Clinical trials: Submucosal Tumors
Esophageal Stricture
Effect of a Combination of Local Steroid Injection With Oral Steroid Administration for the Prevention on Esophageal Stricture After Endoscopic Submucosal Dissection for Early Esophageal Neoplasm
The method of esophageal endoscopic submucosal dissection (ESD) to remove superficial esophageal neoplasms has gained widespread acceptance as an alternative to surgery recently these years especially in Asian countries.
- Trial name
- NCT03039608
- Testing
- combination of local steroid injection（triamcinolone ）with oral steroid administration（prednisone）, oral steroid administration（prednisone）
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Shanghai Zhongshan Hospital
Barrett Esophagus, Barrett Esophagus Adenocarcinoma
A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer
The goal of the study is: The collection of various tissue samples (blood, biopsies and "esophageal brushes") and their analysis.
- Conditions
- Barrett Esophagus, Barrett Esophagus Adenocarcinoma, Adenocarcinoma - GEJ, Gastroenterology
- Trial name
- Endeavor-2 (NCT07455422)
- Testing
- Risk profile disclosure
- Where
- 10 sites in Belgium, Denmark and 5 more
- Volunteers
- 266 people
- Sponsor
- University Hospital, Antwerp
Gastric Submucosal Tumors
A Randomized Controlled Clinical Study on the Application of the Third Space in the Operation of Gastric Submucosal Tumor
Gastric submucosal tumors (SMTs) are rare findings during routine upper endoscopy; the incidence of these lesions may be as high as 0.4%.SMTs display a wide spectrum,ranging from benign to highly malignant, with gastrointestinal…
- Trial name
- RECSINSMTs (NCT03612830)
- Testing
- Laparoscopy endoscopy cooperated surgery, Dan Vinchi robot endoscopy cooperated surgery
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Submucosal Tumor, Pancreas Tumor
25G and 22G Puncture Needles
The screened patients were randomly assigned 25G puncture needles and 22G puncture needles in a 1;1 ratio, based on the computer-generated random order, before receiving an ultrasound endoscope puncture.
- Trial name
- NCT05101772
- Where
- China
- Volunteers
- 73 people
- Sponsor
- Peking Union Medical College Hospital
Rectal Cancer, Rectal Adenocarcinoma
SCARLET - Italian proSpeCtionAl obseRvationaL multicEntre Study on Treatment for recTal pT1 Cancer
The purpose of this prospective, observational, multicenter study is to evaluate the impact of adjuvant radiotherapy or chemoradiotherapy on disease-free survival (DFS) in patients with pathological T1 (pT1) rectal cancer…
- Conditions
- Rectal Cancer, Rectal Adenocarcinoma, Rectal Cancer Patients, Rectal Cancer, Radiotherapy
- Trial name
- SCARLET (NCT07695519)
- Where
- Italy
- Volunteers
- 196 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Cancer
Recurrence Rate After Endoscopic Resection of , Laterally Spreading Tumor Granular Type (LST-G) of the Colon and Rectum: Endoscopic Mucosal Resection vs. Endoscopic Submucosal Dissection
Colorectal cancer is one of the leading causes of cancer-related mortality worldwide. Early-stage non-polypoid neoplastic lesions, particularly Laterally Spreading Tumors - Granular Type (LST-G) larger than 20mm, require…
- Trial name
- ESD vs EMR (NCT06815406)
- Testing
- Endoscopic Mucosal Resection (EMR), Endoscopic Submucosal Dissection (ESD)
- Where
- 5 sites in Italy
- Volunteers
- 282 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Superficial Esophageal Cancer, Oesophageal Adenocarcinoma
Multicenter Prospective Cohort on Esophageal Endoscopic Submucosal Dissection
In France in 2018, there were an estimated 2,074 new cases of esophageal adenocarcinoma and 3,224 cases of squamous cell carcinoma.
- Conditions
- Superficial Esophageal Cancer, Oesophageal Adenocarcinoma, Oesophageal Squamous Cell Carcinoma, Barretts Esophagus With Dysplasia
- Trial name
- FEO (NCT07343869)
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Société Française d'Endoscopie Digestive
Colorectal Cancer, Indocyanine Green
Endoscopic Submucosal Injection of Indocyanine Green Before Laparoscopic Radical Resection for Colorectal Cancer
Prospective registry study of endoscopic submucosal injection of indocyanine green before laparoscopic radical resection for colorectal cancer
- Trial name
- NCT04207489
- Testing
- endoscopic submucosal injection of indocyanine green before laparoscopic radical operation of colorectal cancer
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jilin University
Submucosal Tumor of Gastrointestinal Tract, Gastrointestinal Stromal Tumor (GIST)
Mesenteric Vascular Preconditioning Combined With Laparoscopic and Endoscopic Cooperative Surgery for Submucosal Tumor at the Gastroesophageal Junction
This study is a single-center, prospective, single-arm, exploratory clinical study (phase II exploratory trial). No parallel control group was established in the study, and all subjects who met the inclusion criteria underwent a…
- Trial name
- SAVE-GEJ (NCT07550582)
- Testing
- laparoscopic and endoscopic cooperative surgery
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Endoscopic Submucosal Dissection, Early Gastric Cancer
Efficacy and Safety Study of Endoscopic Submucosal Dissection for Early Gastric Cancer
The purpose of this study is to evaluate the safety and clinical effectiveness of ESD(Endoscopic Submucosal Dissection) for early gastric cancer analyzing short-term and long-term results of endoscopic treatment.
- Conditions
- Endoscopic Submucosal Dissection, Early Gastric Cancer, Multi-center, Single-arm Clinical Trial, Historical Control Group
- Trial name
- ESD (NCT01132469)
- Testing
- Endoscopic Submucosal Dissection
- Where
- South Korea
- Volunteers
- 1,158 people
- Sponsor
- National Evidence-Based Healthcare Collaborating Agency
Stomach Cancer, Undifferentiated Type
Comparison of Endoscopic Resection and Surgery for Early Gastric Cancer With Undifferentiated Histological Type
This multi-center, randomized controlled trial is designed to evaluate clinical effectiveness and cost-effectiveness of ESD for undifferentiated type of EGC meeting the expanded indication compared with surgery.
- Conditions
- Stomach Cancer, Undifferentiated Type, Expanded Indication of Endoscopic Resection
- Trial name
- ERASE-GC (NCT04890171)
- Testing
- Endoscopic submucosal dissection, Surgery
- Where
- South Korea
- Volunteers
- 708 people
- Sponsor
- National Cancer Center, Korea
Indocyanine Green, Gastric Cancer
Randomized Controlled Trial on Effect of Lymph Node Mapping by Indocyanine Green Via Submucosal or Subserosal Injection
The purpose of this study was to evaluate whether submucosal or subserous injection of indocyanine green during laparoscopic lymphadenectomy for patients with gastric cancer was different.
- Conditions
- Indocyanine Green, Gastric Cancer, Injection Site
- Trial name
- NCT04219332
- Testing
- Subserosa injection of indocyanine green, submucosal injection of indocyanine green
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Fujian Medical University
Colonic Polyp, Gastrointestinal Neoplasms
Clinical Study on Continuous Suture of Endoscopic Mucosal Defects
The use of clips to completely clip mucosal defects after ESD/EMR can reduce postoperative adverse events, but the rate of incomplete mucosal defects closure is high.
- Trial name
- NCT05190042
- Testing
- Cotinuous suture, Clips
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Early Gastric Cancer
Usefulness of Probe-based Confocal Laser Endo-microscopy in Delineation of Margin of Early Gastric Cancer for Endoscopic Submucosal Dissection
The aim of this study is to evaluate the usefulness of pCLE (probe-based confocal laser endomicroscopy) compared with conventional chromoendoscopy (CE) for delineating the margin of early gastric cancer (EGC) with endoscopic…
- Trial name
- NCT02189226
- Testing
- Endoscopic submucosal dissection (ESD) with or without probe-based confocal laser endomicroscopy (pCLE)
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Yonsei University
Colorectal Cancer, Colorectal Cancer Stage I
Web-based Learning Module on Optical Diagnosis of Early Colorectal Cancer
International guidelines recommend deciding the treatment of colorectal lesions based on the estimated histology by endoscopic optical diagnosis.
- Trial name
- LODIP (NCT05663788)
- Testing
- E-learning module
- Where
- 12 sites in United States, Japan and 2 more
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Cirrhosis, Esophagogastric Varices
Clinical Management Strategies for Patients With Cirrhosis and Esophagogastric Varices Complicated by Early-stage Upper Gastrointestinal Cancer
Managing early-stage upper gastrointestinal cancer in patients with liver cirrhosis and esophagogastric varices (EGV) poses substantial clinical challenges.
- Conditions
- Cirrhosis, Esophagogastric Varices, Early-stage Upper Gastrointestinal Cancer
- Trial name
- NCT07368309
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Renmin Hospital of Wuhan University
Barretts Esophagus With Dysplasia, Barrett Adenocarcinoma
EMR Versus ESD for Barrett's Neoplasia
Rationale: The optimal technique for removal of visible dysplastic lesions in Barrett's esophagus remains controversial. Endoscopic mucosal resection (EMR) is safe, effective, easy to apply, and has been the most widely used…
- Conditions
- Barretts Esophagus With Dysplasia, Barrett Adenocarcinoma, Esophageal Cancer
- Trial name
- REMOVE-RCT (NCT05276791)
- Testing
- EMR, ESD
- Where
- 6 sites in Netherlands
- Volunteers
- 331 people
- Sponsor
- St. Antonius Hospital
Barrett Esophagus, Adenocarcinoma Esophagus
Outcomes of Endoscopically Resected High-risk Mucosal and Low- and High-risk Submucosal Adenocarcinoma Arising in Barrett's Esophagus
The purpose of this study is to assess lymph node metastasis rate, distant metastasis rate, disease-specific mortality, and overall mortality in patients with Barrett's related T1b and high risk T1a esophageal adenocarcinoma…
- Conditions
- Barrett Esophagus, Adenocarcinoma Esophagus, Submucosal Esophageal Adenocarcinoma, High-risk Mucosal Esophageal Adenocarcinoma
- Trial name
- NCT04818476
- Testing
- diagnostic endoscopic resection
- Where
- 16 sites in Australia, Belgium and 5 more
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colorectal Adenomas, Submucosal Tumors
Endoscopic Full Thickness Resection in the Lower GI Tract With the "Full Thickness Resection Device"
Observational prospective multicenter study to investigate efficacy and safety of endoscopic full thickness resection in the lower GI tract using a novel over-the-scope full thickness resection device.
- Trial name
- WALL-RESECT (NCT02362126)
- Testing
- Endoscopic full thickness resection (EFTR)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Rectal Neuroendocrine Tumor
Endoscopic Treatment of Rectal Neuroendocrine Tumor(NET) Less Than 10mm
Cap-assisted endoscopic mucosal resection (EMR-C) and endoscopic submucosal dissection (ESD) have both been reported to be effective treatment methods for small rectal neuroendocrine tumor (NET) in limited studies.
- Trial name
- NCT03982264
- Testing
- ESD procedure, EMR-C procedure
- Volunteers
- 90 people
- Sponsor
- Nanfang Hospital, Southern Medical University