Clinical trials: Substance Use Disorders, active
Opioid Use Disorder
Social Functioning in Opioid Use Disorder
Problems with social functioning are core to opioid use disorder (OUD), though specific, modifiable social functioning targets and how they relate to OUD treatment outcomes are poorly understood.
- Trial name
- OUD (NCT07044466)
- Testing
- CBT4CBT-Buprenorphine
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Major Depressive Disorder, Substance Use Disorders
Peer-Delivered Behavioral Activation in a CCBHC
Low-income individuals have limited access to evidence-based interventions for mental health. Peer recovery specialists, individuals in recovery from mental health and/or substance use problems, have the potential to increase…
- Trial name
- NCT07219394
- Testing
- Peer Activate, Peer-delivered non-specific services
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Wayne State University
Substance Use Disorder, Alcohol Use Disorder
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who participate in studies safe. It also helps ensure accurate study results.
- Trial name
- NCT06552741
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cigarette Smoking, Veterans
Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment
Veterans with substance use disorders smoke at extraordinarily high rates and have high rates of smoking-related death and disease.
- Trial name
- Co-STOP (NCT07809854)
- Testing
- Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- VA Office of Research and Development
Opioid Use Disorder
OUD (Opioid Use Disorder) Target Trial
In this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids.
- Trial name
- NCT06585709
- Testing
- Active repetitive Transcranial Magnetic Stimulation (rTMS), High Ventral Striatal Reactivity, Low Ventral Striatal Reactivity
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Alcohol Use Disorder (AUD)
The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study
A phase II randomized, double-blind, placebo-controlled clinical trial (RCT) to evaluate the ability of zonisamide (ZON) to decrease alcohol use among treatment-seeking adults with an alcohol use disorder (AUD).
- Trial name
- NCT05134857
- Testing
- Zonisamide
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Washington State University
PTSD - Post Traumatic Stress Disorder, Substance Use Disorder (SUD)
Mechanisms of Written Exposure Therapy in Residential SUD Treatment
The goal of this clinical trial is to learn how Written Exposure Therapy (WET), a brief treatment for PTSD, works among individuals with substance use disorders (SUD) engaged in residential SUD treatment and how biology may…
- Trial name
- NCT07397507
- Testing
- Written Exposure Therapy, Neutral Writing
- Volunteers
- 108 people
- Sponsor
- Mclean Hospital
Substance Abuse, Opioid Abuse (Disorder)
Youth Overdose & Use Reduction in Rural Systems
The goal of this study is to conduct a clinical trial to understand effects of providing multilevel intervention to young people in the legal system.
- Conditions
- Substance Abuse, Opioid Abuse (Disorder), Overdose Prevention, Substance Use Disorder (SUD)
- Trial name
- YOURS (NCT07846735)
- Testing
- Navigator - Flexible Care Management
- Volunteers
- 550 people
- Sponsor
- Seattle Children's Hospital
Diabetes Mellitus, Type 2, Nicotine Dependence, Cigarettes
Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients
Diabetes has become an increasingly serious global health issue. In 2024, approximately 537 million adults were living with diabetes, and this number is projected to rise to 783 million by 2045, representing a 46% increase.
- Trial name
- NCT06924697
- Testing
- Application of GLP-1RAs drugs, DPP-4i group
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai East Hospital
Addiction
Efficacy of a Smartphone App. Designed to Manage Craving & Individual Predictors of Substance Use/Addictive Behavior
Test the Efficacy of a smartphone application designed to manage craving and individual predictors of substance use / addictive behavior among individuals with addictive disorders
- Trial name
- CRAVINGMANAGER (NCT04732676)
- Testing
- Smartphone application
- Where
- France
- Volunteers
- 274 people
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
Alcoholism, Substance-Related Disorders
SMART-r: Substance Monitoring and Active Relapse Tracking Repository
Background: About 1.5 million adults in the US enter alcohol or substance use treatment programs each year. Unfortunately, more than half of patients do not finish their program.
- Trial name
- NCT06676059
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco, Tobacco Abstinence
Quitting Matters Human Immunodeficiency Virus Hybrid Trial
The purpose of this study is to compare the advantages and disadvantages of two approaches for quitting smoking among people living with HIV (PWH).
- Conditions
- Tobacco, Tobacco Abstinence, Smoking Cessation, Smoking Cessation; Tobacco Dependence
- Trial name
- QMH (NCT06883097)
- Testing
- Learn to Quit-HIV (LTQ-H) App, QuitStart
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- Wake Forest University Health Sciences
Cocaine Use Disorder
Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder
In The Netherlands, each year, about 15 thousand people come into treatment because of problems with cocaine use. There is no approved medication for treatment of cocaine addiction and the psychosocial treatment patients receive…
- Trial name
- NCT05529927
- Testing
- Sustained-release Dexamphetamine
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Parnassia Addiction Research Centre
Opioid-use Disorder, Chronic Pain
Randomized Trial of ACT and a Care Management App in Primary Care-based Buprenorphine Treatment
The proposed IMPOWR Research Center at Montefiore-Einstein (IMPOWR-ME) will create a multidisciplinary and synergistic program of research to test multimodal treatments that address both chronic pain and opioid use disorder.
- Trial name
- NCT05039554
- Testing
- Acceptance and commitment therapy, Valera Smartphone Application, Treatment as Usual
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Albert Einstein College of Medicine
Depression, Tobacco Use Disorder
Use of a Smartphone Mobile Application (App) to Enhance Smoking Cessation Treatment
This trial studies how well smartphone mobile applications work in enhancing smoking cessation treatment in current smokers. Smartphone mobile applications may help current smokers quit smoking.
- Conditions
- Depression, Tobacco Use Disorder, Current Every Day Smoker
- Trial name
- NCT03519451
- Testing
- Internet-Based Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Alcohol Use Disorder
Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)
The goal of the project is to evaluate whether donepezil + cognitive remediation therapy is superior to placebo in reducing heavy drinking in patients with alcohol use disorder in a double-blind, placebo-controlled trial.
- Trial name
- NCT05042102
- Testing
- Donepezil + Cognitive remediation therapy (CRT)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- VA Connecticut Healthcare System
Opioid-use Disorder, Opioid Dependence
Young Houston Emergency Opioid Engagement System
The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Opioid Overdose, Opioid Use
- Trial name
- YHEROES (NCT04811014)
- Testing
- Buprenorphine, Naloxone Drug Combination, Individual Counseling, Peer Recovery Support Services
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Use Disorder, Insomnia
Mobile App Intervention for Sleep Problems and Alcohol Use Among Veterans
The goal of this clinical trial is to test the preliminary efficacy of a brief mobile app targeting insomnia symptoms among veterans.
- Trial name
- NCT06487793
- Testing
- Enhanced Insomnia Coach, Sleep hygiene comparator
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Southern California
PTSD - Post Traumatic Stress Disorder, Substance Use
CBITS-RTM Pilot Study
This pilot study, conducted in partnership with juvenile detention centers, evaluates an adapted CBITS-RTM intervention delivered in a detention school setting.
- Trial name
- NCT07682441
- Testing
- Adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS) with a Racial Trauma Module (RTM)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Francisco
Tobacco Dependence
C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics
In a residency clinic in Baltimore, the investigators propose to conduct a pilot RCT comparing a) an avatar-delivered computerized intervention (CI) for tobacco cessation augmented with CHW support and navigation to lung cancer…
- Trial name
- NCT07220356
- Testing
- C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.