Clinical trials: Submucosal Tumors
Early Gastric Cancer Patients Who Were Scheduled for Endoscopic Submucosal Dissection
A Comparison of Efficacy and Safety During Endoscopic Submucosal Dissection Between Dexmedetomidine-remifentanil and Propofol-remifentanil
Adequate, safe sedation is essential for Endoscopic submucosal dissection. Dexmedetomidine is a potent and selective a2-adrenoceptor agonist used for sedative and analgesic effects, but it is limited to use alone.
- Trial name
- NCT01920113
- Testing
- Dexmedetomidine - remifentanil group, Propofol - remifentanil group
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Esophageal Neoplasms, Endoscopic Mucosal Resection
Comparison of 0.4% Hyaluronic Acid Solution Versus Hydroxyethylamide Solution in Submucosal Endoscopic Resections
This is a randomized, single-center clinical trial that will compare the efficacy of two substances used in the submucosal cushion formation stage of endoscopic submucosal resections of early esophageal malignant neoplasms.
- Conditions
- Esophageal Neoplasms, Endoscopic Mucosal Resection, Hyaluronic Acid
- Trial name
- NCT06077981
- Testing
- Submucous Endoscopic Dissection with hydroxyethylamide, Submucous Endoscopic Dissection with Hyaluronic acid (TS-905 Blue Eye)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Submucosal Esophageal Adenocarcinoma, Barrett Esophagus
Prospective Endoscopic Follow-up of Patients With Submucosal and High Risk Mucosal Esophageal Adenocarcinoma
Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or…
- Conditions
- Submucosal Esophageal Adenocarcinoma, Barrett Esophagus, High-risk Mucosal Esophageal Adenocarcinoma
- Trial name
- PREFER (NCT03222635)
- Testing
- Endoscopic follow-up
- Where
- 20 sites in Australia, Belgium and 4 more
- Volunteers
- 225 people
- Sponsor
- Amsterdam UMC
Neoplasm, Stomach, Neoplasm, Colorectal
Endoscopic Submucosal Dissection Registry
This is a patient registry for all cases of pre-neoplastic or early neoplastic digestive tract lesions treated with curative intention by endoscopic submucosal dissection (ESD) technique.
- Conditions
- Neoplasm, Stomach, Neoplasm, Colorectal, Neoplasm, Esophagus, Neoplasm, Duodenal
- Trial name
- ESDREG (NCT06033976)
- Testing
- Endoscopic submucosal dissection (ESD)
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
To Compare the Efficacy and Safety of Hybrid ESD and ESD in the Treatment of Colorectal LST
Endoscopic Therapy for Laterally Spreading Tumors (LSTs)
This study will retrospectively include LST patients who were admitted to 6 medical centers (The Second Affiliated Hospital, College of Medicine, Zhejiang University; The Affiliated Jinhua Hospital, Zhejiang University School of…
- Trial name
- LST (NCT06464874)
- Testing
- Conventional ESD, Hybrid ESD
- Where
- China
- Volunteers
- 890 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Esophageal Squamous Cell Carcinoma (ESCC), High-Grade Intraepithelial Neoplasia
Clinical Application of an AI-based Dissection Trajectory Prediction System (ADTPS) in Endoscopic Submucosal Dissection
In this prospective paired diagnostic study and single-center, randomized controlled trial, patients with early esophageal squamous neoplasia or high-grade intraepithelial neoplasia meeting the inclusion and exclusion criteria…
- Conditions
- Esophageal Squamous Cell Carcinoma (ESCC), High-Grade Intraepithelial Neoplasia, AI-Based Dissection Trajectory Prediction System
- Trial name
- NCT07757906
- Testing
- AI-based Dissection Trajectory Prediction System (ADTPS), Conventional ESD Procedure
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Qilu Hospital of Shandong University
Esophageal Neoplasms
Gravity Assisted Technique for Esophageal Endoscopic Submucosal Dissection (ESD)
This is a prospective data recording study, all patients will receive standard medical care and no experimental interventions will be performed.
- Trial name
- NCT04547881
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Baylor College of Medicine
Rectal Neuroendocrine Tumor
Endoscopic Resection for Small Rectal Neuroendocrine Tumors
In previous single center study, both modified cap-assisted endoscopic mucosal resection (mEMR-C) and endoscopic submucosal dissection (ESD) were reported to be effective for the treatment of small rectal neuroendocrine tumors…
- Trial name
- NCT05429216
- Testing
- mEMR-C procedure, ESD procedure
- Volunteers
- 102 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Gastric Cancer
Magnetic Anchoring Guided Endoscopic Submucosal Dissection for Early Gastric Caner
This study uses magnetic anchored guidance system to treat early gastric cancer by endoscopic mucosal dissection to test the advantages of magnetically anchored guidance system for surgical field exposure during endoscopic…
- Trial name
- MAGESD (NCT04327050)
- Testing
- Magnetic anchored guided endoscopic submucosal dissection
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Gastric Cancer, Colon Nos Polypectomy Tubular Adenoma
Phase III Open-labeled Study of NPO-11 in Patients Undergoing Therapeutic Upper Gastrointestinal Endoscopy
Patients who require therapeutic upper gastrointestinal endoscopy, such as polypectomy, endoscopic hemostasis, percutaneous endoscopic gastrostomy (PEG), endoscopic mucosal resection (EMR) and endoscopic submucosal dissection…
- Conditions
- Gastric Cancer, Colon Nos Polypectomy Tubular Adenoma, Gastric Adenoma
- Trial name
- NCT01411189
- Testing
- Menthol
- Where
- Japan
- Volunteers
- 33 people
- Sponsor
- Nihon Pharmaceutical Co., Ltd
Rectal Neoplasms
Endoscopic Submucosal Dissection vs. Transanal Endoscopic Surgery for Rectal Neoplasia
This prospective observational cohort study aims to compare the clinical and procedural outcomes of Endoscopic Submucosal Dissection (ESD) and Transanal Minimally Invasive Surgery (TAMIS) for the treatment of early-stage rectal…
- Trial name
- ESTER (NCT06902701)
- Testing
- Endoscopic Submucosal Dissection (ESD), Transanal Endoscopic Surgery (TES)
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Turkish Society of Colon and Rectal Surgery
Colonic Polyps
Circumferential Submucosal Incision Endoscopic Mucosal Resection Versus Conventional Endoscopic Mucosal Resection of Colonic Polyps
That Circumferential Submucosal Incision Endoscopic Mucosal Resection (CSI-EMR) will be at least as safe but more effective than conventional EMR for injection assisted EMR of large laterally spreading tumour and sessile polyps…
- Trial name
- CSIEMR (NCT01369316)
- Testing
- Circumferential Submucosal Incision Resection, Endoscopic Mucosal Resection
- Where
- Australia
- Sponsor
- Professor Michael Bourke
Gastric Submucosal Tumors, Endoscopic Full Thickness Resection (EFTR)
EDLS-clips in Endoscopic Full-thickness Resection
A retrospective analysis was conducted on patients who visited from March 2022 to May 2024 and underwent endoscopic full-thickness resection and double-layer suture with titanium clips under endoscopy.
- Trial name
- NCT07305038
- Testing
- endoscopic double-layer suturing method with metallic clips
- Where
- China
- Volunteers
- 43 people
- Sponsor
- First Hospital of China Medical University
Esophageal Stricture, Esophageal Neoplasms
Tranilast Vs. Steroids to Prevent Esophageal Stricture (TAPES) After Endoscopic Resection for Superficial Neoplasms
The goal of this clinical trial is to learn if tranilast works to prevent esophageal stricture after circumferential endoscopic submucosal dissection (cESD) in adults.
- Trial name
- TAPES (NCT06643689)
- Testing
- Tranilast, Dexamethasone
- Where
- 3 sites in China
- Volunteers
- 394 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Endoscopic Submucosal Dissection, Gastric Neoplasm
Learning Curve for Gastric Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) for early gastric cancer is a widely accepted treatment option of expanded indication worldwide.
- Trial name
- NCT05265221
- Testing
- Endoscopic submucosal dissection
- Where
- South Korea
- Volunteers
- 356 people
- Sponsor
- Soonchunhyang University Hospital
Gastric Cancer, Gastric Adenoma
The Efficacy of Topical Bupivacaine and Triamcinolone Acetonide Injection in the Relief of Pain After Endoscopic Submucosal Dissection for Gastric Neoplasia: A Randomized Double-blind, Placebo-controlled Trial
Although pain is a common complication of endoscopic submucosal dissection (ESD), management strategies are inadequate. bupivacaine is used for visceral pain control in chronic pain and in pain associated with surgery in clinical…
- Trial name
- NCT01961752
- Testing
- Saline, Bupivacaine + saline, Bupivacaine + triamcinolone acetonide
- Where
- South Korea
- Volunteers
- 111 people
- Sponsor
- Yonsei University
Endoscopic Resection, Early Gastric Cancer
Submucosal Pressure Ejection Endoscopic Dissection for Early Gastric Cancer: a Retrospective Cohort Study
Endoscopic submucosal dissection (ESD) is a technically difficult and time-consuming procedure. Several water-jet knives have been developed to address this issue.
- Trial name
- NCT07453433
- Where
- China
- Volunteers
- 548 people
- Sponsor
- Shanghai East Hospital
Head and Neck Cancer, Esophageal Cancer Stage
Outcomes of A Novel Treatment Decision of Patients With Esophageal and Head and Neck Carcinoma Synchronously
To summarise the outcomes of a treatment decision of patients with superficial esophageal carcinoma synchronously associated with head and neck cancer, that is endoscopic treatment for the superficial esophageal carcinoma plus…
- Trial name
- NCT03450447
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Yanqing Li
Esophagus Cancer, Radiotherapy
A Clinical Study of Non-curative Resection Plus Radiotherapy After Endoscopic ESD for Superficial Esophageal Squamous Cell Carcinoma
The goal of observational study is to learn about the outcomes of the participants. The main questions it aims to answer are: 1.
- Conditions
- Esophagus Cancer, Radiotherapy, Endoscopic Mucosal Resection
- Trial name
- NCT06160557
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xiaomeng Zheng
Uterine Fibroids, Leiomyoma
Hysteroscopic Cryomyolysis for the Treatment of Submucosal Leiomyomata
The purpose of the current study is to evaluate the technical success, safety and procedure feasibility of hysteroscopic cryoablation treatment of symptomatic uterine fibroids in women who do not desire further pregnancies using…
- Conditions
- Uterine Fibroids, Leiomyoma, Menorrhagia
- Trial name
- NCT00731341
- Testing
- Cryoablation for the treatment of uterine fibroids
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Boston Scientific Corporation