Clinical trials: Submucosal Tumors
Gastric Neoplasm
Use of Lidocaine in Endoscopic Submucosal Dissection
The primary purpose of this study is to investigate the effects of lidocaine on the total administered dose of fentanyl during sedation for endoscopic mucosal resection.
- Trial name
- NCT02543411
- Testing
- Lidocaine 1%, Normal saline
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Severance Hospital
Barrett Esophagus, Esophageal Neoplasm
ESD for the Treatment of Early Barrett's Neoplasia
This study assesses the quality of the resection of early neoplasia arinsing in Barrett's esophagus using endoscopic submucosal dissection.
- Trial name
- ESTEBAN (NCT02583087)
- Testing
- endoscopic submucosal dissection
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hôpital Cochin
Gastric Dysplasia, Gastric Cancer in Situ
Endoscopic Closure of Gastric ESD Defect
This is a pilot study to investigate the usefulness of closure of mucosal defect after gastric endoscopic submucosal dissection (ESD) in patients that are at high risk of post-procedural haemorrhage.
- Trial name
- NCT04282707
- Testing
- Endoscopic closure of ESD defect, Gastric ESD without closure of ESD defect
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Gastric Neoplasm, Early Gastric Cancer
RCT of Gastric ESD With or Without Epineprhine Added Solution
This is an international multi-center randomised controlled study comparing outcomes of gastric endoscopic submucosal dissection (ESD) with or without addition of epinephrine in the submucosal injection solution.
- Trial name
- NCT04032119
- Testing
- Endoscopic submucosal dissection, Epinephrine
- Where
- 7 sites in Hong Kong, Japan and 2 more
- Volunteers
- 800 people
- Sponsor
- Chinese University of Hong Kong
Tumor
Follow-up of the Natural Course of the Small EUS-suspected Gastric Gastointestinal Stromal Tumors
Gastric gastrointestinal stromal tumors (GISTs) less than 2 cm are usually followed up conservatively. However, little is known about the natural course of small GISTs.
- Trial name
- NCT01084460
- Sponsor
- National Taiwan University Hospital
Colorectal Tumor
Transanal Tube Drainage in Endoscopic Submucosal Dissection of the Colorectal Tumor
We design the clincal trial to investigate the efficacy of transanal tube drainage in colorectal ESD.
- Trial name
- NCT02973490
- Testing
- Transanal Tube Drainage
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Fudan University
Gastrointestinal Neoplasms, Gastric Cancer
Endoscopic Submucosal Dissection Registry
The purpose of this study is to monitor the success rates and completion rates for endoscopic submucosal dissection (ESD) for gastrointestinal (GI) cancers.
- Trial name
- ESD Registry (NCT01415609)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Tumors of the Pancreas, Submucosal Tumor of Gastrointestinal Tract (Disorder)
Prospective Evaluation of the Diagnostic Efficacy of a EUS Guided FNB Needle (AQUIRE®)
The present study investigates the efficacy of a new Endoultrasound guided fine needle biopsy (EUS-FNB) device (AquireTM Boston Scientific= AQUIRE®) for obtaining histological tissue cylinders in the diagnosis of solid pancreatic…
- Conditions
- Tumors of the Pancreas, Submucosal Tumor of Gastrointestinal Tract (Disorder), Lymph Node Disease
- Trial name
- NCT03621852
- Testing
- Endoultrasound guided FNB
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Philipps University Marburg
Early Gastric Cancer, Gastric Adenoma
Fibrin Glue After ESD for High Risk Patients of Bleeding
It is a prospective randomized controlled study to look for effectiveness of fibrin glue to prevent bleeding in high-risk patients after endoscopic submucosal dissection in gastric neoplasm.
- Trial name
- NCT04602689
- Testing
- Human fibrinogen concentrate
- Where
- South Korea
- Volunteers
- 134 people
- Sponsor
- Seoul National University Hospital
Colorectal Neoplasms, Colonic Polyps
A Novel Clinical Decision Support Tool to Predict Submucosal Invasive Cancer Within Large Non-Pedunculated Colorectal Polyps
Colorectal cancer can be effectively prevented by removal of pre-malignant polyps during colonoscopy. Large (>=20mm) non-pedunculated colorectal polyps (LNPCPs) require careful assessment before treatment.
- Trial name
- NCT07705880
- Where
- Belgium
- Volunteers
- 886 people
- Sponsor
- University Hospital, Ghent
Malignant Colorectal Polyp, Colorectal Cancer
Malignant Polyp Registry
The purpose of this study is to learn more about malignant colorectal polyps (early colorectal cancers removed during colonoscopy) and the risk that cancer remains, comes back, or spreads after the polyp is removed.
- Conditions
- Malignant Colorectal Polyp, Colorectal Cancer, T1 Colorectal Cancer
- Trial name
- NCT07619079
- Testing
- Questionnaires
- Where
- 7 sites in United States
- Volunteers
- 500 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Uterine Cervical Dysplasia
Lidocaine Spray Compared With Submucosal Injection During LEEP: a Randomized Controlled Trial
Loop Electrosurgical Excision Procedure (LEEP) is a widely used minor surgical procedure for diagnosis and treatment of cervical intraepithelial neoplasia.
- Trial name
- NCT01505920
- Testing
- Lidocaine spray, Lidocaine submucosal injection
- Where
- Thailand
- Volunteers
- 101 people
- Sponsor
- Chiang Mai University
Robot Surgery, Endoscopic Submucosal Dissection (ESD)
Efficacy and Safety of Robot-assisted Endoscopic Submucosal Dissection for Colorectal Neoplasm
The objective of this study is to investigate the role of the flexible auxiliary single-arm transluminal endoscopic robot (FASTER) system in colorectal endoscopic submucosal dissection (ESD) and to validate its superiority over…
- Conditions
- Robot Surgery, Endoscopic Submucosal Dissection (ESD), Colorectal Neoplasms
- Trial name
- NCT06973083
- Testing
- FASTER-assisted ESD, Conventional ESD
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Shandong University
Esophageal Neoplasm, Esophageal Polyp
Monopolar and Bipolar in Esophageal ESD
The objective of this study is to prospectively document the efficacy and clinical outcomes of Endoscopic Submucosal Dissection procedure that utilize either a novel Bipolar-Current ESD device or the standard monopolar…
- Conditions
- Esophageal Neoplasm, Esophageal Polyp, Endoscopic Submucosal Dissection, Bipolar Electocautery
- Trial name
- NCT05736705
- Testing
- Endoscopic Submucosal Dissection, Bipolar electrocautery knife
- Where
- United States
- Sponsor
- Baylor College of Medicine
Endoscopic Resection, Early Gastric Cancer
Water-injecting Endoscopic Submucosal Dissection for Early Gastric Cancer: a Retrospective Cohort Study
Endoscopic submucosal dissection (ESD) is a technically difficult and time-consuming procedure. Several water-jet knives have been developed to address this issue.
- Trial name
- NCT07244471
- Where
- China
- Volunteers
- 548 people
- Sponsor
- Shanghai East Hospital
Early Gastric Cancer or Gastric Adenoma
Pilot Trial on Efficacy of Single Dose Perioperative Intravenous Dexamethasone for Pain Relief After Endoscopic Submucosal Dissection
Besides major ESD-related complications, minor adverse events after ESD are also commonly noticed. Pain is one of minor ESD-related complications. .
- Trial name
- NCT02037399
- Testing
- intravenous dexamethasone, intravenous normal saline
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Colorectal Cancer, Colorectal Polyp
Accuracy for Predicting Deep Submucosal Invasion
The main aim of this study is to determine whether the assessment of the invasive pattern based on NBI with dual focus/magnification or BLI with magnification ± chromoendoscopy (NBI+CE) for predicting deep invasion is…
- Trial name
- NBIBLI (NCT03748667)
- Testing
- White light endoscopy (WLE), NBI/BLI +/- chromoendoscopy (NBIBLI +/- CE)
- Where
- 14 sites in United States, Japan and 1 more
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
High Grade Intraepithelial Neoplasia, Barrett Adenocarcinoma
ESD Versus EMR for Treatment of Early Barrett's Adenocarcinoma
Conventional techniques of endoscopic mucosal resection (EMR) by snare resection do usually not achieve resection of gastrointestinal mucosal neoplastic lesions larger than 1 cm in diameter in a single piece.
- Trial name
- NCT01871636
- Testing
- Endoscopic mucosal resection, Waterjet-assisted ESD, HybridKnife
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Evangelisches Krankenhaus Düsseldorf
Gastric Cancer
Effects of Ilaprazole on Ulcer Healing Rate and Prevention of Gastrointestinal Bleeding in the Patients Undergone ESD.
This study compared Ulcer healing rate of Ilaprazole 20mg or Rabeprazole 20mg in the patients undergone Endoscopic Submucosal Dissection for Gastric Adenoma or Early Gastric Cancer and investigated Prevention of gastrointestinal…
- Trial name
- NCT02638584
- Testing
- Ilaprazole, Rabeprazole
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Submucosal Tumor of Gastrointestinal Tract
Diagnostic Accuracy of SurePath™ in EUS-FNA
It is a prospective randomized controlled study to evaluate the diagnostic accuracy of SurePath™ liquid-based cytology in endoscopic ultrasound-guided sampling.
- Trial name
- NCT05394129
- Testing
- SurePath™
- Where
- South Korea
- Volunteers
- 89 people
- Sponsor
- Seoul National University Hospital