Clinical trials: Substance Dependence
Alcohol Use Disorder, Alcohol Dependency
Project Relay Model for Recruiting Alcohol Dependent Patients in General Hospitals
The purpose of this study is to evaluate the Relay Model helping alcohol dependent patients at a general hospital to start specialized alcohol treatment in order to assess i) efficacy, ii) cost-effectiveness and iii) overall…
- Trial name
- Relay (NCT02188043)
- Testing
- Relay Model
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- University of Southern Denmark
Alcohol-Related Disorders
Melatonin Use for Sleep Problems in Alcohol Dependent Patients
A double blind Randomized Controlled Trial with two arms will be used. Subjects with Alcohol use disorder and sleep problems will be recruited and assigned randomly to the active treatment Melatonin or Placebo arms.
- Trial name
- NCT03043443
- Testing
- Melatonin
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Dependence, Cigarettes
The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products
This study plans to investigate whether using electronic cigarettes (e-cigarettes) or skin patches containing nicotine affects switching from smoking conventional combustible (burning) cigarettes.
- Trial name
- ENDS-Switch (NCT03492463)
- Testing
- Nicotine patch, E-cigarettes, Non-nicotine e-cigarettes
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Duke University
Methamphetamine Dependence, Methamphetamine Withdrawal
Characterizing Methamphetamine Withdrawal in Recently Abstinent Methamphetamine Users: A Pilot Study
Methamphetamine use has escalated in recent years. Methamphetamine use has also spread throughout the country. Although much information has been gathered on the treatment of cocaine abuse, very little information has been…
- Trial name
- NCT00653263
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Arkansas
Opioid-Related Disorders, Drug Overdose
Prescribe to Save Lives
The U.S. is in the midst of an epidemic of opioid overdose deaths. The common use of opioids among persons living with HIV, along with their common use of benzodiazepines, has resulted in high rates of opioid overdose among this…
- Trial name
- PTSL (NCT03175640)
- Testing
- Implementation intervention
- Where
- 2 sites in United States
- Volunteers
- 294 people
- Sponsor
- Baystate Medical Center
Opioid-Related Disorders, Opioid Dependence
An Innovative Intervention for OUD Treatment
The Bridge Device (BD) is a neuromodulator medical device that has been cleared by the FDA for Opioid Use Disorder (OUD) treatment.
- Conditions
- Opioid-Related Disorders, Opioid Dependence, Opioid Addiction, Opioid Withdrawal
- Trial name
- Bridge (NCT04325659)
- Testing
- Bridge Device, Lofexidine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Breast Cancer, Smoking
Brief Smoking Intervention for Women Undergoing Breast Cancer Surgery
The primary purpose of this study is to examine the effect of a brief preoperative smoking intervention on postoperative complications in women undergoing breast cancer surgery.
- Trial name
- NCT00299117
- Testing
- Brief preoperative smoking intervention
- Where
- 3 sites in Denmark
- Volunteers
- 130 people
- Sponsor
- Herlev Hospital
Marijuana Abuse, Mood Disorders
Effectiveness of Buspirone and Motivational Enhancement Therapy for the Treatment of Marijuana Dependence - 1
This study will assess the effectiveness of a combination of buspirone and motivational interviewing therapy in the treatment of marijuana dependence.
- Trial name
- NCT00149617
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Medical University of South Carolina
Breast Feeding, Opioid-Related Disorders
Methadone Levels in Breast Milk of Women Taking Methadone for Opiate Addiction - 2
Methadone is a drug that offers significant therapeutic benefits to opiate dependent women who are pregnant. Currently, it is the treatment of choice for this group of people.
- Trial name
- NCT00218010
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Abuse, Cocaine Dependence
Reward Processing in Cocaine Addiction
Background: Cocaine affects the brain's ability to process information. However, different people respond to cocaine in different ways, and differences in brain structure and function may affect how cocaine alters brain activity.
- Trial name
- NCT01036074
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Cocaethylene as a Treatment for Cocaine Dependence - 1
Cocaine has been cited as the primary drug threat in the United States. The purpose of this study is to determine if cocaethylene, used as a prototype drug, is a safe and effective treatment for cocaine dependence.
- Trial name
- NCT00124696
- Testing
- Cocaethylene
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence
ALK33-005: A Study of ALKS33 (RDC-0313) in Adults With Alcohol Dependence
This study will evaluate the safety and efficacy of ALKS33 (RDC-0313) compared with placebo in adults with alcohol dependence. There will be 11 study visits conducted over a period of about 4 months.
- Trial name
- NCT00981617
- Testing
- ALKS33 (RDC-0313) (1 mg), ALKS33 (RDC-0313) (2.5 mg), ALKS33 (RDC-0313) (10 mg)
- Where
- 27 sites in United States
- Volunteers
- 406 people
- Sponsor
- Alkermes, Inc.
Diabetes Mellitus, Type 2, Nicotine Dependence, Cigarettes
Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients
Diabetes has become an increasingly serious global health issue. In 2024, approximately 537 million adults were living with diabetes, and this number is projected to rise to 783 million by 2045, representing a 46% increase.
- Trial name
- NCT06924697
- Testing
- Application of GLP-1RAs drugs, DPP-4i group
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai East Hospital
Alcoholism, Cocaine Dependence
Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence - 1
The purpose of this study is to see whether naltrexone is safe and useful in preventing alcohol relapse, as well as in decreasing craving for alcohol in people with a diagnosis of alcohol and cocaine dependence.
- Trial name
- NCT00218660
- Testing
- Naltrexone, BRENDA, CBT
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Pennsylvania
Use; Tobacco, Harmful, Alcohol Abuse
Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use
The purpose of the project is to improve adolescent behavioral counseling services in healthcare settings with a new Internet/Intranet-based Motivational Enhancement Therapy (iMET) intervention that targets the use of tobacco…
- Conditions
- Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
- Trial name
- NCT00907309
- Testing
- iMET, iMET/TE
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Boston Children's Hospital
Alcohol Abuse, Alcoholism
Consequences of At-risk Alcohol Consumption in ICU Patients
At-risk drinking is known to cause a high incidence of alcohol withdrawal syndrome which has a high impact on morbidity and mortality.
- Trial name
- NCT03565016
- Testing
- no interventional study
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Nantes University Hospital
Nicotine Dependence
Glucocorticoid Antagonist Treatment for Tobacco Use Disorder
The purpose of this protocol is to examine whether mifepristone, a medication with glucocorticoid receptor antagonist activity, may be a potential treatment for Tobacco Use Disorder (TUD).
- Trial name
- NCT03248713
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Cocaine Use, Cocaine Dependence
Effect of rTMS on Neurotrophines Levels in CUD
Brief Summary: Background: Cocaine use disorders (CUD) is a multifactoral disease, involving several brain areas. One of the most investigated is the Dorsolateral Prefrontal Cortex (DLPFC) involved in impulsiveness control.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Abuse, Neurotropism
- Trial name
- BDNFcoca (NCT05824221)
- Testing
- rTMS
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Nicotine Dependence
Nicotinic Modulation of the Default Network of Resting Brain Function
Background: A brain circuit called the default network is the brain circuit that is active when the brain is at rest; that is, when individuals are not concentrating on specific tasks.
- Trial name
- NCT01240616
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence
Treatment for Alcohol Dependence With Gabapentin
Alcohol use disorders are present across medical specialties, with alcohol-related deaths particularly prevalent in the categories of injury, liver cirrhosis, cancer, cardiovascular disease, disorders of the peripheral nerves and…
- Trial name
- TAG (NCT02771925)
- Testing
- Gabapentin 2g/day divided in two doses for 24 weeks
- Where
- India
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Dayanand Medical College and Hospital