Clinical trials: Submucosal Tumor
Esophageal Stricture, Esophageal Neoplasms
Tranilast Vs. Steroids to Prevent Esophageal Stricture (TAPES) After Endoscopic Resection for Superficial Neoplasms
The goal of this clinical trial is to learn if tranilast works to prevent esophageal stricture after circumferential endoscopic submucosal dissection (cESD) in adults.
- Trial name
- TAPES (NCT06643689)
- Testing
- Tranilast, Dexamethasone
- Where
- 3 sites in China
- Volunteers
- 394 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
To Compare the Efficacy and Safety of Hybrid ESD and ESD in the Treatment of Colorectal LST
Endoscopic Therapy for Laterally Spreading Tumors (LSTs)
This study will retrospectively include LST patients who were admitted to 6 medical centers (The Second Affiliated Hospital, College of Medicine, Zhejiang University; The Affiliated Jinhua Hospital, Zhejiang University School of…
- Trial name
- LST (NCT06464874)
- Testing
- Conventional ESD, Hybrid ESD
- Where
- China
- Volunteers
- 890 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Endoscopic Submucosal Dissection, Gastric Neoplasm
Learning Curve for Gastric Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) for early gastric cancer is a widely accepted treatment option of expanded indication worldwide.
- Trial name
- NCT05265221
- Testing
- Endoscopic submucosal dissection
- Where
- South Korea
- Volunteers
- 356 people
- Sponsor
- Soonchunhyang University Hospital
Colorectal Cancer
Development of a New Simplified Tool to Predict LNPCPs Histology and Assess the Risk of Submucosal Invasive Cancer. The Colorectal Regular-Irregular Score
Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer related death. It can be prevented by endoscopic detection and complete resection of colorectal polyps.
- Trial name
- CRIS (NCT07584486)
- Testing
- Learning tool (CRIS/JNET), Learning tool (JNET/CRIS)
- Where
- Belgium
- Volunteers
- 764 people
- Sponsor
- University Hospital, Ghent
Barrett's Esophagus, High-grade Dysplasia in Barrett Esophagus
Eradicating Barrett's Esophagus Using Radiofrequency Ablation or a Novel Hybrid Argon Plasma Coagulation Technique
Lay summary: Barrett's Esophagus (BE) involves a change of the esophagus lining (BE epithelium) which in a small proportion of patients could be the starting point for the development of cancer (esophageal adenocarcinoma).
- Conditions
- Barrett's Esophagus, High-grade Dysplasia in Barrett Esophagus, Low Grade Dysplasia in Barrett Esophagus
- Trial name
- BURN (NCT03621319)
- Testing
- Hybrid argon plasma ablation (HAPC), Radiofrequency ablation (RFA)
- Where
- 13 sites in United States
- Volunteers
- 41 people
- Sponsor
- Erbe Elektromedizin GmbH
Gastric GIST, Submucosal Tumor of Stomach
Laparoscopic Management of Gastrointestinal Stromal Tumor of Stomach
Gastric GISTs are rare neoplasms that require excision for cure. Although the feasibility of laparoscopic resection of gastric GIST less than 2cms has been established, the feasibility, safety and long-term efficacy of these…
- Trial name
- NCT03722056
- Testing
- Laparoscopic resection
- Volunteers
- 42 people
- Sponsor
- GEM Hospital & Research Center
Gastric Neoplasm
Use of Lidocaine in Endoscopic Submucosal Dissection
The primary purpose of this study is to investigate the effects of lidocaine on the total administered dose of fentanyl during sedation for endoscopic mucosal resection.
- Trial name
- NCT02543411
- Testing
- Lidocaine 1%, Normal saline
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Severance Hospital
Early Gastric Cancer
Sentinel Node Resection With or Without LECS After Noncurative ESD for EGC
For patients with non-curative resection after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC), complementary surgery is generally recommended.
- Trial name
- Co-SNARE (NCT07295002)
- Testing
- ICG-guided lymphadenectomy, Laparoscopic and endoscopic cooperative surgery (LECS)
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Region Stockholm
Esophageal Neoplasms
Gravity Assisted Technique for Esophageal Endoscopic Submucosal Dissection (ESD)
This is a prospective data recording study, all patients will receive standard medical care and no experimental interventions will be performed.
- Trial name
- NCT04547881
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Baylor College of Medicine
Head and Neck Cancer, Esophageal Cancer Stage
Outcomes of A Novel Treatment Decision of Patients With Esophageal and Head and Neck Carcinoma Synchronously
To summarise the outcomes of a treatment decision of patients with superficial esophageal carcinoma synchronously associated with head and neck cancer, that is endoscopic treatment for the superficial esophageal carcinoma plus…
- Trial name
- NCT03450447
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Yanqing Li
Early Gastric Cancer, Colon Neoplasia
Magnetic Guided Counetrtraction During Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) is a technique that allows curative treatment of early gastrointestinal neoplasia with organ preservation. However, it is a technically demanding procedure.
- Trial name
- NCT06962293
- Testing
- MAG-ESD assisted ESD
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Barrett Esophagus, Adenocarcinoma Esophagus
Outcomes of Endoscopically Resected High-risk Mucosal and Low- and High-risk Submucosal Adenocarcinoma Arising in Barrett's Esophagus
The purpose of this study is to assess lymph node metastasis rate, distant metastasis rate, disease-specific mortality, and overall mortality in patients with Barrett's related T1b and high risk T1a esophageal adenocarcinoma…
- Conditions
- Barrett Esophagus, Adenocarcinoma Esophagus, Submucosal Esophageal Adenocarcinoma, High-risk Mucosal Esophageal Adenocarcinoma
- Trial name
- NCT04818476
- Testing
- diagnostic endoscopic resection
- Where
- 16 sites in Australia, Belgium and 5 more
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colonic Polyps
Circumferential Submucosal Incision Endoscopic Mucosal Resection Versus Conventional Endoscopic Mucosal Resection of Colonic Polyps
That Circumferential Submucosal Incision Endoscopic Mucosal Resection (CSI-EMR) will be at least as safe but more effective than conventional EMR for injection assisted EMR of large laterally spreading tumour and sessile polyps…
- Trial name
- CSIEMR (NCT01369316)
- Testing
- Circumferential Submucosal Incision Resection, Endoscopic Mucosal Resection
- Where
- Australia
- Sponsor
- Professor Michael Bourke
Neuroendocrine Tumors
Device Assisted Full Thickness Resection Versus Endoscopic Submucosal Dissection for Duodenal Neuroendocrine Tumors
Introduction : The incidence of duodenal neuroendocrine tumors (DNETs) is increasing. Endoscopic resection is recommended for the management of small DNETs measuring ≤10 mm.
- Trial name
- DNET (NCT06121752)
- Testing
- Endoscopic submucosal dissection, EFTR
- Where
- India
- Volunteers
- 54 people
- Sponsor
- Asian Institute of Gastroenterology, India
Esophageal Squamous Cell Carcinoma (ESCC), High-Grade Intraepithelial Neoplasia
Clinical Application of an AI-based Dissection Trajectory Prediction System (ADTPS) in Endoscopic Submucosal Dissection
In this prospective paired diagnostic study and single-center, randomized controlled trial, patients with early esophageal squamous neoplasia or high-grade intraepithelial neoplasia meeting the inclusion and exclusion criteria…
- Conditions
- Esophageal Squamous Cell Carcinoma (ESCC), High-Grade Intraepithelial Neoplasia, AI-Based Dissection Trajectory Prediction System
- Trial name
- NCT07757906
- Testing
- AI-based Dissection Trajectory Prediction System (ADTPS), Conventional ESD Procedure
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Qilu Hospital of Shandong University
RECTAL NEOPLASMS
Transanal Endoscopic Microsurgery Versus Endoscopic Submucosal Dissection For Large Rectal Adenomas
Objective: Recent non-randomized studies suggest that extended endoscopic submucosal dissection (ESD) is equally effective in removing large rectal adenomas as transanal endoscopic microsurgery (TEM).
- Trial name
- TEMENDO (NCT01023984)
- Testing
- TEM - Transanal Endoscopic Microsurgery, ESD - Endoscopic Submucosal Dissection
- Where
- Italy
- Sponsor
- European Association for Endoscopic Surgery
Delayed Bleeding
Comparison of Proton Pump Inhibitor and H2 Receptor Blocker on Prevention of Bleeding From Iatrogenic Ulcer After Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Randomized Controlled Trial
after endoscopic submucosal dissection(ESD) of early gastric cancer, conventional proton pump(PPI) inhibitors and H2 receptor antagonists have a controversial effect on preventing bleeding from artificial ulcers.
- Trial name
- NCT01179724
- Testing
- high dose proton pump inhibitor, H2RB
- Where
- South Korea
- Volunteers
- 206 people
- Sponsor
- Samsung Medical Center
Esophagus Cancer, Radiotherapy
A Clinical Study of Non-curative Resection Plus Radiotherapy After Endoscopic ESD for Superficial Esophageal Squamous Cell Carcinoma
The goal of observational study is to learn about the outcomes of the participants. The main questions it aims to answer are: 1.
- Conditions
- Esophagus Cancer, Radiotherapy, Endoscopic Mucosal Resection
- Trial name
- NCT06160557
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xiaomeng Zheng
Stomach Neoplasms
Water-jet Assisted ESD vs Conventional ESD Technique for Treating Early Gastric Cancer
1. Introduction The aim of the study is to evaluate the efficacy and safety of ESD by use of a new water-jet assisted ESD system using the HybridKnife® in patients with early gastric neoplastic lesions in comparison to the…
- Trial name
- NCT01943253
- Testing
- Conventional ESD, Hybridknife ESD
- Where
- Germany
- Volunteers
- 117 people
- Sponsor
- Shanghai Zhongshan Hospital
Colorectal Cancer, Colorectal Cancer Stage I
Web-based Learning Module on Optical Diagnosis of Early Colorectal Cancer
International guidelines recommend deciding the treatment of colorectal lesions based on the estimated histology by endoscopic optical diagnosis.
- Trial name
- LODIP (NCT05663788)
- Testing
- E-learning module
- Where
- 12 sites in United States, Japan and 2 more
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa