Clinical trials: Submental Fat
Submental Fat
Evaluation the Effects of Various Treatments on RZL-012-Induced Adverse Events
This is a Phase 2, open-label, 2-stage, adaptive-design study in which subjects will be randomized into one of 5 treatment groups comprised of RZL-012 with or without additional study treatments:
- Trial name
- NCT05476679
- Testing
- RZL-012, RZL-012+Lidacaine injection prior treatment, RZL-012+Medrol
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Raziel Therapeutics Ltd.
Submental Fat
Evaluate the Efficacy and Safety of MT921 in Subjects With Moderate to Severe Submental Fat
The purpose of this study is to evaluate the Efficacy and Safety of MT921 in Subjects with Moderate to Severe Submental fat compared with Placebo.
- Trial name
- NCT05195112
- Testing
- MT921
- Where
- South Korea
- Volunteers
- 240 people
- Sponsor
- Medy-Tox
Moderate or Severe Submental Fullness
Phase 2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat
Phase 2 trial to evaluate the safety and potential efficacy of one concentration of deoxycholic acid injection, given in three dosing paradigms, compared to placebo for the reduction of submental fat (fat beneath the chin).
- Trial name
- NCT00618618
- Testing
- Deoxycholic Acid Injection
- Where
- 7 sites in Australia, Canada and 1 more
- Volunteers
- 73 people
- Sponsor
- Kythera Biopharmaceuticals
Body Fat Disorder
CoolSculpting and RF for the Submental
The purpose of this study is to evaluate the safety and efficacy of sequential use of CoolSculpting (Cryolipolysis) and radiofrequency treatment of the submental and submandibular area.
- Trial name
- CRT (NCT03873779)
- Testing
- The ZELTIQ System
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Excess Submental Fat ("Double Chin")
Safety and Feasibility Study of XAF5 Gel for Reduction of Submental Fat
This study will test the effects of XAF5 Gel (applied to skin each night for 6 weeks) on excess submental fat, also known as double chin. The study will also assess the safety and tolerability of XAF5 Gel.
- Trial name
- NCT01990326
- Testing
- XAF5 Gel
- Volunteers
- 27 people
- Sponsor
- Topokine Therapeutics, Inc.
Submental Fat
An Open-label Study That Will Test a Second Treatment Session of RZL-012.
This is a Phase 2, open-label study in which subjects seeking further improvement of their SMF will be treated with a second treatment session of RZL-012.
- Trial name
- NCT05763160
- Testing
- RZL-012
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Raziel Therapeutics Ltd.
Body Fat Disorder
Subcutaneous Fat Reduction in the Submental Area
Study to Evaluate Non-Invasive Subcutaneous Fat Reduction in the Submental Area using Cryolipolysis. Healthy adult men and women with submental skin fold thickness > 1cm who desire reduction of submental fat.
- Trial name
- NCT02298322
- Testing
- CoolSculpting System
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Treatment for Submental Fat
Clinicial Trial to Evaluate the Efficacy and Safety of DWJ211 in Patient With Moderate or Severe Submental Fat
evaluate the efficacy and safety of DWJ211 in patient with moderate or severe submental fat
- Trial name
- SMF (NCT03224117)
- Testing
- DWJ211, Normal saline
- Where
- 3 sites in South Korea
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Healthy
Open-Label Pharmacokinetic Study of Final Formulations of ATX-101
The objectives of this trial are to evaluate the safety and tolerability of ATX-101 injections and to characterize the pharmacokinetic profile of the two ATX-101 formulations.
- Trial name
- NCT01632917
- Testing
- ATX-101 - U.S., ATX-101 - EU
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Submental Fat
Evaluate the Efficacy and Safety of DWJ211 in Patient With Moderate or Severe Submental Fat
Evaluate the efficacy and safety of DWJ211 in patient with moderate or severe submental fat
- Trial name
- SMF (NCT03946592)
- Testing
- Normal saline, DWJ211
- Where
- South Korea
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Weight Loss
An Evaluation of the Effect of the Erchonia Laser for Non-invasive Reduction of Submental Fat
The purpose of this clinical study is to determine the effectiveness of the Erchonia® CFL (manufactured by Erchonia Corporation (the Company), in providing noninvasive fat reduction in the submental area.
- Trial name
- NCT05954065
- Testing
- Erchonia CFL Laser
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Erchonia Corporation
Submental Fullness
Evaluation of the Safety and Effectiveness of BELKYRA® Inj. for the Treatment of Patients With Submental Fullness Due to Submental Fat: A Postmarketing Surveillance Study in Korea
The purpose of this PMS study is to evaluate the safety and effectiveness of BELKYRA Inj. used according to the dose specified in the instructions for use, for the treatment of patients with SM fullness due to SMF, through active…
- Trial name
- NCT03691415
- Testing
- BELKYRA Inj.
- Where
- 4 sites in South Korea
- Volunteers
- 71 people
- Sponsor
- Allergan
Moderate to Severe Convexity of Submental Fat, Safety
Safety Study of ATX-101 (Deoxycholic Acid) in Subjects With Mild or Extreme Fullness of Submental Fat
The objectives of this study are to explore the safety and efficacy of subcutaneous injections of Deoxycholic Acid relative to placebo, in the submental area in patients with mild or extreme fullness of the submental fat and…
- Conditions
- Moderate to Severe Convexity of Submental Fat, Safety, Efficacy
- Trial name
- NCT02035267
- Testing
- Deoxycholic Acid
- Where
- 8 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Submental Fat
A Phase II Study to Evaluate the Efficacy and Safety of MT921 in Subjects With Moderate to Severe Submental Fat
This study is a randomized, double-blind, placebo-controlled, dose-ranging, parallel, multi-center, phase II study to evaluate the efficacy and safety of MT921 in subjects with moderate to severe submental fat.
- Trial name
- NCT04144049
- Testing
- MT921
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Medy-Tox
Submental Fat, Healthy
Long Term Follow-up Study on Safety and Maintenance of Efficacy of ATX-101
This was a long-term follow-up study of participants who completed Kythera-sponsored trials of ATX-101 (06-03, 07-07, 09-15)
- Trial name
- NCT02159729
- Testing
- ATX-101 (1 mg/cm^2), ATX-101 (2 mg/cm^2), ATX-101 (4 mg/cm^2)
- Where
- 20 sites in United States, Australia and 2 more
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Fat Burn
Evaluation of the BTL-785F Device for Submental Fat Reduction and Neck Rejuvenation
This study will evaluate the clinical safety and the performance of the BTL-785F system equipped with the BTL-785-7 applicator for non-invasive reduction of submental fat and skin laxity treatment.
- Trial name
- NCT06274177
- Testing
- BTL-785-7
- Where
- 4 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Body Fat Disorder
Submental Study (Sequential Treatment Approach)
Evaluate the safety and efficacy of subcutaneous fat layer reduction in the submental area using multiple therapeutic tools.
- Trial name
- CMK (NCT03510598)
- Testing
- The ZELTIQ CoolSculpting System, Kybella 20 MG in 2 ML Injection
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Moderate or Severe Submental Fullness
Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat
To evaluate the safety and efficacy of deoxycholic acid injection in the reduction of submental fat (fat below the chin).
- Trial name
- NCT01294644
- Testing
- Deoxycholic acid injection
- Where
- 29 sites in Belgium, France and 4 more
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Moderate or Severe Submental Fullness
Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area
To evaluate the safety and efficacy of deoxycholic acid injection in the reduction of submental fat (fat below the chin).
- Trial name
- NCT01546142
- Testing
- Deoxycholic acid injection
- Where
- 35 sites in United States, Canada
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Healthy
Evaluate the Efficacy and Safety of AYP-101 for the Reduction of Submental Fat in Chin Area
To Evaluate Efficacy and Safety of AYP-101 S.C injection for the Reduction of Submental Fat in Adults
- Trial name
- NCT06256445
- Testing
- Polyene Phosphatidylcholine
- Where
- South Korea
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- AMIpharm Co., Ltd.