Clinical trials: Substance Abuse Problem
Opioid Use Disorder
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
This study will evaluate the safety, effectiveness and tolerance of low doses of oral naltrexone along with buprenorphine to treat opioid use disorder prior to the first injection of VIVITROL.
- Trial name
- NCT02537574
- Testing
- NTX/BUP, NTX/PBO-B, PBO-N/PBO-B
- Where
- 20 sites in United States
- Volunteers
- 380 people
- Sponsor
- Alkermes, Inc.
Alcohol-Related Disorders, Alcohol Use Disorders
Adaptive Interventions for Problem Drinkers
The purpose of this study is to understand how certain interventions help people reduce or quit their drinking and how certain interventions may help best at certain points in time in the change process.
- Conditions
- Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism
- Trial name
- NCT02511808
- Testing
- Brief Advice, Motivational Interviewing, Behavioral Self-Control Training
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Northwell Health
Substance Use Disorders, Mental Illness
Screening, Brief Intervention and Referral to Treatment for Substance Abuse in Mental Health Treatment Settings
An estimated 40% of patients in mental health treatment settings engage in hazardous alcohol and/or drug use. One model of intervention that has been shown effective in medical settings to reduce alcohol use and/or promote…
- Trial name
- SBIRT in MH (NCT01883791)
- Testing
- SBIRT, Health Education
- Where
- 2 sites in United States
- Volunteers
- 1,080 people
- Sponsor
- University of California, Los Angeles
Cannabis Dependence, Tobacco Use
Characterization of the Pattern of Consumption and Withdrawal Syndrome From Dual Cannabis and Tobacco Use
Aims: To characterize the pattern of cannabis and tobacco use and withdrawal symptoms in people who start treatment for cannabis use disorders (exclusive cannabis, concurrent and/or simultaneous with various tobacco products)…
- Conditions
- Cannabis Dependence, Tobacco Use, Withdrawal Syndrome, Substance Abuse
- Trial name
- DuCATA_GAMCaT (NCT05512091)
- Volunteers
- 282 people
- Sponsor
- Cristina Martínez Martínez
Substance Use, Sexual Risk Behaviors
Targeting HIV Risk Behaviors in Juvenile Drug Court-Involved Youth
This study is designed to gain knowledge about effective interventions for reducing HIV risk in a high risk population. A new Risk Reduction Therapy for Adolescents (RRTA) will be compared to usual services received by youth in…
- Trial name
- NCT01511380
- Testing
- Risk Reduction Therapy for Adolescents, Usual services
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Medical University of South Carolina
Pre-natal Cocaine Exposure, Risk-Taking
Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults
Reward processing will be examined in prenatally exposed emerging adults in a longitudinal design. Participants will be followed for one year to see if neural markers of reward processing prospectively predict risk-taking…
- Trial name
- NCT03268759
- Testing
- fMRI
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Divorce, Drug Abuse
Multi-court Trial of NBP to Prevent Substance Abuse and Mental Health Disorders (MTC)
This application requests funding to conduct a randomized effectiveness trial of The New Beginnings Program (NBP) delivered through a partnership of domestic relations courts, community service providers and the NBP research…
- Conditions
- Divorce, Drug Abuse, Mental Health Disorder
- Trial name
- MTC (NCT06132971)
- Testing
- New Beginnings Program
- Where
- United States
- Volunteers
- 2,415 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Hypertension, Substance Abuse
Linking Former Inmates to Primary Care
The Transitions Clinic Network (TCN)aims to connect former inmates to primary care using trained, culturally competent primary care providers and community health workers (CHWs).
- Conditions
- Hypertension, Substance Abuse, Asthma, Depression
- Trial name
- NCT01863290
- Testing
- Primary care redesign
- Where
- 11 sites in United States, Puerto Rico
- Volunteers
- 816 people
- Sponsor
- Yale University
Medication Adherence, Substance Abuse, Intravenous
A Randomized Trial of Vaccine Adherence in Young Injection Drug Users
The purpose of this study is to compare the effects of (a) immunization setting and (b) outreach worker support on young injection drug users' (IDU) adherence to a multiple dose immunization schedule with a combined hepatitis A…
- Conditions
- Medication Adherence, Substance Abuse, Intravenous, Risk Behavior, Hepatitis A
- Trial name
- UFO VAX (NCT00244374)
- Testing
- Hepatitis A & B vaccine, Outreach, AIC
- Where
- United States
- Volunteers
- 546 people
- Sponsor
- University of California, San Francisco
Mentally Ill Persons, Substance Abuse
HIV Prevention Among Substance Abusing SMI
This study seeks to examine the effectiveness of translating two proven interventions, RESPECT, and the NIDA Community Based Outreach Model, into one program of education, PATH, to be delivered by case managers to their seriously…
- Conditions
- Mentally Ill Persons, Substance Abuse, HIV Infections
- Trial name
- NCT00447720
- Testing
- PATH
- Where
- United States
- Volunteers
- 238 people
- Sponsor
- University of Pennsylvania
Substance Abuse Disorder
Examining Clinical Research Participation for Substance Abuse Disorder Patient
Clinical study participation percentages haven't always been fully representative of a given demographic. The goal is to find out which aspects of a clinical trial may make it more difficult for patients to take part or see it…
- Trial name
- NCT05881369
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Substance Abuse
Youth Substance Use Prevention/Reduction Through Science-based Drug Abuse Education
Our primary goal is to conduct a pilot study of the effects of a new potential strategy for youth substance abuse prevention - science-based drug education integrated into the high school science curriculum.
- Trial name
- NCT00612482
- Testing
- drug prevention curriculum
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Drug Abuse
Multidisciplinary Approach to Reduce Injury and Substance Abuse
The primary purpose of the project entitled: Multidisciplinary Approach to Reduce Injury and Substance Abuse, which is funded by the National Institute on Drug Abuse (5R01DA026088-02), is to compare the effectiveness of brief…
- Trial name
- NCT01048359
- Testing
- Brief advice, Brief Intervention plus Booster, Brief Intervention
- Where
- United States
- Volunteers
- 417 people
- Sponsor
- University of Texas at Austin
Substance Abuse
A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements (CDEs) Into the Electronic Health Record (EHR) in Large Primary Care Settings ("CDE-EHR-PC" Study), Phase 3
This is a 4-phase study to implement the NIDA CDEs in primary care settings. Collecting and utilizing the CDEs in clinical practice requires a strategy for implementing screening to collect substance use information that…
- Trial name
- NCT02963948
- Testing
- Meetings with implementation leader(s), the SAAS survey, Patient surveys
- Where
- 2 sites in United States
- Volunteers
- 113,123 people
- Sponsor
- NYU Langone Health
Substance Abuse Disorder, Exercise
The Effect of Inspiratory Muscle Training With Substance Use Disorder
The aim was to investigate the effectiveness of inspiratory muscle training on dyspnoea, pulmonary function, respiratory muscle strength, cough capacity, functional exercise capacity, substance craving, depression, anxiety and…
- Conditions
- Substance Abuse Disorder, Exercise, Pulmonary Function, Rehabilitation
- Trial name
- NCT06961838
- Testing
- Inspiratory muscle training programme, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Uskudar University
Substance Abuse
Monitoring and Feedback in Substance Abuse Treatment
This is a three-staged study to develop and evaluate a monitoring instrument and associated intervention, as follows: Stage 1 - Develop and determine the reliability, validity, and sensitivity to change of a brief…
- Trial name
- NCT01465490
- Testing
- Monitoring and Feedback Intervention
- Where
- 4 sites in United States
- Volunteers
- 327 people
- Sponsor
- Treatment Research Institute
Alcohol Abuse
Family Check-Up for Adolescents and Siblings
A two group randomized design will be used to test the primary hypothesis that the experimental intervention will reduce alcohol consumption and alcohol-related negative consequences significantly more than a comparison…
- Trial name
- NCT00925340
- Testing
- Family Check Up, Psychoeducation
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Brown University
Condomless Sex, Human Immunodeficiency Virus (HIV)
Cape Town Young Women's Health CoOp
This two-arm cluster randomized trial tested a gender-focused comprehensive HIV testing and counselling (HTC) program, the Young Women's Health CoOp (YWHC) with a standard HTC program and targeted female adolescents (aged 16-19)…
- Conditions
- Condomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infections (STIs), Alcohol and Drug Use
- Trial name
- NCT02974998
- Testing
- Young Women's Health CoOp (YWHC), Standard HTC
- Where
- South Africa
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- RTI International
Hepatitis C, Substance Abuse
Psychoeducation for Hepatitis and Alcohol Behaviors
The proposed project will apply a unique, effective family-responsive psychoeducation program, PsychoEducation Responsive to Families (PERF), for Hepatitis C Virus (HCV) treatment.
- Trial name
- NCT00598416
- Testing
- Family-Responsive Psychoeducation Program (PERF)
- Where
- United States
- Volunteers
- 556 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Buprenorphine, HIV
Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM)
The purpose of this study is to assess the feasibility, cost and effectiveness of interventions designed to integrate buprenorphine treatment for opioid dependence into HIV primary care in ten HIV care centers in the U.S.
- Conditions
- Buprenorphine, HIV, Drug Abuse, Drug Addiction
- Trial name
- BELIEVE (NCT00798538)
- Testing
- Services will be provided at one site, Services remain dispersed; i.e., not centralized to one-location or provider.
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University