Clinical trials: Substance-Related Disorder
Drug Abuse
A First Study in Healthy Volunteers of a New Mobile Phone Application Measuring the Eyes Before and After Medication
This is a pre-market, explorative, early feasibility, pilot, controlled clinical investigation designed to collect initial clinical data on the medical device Previct Drugs.
- Trial name
- NCT05731999
- Testing
- Previct Drugs
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kontigo Care AB
Smoking, Alcoholism
Combination Nicotine Replacement for Alcoholic Smokers
The overall objective of the study is to develop recommendations for treatment programs to help alcoholic smokers to stop smoking.
- Trial name
- NCT00064844
- Testing
- Cognitive Behavior Therapy for alcohol and smoking cessation, Nicoderm CQ nicotine patch, Nicotine gum - Nicorette®
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Yale University
Drug Dependence
Oxytocin and Cognitive Behavioral Therapy in Drug Dependence
Background: The therapeutic alliance between therapist and patient may contribute to favorable outcomes in all types of psychotherapy, including cognitive behavioral therapy (CBT) for drug dependence.
- Trial name
- NCT00975416
- Testing
- Cognitive Behavioral Therapy, Intranasal Oxytocin
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcoholism
Modulation of Pharmacologically Induced Alcohol Craving in Recently Detoxified Alcoholics
This study will determine if acamprosate, a drug approved to treat alcoholism, decreases alcohol cravings in alcohol-dependent subjects following infusions of yohimbine and mCPP.
- Trial name
- NCT00605904
- Testing
- Acamprosate, Yohimbine, mCPP
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
Effect of Endotoxin on Alcohol Consumption
For this protocol, the investigators plan to collect pilot data to examine the effect of endotoxin on drinking behavior in the human laboratory.
- Trial name
- NCT04527185
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Yale University
Bipolar Depression
The Use of a Mitochondrial Enhancement Treatment in Bipolar Disorder
The primary objective of this 15-week clinical trial is to test the hypothesis that treatment with two proven mitochondrial enhancers, acetyl-L-carnitine (ALCAR) and α-lipoic acid (ALA), has significantly greater efficacy than…
- Trial name
- NCT00719706
- Testing
- acetyl-l-carnitine PLUS alpha-lipoic acide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mclean Hospital
Alcohol Dependence, Stress Disorders, Post-Traumatic
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
Prazosin is an alpha-1 adrenergic receptor antagonist that has been used successfully in the treatment of trauma nightmares and sleep disturbance in combat veterans with PTSD, and alcohol dependence.
- Trial name
- NCT00744055
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Yale University
Opioid Abuse, Unspecified
Application of Economics & Social Psychology to Improve Opioid Prescribing Safety Trial 1: EHR Nudges
The opioid epidemic has had a tremendous negative impact on the health of persons in the U.S. The objective of the trial 1 of Application of Economics \& Social psychology to improve Opioid Prescribing Safety (AESOPS-T1), is to…
- Trial name
- AESOPS-T1 (NCT04477304)
- Testing
- Opioid Naive, OR, At-risk for long-term use, OR, Long-term opioid recipient
- Where
- United States
- Volunteers
- 555 people
- Sponsor
- University of Southern California
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Stress Disorders, Post-Traumatic, Depressive Symptoms
Mindfulness-based Intervention to Address PTSD in Trauma-exposed, Homeless Women
Posttraumatic stress disorder (PTSD) is a major public health concern that disproportionately effects minorities and those with low-socioeconomic status, such as homeless women, creating a critical health disparity.
- Conditions
- Stress Disorders, Post-Traumatic, Depressive Symptoms, Hydrocortisone, Substance Use
- Trial name
- NCT04605198
- Testing
- Modified Mindfulness-based Stress Reduction, Health Promotion Wellness Classes
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- University of California, Los Angeles
Opioid Use Disorder, Substance Use Disorder
Neurofeedback During Naturalistic Stimuli to Reduce Craving in Heroin Addiction
Support groups are an important component of addiction treatment, where individuals at more stable stages of their recovery help others by sharing personal experiences.
- Conditions
- Opioid Use Disorder, Substance Use Disorder, Heroin Use Disorder
- Trial name
- NCT07344233
- Testing
- Real-time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Smoking Cessation, Smoking, Tobacco
Helping Poor Smokers Quit
Using a 2x2 randomized factorial design, we will conduct a statewide field trial in Missouri to compare the relative and combined effects of these two strategies for augmenting an existing, evidence-based tobacco quitline…
- Conditions
- Smoking Cessation, Smoking, Tobacco, Smoking, Cigarette, Smoking, Pipe
- Trial name
- NCT03194958
- Testing
- Specialized Quitline, Basic Needs Navigator
- Where
- United States
- Volunteers
- 1,944 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Opioid-Related Disorders, Opiate Dependence
Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Dependence
The purpose of the study was to assess the efficacy of induction treatment with buprenorphine/naloxone (BNX) sublingual tablet s compared with induction treatment with buprenorphine only.
- Trial name
- NCT01848054
- Testing
- Buprenorphine/naloxone sublingual tablets, Buprenorphine
- Where
- 14 sites in United States
- Volunteers
- 313 people
- Sponsor
- Orexo AB
Cocaine-Related Disorders
Lorcaserin in the Treatment of Cocaine Use Disorder
The objective of this study is to evaluate the efficacy and safety of lorcaserin in the treatment of cocaine use disorder.
- Trial name
- NCT03007394
- Testing
- Lorcaserin
- Where
- 12 sites in United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Dependence
A Study of Adult Outpatients With Opioid Dependence Transitioned From a Daily SL Buprenorphine to Probuphine® Subdermal Implants
The primary objective of the study is to demonstrate maintenance of treatment efficacy when transferring adult outpatients with opioid dependence, who are clinically stabilized on 8 mg or less of sublingual (SL) buprenorphine…
- Trial name
- PRO-814 (NCT02180659)
- Testing
- sublingual buprenorphine tablets, Buprenorphine implant
- Volunteers
- 177 people
- Sponsor
- Titan Pharmaceuticals
Bipolar Disorder, Alcohol Abuse
Efficacy and Tolerability of Topiramate in Treatment of Bipolar Mania and Alcohol Use in Adolescents and Young Adults
The purpose of this research study is to study the effects (both good and bad) of combining quetiapine and topiramate for treating symptoms of bipolar mania (an illness with periods of elation, excessive excitement, irritability…
- Trial name
- NCT00550394
- Testing
- Quetiapine and Topiramate
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Cincinnati
Alcohol Consumption, Alcohol Use Disorder
Step Away: Comparing a Chatbot-delivered Alcohol Intervention With a Smartphone App
A wide gap exists between the number of people needing alcohol treatment and those actually receiving it. This study builds on a previous one that indicated that smartphone-based intervention can help increase the number of…
- Trial name
- NCT04447794
- Testing
- Step Away Chatbot, Step Away App
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- University of Alaska Anchorage
Tobacco Dependence, Nicotine Dependence
Studying the Effects of Administration of Polyunsaturated Fatty Acids (PUFAS) of Omega-3 Series in Nicotine Dependence
Nicotine dependence may prolong the exposure to toxic substances that cause various diseases. The Central Nervous System (CNS) is consisted by a large amount of Polyunsaturated Fatty Acids (PUFAS) from omega-3 serie.
- Trial name
- NCT01735279
- Testing
- Omega 3
- Where
- Brazil
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Alcoholism, Stress Disorders, Post-Traumatic
Reducing Alcohol Use & Post-traumatic Stress Disorder (PTSD) With Cognitive Restructuring & Experiential Acceptance
The purpose of this study is to determine whether an experiential acceptance therapy intervention is effective in the treatment of alcohol dependency and post-traumatic stress disorder (PTSD) symptoms in individuals who suffer…
- Trial name
- COPE (NCT00760994)
- Testing
- Experiential acceptance, Cognitive restructuring, No-intervention control: Nutrition information
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Addiction Nicotine
Self-activation in Individuals With and Without Nicotine Dependence
The purpose of this study is to see if a non-medication intervention can increase motivation and reward processing to non-drug reward cues (for example, a picture of one's favorite food) in individuals with and without nicotine…
- Trial name
- NCT03170258
- Testing
- Neurofeedback (from fMRI and/or EEG)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Duke University
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