Clinical trials: Subjects With Type 2 Diabetes Mellitus.
Type 2 Diabetes
Metabolic Effects of Gastrointestinal Surgery in T2DM
Gastric bypass surgery resolves type 2 diabetes mellitus (T2DM) without the need for diabetes therapy in ~80% of patients. Moreover, improvement in insulin sensitivity and glucose homeostasis occurs within days after surgery…
- Trial name
- NCT01771185
- Testing
- Duodenal jejunal bypass plus sleeve gastrectomy, Best medical treatment (Metformin ; gliclazide)
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Obesity, Adiposity
GIP/GLP-1 Co-Activity in Subjects With Obesity: Lowering of Food Intake
We aim to delineate the effects of separate and combined infusion of GIP and GLP-1 on food intake, appetite, bone health and fat metabolism in overweight/obese subjects.
- Conditions
- Obesity, Adiposity, Type 2 Diabetes
- Trial name
- GASOLIN (NCT02598791)
- Testing
- IIGI+GIP, IIGI+GLP-1, OGTT
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes Mellitus, Type 2, NASH - Nonalcoholic Steatohepatitis
Effect of Oral Anti-diabetic Medication on Liver Fat in Subjects With Type II Diabetes and Non-alcoholic Fatty Liver
This randomized clinical trial aims to compare the effect of the pioglitazone and SGLT2 inhibitor combination on liver fat mass, as compared to either drug used alone, with or without background medical therapy of metformin…
- Conditions
- Diabetes Mellitus, Type 2, NASH - Nonalcoholic Steatohepatitis, NAFLD
- Trial name
- NCT04976283
- Testing
- Pioglitazone, Empagliflozin, Pioglitazone + Empagliflozin
- Where
- Pakistan
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Getz Pharma
Diabetes, Diabetes Mellitus, Type 2
Efficacy of Repaglinide in Subjects With Type 2 Diabetes
This trial is conducted in Europe. The aim of this trial is to compare the efficacy of repaglinide to glyburide and placebo on hepatic glucose metabolism in subjects with type 2 diabetes.
- Trial name
- NCT01698931
- Testing
- repaglinide, glyburide
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 2
Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes
This trial is conducted in Europe. The trial is designed to show the effect of treatment with liraglutide or placebo on blood glucose control after 14 weeks in subjects with type 2 diabetes.
- Trial name
- NCT00154401
- Testing
- liraglutide
- Where
- 39 sites in Denmark, France and 2 more
- Volunteers
- 177 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
Safety and Efficacy of INCB013739 Plus Metformin Compared to Metformin Alone on Glycemic Control in Type 2 Diabetics
Determine the effect of treatment with INCB013739 administered as an 'add-on' to metformin therapy in type 2 diabetic subjects on safety and tolerability and glycemic control.
- Trial name
- NCT00698230
- Testing
- INCB013739, Metformin
- Where
- 68 sites in United States, Puerto Rico
- Volunteers
- 302 people
- Sponsor
- Incyte Corporation
Diabetes Mellitus, Type 2
Extension to Study 200952 to Evaluate the Long-term Safety, Tolerability and Pharmacodynamics of Albiglutide Liquid Drug Product in Type 2 Diabetes Mellitus Subjects
Albiglutide has been developed for the treatment of type 2 diabetes mellitus (T2DM) as an adjunct to diet and exercise, as monotherapy, or in combination with existing therapies and has been approved by the United States (US)…
- Trial name
- NCT02750930
- Testing
- Albiglutide, Auto-injector
- Where
- 27 sites in United States
- Volunteers
- 8 people
- Sponsor
- GlaxoSmithKline
Diabetes, Diabetes Mellitus, Type 2
Comparison of Insulin Detemir or Insulin Glargine as Add on to Oral Antidiabetic Drugs in Type 2 Diabetes
This trial is conducted in Europe and the United States of America (USA). The aim of the trial is to test if Insulin Detemir as add-on to current Oral Antidiabetic Drug treatment is at least as effective as Insulin Glargine as…
- Trial name
- NCT00283751
- Testing
- insulin detemir, insulin glargine
- Where
- 96 sites in United States, Austria and 5 more
- Volunteers
- 583 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
A Study To Assess GW677954 Used In Combination With Insulin In Subjects Who Have Type 2 Diabetes Mellitus
Many drugs used for the treatment of Type 2 Diabetes Mellitus cause the body to retain water. This study will assess whether or not GW677954 causes the body to retain fluid.
- Trial name
- NCT00437164
- Testing
- Insulin, Oral GW677954 Capsules (15 mg)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Healthy, Type 2 Diabetes
The Effect of Whey Protein Consumed as a Pre-meal on Postprandial Lipemia in Healthy and Subjects With Type 2 Diabetes
Cardiovascular disease (CVD) is one of the most important and frequent causes of death. Postprandial lipidemia (PPL) is an independent risk factor for CVD, besides the traditional risk factors e.g.
- Trial name
- PREMEAL 3 (NCT02343471)
- Testing
- 20 g whey protein
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Insulin Resistance, Type 2 Diabetes
Endothelial Function in Patients With Type 2 Diabetes Versus Healthy Subjects
The aim of the study is to evaluate the effect of hyperinsulinemia and postprandial changes in plasma glucose and lipids concentrations on the endothelial function together with other metabolic parameters in patients with type 2…
- Trial name
- EndoPat (NCT01946347)
- Testing
- mixed meal, Acute in vivo induced hyperinsulinemia
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical and Experimental Medicine
Type 2 Diabetes, Obesity
Evaluation of the Tantalus System in Type 2 Diabetic Subjects
Metacure MC PT TAN2005-013 feasibility study is a prospective, multi-center, study to evaluate the safety and functionality of the TANTALUS System, in the treatment of obese T2DM patients, and to assess the effect of GCT …
- Trial name
- NCT00276471
- Testing
- Implantable pulse generator and electrodes
- Where
- Austria
- Volunteers
- 18 people
- Sponsor
- MetaCure Limited
Type 2 Diabetes
A Study of HDM1005 in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone
This study is a multicenter, randomized, double-blind, placebo-controlled , phase 3 clinical trial aimed at evaluating the efficacy and safety of HDM1005 versus placebo in subjects with T2DM inadequate glycemic control with diet…
- Trial name
- NCT07394114
- Testing
- HDM1005 1, HDM1005 2
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Diabetes Mellitus
Insulin Glulisine, Insulin Lispro and Insulin Glargine in Type 1 or 2 Diabetes Mellitus
Primary: To compare the efficacy and safety of Insulin Glulisine to Insulin Lispro in subjects with type 1 or type 2 diabetes mellitus. To compare the frequency of hypoglycemia of Insulin Glulisine to Insulin Lispro.
- Trial name
- NCT00467376
- Testing
- Insulin Glulisine, Lispro, Insulin Glargine
- Where
- China
- Volunteers
- 485 people
- Sponsor
- Sanofi
Type2 Diabetes Mellitus, Hyperglycemia
Heart Rate During Exercise in Type 2 Diabetes
Exercise training is a cornerstone for the prevention and treatment of metabolic disorders and associated cardiometabolic complications such as type 2 diabetes mellitus (T2D) and hypertension.
- Conditions
- Type2 Diabetes Mellitus, Hyperglycemia, Heart Rate, Exercise Training
- Trial name
- HRinT2DM (NCT03917576)
- Testing
- Behavioral, Exercise training intervention
- Where
- Chile
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad de Los Lagos
Periodontal Diseases
Quantification of Proteomes: L-plastin , Lipocalin and Adiponectin in Chronic Periodontitis and Diabetic Subjects
The quantification of the proteomes : L-plastin, lipocalin and adiponectin was analysed in the subgingival tissue samples of generalized severe chronic periodontitis patients with and without diabetes mellitus.The demographic and…
- Trial name
- NCT03391349
- Volunteers
- 70 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Diabetes Mellitus, Type 2, Overweight and Obesity
Effect of a Low-calorie and High-protein Diet Specially Rich in Animal Protein Compared to a Low-calorie and High-protein Diet Specially Rich in Plant Protein on Glucose Metabolism in Subjects With Prediabetes or Type 2 Diabetes and Overweight or Obesity.
The aim of the study is to explore the effect of a low-calorie diet rich in protein (with a content of 35% of the total calories of the diet), mostly coming from animal sources (75% of total protein), compared to a hypocaloric…
- Conditions
- Diabetes Mellitus, Type 2, Overweight and Obesity, PreDiabetes
- Trial name
- NCT05456347
- Testing
- Low-calorie and high-protein diet with the majority of protein coming from animal sources., Low-calorie and high-protein diet with the majority of protein coming from plant sources.
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad de Zaragoza
Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease
Efficacy Study of Diacerein on Glycemic Control and Liver Fat in Type 2 Diabetes Subjects
This study is conducted to test the hypothesis that in uncontrolled type 2 diabetic adults treatment with diacerein will improve glycemic control and will reduce liver fat within a 24 month period.
- Trial name
- DGCLFT2DM (NCT02242149)
- Testing
- Diacerein
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Diabetes, Diabetes Mellitus, Type 1
Observational Study to Evaluate Safety of Levemir® in Type 1 and Type 2 Diabetes
This study is conducted in Asia. The aim of this observational study is to evaluate the incidence of adverse events while using Levemir® under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00700765
- Testing
- insulin detemir
- Where
- Indonesia
- Volunteers
- 1,531 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A 3-fold Crossover Bioequivalence Study Between Glucobay Orally Disintegrating Tablet (ODT) and Glucobay Standard Tablet
To establish the bioequivalence between Glucobay ODT (Orally Disintegrating Tablet) taken without or with water and the Glucobay standard tablet taken with water
- Trial name
- NCT01388153
- Testing
- Acarbose (Glucobay ODT, BAYG5421), Acarbose (Glucobay, BAYG5421)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
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