Clinical trials: Substance Abuse Disorders
Substance Abuse
Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial
This placebo-controlled, double-blind, randomized pilot clinical trial will evaluate atomoxetine (Strattera®) for the treatment of cocaine dependence.
- Trial name
- NCT00617201
- Testing
- atomoxetine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Opioid-use Disorder, Opioid Use
PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Opioid-Naive Population
The objective of this research is to assess the effects of electronic health record (EHR)-based decision support tools on primary care provider (PCP) decision-making around pain treatment and opioid prescribing.
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Abuse
- Trial name
- PRINCE (NCT04601493)
- Testing
- Choice Architecture Nudge, PMP Integration & Nudge
- Where
- United States
- Volunteers
- 631 people
- Sponsor
- University of Minnesota
Cannabis Dependence, Cannabis Withdrawal
Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using…
- Trial name
- SCCAN (NCT00656487)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Scripps Research Institute
Infection, Alcohol Abuse
Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure
This study plans to learn more about people who are sick in the hospital with a lung infection, or respiratory failure. Respiratory failure, or severe lung failure, is a life-threatening disease.
- Conditions
- Infection, Alcohol Abuse, Drugs of Abuse, Lung Injury
- Trial name
- NCT02299921
- Testing
- Characterize alcohol and drug use
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Opioid Related Disorders, Opiate Addiction
Evaluation of Drug Utilization Patterns for Extended Release/Long Acting Opioids and Comparator Products
A drug utilization study will be performed to describe trends in the number of prescriptions and patients for class REMS ER/LA opioids and comparator products.
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02925806
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 5,575,834 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Cannabis Use Disorder
Teen Marijuana Check-Up
This study will test a behavioral intervention tailored for adolescents who smoke marijuana and have concerns about their use. The study's purpose is to determine whether this intervention (two-sessions of motivational…
- Trial name
- NCT01109563
- Testing
- Marijuana Check-Ins
- Volunteers
- 252 people
- Sponsor
- Denise Walker
Study Focuses on Brain Morphology and Cognition in Older Subjects
Cannabis Effects on Brain Morphology in Aging
Marijuana (Cannabis sativa) is the most widely used illicit drug worldwide, with 17.4 million Americans reporting past month use in 2010 and 4.6 million meeting criteria for dependence, underscoring the public health importance…
- Trial name
- CAN (NCT01874886)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Smoking, Alcohol Abuse
Dynamic Assessment and Referral System - Evaluation
The investigators study will use a randomized controlled design. Eligible and consenting participants will be randomly assigned to one of two conditions: (1) DARSSA Intervention condition, or (2) Minimal Intervention Control…
- Conditions
- Smoking, Alcohol Abuse, Drug Abuse
- Trial name
- DARSSA (NCT01153373)
- Testing
- Self-administered computerized assessment for tobacco, substance abuse, and alcohol use., Self-Administered Computerized Assessment and Counseling for Tobacco, Alcohol, and Substance Abuse
- Where
- United States
- Volunteers
- 758 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Cocaine Abuse, Cocaine-Related Disorders
Progesterone for the Treatment of Cocaine Dependence - 1
Past research has demonstrated that cocaine dependent women experience less severe responses to cocaine during the luteal phase of the menstrual cycle, when estrogen and progesterone concentrations are high.
- Trial name
- NCT00218257
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Minnesota
Depression, Anxiety
Nexalin Therapy as a Viable Adjunctive Treatment for Substance Use Disorders
The purpose of this research study is to determine whether Nexalin Trans-cranial Electrical Stimulation (TES) is a viable adjunctive treatment of substance use treatments.
- Conditions
- Depression, Anxiety, Insomnia, Substance Abuse
- Trial name
- NCT03540745
- Testing
- TES Treatment
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Arizona
Abuse, Drug
A Study to Assess the Abuse Potential of Intranasal Cebranopadol
The purpose of this study to Assess the Abuse Potential of Intranasal Cebranopadol Compared to Oxycodone and Placebo in Healthy, Nondependent Recreational Opioid Users.
- Trial name
- NCT06453265
- Testing
- Cebranopadol- 600 ug, Cebranopadol- 800ug, Cebranopadol- 1000ug
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tris Pharma, Inc.
Cannabis Dependence
Neural Indices Associated With Relapse in Cannabis Dependence
The aim of this fMRI study is to investigate neural indices of relapse in cannabis dependence. The development and maintenance of drug addictions have been associated with deficits in cognitive control, craving and impaired…
- Trial name
- NCT02801422
- Testing
- fMRI
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
HIV
Prevention for Positives: An RCT Among Vietnamese HIV-positive IDU
The purpose of this study is to determine whether a combined individual and structural level stigma reduction intervention is effective in reducing high risk injecting and sexual behaviors among HIV positive injecting drug users.
- Trial name
- NCT01689545
- Testing
- Individual level, Structural level, Individual level standard of care
- Where
- Vietnam
- Volunteers
- 2,175 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Psychiatric Disorder, Somatic Symptom
National Investigation in College and High School Among Adolescents on Health and Substances at the FSEF
For the clinical component: Describe the young people hospitalised in residential care at the FSEF, in particular through vulnerability factors and their psychosocial repercussions (school level, repetition, intensity of…
- Conditions
- Psychiatric Disorder, Somatic Symptom, Traumatic Injury
- Trial name
- EnCLASS-FSEF (NCT05225441)
- Where
- France
- Volunteers
- 598 people
- Sponsor
- Fondation Santé des Étudiants de France
Depression, Post-traumatic Stress Disorder
Evaluating Implementation Strategies to Scale-up Transdiagnostic Evidence-based Mental Health Care in Zambia
This study utilizes a Hybrid Type 1 multi-arm parallel group randomized control design to compare the effectiveness of an evidence-based treatment (CETA) delivered either in-person or via telephone, compared with a treatment as…
- Conditions
- Depression, Post-traumatic Stress Disorder, Anxiety, Substance Abuse
- Trial name
- NCT03458039
- Testing
- In-person CETA, Telephone CETA, Treatment as Usual (TAU)
- Where
- Zambia
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
ADHD, Attention Deficit Hyperactivity Disorder
Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk
The study team will examine the effects of FDA approved stimulant and non-stimulant medications for ADHD, among youth with ADHD and with and without Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD), on reward systems…
- Trial name
- MPH-ATX (NCT03781765)
- Testing
- Methylphenidate, Atomoxetine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Drug Abuse, Alcohol Abuse
The Therapeutic Workplace Intervention in Community Settings
Methadone is effective for heroin addiction, but many methadone patients continue to use cocaine. High magnitude and long-duration voucher-based abstinence reinforcement, in which participants receive vouchers exchangeable for…
- Trial name
- NCT01841892
- Testing
- Community Therapeutic Workplace
- Where
- United States
- Sponsor
- University of Maryland, Baltimore County
Psychosis, Cannabis Use Disorder
Testing the Efficacy of the Cannabis Clinic for Patients With Psychosis (CCP) Intervention for Cannabis Use Reduction/Cessation in Patients With First Episode Psychosis (FEP)
People suffering from psychosis who use cannabis experience more relapses, long and compulsory admissions, with huge costs to the individual, families and health services.
- Conditions
- Psychosis, Cannabis Use Disorder, First Episode Psychosis (FEP)
- Trial name
- CCP RCT (NCT07245212)
- Testing
- CCP Intervention
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- King's College London
Autism Spectrum Disorder
The Effects of Medical Cannabis in Children With Autistic Spectrum Disorder
Children with autism spectrum disorder (ASD) commonly exhibit comorbid symptoms such as aggression, hyperactivity and anxiety. Data on the effects of cannabidiol rich cannabis extract use for ASD is promising but still limited.
- Trial name
- NCT05212493
- Testing
- Cannabis oil
- Where
- Israel
- Volunteers
- 128 people
- Sponsor
- Assaf-Harofeh Medical Center
HIV/AIDS, Substance Abuse
Directly Observed Antiretroviral Therapy Among Active Drug Users
The goal of this randomized, controlled trial is to compare the effectiveness of a community-based program of providing supervised antiretroviral therapy to HIV-positive drug users, compared to having the patients take the…
- Trial name
- NCT00367172
- Testing
- Directly Administered Antiretroviral Therapy
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Yale University