Clinical trials: Substance Related Disorder
Stress Disorders, Post-Traumatic, Depressive Symptoms
Mindfulness-based Intervention to Address PTSD in Trauma-exposed, Homeless Women
Posttraumatic stress disorder (PTSD) is a major public health concern that disproportionately effects minorities and those with low-socioeconomic status, such as homeless women, creating a critical health disparity.
- Conditions
- Stress Disorders, Post-Traumatic, Depressive Symptoms, Hydrocortisone, Substance Use
- Trial name
- NCT04605198
- Testing
- Modified Mindfulness-based Stress Reduction, Health Promotion Wellness Classes
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- University of California, Los Angeles
Narcotic Abuse
Aprepitant Effects on Oxycodone Response
Addressing the issue of opioid dependence and tolerance has public health implications for the treatment of opioid abuse (both heroin as well as pharmaceutical opioids) and for the treatment of pain.
- Trial name
- NCT00999544
- Testing
- Aprepitant 0mg, Aprepitant 40mg, Aprepitant 200mg
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Opioid Use Disorder
Oxytocin, Stress, Craving, Opioid Use Disorder
Although stress has long been linked to substance use, craving and relapse, there are no available medications that target stress-induced substance use disorder (SUD).
- Trial name
- OSCO (NCT04051619)
- Testing
- intranasal oxytocin, 40 IU, twice a day for 7 days
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brown University
Alcohol Use Disorder
Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control
The purpose of this study is to determine whether the catechol-O-methyltransferase (COMT) inhibitor tolcapone, relative to placebo, reduces alcohol drinking and alcohol cue-elicited brain activation and increases brain activation…
- Trial name
- NCT02949934
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Hepatitis C, Opioid-Related Disorders
The Kentucky Viral Hepatitis Treatment Study
The overarching goal of the Kentucky Viral Hepatitis Treatment Project (KeY Treat) is to increase hepatitis C virus (HCV) treatment access and delivery in a rural Appalachian community, which is in the midst of the…
- Conditions
- Hepatitis C, Opioid-Related Disorders, Injection Drug Use
- Trial name
- KeY Treat (NCT03949764)
- Testing
- Sofosbuvir/velpatasvir (Epclusa®)
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- Jennifer Havens
Acute Pancreatitis (AP), Gallstone Pancreatitis
Pentoxifylline Treatment in Acute Pancreatitis (AP)
The purpose of this study was to determine the effects (good and bad) of giving a drug called pentoxifylline to patients with acute pancreatitis.
- Conditions
- Acute Pancreatitis (AP), Gallstone Pancreatitis, Alcoholic Pancreatitis, Trauma Acute Pancreatitis
- Trial name
- AP (NCT02487225)
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Mayo Clinic
Substance Use Disorders, Depression
Study of a Transdiagnostic, Emotion-focused Group Intervention for Young Adults With Substance Use Disorders
The overall aim of this pilot study is to conduct a preliminary trial to evaluate the acceptability and feasibility of adding a transdiagnostic, emotion-focused group intervention (the Unified Protocol, UP) to treatment as usual…
- Conditions
- Substance Use Disorders, Depression, Anxiety, Emotional Disorder
- Trial name
- ARMS UP (NCT03315208)
- Testing
- Unified Protocol (UP), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Hepatitis C, Opiate Dependence
Effective Treatment of Hepatitis C in Substance Users
We hypothesize that integrating Hepatitis C into methadone and buprenorphine treatment will improve Hepatitis C outcomes as well as drug treatment outcomes in patients who are addicted to opiates.
- Trial name
- NCT00633243
- Testing
- Modified Directly Observed Therapy (mDOT), Self-Administered Therapy (SAT)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Substance Use Disorders
Mindfulness Based Relapse Prevention: Efficacy and Mechanisms
The broad, long-term objective of the proposed randomized clinical trial is to evaluate the efficacy, moderators and mechanisms of change of two cognitive-behavioral aftercare treatments for alcohol and other drug (AOD) use…
- Trial name
- MBRP (NCT01159535)
- Testing
- Mindfulness Based Relapse Prevention, Relapse Prevention, Treatment as Usual
- Where
- United States
- Volunteers
- 286 people
- Sponsor
- University of Washington
Musculoskeletal Pain, Chronic Pain
Living in Full Even With Pain Study
This project will increase our understanding of the mechanisms underlying changes in opioid medication use associated with three psychosocial chronic pain (CP) treatments.
- Trial name
- LIFE (NCT03916276)
- Testing
- Cognitive Therapy (CT), Mindfulness Meditation (MM), Behavioral Activation (BA)
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of Washington
Hepatitis, Alcoholic
Pentoxifylline for Acute Alcoholic Hepatitis (AAH)
The goal of this study is to demonstrate the effectiveness of pentoxifylline compared to placebo in AAH while studying putative mechanisms that are plausible and testable.
- Trial name
- NCT00205049
- Testing
- pentoxifylline
- Volunteers
- 4 people
- Sponsor
- University of Wisconsin, Madison
Tobacco Use Disorder, Medication Adherence
Varenicline Smoking Cessation Treatment for Methadone Maintenance Patients
This randomized trial will evaluate whether varenicline directly observed therapy provided at a methadone clinic is more efficacious than self-administered varenicline for promoting smoking cessation and enhancing adherence.
- Trial name
- NCT01378858
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Albert Einstein College of Medicine
Continuous Methamphetamine Abuse
Monoamine Antagonist Therapies for Methamphetamine Abuse Prazosin
This protocol will test the safety, effectiveness and the metabolism and action of prazosin as a potential therapy for methamphetamine abuse. This will be accomplished by performing a series of human laboratory studies.
- Trial name
- MATMA (NCT01178138)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Fetal Alcohol Spectrum Disorders
Efficacy Trial of the FMF Connect Mobile Health Intervention
The purpose of this study is to test a new smartphone "app" for parents/caregivers of children with fetal alcohol spectrum disorder (FASD). The app is called Families Moving Forward (FMF) Connect.
- Trial name
- NCT05028517
- Testing
- FMF Connect, Coaching
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Nicotine Dependence
Study Two on the Effectiveness of Mindfulness Training for Smokers
The MTS2 study enrollment goal is N=240 adult smokers randomized to study treatments. The study design includes two randomized arms to compare matched intensive interventions and a third non-randomized option for participants who…
- Trial name
- MTS2 (NCT01299909)
- Testing
- Integrated Training for Smokers, Mindfulness Training for Smokers, Quitline
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Wisconsin, Madison
Alcohol Dependence, Cocaine Dependence
Human Behavioral Pharmacology Laboratory (HBPL) Study of Varenicline's Impact on Cocaine and Alcohol Craving
This is a Phase II within-subjects double-blind placebo-controlled human laboratory study. The purpose of the study is to determine the efficacy of varenicline (Chantix) for reducing cue-induced cocaine and alcohol craving.
- Trial name
- NCT01151813
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Tobacco Use Disorder
Comparison Across Treatment Conditions to Reduce Smokeless Tobacco Use
Smokeless tobacco (ST), which includes both chewing tobacco and snuff, has health risks associated with its use. While treatment programs that focus on stopping tobacco use may be effective, past research has shown that…
- Trial name
- NCT00218296
- Testing
- Usual Care Group, Reduction Group
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Alcohol Use Disorder
Ibudilast and Withdrawal-Related Dysphoria
Alcohol use disorder (AUD) is a prevalent and disabling psychiatric disorder with few, and only moderately efficacious, treatment options.
- Trial name
- NCT03489850
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, Los Angeles
Nicotine Dependence
Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use
The goal of this research is to understand the potential impact of two new FDA strategies to ensure the availability of safer Alternative Nicotine Delivery Systems (ANDS) and to reduce the nicotine content in combustible…
- Trial name
- NCT04084210
- Testing
- Juul Electronic cigarette, Very Low Nicotine Cigarettes, Active Nicotine Patch
- Where
- 2 sites in United States
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alcohol Dependence
Citalopram Effects on Craving and Dopamine Receptor Availability in Alcoholics
Alcohol use disorders (AUDs) are highly prevalent among U.S. civilians, and even more prevalent in the U.S. Veteran population. AUDs are frequently co-morbid with depressive symptoms in psychiatric clinical populations, resulting…
- Trial name
- CECDRAAD (NCT01657760)
- Testing
- citalopram
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.