neurological sequelae among survivors is 10 to 20%.The causes of…
- Trial name
- TRIVASOSTIM (NCT02482883)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Hyponatremia, Subarachnoid Hemorrhage
Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage
Hyponatremia is defined as a plasma sodium concentration below 135 mmol / L. This is a common occurrence (20-50%) during subarachnoid hemorrhage (SAH). Its appearance is often associated with vasospasm.
- Conditions
- Hyponatremia, Subarachnoid Hemorrhage, SIADH
- Trial name
- NAT-URE (NCT04552873)
- Testing
- Urea
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Grenoble
Traumatic Brain Injury, Subarachnoid Hemorrhage
Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing
The aim of the initial proposal was to evaluate, in the context of optimal medical management, the impact of a bedside system of cerebral perfusion pressure (CPP) information feedback on nursing moment-to-moment management of…
- Trial name
- NCT00194441
- Testing
- Bedside display of cerebral perfusion pressure information
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Washington