Clinical trials: Substance-Related Disorder
Health Behaviors, Obesity
Goal Setting for Health Behavior and Psychosocial Issues in Primary Care
The purpose of this delayed cluster randomized intervention trial is to evaluate primary care strategies to increase goal setting, shared decision-making and evidence-based support and counseling for health behaviors and…
- Conditions
- Health Behaviors, Obesity, Substance Abuse, Anxiety
- Trial name
- MOHR (NCT01825746)
- Testing
- Implementation of the MOHR assessment in primary care workflow
- Where
- 8 sites in United States
- Volunteers
- 3,591 people
- Sponsor
- Virginia Commonwealth University
Opioid-use Disorder, Cocaine Use Disorder
Navigation Services to Avoid Rehospitalization (NavSTAR)
This study will examine the clinical effectiveness and health economic profile of services to link hospital patients with substance use disorders to addiction treatment, promote their medical stabilization, and reduce hospital…
- Conditions
- Opioid-use Disorder, Cocaine Use Disorder, Alcohol Use Disorder
- Trial name
- NavSTAR (NCT02599818)
- Testing
- NavSTAR
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Friends Research Institute, Inc.
Evaluate PK Profile, Evaluate PD Profile
A Study Testing the Effects of Different THC Doses on Psychological and Biological Function
The goal of this clinical trial is to learn how a investigational medicinal product (THC) affects psychological and physical responses in healthy adults with prior cannabis use experience.
- Conditions
- Evaluate PK Profile, Evaluate PD Profile, Healthy Adults, Safety and Tolerability in Healthy Volunteers
- Trial name
- DRATT (NCT07346690)
- Testing
- AVCN319301b (6mg), AVCN319301b (9mg), AVCN319301b (15mg)
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Calgary
HEART DISEASE, Liver Failure
Somatic Disease Among Alcohol Abusers in an Out-day Patients' Clinic
Alcohol abuse is associated with a variety of clinical diseases, but studies on prevalence of different somatic diseases among alcohol abusers are lacking. Studies on populations in an out-day patients' clinic are also lacking.
- Conditions
- HEART DISEASE, Liver Failure, DEPRESSIVE DISORDER, Alcoholic Neuropathy
- Trial name
- NCT01081197
- Testing
- Psychiatric and somatic examinations and ,if clinical indicated, treatment
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Helse Nord-Trøndelag HF
Opioid Use Disorder
Ketones for Opioid Craving
The goal of this clinical trial is to learn if ketone supplementation (KS) works to reduce craving for opioids for adults with opioid use disorder (OUD) undergoing in-patient acute withdrawal management.
- Trial name
- NCT07128524
- Testing
- Treatment with Ketone Supplement
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Drug Use, Drug Abuse
Prevention of Post Sexual Assault Stress
The purpose of this study is to evaluate whether a brief intervention in video format, that includes education about reactions to assault and modeling of adaptive coping strategies, designed to reduce post assault drug use or…
- Conditions
- Drug Use, Drug Abuse, Posttraumatic Stress Disorder
- Trial name
- NCT01430624
- Testing
- PPRS, PIRI
- Where
- 2 sites in United States
- Volunteers
- 245 people
- Sponsor
- Medical University of South Carolina
Depression, Anxiety
Systematic Screening for Comorbid Psychological Conditions in Cardiac ACSC Patients With Multimorbidity in the ED
EMASPOT assesses the prevalence and impact of mental health conditions in multimorbid emergency patients with cardiac ACSC on transsectoral utilisation of health care services.
- Conditions
- Depression, Anxiety, Somatoform Disorders, Alcohol Abuse
- Trial name
- EMASPOT (NCT03188861)
- Where
- Germany
- Volunteers
- 650 people
- Sponsor
- Charite University, Berlin, Germany
Alcohol Addiction
Study of the Opioid Modulation of the Effect of Alcohol on the Dopaminergic Reward System
About 10% of the calculable loss of health and quality of life in industrial countries can be attributed to excessive alcohol consumption.
- Trial name
- NCT03854942
- Testing
- Naltrexone
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Substance-Related Disorders
Neurobiology and Pharmacokinets of Acute MDMA Administration
Background: 3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is a synthetic psychoactive drug that has shown a steep increase in recreational use and abuse by young people in recent years.
- Trial name
- NCT01148342
- Testing
- MDMA, (+/-)3,4-methylenedioxymethamphetamine Hydrochloride, MDMA HCI Capsules
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorder
Project IMPACT: In-the-Moment Protection From Automatic Capture by Trigger
Despite conscious intentions to remain abstinent, persons with substance use disorders often find that negative emotions and environmental cues automatically "trigger" drinking and other substance use.
- Trial name
- NCT02579317
- Testing
- Resonance Breathing, Non-Resonance Breathing
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Rutgers, The State University of New Jersey
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent)
An Opioid Prescribing Nudge
Analyze baseline concurrent opioid prescribing metrics at the individual prescriber level in the Duke Health System on the identified three main outcome measures.
- Conditions
- Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior
- Trial name
- OHS (NCT04069403)
- Testing
- Automated Reports on prescription patterns for their patients
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Duke University
HBV, Alcoholic Hepatitis
Chronic Hepatitis B Virus Clinical Epidemiology in a Representative Sample of Zambian Adults
The purpose of this study is to recruit a random and representative sample of individuals within several Zambian communities for markers of Hepatitis B Virus (HBV) and to characterize chronic HBV infection and indications for…
- Conditions
- HBV, Alcoholic Hepatitis, Liver Fibroses
- Trial name
- HEP-ZED (NCT03149627)
- Testing
- Estimates - prevalence of lifetime/chronic HBV infection
- Where
- Zambia
- Volunteers
- 5,003 people
- Sponsor
- University of Alabama at Birmingham
Misuse of Prescription Only Drugs
Assessment of the Prescriber's and the Pharmacies Overview of Patient Medication by Use of the Fidelity Coefficient.
The purpose of this study is to twofold. The investigators wish to introduce a new patient-descriptive parameter, the 'Fidelity Coefficient', and use it to assess and compare the overview of patient's medication possessed by the…
- Trial name
- NCT01128660
- Where
- Denmark
- Volunteers
- 283,388 people
- Sponsor
- University of Southern Denmark
Chronic Pain, Pain
A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain
This Phase 2 study will evaluate whether multiple doses of cebranopadol suppress opioid withdrawal signs and symptoms compared with placebo in adults with chronic pain who are physically dependent on prescribed opioids.
- Conditions
- Chronic Pain, Pain, Opioid Withdrawal (Disorder), Opioid Use Disorder
- Trial name
- NCT07874620
- Testing
- Cebranopadol
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Adneuris Therapeutics, Inc.
Opioid Dependence
XRB vs. SLB in Jail and at Re-entry: Pilot, Proof of Concept
This is a pilot proof-of-concept randomized controlled trial, open-label and unblinded, examining the feasibility and acceptability of Buprenorphine extended-release vs.
- Trial name
- NCT03604159
- Testing
- Buprenorphine Extended Release, Sublingual Buprenorphine (SUBOXONE, Zubsolv, or generic tablets)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Cannabis Dependence, Nicotine Dependence
Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence
The investigators are conducting a Stage 1 pilot feasibility study at McLean Hospital to develop and refine a Cognitive Behavioral Therapy (CBT) intervention.
- Trial name
- CBT-MJ-NIC (NCT01292642)
- Testing
- Cognitive Behavioral Therapy, Nicotine Replacement Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mclean Hospital
Binge Drinking, Alcohol-Related Disorders
Biomarkers of Alcohol After an Experimental Administration of Alcohol Simulating a "Binge Drinking" Episode
The purposes of this study are 1) to determine the pharmacokinetics of alcohol after experimental administration of alcohol simulating a "binge-drinking" episode in young adults 2) to determine the profile of biomarkers of acute…
- Trial name
- BINGE (NCT03931018)
- Testing
- Alcohol
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fundació Institut Germans Trias i Pujol
Alcohol Use Disorder
Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism
The purpose for this study is to observe the real world experience of participants who are receiving psilocybin in the context of (alcoholism) Alcohol Use Disorder without intervening in the model of care.
- Trial name
- NCT07189988
- Testing
- psilocybin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Healing Advocacy Fund
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD
The current study will modify an already existing therapy for individuals with substance use disorders to address Post Traumatic Stress Disorder (PTSD) in women enrolled in substance use disorders (SUD) treatment who suffer with…
- Trial name
- NCT02755103
- Testing
- Mindfulness Based Relapse Prevention (MBRP)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Tobacco Use Disorder, Oral Nicotine Pouch Use
Switching to Potential Reduced Exposure Products in Adult Smokers
This study aims to assess the feasibility, acceptability, and the potential harm reduction of switching to potentially lower risk, oral nicotine pouches in adult smokers.
- Conditions
- Tobacco Use Disorder, Oral Nicotine Pouch Use, Smoking Behaviors, Harm Reduction
- Trial name
- ZYN (NCT04250727)
- Testing
- ZYN
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.