Clinical trials: Substance Related Disorders
Smoking, Cigarette, Smoking, Tobacco
Examination of Low Wattage and High Wattage E-Cigarettes
The overall aim of the proposed study is to evaluate the effect of switching from conventional cigarettes to either a LWe or HWe on smoking behavior, product use patterns and continued use, as well as biomarkers of toxicant…
- Conditions
- Smoking, Cigarette, Smoking, Tobacco, Nicotine Dependence, Exposure to Toxic Agent
- Trial name
- SWITCH (NCT03113136)
- Testing
- Low wattage E cigarette device, High wattage E cigarette device, Usual brand cigarette
- Where
- United States
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Nicotine Dependence
Testing Financial Incentive Interventions in Dyadic-Smoker Couples
The proposed study investigates the feasibility and efficacy of FITs in dual-smoker couples [DSCs]. The core design is a three-group mixed repeated measures design, in which participants are randomized into one of three…
- Trial name
- NCT04832360
- Testing
- Financial Incentives
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Opioid-use Disorder, Tobacco Use Disorder
Adjunctive Transcranial Stimulation to Reduce Impulsivity in Opiate Use Disorder
The goal of this study is to examine the effect of four sessions of theta burst stimulation (TBS) versus sham TMS on attentional bias for smoking and opioid cues versus neutral stimuli in a population of patients with tobacco use…
- Trial name
- NCT05049460
- Testing
- Theta Burst Stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Gopalkumar Rakesh
Chronic Pain, Chronic Low Back Pain
Pain Research: Innovative Strategies With Marijuana
This study tests the effects of cannabinoid levels in blood on pain relief, inflammation, and cognitive dysfunction in chronic pain patients who choose to use edible cannabis.
- Conditions
- Chronic Pain, Chronic Low Back Pain, Cannabis Use
- Trial name
- PRISM (NCT03522324)
- Testing
- Cannabis Edible
- Where
- United States
- Volunteers
- 268 people
- Sponsor
- University of Colorado, Boulder
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
While the prevalence of smoking in the United States general population has declined over the past 50 years, there has been little to no decline among people with mental health conditions.
- Trial name
- NCT04090879
- Testing
- Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Use Disorder
Ibudilast for the Treatment of Alcohol Use Disorder
This study is a double-blind, placebo-controlled randomized clinical trial of Ibudilast (IBUD) (50mg twice a day) for the treatment of Alcohol Use Disorder (AUD).
- Trial name
- NCT03594435
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of California, Los Angeles
Alcoholism, Nicotine Dependence
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
The overall hypothesis of this line of research is that varenicline will decrease alcohol consumption and tobacco use and will increase alcohol and tobacco abstinence rates.
- Trial name
- NCT01169610
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Substance Withdrawal Syndrome
Signs and Symptoms of Opioid-associated Iatrogenic Withdrawal in Critically Ill Adults
Mechanically ventilated critically ill adults may require prolonged administration of opioids to facilitate ventilator support and maintain comfort.
- Trial name
- SOWA-ICU (NCT03435614)
- Testing
- Opioids
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Marc M. Perreault
Opioid-related Disorders
Abuse Liability of Suboxone Versus Subutex
The study is designed to compare the abuse liabilities of intravenous buprenorphine and buprenorphine/naloxone in individuals who are physically dependent on sublingual buprenorphine.
- Trial name
- NCT00710385
- Testing
- Heroin, Naloxone, Low Bup Dose
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Alcoholism
ALK21-003: Study of Medisorb® Naltrexone (VIVITROL®) in Alcohol-Dependent Adults
This was a Phase 3, multicenter, randomized, double-blind, placebo-controlled study conducted in subjects diagnosed with alcohol dependence as defined by the Diagnostic and Statistical Manual of Mental Disorders, 4th Ed.
- Trial name
- NCT01218958
- Testing
- Medisorb naltrexone 190 mg, Medisorb naltrexone 380 mg
- Volunteers
- 624 people
- Sponsor
- Alkermes, Inc.
Bladder Cancer, Cervical Cancer
Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking
RATIONALE: A stop-smoking plan that includes health education counseling and bupropion may help African-American smokers stop smoking.
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00666978
- Testing
- smoking cessation intervention, bupropion hydrochloride, gene expression analysis
- Where
- 2 sites in United States
- Volunteers
- 540 people
- Sponsor
- Lisa Sanderson Cox, PhD
Mental Illness
Evaluating Vocational Materials for Incarcerated Veterans With Mental Illness or Substance Abuse
The purpose of this research is to test the usefulness of a vocational rehabilitation program for veterans with a history of felonies who also have a mental illness or have substance dependency.
- Trial name
- NCT00648115
- Testing
- Basic Vocational Services, Self-Study, Group Program
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- VA Office of Research and Development
HIV/AIDS, Alcohol Abuse
An Economic and Relationship-strengthening Intervention for HIV-affected Couples Who Drink Alcohol in Malawi
A couples-based alcohol-reduction and economic and relationship-strengthening intervention for HIV-affected couples in Malawi.
- Trial name
- NCT04906616
- Testing
- Mlambe
- Where
- Malawi
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depression, Dual Diagnosis
Open-Label Creatine Study for Female Meth Users
Study Purposes and Objectives: The objectives should be stated in such a way that the reader can determine the appropriateness of the study design. If appropriate, state the specific hypotheses being tested and/or study aims.
- Conditions
- Depression, Dual Diagnosis, Substance Use
- Trial name
- NCT02189915
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Opioid Use Disorder
Cannabidiol in the Treatment of Opioid Use Disorder
The long-term goal of the project is to determine whether cannabidiol (CBD) can reduce craving and relapse in individuals with opioid use disorder (OUD).
- Trial name
- NCT06206291
- Testing
- Cannabidiol (CBD) 200mg, Cannabidiol (CBD) 400mg
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Yasmin Hurd
Nicotine Dependence
Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers
The purpose of this study is to better characterize differences in mood, attention, brain activation patterns underlying the beneficial effects of pharmacological treatments previously demonstrated to be help individuals…
- Trial name
- NCT01048944
- Testing
- Bupropion SR, Nicotine Patch
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- Southern Illinois University Carbondale
Alcoholic Hepatitis
IL-1 Signal Inhibition in Alcoholic Hepatitis
Alcoholic hepatitis (AH) is a florid presentation of alcoholic liver disease characterized by liver failure in the context of recent and heavy alcohol consumption.
- Trial name
- ISAIAH (NCT03775109)
- Testing
- Canakinumab 150mg/ml solution for injection
- Where
- 16 sites in United Kingdom
- Volunteers
- 55 people
- Sponsor
- Imperial College London
Nicotine Dependence
A Study to Help People Quit Smoking.
You are invited to participate in a research study at the VA Connecticut Healthcare System (West Haven campus) that examines whether a medication called galantamine can improve your learning and memory, and also help you to quit…
- Trial name
- NCT01880099
- Testing
- Galantamine 8mg, Galantamine 16mg
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Alcoholism
A Novel Compound for Alcoholism Treatment: A Translational Strategy - Part II
Background: Hormones are naturally occurring chemicals in the body. Ghrelin is a hormone that stimulates appetite. It may also stimulate alcohol cravings and use.
- Trial name
- NCT02707055
- Testing
- PF-05190457
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Substance Use Disorder
The Tobacco, Alcohol, Prescription Medication and Other Substances Tool
The purpose of the study is to develop and validate a questionnaire to screen and assess adult primary care patients for tobacco, alcohol, prescription drug, and drug use and problems related to their use.
- Trial name
- CTN0059 (NCT02110693)
- Testing
- Interviewer and tablet administration of the TAPS Tool
- Where
- 4 sites in United States
- Volunteers
- 2,057 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.