Clinical trials: Subfertility
Ovarian Failure, Thyroid Diseases
Thyroid Function and Autoimmunity in Subfertility Women and Assisted Reproductive Therapy
The assessment of ovarian reserve is well established based on the dosage of anti-Mullerian hormone (AMH). The clinical applicability of detecting thyroid autoantibodies levels has been discussed as a potential marker of…
- Trial name
- NCT06394466
- Testing
- Non Applicable
- Where
- Brazil
- Volunteers
- 453 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Subfertility
Assessment of Intralipid Efficacy in Women With Unexplained Recurrent Implantation Failure
The study will include 100 women with unexplained recurrent implantation failure undergoing IVF/ICSI cycle. Patients fulfilling the inclusion criteria will be randomised into two groups.
- Trial name
- NCT02487940
- Testing
- Intralipid 20%, Normal saline
- Volunteers
- 100 people
- Sponsor
- Dar El Teb Institute
Male Subfertility
Role of Immunoglobulin in Male Infertility
to investigate the role of IVIG in male infertility and to determine its benefits in term of semen parameters and assisted reproduction outcome
- Trial name
- NCT06423989
- Testing
- IVIG
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dr Salma kafeel Qureshi
Adenomyosis of Uterus
Association of Ultrasound Features of the Myometrium Suggestive of Adenomyosis and Clinical Symptoms
The goal of this study/research is to assess the relationship between ultrasound features of the myometrium suggestive of adenomyosis and clinical symptoms of adenomyosis and to establish a reporting system for adenomyosis…
- Trial name
- MUSA3 (NCT07397715)
- Where
- 5 sites in Belgium, Poland and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Swiss GO Trial Group
Sub Fertility, Male, Fertility Disorders
Effects of a Fasting Mimicking Diet on Sperm Quality
This study investigates the effect of repetitive cycles of a Fasting Mimicking Diet (3x5 days in six months) on sperm quality in men
- Conditions
- Sub Fertility, Male, Fertility Disorders, Sperm Count, Low
- Trial name
- KiWu-B (NCT04908774)
- Testing
- Fasting Mimicking Diet
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Charite University, Berlin, Germany
Infertility, Male, Subfertility, Male
Impact of A Nutritional Supplements' Combination (FERTILIS) on Male Infertility
Infertility is a major health problem affecting up to 15% of couples of reproductive age globally. For several years, it was assumed that most reproductive problems could be attributed to the female partner, but research in…
- Trial name
- FERTILIS (NCT04193358)
- Testing
- FERTILIS HOMME®
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Infertility, Subfertility
Ovarian Response Prediction in In Vitro Fertilization (IVF) Patients
The aim of the study is to explore ovarian response in terms of oocyte numbers after ovarian stimulation in a fixed gonadotropin dose GnRH-antagonist protocol by endocrine (AMH, FSH), demographic (age), sonographic (antral…
- Trial name
- NCT01206803
- Testing
- Ovarian stimulation in a GnRH-antagonist protocol
- Where
- 5 sites in Germany, Norway
- Volunteers
- 294 people
- Sponsor
- University Hospital Schleswig-Holstein
Subfertility
Comparison of the Number of Oocytes Obtained Between Chinese and Caucasian Women in IVF Treatment
IVF is a well-established method to treat various causes of infertility. Some studies have suggested that ethnicity affects the success of IVF.
- Trial name
- NCT02748278
- Testing
- Transvaginal ultrasound-guided oocyte retrieval, Embryo transfer
- Where
- China
- Volunteers
- 192 people
- Sponsor
- The University of Hong Kong
Subfertility, Assisted Reproduction
Evaluation of the Role of Follicular Sensitivity Index in the Prediction of Pregnancy in Women Undergoing ICSI/IVF Without Polycystic Ovarian Syndrome
1000 women with infertility who are already decided to be treated with ICSI will be subjected to full history taking and clinical examination.
- Trial name
- NCT02158026
- Where
- 2 sites in Egypt
- Volunteers
- 1,000 people
- Sponsor
- Cairo University
Endometritis; Chronic, Subfertility
The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI
Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems.
- Trial name
- FLORA (NCT05337072)
- Testing
- Microbiome study
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Local Endometrial Injury in Fresh Embryo Transfer Cycles
The application of in-vitro fertilization (IVF) has provided remarkable opportunities for infertile couple to conceive in the last four decades.
- Trial name
- LEI (NCT01844453)
- Testing
- Endometrial Biopsy
- Where
- Canada
- Volunteers
- 360 people
- Sponsor
- McGill University
Hyperprolactinemia, Subfertility
Hyperprolactinaemia Management in Reproductive Services at University Hospital of Coventry and Warwickshire
Hyperprolactinaemia and thyroid disorders can significantly reduce fertility by causing ovulatory dysfunction. There is no evidence to suggest treatment of hyperprolactinaemia in the presence of regular ovulatory menstruation…
- Conditions
- Hyperprolactinemia, Subfertility, Subclinical hypothyroïdism
- Trial name
- NCT03569787
- Testing
- MRI Pituitary
- Where
- United Kingdom
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Subfertility, Anovulatory
The Effects of an Intensive Lifestyle Intervention on Reproductive Outcomes
This is a study to determine whether a low calorie diet using meal replacement shakes compared to current counseling about diet, followed by 3 cycles of clomiphene citrate (if needed) will result in: 1) improvements in ability to…
- Conditions
- Subfertility, Anovulatory, Obese
- Trial name
- NCT01894074
- Testing
- Intensive Dietary Intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Amy E Rothberg
Subfertility
Preimplantation Genetic Testing for Aneuploidy of Polar Bodies
This study intends to randomly group the patients with advanced maternal age and poor ovarian response, and the study group will undergo polar body biopsy, and the next-generation sequencing(NGS) technology will be used to…
- Trial name
- NCT04538560
- Testing
- polar body biopsy
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Subfertility
Evaluation of the Optimal Dose of GnRH Agonist for Triggering Final Oocyte Maturation in High Risk OHSS Patients
The present study aims to investigate whether the dosage of the GnRH agonist used for triggering final oocyte maturation affects the maturity of the oocytes retrieved in high risk for OHSS patients undergoing ovarian stimulation…
- Trial name
- ATD (NCT01973842)
- Testing
- 0.1 mg triptorelin, 0.2 mg triptorelin, 0.4 mg triptorelin
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Aristotle University Of Thessaloniki
Fertility, Male, Sub-Fertility, Male
Study of the Consumer Use of a New Home Test to Measure Sperm Concentration
The objective of the study is to evaluate the agreement in measurement of sperm concentration in human semen between lay users with TRAK and a recognized reference method.
- Trial name
- NCT02475395
- Testing
- TRAK device
- Where
- 3 sites in United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Sandstone Diagnostics
Metabolic Syndrome X, Infertility
Female Subfertility: a Metabolic and Vascular Profile
Introduction: Overall, 10 - 15% of couples seek specialist help once in their lives when a spontaneous pregnancy does not occur.
- Trial name
- NCT02136472
- Where
- Netherlands
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Infertility, Subfertility
The Microbiome in Subfertility and Assisted Reproductive Technologies (ART)
To assess the impact of the female genital microbiome on ART outcome.
- Trial name
- NCT03105453
- Testing
- 3 Sampling points
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Subfertility
DHEA Versus Placebo in Women With Poor Ovarian Response
440 women with expected poor ovarian response undergoing IVF/ICSI (intracytoplasmic sperm injection) will be randomly divided into 2 groups using computer generated random numbers .
- Trial name
- DHEA (NCT02561793)
- Testing
- DHEA
- Where
- 2 sites in Egypt
- Volunteers
- 440 people
- Sponsor
- Cairo University
Subfertility
Fixed Versus Flexible Gonadotropin-releasing Hormone (GnRH) Antagonist Initiation
This is a comparison of pregnancy achievement between two GnRH antagonist protocols which differ in the timing of GnRH antagonist initiation.
- Trial name
- NCT01005784
- Testing
- Cetrorelix (Cetrotide)
- Where
- Greece
- Volunteers
- 146 people
- Sponsor
- Aristotle University Of Thessaloniki