Clinical trials: Substance-Related Disorder
Alcoholic Hepatitis
Treatment of Severe Alcoholic Hepatitis With Corticoids Plus N Acetyl Cysteine Versus Corticoids Alone
35% of Acute Alcoholic Hepatitis patients (AAH) do not respond to corticoids and died after 6 months. Chronic alcohol abuse depletes glutathione in the hepatocytes and makes the latter more sensitive to excessive TNFα levels.
- Trial name
- HAA-NAC (NCT00863785)
- Testing
- Corticoids plus N Acetyl Cysteine
- Where
- 13 sites in France
- Volunteers
- 174 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
HIV-1-infection
Uganda PrEP and Harm Reduction Evaluation
This is an evaluation of programs to integrate PrEP into existing services for PWUD. PrEP will be delivered according to Uganda national guidelines and data from national monitoring and evaluation forms will be leveraged to…
- Trial name
- NCT05040308
- Testing
- Integrating PrEP delivery
- Where
- Uganda
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Washington
Habituation
Conditioned Pain Modulation Using Painful Cutaneous Electrical Stimulation or Simply Habituation?
Painful cutaneous electrical stimulation (PCES) and corresponding evoked potentials led to a significant pain relief and decrease of evoked potentials and has been used to analyze conditioned pain modulation (CPM).
- Trial name
- NCT03237650
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Alcoholism
Pharmacogenetic Treatments for Alcoholism
Heavy drinking can cause serious health, family, and economic problems. Finding treatments that are effective in decreasing heavy drinking among alcohol-dependent individuals is, therefore, an important scientific and health…
- Trial name
- NCT01591291
- Testing
- Ondansetron + Brief Behavioral Enhancement Treatment
- Where
- 2 sites in United States
- Sponsor
- University of Virginia
Substance-Related Disorders
Family Therapy Via Video Teleconference for Substance-Abusing Rural Adolescents
The current proposal is a randomized clinical trial testing the efficacy of Functional Family Therapy (FFT) administered by video teleconference (FFT-V) in the homes of substance abusing adolescents.
- Trial name
- RAFT (NCT01751217)
- Testing
- Functional Family Tx, Services as Usual
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Oregon Research Institute
Alcohol Withdrawal
Liver Stiffness Measurement in Alcohol-dependent Subjects in Relation to Abstinence After Withdrawal
This study is complementary to the main study "Brain Derived Neurotrophic Factor Serum Levels Evolution During the Six Months After Alcohol Withdrawal " NCT01491347.
- Trial name
- NCT02202148
- Where
- France
- Volunteers
- 195 people
- Sponsor
- Centre Hospitalier Esquirol
Alcohol Use Disorder, Post Traumatic Stress Disorder
Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma
The U.S. Deaf community - more than 500,000 Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure as compared to the…
- Trial name
- NCT03845985
- Testing
- Seeking Safety + Signs of Safety toolkit
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Dependence
Citicoline for Alcohol Dependence
The purpose of this study is to determine if citicoline, as an add-on therapy, will help reduce alcohol use in outpatients with alcohol dependence.
- Trial name
- NCT02074735
- Testing
- Citicoline
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Texas Southwestern Medical Center
Opioid Use, Alcohol Drinking
TACUNA (Traditions and Connections for Urban Native Americans)
This study responds to Request For Application-DA-19-035, HEAL (Helping End Addiction Long Term) initiative: Preventing OUD in Older Adolescents and Young Adults (ages 16-30) by developing and implementing a culturally centered…
- Conditions
- Opioid Use, Alcohol Drinking, Marijuana Use
- Trial name
- TACUNA (NCT04617938)
- Testing
- TACUNA plus Wellness Circle, Opioid Education Workshop
- Where
- 3 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- RAND
Opioid-use Disorder
Obstetric Pain Management for Women With Opioid Use Disorder (QUEST)
This is a mixed methods longitudinal observational study to assess patient and provider perspectives on pain and pain management among pregnant women with opiate use disorder (OUD).
- Trial name
- QUEST (NCT04308655)
- Testing
- Interview, Surveys
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cocaine Dependence
Multisite Controlled Trial of Cocaine Vaccine
The purpose of this study is to test the efficacy of a newly developed active vaccine against cocaine (TA-CD).
- Trial name
- TA-CD (NCT00969878)
- Testing
- TA-CD Vaccination
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- Baylor College of Medicine
Schizophrenia, Alcoholism
Risperidone and Desipramine in Alcohol Use and Schizophrenia
Note: In June 2013, the study design was changed from a randomized controlled study of risperidone + despiramine vs. risperidone vs. placebo to an open label pre-post study of risperidone (or risperidone-like drug) + desipramine.
- Conditions
- Schizophrenia, Alcoholism, Dual Diagnosis
- Trial name
- RADIAUS (NCT01411085)
- Testing
- Risperidone + Desipramine
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Methamphetamine Dependence, Substance Abuse
RTI-336 as a Treatment for Methamphetamine Dependence
The purpose of this study is to evaluate the safety and efficacy of RTI-336 as a treatment for methamphetamine (METH) dependence in non-treatment-seeking METH-dependent volunteers.
- Conditions
- Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
- Trial name
- NCT01601717
- Testing
- RTI-336
- Sponsor
- Baylor College of Medicine
Chronic Pain
The Effect of Cannabis on Pain and Related Quality Of Life Outcomes In Chronic Pain: A Prospective Open-Label Study
The objective of the current study is to prospectively assess the effect of cannabis on pain and functional outcomes in a large group of patients with chronic pain.
- Trial name
- NCT02388217
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Hadassah Medical Organization
Cocaine Dependence, Alcohol Dependence
HBPL Study of the Impact of the NK1 Antagonist Aprepitant
The proposed research will focus on investigating the determinants and consequences of CAD via measurement of physiological, behavioral and subjective effects of physiologic and psychologic stress cues in CAD volunteers in the…
- Trial name
- NCT01176591
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pennsylvania
Schizophrenia, Nicotine Dependence
Music to Reduce Use of Smoking in Patients With Schizophrenia
The purpose of this study is to explore the impact of self-selected music listening which targets disrupting the reward process maintaining smoking and additionally attenuating the reward processing deficits associated with…
- Conditions
- Schizophrenia, Nicotine Dependence, Smoking, Tobacco
- Trial name
- NCT03190161
- Testing
- Music session
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alcohol Abuse
Impact of a Brief Motivational Interview on Drinking Behaviors of At Risk Drinkers Screened in the Emergency Room
Alcohol abuse is associated with injury, chronic illness, absenteeism from work, and social costs to families and communities. The goal of this project is to translate motivational interventions successful in the primary care…
- Trial name
- NCT00183183
- Testing
- Screening and Brief Intervention
- Where
- 15 sites in United States
- Volunteers
- 1,137 people, healthy volunteers welcome
- Sponsor
- UConn Health
Substance Abuse
Parent-Adolescent Interactions and Adolescent Development
The purpose of this study is to observe parent-adolescent interactions and to examine the parenting behaviors and adolescent emotional and physiological responses that are associated with youth's substance use.
- Trial name
- PAIT (NCT01572441)
- Where
- 2 sites in United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- George Mason University
Tobacco Use Disorder
Medicinal Nicotine for Preventing Cue Induced Craving
The purpose of this study is to determine if changing the timeframe (relative to cue presentation) at which the nicotine lozenge is given can attenuate the increase in symptoms of tobacco craving and withdrawal that occur when…
- Trial name
- NCT02347605
- Testing
- Nicotine lozenge 4 mg
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Minnesota
Alcohol Dependence, Alcohol Abuse
Sweet Preference and Alcohol Craving
Purpose: The proposed 2-year investigation will be the first double-blind, placebo-controlled trial examining the hedonic response to sweet taste (HRST) as a phenotypic predictor of naltrexone (NTX) response in alcohol…
- Trial name
- SweetNal (NCT01296646)
- Testing
- Naltrexone, Brenda Therapy Sessions
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of North Carolina, Chapel Hill
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