Clinical trials: Substance Addiction
Opioid-Related Disorders, Drug Addiction
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study
This is a sub-study of NIDA CTN Protocol 0080: Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs; Unique protocol ID: 2019-0429-1).
- Conditions
- Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse
- Trial name
- MOMs-INO (NCT03911739)
- Testing
- Buprenorphine Injection, Buprenorphine Sublingual Product
- Where
- 10 sites in United States
- Volunteers
- 71 people
- Sponsor
- T. John Winhusen, PhD
Methamphetamine Abuse, Methamphetamine-dependence
Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder
Methamphetamine use disorder (MUD) is becoming an increasing public health concern in Canada. While the evidence on the efficacy and safety of prescription psychostimulants for the treatment of MUD is promising, the knowledge on…
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance Abuse
- Trial name
- NCT06788587
- Testing
- LDX-01 plus TAU
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Substance Use Disorders, Behavioral Health
Mindfulness and Meditation-Based Relapse Prevention for Substance Use Disorders
Mindfulness and meditation based relapse prevention has been proposed as an adjunctive approach for individuals with substance use disorders (SUDs).
- Conditions
- Substance Use Disorders, Behavioral Health, Addiction Psychological, Addiction Disorders
- Trial name
- MBRP-SUD (NCT07417579)
- Testing
- Mindfulness and Meditation-Based Relapse Prevention Program
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Bout Me Healing
Methamphetamine Abuse, Methamphetamine-dependence
Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces days of use in adults who use methamphetamine better than the usual treatment provided by the clinic.
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
- Trial name
- NCT05854667
- Testing
- Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
- Where
- 4 sites in Canada
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
PTSD, Addiction
Adaptation of the ECCCLORE Program for Patients With Addictive and Traumatic Problems
Complex posttraumatic stress disorder (cPTSD) is characterized by chronic and pervasive disruptions in emotion regulation, identity, and relationships following prolonged or multiple exposures to trauma.
- Conditions
- PTSD, Addiction, Substance Use Disorders, CBT
- Trial name
- PEAT (NCT07193914)
- Testing
- ECCCLORE program
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Stimulant Dependence, Methamphetamine-dependence
Pilot TMS for Methamphetamine Use Disorder
This is a pilot study to test the feasibility of a recruitment strategy and study protocol to examine the effects of a dual target transcranial magnetic stimulation treatment in methamphetamine use disorder.
- Conditions
- Stimulant Dependence, Methamphetamine-dependence, Addiction, Drug
- Trial name
- NCT04449055
- Testing
- Transcranial Magnetic Stimulation--DPFC first, MPFC second, Transcranial Magnetic Stimulation--MPFC first, DPFC second
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ryan M. Carnahan
HIV Infections, Substance Use Disorders
Peer Supported Collaborative Care Mental Health and Substance Use Disorder Care
This is a research study to assess the effectiveness of a peer-led collaborative care model for integrating treatment for substance use and or mental health disorders into HIV care settings.
- Conditions
- HIV Infections, Substance Use Disorders, Mental Health Disorder, Addiction
- Trial name
- NCT04601064
- Testing
- Collaborative Care Model
- Where
- United States
- Volunteers
- 405 people
- Sponsor
- Johns Hopkins University
Smoking, Nicotine
Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking
Tobacco use is the leading cause of preventable death in the U.S., with 480,000 deaths per year and 7.7 million deaths globally.
- Conditions
- Smoking, Nicotine, Tobacco, Addiction
- Trial name
- NCT07328594
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Legacy Health System
Drug Craving Levels Among Individuals With Substance Addiction, Depression Levels Among Individuals With Substance Addiction
The Effects of Exercise and Music Combination on Drug Cravings, Depression and Self-Efficacy Among Drug Addicts
This study focuses on the rehabilitation of drug addicts by combining exercise and music, to find out whether exercise and exercise combined with music of different rhythms will have an improvement for drug addicts. 1.
- Conditions
- Drug Craving Levels Among Individuals With Substance Addiction, Depression Levels Among Individuals With Substance Addiction, Self-efficacy Among Individuals With Substance Addiction
- Trial name
- NCT07279246
- Testing
- Sports group, Exercise combined with fast-paced music group, Exercise combined with slow-tempo music group
- Where
- Malaysia
- Volunteers
- 92 people
- Sponsor
- WEIPENG DUAN
Addiction, Depression/Anxiety
Healing Lodge First Face Training Evaluation Study
The purpose of this study is to evaluate a culturally grounded training program, xaʔtus (meaning First Face) for Mental Health. This program will train community members in how to recognize and respond to youth and adults…
- Conditions
- Addiction, Depression/Anxiety, Trauma, Psychological, Self-harm
- Trial name
- NCT06290180
- Testing
- First Face for Mental Heatlh
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
HIV Infections, Substance Use Disorders
Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation
The goal of this clinical trial is to evaluate the effectiveness of a social network intervention to recruit people who inject drugs and their networks for HIV testing and linkage to HIV prevention and treatment services in…
- Conditions
- HIV Infections, Substance Use Disorders, Addiction, Opioid Use
- Trial name
- NCT06103370
- Testing
- Peer-educator-based network
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Johns Hopkins University
Substance-Related Disorders, Opioid Medication Assisted Treatment
Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence
The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) among low-income, minority individuals…
- Conditions
- Substance-Related Disorders, Opioid Medication Assisted Treatment, Opioid Use Disorder, Opioid Use
- Trial name
- HEAL Together (NCT05299515)
- Testing
- Peer-Delivered Behavioral Activation ("Peer Activate")
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Maryland, College Park
Drug Addiction, Polysubstance Addiction
Mapping And Preventing Relapse Risk in Polydrug Users
This Interventional two-arm comparative study will evaluate whether a mindfulness-based strategy (MBS) improves outcomes for adults with substance use disorders (polydrug users) compared with treatment-as-usual (TAU).
- Trial name
- NCT07161986
- Testing
- Mindfullness based Sobriety (MBS)
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Institute of Psychology, Chinese Academy of Sciences
Neuropathic Pain, Anxiety Disorder/Anxiety State
Predictive and Impact of Pain After 6 Months of Radiotherapy, in Head and Neck Cancer
Head and neck cancers are a source of complications and after-effects related to the disease and treatment. These cancers and their treatment alter the quality of life of patients and generate pain with physical and psychological…
- Conditions
- Neuropathic Pain, Anxiety Disorder/Anxiety State, Pain, Chronic, Alcohol Use Disorder
- Trial name
- DIP-CAOS (NCT05505188)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
Drug Addiction
The Health of Women Monitored in the Addiction Department of the Strasbourg University Hospitals
The health of women suffering from addiction is little known and little explored in the literature. Indeed, they represent only 20% of addicted patients in general and are encountered primarily during pregnancy or complex…
- Trial name
- Santé-Fem (NCT07033728)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Strasbourg, France
Opioid Use Disorder, Pregnancy Related
Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD
The primary objective of this study is to evaluate the ability of TOME to increase Medication for Opioid Use Disorder (MOUD) and opioid-overdose knowledge in pregnant and postpartum persons.
- Conditions
- Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse
- Trial name
- TOME (NCT06262347)
- Testing
- Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
- Where
- 6 sites in United States
- Volunteers
- 131 people
- Sponsor
- T. John Winhusen, PhD
Drug Addiction, Employment
Long-Term Treatment of Opioid Use Disorder
Poverty and opioid addiction are interrelated and chronic problems which have not been addressed adequately. The Therapeutic Workplace could treat the many adults with opioid use disorder who are unemployed and live in poverty.
- Trial name
- NCT05534815
- Testing
- Employment-based abstinence reinforcement
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Northern Michigan University
Alcohol Use Disorder, Stress Reaction
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder.
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- A03 (NCT06105853)
- Testing
- Trier Social Stress Test, Barlab Cue-Exposure, Functional magnetic resonance imaging
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Depression, Dual Diagnosis
A Randomized Double-Blind Controlled Trial of Creatine in Female Methamphetamine Users
Methamphetamine (MA) addiction is a public health concern that causes substantial harm to individual users, and imposes an economic burden in the U.S. totaling up to $48.3 billion annually.
- Conditions
- Depression, Dual Diagnosis, Drug Addiction
- Trial name
- NCT02192931
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Perry Renshaw
Drug Addiction
The Cognitive Neural Mechanisms and Neuroregulatory Interventions of Realistic Creative Problem-solving Under the Effects of Drug Addiction
Drug addiction persists as a significant global social concern with a negative impact on social harmony and stability that cannot be ignored.
- Trial name
- NCT06917534
- Testing
- Transcranial direct current stimulation
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yifan Wang