Clinical trials: Substance Use Disorder, active
Substance Abuse, Substance Addiction
The Trans-Led Care Study
This study is testing a new mutual-help group called "the TLC program" for transgender adults who use substances or are recently in recovery.
- Conditions
- Substance Abuse, Substance Addiction, Substance Use Disorder (SUD), Substance Use (Drugs, Alcohol)
- Trial name
- TLC (NCT06880705)
- Testing
- The TLC Program
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Illinois Institute of Technology
Opioid Use Disorder
Evaluation of a Patient Decision Aid for Emergency Department Initiated Buprenorphine
This study aims to develop and pilot test a patient decision aid (PtDA) for emergency department (ED)-initiated buprenorphine treatment for opioid use disorder (OUD).
- Trial name
- NCT07278518
- Testing
- Patient Decision Aid for Opioid Use Disorder
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Substance Use Disorders
Enhancing Substance Use Treatment Services to Decrease Dropout and Improve Outpatient Treatment Utilization in Emerging Adults
Emerging adults (ages 18-25) are at higher risk for substance use disorders, including opiate addiction, than any other age group but are also more likely to drop out early from substance use treatment services.
- Trial name
- P2P (NCT05374395)
- Testing
- Peer Recovery Support-Delivered Dropout Prevention enhancement
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- UConn Health
Opioid Use Disorder, Digital Health Intervention
Pilot Testing of the emPath Platform to Improve Medication for Opioid Use Disorder (MOUD) Linkage and Retention Among Adults With Opioid Use Disorder in Durham, North Carolina
This pilot study will evaluate the emPath digital platform, a platform designed to improve access to and retention in low-barrier telemedicine for delivery of medication for opioid use disorder (MOUD) among adults with opioid use…
- Conditions
- Opioid Use Disorder, Digital Health Intervention, Telemedicine, Outreach Intervention
- Trial name
- NCT07810322
- Testing
- emPath Intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Nicotine Use Disorder
Real-time eCounselling for Nicotine Addiction
The goal of this clinical trial is to pilot an eHealth intervention (real-time telecounselling) in nicotine addiction. The main questions it aims to answer are: Is the intervention likely to be efficacious in preventing an…
- Trial name
- NCT06544057
- Testing
- CBT-MI
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Overcome
Mindfulness, Guanfacine
Combined Guanfacine and Mindfulness Meditation as an Adjunct to Buprenorphine Maintenance in Opioid Use Disorder
The US is currently going through an opioid crisis, and while Medication Assisted Treatments such as buprenorphine (BUP) have proved highly effective at stabilizing the neurobiology underlying acute withdrawal, they have been…
- Conditions
- Mindfulness, Guanfacine, Opioid Use Disorder
- Trial name
- NCT06642181
- Testing
- Guanfacine pharmacotherapy, Mindfulness Oriented Recovery Enhancement (MORE)
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Rutgers, The State University of New Jersey
Opioid Use Disorder
Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose
The investigators aim to test the effectiveness of a high maintenance daily dose of buprenorphine (24 mg) for improving outcomes among patients who used fentanyl compared to the standard daily dose (16 mg).
- Trial name
- Optimal Bup (NCT06316830)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Rhode Island Hospital
Opioid Use Disorder
Mobile Peer Support for OUD Recovery
The COVID-19 pandemic puts individuals recovering from opioid use disorders (OUDs), an already vulnerable population, at increased risk of overdose due to decreased access to treatment, decreased social support, and increased…
- Trial name
- MPS (NCT05405712)
- Testing
- Mobile Phone App
- Where
- 2 sites in United States
- Volunteers
- 1,300 people
- Sponsor
- Brown University
Opioid-use Disorder
Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder
This study will evaluate the effectiveness of a new pharmacological approach to increase efficacy of treatment with extended release naltrexone (XR-naltrexone) for individuals with opioid use disorder by combining it with…
- Trial name
- COMBO (NCT05011266)
- Testing
- Buprenorphine/naloxone
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- New York State Psychiatric Institute
Social Isolation or Loneliness, Anxiety
Health Surveillance at Constructor University Bremen (CUB)
The aim of Health Surveillance is to analyze and describe the state of health of students at Constructor University, key influencing factors and individual resources by using mixed-method design.
- Conditions
- Social Isolation or Loneliness, Anxiety, Anxiety Depression (Mild or Not Persistent), Health Behavior
- Trial name
- CUB-HS2025 (NCT06899308)
- Testing
- questionnaire
- Where
- 2 sites in Germany
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- Jacobs University Bremen gGmbH
Behavior, Health
Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth
The goal of this clinical trial is to deliver a computer-based working memory training program to improve delay discounting (DD) and prevent substance misuse among at-risk adolescents in a traditionally underserved area.
- Trial name
- NCT06242704
- Testing
- Working Memory Training, Working Memory
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Alcohol Use Disorder
HD-tACS for Alcohol Use Disorder
This study aims to systematically explore the effectiveness of accelerated HD-tACS in treating AUD, particularly its efficacy in reducing alcohol craving and preventing relapse in AUD patients.
- Trial name
- NCT07808190
- Testing
- HD-tACS
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shanghai Mental Health Center
Opioid Use Disorder
Measurement Based Care in Opioid Treatment Programs
The goal of this HEAL Initiative study is to enhance the measurement, quality, and equity of care delivered in 20 community opioid treatment programs (OTPs) by creating and using measurement-based care (MBC) tools and systems.
- Trial name
- NCT06965010
- Testing
- Measurement-based care, Measurement As Usual
- Where
- United States
- Volunteers
- 3,650 people
- Sponsor
- University of Pittsburgh
Alcohol Use Disorder
Evaluating the Effectiveness of Implementation Intentions to Strengthen Approach-avoidance Training
Approach Bias Modifcation corresponds to computerized interventions designed to change a cognitive bias (i.e., the approach bias) that may contribute to the maintenance of Alcohol Use Disorder.
- Trial name
- IMBA (NCT06211959)
- Testing
- Approach Bias Modification with Implementation Intentions
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Clinique de la Mitterie
Alcohol Use Disorder
Enhancing Prospective Thinking in Early Recovery (HOME)
The goal of this clinical trial is to use a novel virtual reality intervention to test for efficacy in reducing alcohol use and increasing abstinence, with concomitant increases in future self-identification, future time…
- Trial name
- HOME (NCT06302413)
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Indiana University
PTSD - Post Traumatic Stress Disorder, Substance Use Disorder (SUD)
Mechanisms of Written Exposure Therapy in Residential SUD Treatment
The goal of this clinical trial is to learn how Written Exposure Therapy (WET), a brief treatment for PTSD, works among individuals with substance use disorders (SUD) engaged in residential SUD treatment and how biology may…
- Trial name
- NCT07397507
- Testing
- Written Exposure Therapy, Neutral Writing
- Volunteers
- 108 people
- Sponsor
- Mclean Hospital
Depression - Major Depressive Disorder, Alcohol Use Disorder
ACT_for Alcohol Use Disorder and Depression
Alcohol use disorders (AUDs) and depressive disorders frequently coexist, complicating the clinical management of patients suffering from them.
- Trial name
- NCT06620276
- Testing
- Acceptance and Commitment Therapy, Ketamine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cannabis Use, Substance Use Disorder (SUD)
Research Investigating Drug Effects-2 (RiDE-2)
The purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs.
- Conditions
- Cannabis Use, Substance Use Disorder (SUD), Healthy
- Trial name
- RiDE-2 (NCT06758596)
- Testing
- THC
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Opioid Use Disorder
Wellcome Leap Psilocybin for OUD
Investigators will recruit 36 individuals on MAT for OUD for a double-blind, placebo-controlled design to determine whether PEX010 (25-mg/d) shows preliminary efficacy on neural correlates of neurocognition and on clinical…
- Trial name
- NCT06786325
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Anna Rose Childress, Ph.D.
Anabolic Androgenic Steroid Use, Substance-Related Disorders
Anabolic-Androgenic Steroid Use Among Gym-Goers
This randomized controlled trial will evaluate the efficacy of a Transtheoretical Model (TTM)-based behavior-change intervention, delivered through stage-matched counseling sessions, on anabolic-androgenic steroid (AAS) use among…
- Trial name
- TTM - AAS (NCT07702110)
- Testing
- TTM-Based Intervention for AAS Use Reduction A structured, multi-session counseling intervention grounded in the Transtheoretical Model. Content and techniques (e.g., consciousness raising, decisional
- Where
- Iraq
- Volunteers
- 120 people
- Sponsor
- Alaa Yousif Ayed Ahmed
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