Clinical trials: Substance- Related Disorder
Stress, Alcoholism
Chronic Alcohol and Brain Stress Circuit Response
Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol…
- Trial name
- NCT01031264
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder
Lemborexant Augmentation of Naltrexone for Alcohol Craving and Sleep
The purpose of this study to evaluate the effects of naltrexone plus lemborexant augmentation compared to naltrexone plus placebo on cue-induced and non-cued alcohol cravings in people with alcohol use disorder and insomnia.
- Trial name
- NCT05458609
- Testing
- Lemborexant 10 mg, Naltrexone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Baylor College of Medicine
Opioid Use Disorder, Pregnancy Related
Open Trial of Technology-Enhanced Behavioral Intervention for Buprenorphine Retention in Pregnant and Postpartum People
This study involves testing how useful a technology-enhanced intervention is for pregnant people prescribed buprenorphine for the management of opioid use disorder.
- Trial name
- NCT06496230
- Testing
- Empowering Pregnant Women and People Receiving Medications for Opioid Use Disorder
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Substance Use
Impact of a Computer-Assisted SBIRT Program in an HIV Care Setting
The goal of this research is to assess the impact of the "screening, brief intervention, and referral to treatment" (SBIRT) intervention strategy for harmful substance use among HIV-positive people.
- Trial name
- SBIRT (NCT01300806)
- Volunteers
- 210 people
- Sponsor
- University of California, San Francisco
Alcohol Use, Unspecified, Substance Use
ANCHORS Alcohol & Sexual Health Study: UH3 Project
80 young adult men will complete an initial survey and receive 1 of 2 types of alcohol and sexual health education and information to encourage prevention of alcohol-related problems, HIV and other sexually transmitted infections…
- Conditions
- Alcohol Use, Unspecified, Substance Use, Sex Behavior
- Trial name
- NCT04331704
- Testing
- PrEP acronym (pre-exposure prophylaxis), Initial Web Survey, Interactive Voice Response (IVR) monitoring
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Florida
Opioid Overdose
Naloxone Nasal Spray Pharmacokinetic Study
This study aims to compare the pharmacokinetics of naloxone when administered as the Mitovie nasal spray (Test Product) and as a solution for injection (Comparator Product) administered intranasally using a mucosal atomization…
- Trial name
- NCT01622504
- Testing
- MVP005, Naloxone hydrochloride solution for injection with mucosal atomization device
- Where
- Jordan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Mitovie Pharma Ltd
Constipation
TD-1211 Single-Dose Study in Elderly and Young Healthy Subjects
The purpose of this study is to measure the way in which TD-1211 is absorbed and eliminated by the body and to evaluate whether it is safe and well tolerated.
- Trial name
- NCT01655771
- Testing
- TD-1211 Dose 1, TD-1211 Dose 2
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Glycyx Therapeutics
Alcoholism
Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects With Alcohol Dependence
Background: This study is being done to examine the role of a chemical GABA in the brain of alcohol dependent patients. GABA is the chief inhibitory neurotransmitter in the central nervous system.
- Trial name
- NCT01904487
- Testing
- [11C]flumazenil, Tiagabine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran
Alcoholic Cirrhosis, Alcohol Abstinence
Safety & Efficacy of Baclofen for Alcohol Withdrawal in Chronic Liver Disease With Active Alcohol Consumption
This study examines the safety and effectiveness of baclofen as a treatment for alcohol withdrawal in patients with chronic liver disease who continue drinking.
- Conditions
- Alcoholic Cirrhosis, Alcohol Abstinence, Alcohol Withdrawal, Medication Toxicity
- Trial name
- BAWIC (NCT06840652)
- Testing
- Baclofen
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Corporacion Parc Tauli
Substance Abuse, Families
Family-Based Drug Services for Young Disaster Victims
This protocol seizes this rare scientific opportunity to test an integrative family based model to address youths' coexisting substance abuse and trauma in the wake of Hurricane Katrina.
- Conditions
- Substance Abuse, Families, Trauma
- Trial name
- Katrina (NCT01859000)
- Testing
- Multidimensional Family Therapy, Group CBT
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Miami
Tobacco Use Disorder
Smoking Cessation Behavioral Treatment Study
The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT).
- Trial name
- NCT03948893
- Testing
- Mindfulness-Oriented Recovery Enhancement (MORE), Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Opiate Addiction
On-site Evaluation of Substances Consumption on Opiate Maintenance
In France, General Practitioners (GPs) are widely involved in opiate maintenance treatment (OMT) by initially prescribing buprenorphine and monitoring patients under buprenorphine and methadone.
- Trial name
- ESUB-MG (NCT02345655)
- Testing
- urine drug testing, no test
- Where
- 5 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Toulouse
Opioid Use Disorder
START NOW in the Treatment of Opioid Addicted Individuals
This investigation involves a partially randomized clinical trial examining the effectiveness of combining buprenorphine/naloxone MAT with START NOW, a skills-based psychosocial intervention modified specifically for the…
- Trial name
- NCT05552040
- Testing
- START NOW Group
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Carilion Clinic
Sexual Violence, Posttraumatic Stress Disorder
Testing STAR and TexSTAR: A Video and Text Messaging Intervention
This NIDA-funded HEAL Initiative: Opioid Use Disorder Care Pathways for Individuals with Histories of Exposure to Violence R61 seeks to develop and test a brief video intervention to deliver during Sexual Assault Nurse Examiner…
- Conditions
- Sexual Violence, Posttraumatic Stress Disorder, Opioid Use, Opioid Misuse
- Trial name
- NCT06456190
- Testing
- Skills Training in Active Recovery (STAR) Video, Text Skills Training in Active Recovery (TextSTAR) program
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Wisconsin, Madison
Alcohol Use Disorder
Virtual Reality (VR) NATURE - Alcohol Use Disorder (AUD)
This pilot randomized clinical trial will evaluate the feasibility, acceptability, and preliminary effectiveness of immersive Virtual Reality (VR) nature intervention among adults with at least moderate depression symptoms…
- Trial name
- NCT07413458
- Testing
- Virtual Reality (VR) -nature treatment, Survey completion
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Hepatitis C, Substance Use Disorders
Hepatitis C Treatment in PWIDs: MAT or Syringe Exchange Assisted-therapy vs Standard of Care
hepatitis C virus (HCV) has traditionally been treated in subspecialty health centers given the complexity of older pegylated interferon containing regimens, formerly the standard of care.
- Conditions
- Hepatitis C, Substance Use Disorders, Substance Abuse, Intravenous
- Trial name
- NCT03093415
- Testing
- elbasvir-grazoprevir (50 mg/100 mg)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
MASLD, Liver Cirrhosis, Alcoholic
Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients With Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement
The aim of this clinical trial is to investigate the development of cardiac decompensation following transjugular intrahepatic portosystemic shunt (TIPSS) implantation in order to draw conclusions for future treatment methods or…
- Conditions
- MASLD, Liver Cirrhosis, Alcoholic, Cirrhosis of Liver, Heart Decompensation
- Trial name
- EVALUATION (NCT06814990)
- Testing
- Cardiac MRI, Blood samples, Echocardiography
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Stephanie Gräger
Alcohol Abuse
Deep Repetitive Transcranial Magnetic Stimulation for Alcohol Use Disorder
dTMS intervention to reduce recurrent alcohol abuse among alcohol users who are abstinent for at least 5 days.
- Trial name
- NCT02691390
- Testing
- Active dTMS
- Volunteers
- 51 people
- Sponsor
- Soroka University Medical Center
Orthopedic Disorder, Nontraumatic Injury
Web-based Mind-body Program for Comorbid Nontraumatic Upper-extremity Condition and Risky Substance Use
The investigator aims to conduct an open pilot study (N=6; 5 completers) to test the feasibility, acceptability, and credibility of an asynchronous web-based mind-body intervention (Toolkit for Resilient Life beyond Pain and…
- Conditions
- Orthopedic Disorder, Nontraumatic Injury, Substance Use, Upper Extremity Problem
- Trial name
- NCT06366633
- Testing
- Web-TIRELESS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Jafar Bakhshaie
Substance Use Disorders
Substance Use Disorder, Brain and Behavioral Regulation
The proposed project seeks to explore the effects of a neuroregulation paradigm named Z-Score Quantitative Electroencephalogram (QEEG) guided sLORETA neurofeedback (ZQLN) on optimizing brain electrophysiological activity and…
- Trial name
- NCT05910749
- Testing
- QEEG-Guided sLoreta Neurofeedback Training
- Where
- Puerto Rico
- Sponsor
- University of Puerto Rico