Clinical trials: Substance Misuse
Alcohol Use Disorder, Mild Cognitive Impairment
rTMS in Older Adults With MCI and AUD
Alcohol misuse is a risk factor for early onset cognitive impairment, contributing to 10% of early onset dementia, with risk corresponding to consumption.
- Conditions
- Alcohol Use Disorder, Mild Cognitive Impairment, Transcranial Magnetic Stimulation
- Trial name
- NCT05896332
- Testing
- Active, Open Label iTBS-rTMS
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, Risk Behavior, Health
Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention
This randomized control trial study among Pre-exposure prophylactic users (PrEP) aims to learn and determine the efficacy of Screening, brief intervention, and referral to treatment (SBRIT) in reducing the risk of alcohol use.
- Conditions
- Alcohol Use Disorder, Risk Behavior, Health, Dysbiosis, HIV Infections
- Trial name
- SEAL (NCT06005298)
- Testing
- Screening, Brief Intervention, Referral to Treatment (SBIRT)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shirish S Barve
Chronic Pain, Opioid Use Disorder
Pain Self-Management and Treatment Engagement for Patients Taking Opioids
The goal of this study is to learn if Pain Self-Management (PSM) can improve chronic pain care in individuals with opioid misuse or opioid use disorder (OUD) The main questions it aims to answer are: Does PSM help participants…
- Conditions
- Chronic Pain, Opioid Use Disorder, Opioid Misuse and Addiction
- Trial name
- TREETOP (NCT06855732)
- Testing
- Usual Care, Pain Self-Management
- Where
- 17 sites in United States
- Volunteers
- 204 people
- Sponsor
- University of Pittsburgh
Alcohol Use Disorder, Alcohol Misuse
Intranasal Oxytocin for the Treatment of Alcohol Use Disorder
Primary: The primary objective of the study is to compare the efficacy of intranasal oxytocin in reducing the weekly percentage of heavy drinking days over the 10 weeks of maintenance treatment among subjects with moderate to…
- Trial name
- NCT03878316
- Testing
- Instranasal Oxytocin
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Nitrous Oxide, Drug Abuse
Nitrous Oxyde Misuse Among Teenagers Consulting in an Addictology Center Dedicated to Young Drug Users in Montpellier
Nitrous oxide gas is used in several application areas : medical as an anesthetic drug ; in food industry as a foaming and a mixing agent ; industrial to speed combustion.
- Trial name
- NC (NCT04301024)
- Testing
- assessing the nitrous oxide misuse
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Opioid-use Disorder, Opioid Misuse
Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes
The Care Continuity Program (CCP), a product of Sure Med Compliance, is a novel, online patient self-assessment used by prescribers of opioids to better identify patient risk factors and therapy benefit.
- Conditions
- Opioid-use Disorder, Opioid Misuse, Opioid Use, Chronic Pain
- Trial name
- NCT04945525
- Testing
- Care Continuity Program
- Where
- United States
- Volunteers
- 1,840 people
- Sponsor
- Sure Med Compliance
Post-Traumatic Stress Symptoms, Problematic Use of Alcohol or Other Drugs
Web-based CBT for Recent Veterans Experiencing Problems With Trauma Symptoms or Alcohol/Drug Use
The proposed study involves developing and evaluating an interactive, web-based CBT intervention for OEF/OIF Veterans with hazardous or problematic substance use and PTSD symptoms (PTSD or subsyndromal PTSD).
- Trial name
- Web CBT (NCT01710943)
- Testing
- Web-based Cognitive Behavioral Treatment
- Where
- 2 sites in United States
- Volunteers
- 216 people
- Sponsor
- National Development and Research Institutes, Inc.
Drug Overdose, Opioid Related Disorders
Safety and Health Intervention Project
Use of opioid medications for treatment of pain has increased greatly in the U.S., with the average quantity of prescribed opioids increasing 700% in a decade, from ~100 morphine milligram equivalents (MME) per person to ~700 MME…
- Trial name
- SHIP (NCT02152397)
- Testing
- Therapist-led brief intervention (TBI)
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- University of Michigan
Behavior
An Assessment of SAFE (Swift Accountable Fair Enforcement) in Cochise County
This is a Cochise County experiment with innovative probation supervision practices. Subjects are assigned to one of three supervision conditions.
- Trial name
- NCT01359137
- Testing
- Probation as usual, Deferred Jail, Arizona's SAFE
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Pepperdine University
Pain
Study of Medication Compliance - a Comparison of Patients in Pain Management and Pre-surgical Patients
In this study medication compliance regarding current drug use is investigated using toxicological analyzes in two patient groups: patients from a pain management department and pre-surgical control patients.
- Trial name
- NCT01625065
- Where
- Germany
- Volunteers
- 343 people
- Sponsor
- Ruhr University of Bochum
Schizophrenia, Schizoaffective Disorder
Adapted Cognitive/Affective Remediation for Cannabis Misuse in Schizophrenia
This study will integrate and adapt a cognitive remediation (Cognitive Enhancement Therapy [CET]) and an affect regulation (Personal Therapy [PT]) intervention for 50 individuals with schizophrenia that misuse cannabis.
- Trial name
- NCT01292577
- Testing
- CET/PT, Treatment as Usual
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Pittsburgh
Opioid Use, Pain, Postoperative
Collaborative Opioid Taper After Trauma: Preventing Opioid Misuse and Opioid Use Disorder
The investigators will enroll 100 participants using a randomized control trial design to implement and evaluate an individualized opioid taper program supporting rural Primary Care Physicians (PCPs) caring for patients with…
- Conditions
- Opioid Use, Pain, Postoperative, Opioid Use, Unspecified, Trauma
- Trial name
- NCT04275258
- Testing
- Provide assistance to subject's rural PCP pertaining to subject/patient pain management goals and opioid taper plan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Heart Arrest, Out-Of-Hospital, Opioid Overdose
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest
The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs.
- Conditions
- Heart Arrest, Out-Of-Hospital, Opioid Overdose, Naloxone
- Trial name
- NOPACA (NCT06251609)
- Testing
- Naloxone 2 MG, Saline 2ml
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of California, San Francisco
Parenting, Parent-Child Relations
Parenting Young Children Study
Opioid use is rising at unprecedented levels and has reached epidemic proportions in some areas of the country, particularly rural areas.
- Conditions
- Parenting, Parent-Child Relations, Opioid Misuse, Opioid Use Disorder
- Trial name
- NCT05180487
- Testing
- Family Check-Up
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Prescription Drug Abuse (Not Dependent)
Mobile Application for Prescription Drug-Abuse Education (MAPDE)
The aims of this pilot study are: (1) to assess the feasibility and acceptability of a mobile application to educate military members about the risks of prescription drug misuse; (2) to determine if there is evidence that the…
- Trial name
- MAPDE (NCT03165175)
- Testing
- prescription drug-abuse education smartphone application
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Naval Health Research Center
Substance Use Disorders, Youth Protection Services
Adapting Personality-Targeted Interventions for Reducing Substance Misuse and Related Outcomes in Youth in Youth Protection Services
Substance use problems are major concern in adolescents involved in Youth Protection Services. However, there is an enormous gap between the needs and availability of interventions for youth with substance use problems in the…
- Conditions
- Substance Use Disorders, Youth Protection Services, Early Intervention, Prevention
- Trial name
- NCT04162977
- Testing
- Personality-targeted Interventions
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- St. Justine's Hospital
Alcohol Misuse
Bridging Opportunities for Substance Use Screening and Treatment for Teens With Chronic Illness
Adolescents with a chronic medical condition (A-CMC) are more likely to misuse and initiate alcohol and other drugs (AOD) at younger ages compared to adolescents without CMCs.
- Trial name
- BOSSTT (NCT07446075)
- Testing
- Screening, Brief Intervention, and Referral to Treatment (SBIRT)
- Volunteers
- 50 people
- Sponsor
- Faith Summersett Williams
Overdose, Risk Behavior
The Impact of a Web-Based Naloxone Intervention Under Standing Orders to Patients Prescribed Chronic Opioid Therapy
In the setting of naloxone standing orders, this study will assess the impact of a targeted, web-based overdose prevention and naloxone intervention for patients prescribed chronic opioid therapy.
- Trial name
- NCT03337009
- Testing
- Naloxone Navigator (NN)
- Where
- United States
- Volunteers
- 1,004 people
- Sponsor
- Kaiser Permanente
Intensive Care (ICU), Critical Illness
Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin
The goal of this observational study is to learn whether hazardous alcohol consumption, measured objectively by carbohydrate-deficient transferrin (CDT) levels at intensive care unit (ICU) admission, is associated with worse…
- Conditions
- Intensive Care (ICU), Critical Illness, Alcohol Misuse
- Trial name
- IMPACT (NCT07632716)
- Testing
- Carbohydrate-Deficient Transferrin (CDT) Measurement
- Where
- Austria
- Volunteers
- 800 people
- Sponsor
- Medical University of Vienna
Misuse, Opioid
Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
To learn about the effectiveness of taking the antipsychotic medication olanzapine to help lower opioid craving.
- Trial name
- NCT06200181
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- M.D. Anderson Cancer Center