Clinical trials: Substance-Related Disorder
Alcohol; Use, Problem
Using EMA Data to Inform a Web-intervention for Couples Concerned About Drinking
Alcohol misuse is a prevalent and serious problem with significant harms to society, individuals, and their relationships. Romantic partners have a strong influence on their partner's behavior, uniquely positioning them as a…
- Trial name
- NCT06501677
- Testing
- WBI
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Stanford University
Opioid Use Disorder, Intimate Partner Violence (IPV)
Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery
Using a hybrid type 1 effectiveness-implementation approach, this study aims to evaluate the impact of a novel stepped care model ("PCT+2HOPE") versus treatment as usual (TAU) on increasing retention in community-based medication…
- Conditions
- Opioid Use Disorder, Intimate Partner Violence (IPV), Post Traumatic Stress Disorder PTSD
- Trial name
- STRONGER (NCT07115030)
- Testing
- PCT+2HOPE
- Where
- 3 sites in United States
- Volunteers
- 532 people
- Sponsor
- Yale University
Substance Use Disorder (SUD)
Preventing Overdose and Promoting Recovery Through Court Navigation
This project is a hybrid type I clinical trial to assess the effectiveness and implementation determinants of a peer-led court navigation program for people who use drugs and are passing through county courthouses.
- Trial name
- POPCORN (NCT07700407)
- Testing
- CourtConnect, Information Only
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- RTI International
Substance Use Disorders
Recovery Management Checkups for Primary Care Experiment
National data show that only 8% of people with past-year substance use disorders (SUD) received any treatment for these disorders in the past year, resulting in high costs, both in terms of their own health and functioning and…
- Trial name
- RMC-PC (NCT03746756)
- Testing
- SBIRT, SBIRT+RMC-PC
- Where
- 4 sites in United States
- Volunteers
- 266 people
- Sponsor
- Chestnut Health Systems
Alcohol Use Disorder, Addiction
Portrayal of Hospital Alcohol Detoxification in France
Even if hospital alcohol detoxifications are frequent in France, their caracteristicscharacteristics remain unknown. The investigators aim to describe the clinical and paraclinical caracteristicscharacteristics of their patients…
- Conditions
- Alcohol Use Disorder, Addiction, Alcohol Withdrawal Syndrome
- Trial name
- Alcostop (NCT04973202)
- Testing
- Stay for alcohol detoxification
- Where
- France
- Volunteers
- 50,000 people
- Sponsor
- University Hospital, Montpellier
Obsessive - Compulsive Disorder, Obsessive Compulsive Disorder (OCD)
Assessments of Obsessive-compulsive Symptoms in Patients With Substances Use Disorder
This observational, cross-sectional case-control study evaluates obsessive-compulsive symptoms among adults with substance use disorder compared with a demographically similar control group without substance use disorder.
- Conditions
- Obsessive - Compulsive Disorder, Obsessive Compulsive Disorder (OCD), Obsessive Compulsive Behavior, Substance Abuse Disorder
- Trial name
- NCT07395453
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cannabis Dependence
Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence
This is an 8 week, outpatient research study testing the use of long-acting naltrexone (Vivitrol) as a treatment for marijuana dependence.
- Trial name
- NCT02088177
- Testing
- Long-acting injectable naltrexone
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
Sleep Disturbance, Sleep Problems
Transdiagnostic Sleep Intervention to Improve Mental Health in Adolescents
This cluster randomized controlled trial will evaluate whether a brief, school-based group adaptation of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) improves sleep and mental health in…
- Conditions
- Sleep Disturbance, Sleep Problems, Substance Use (Drugs, Alcohol), Anxiety
- Trial name
- SLEEP-TEEN (NCT07865728)
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction, Healthy habits psychoeducation
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Alcohol-Related Disorders
AlcoChange: An Open Label Pilot Study of Smartphone Monitoring for Alcoholic Liver Disease
Alcohol contributes to over 5% of deaths worldwide, and death rates from alcohol-related liver disease (ARLD) in the UK continue to rise sharply.
- Trial name
- NCT03474328
- Testing
- AlcoChange
- Volunteers
- 60 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Alcohol Abuse, Drug Abuse
Adolescent Family-Based Alcohol Prevention
This study explores whether giving families a choice of family-based prevention programs to prevent adolescent alcohol use will make a difference in program recruitment, retention, completion, as well as adolescent outcomes.
- Trial name
- NCT00858065
- Testing
- Strengthening Families Program (SFP), Family Matters
- Where
- 2 sites in United States
- Volunteers
- 1,228 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Opioid Dependence
An Assessment of Fentanyl Dose Requirements in Opioid-maintained Individuals
This study seeks to determine the suitable doses of fentanyl with acceptable adverse effect and safety profile in opioid-dependent patients.
- Trial name
- FEN001 (NCT01358500)
- Testing
- Fentanyl
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- University of Adelaide
Alcohol Use Disorder
PT150 Drug for Use in Alcohol Use Disorder
The goal of this study is to learn if PT150 can reduce the behavioral and physical effects of stress, alcohol, and alcohol use in people with alcohol use disorder.
- Trial name
- NCT06712602
- Testing
- alcohol, Stress-Induction, PT150
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Pop Test Oncology LLC
Opioid-Related Disorders
Buprenorphine Maintenance for Opioid Addicts - 1
The purpose of this study is to evaluate the efficacy of buprenorphine and desipramine in treatment of opiate and cocaine dependence.
- Trial name
- NCT00000202
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- Yale University
Glioblastoma, Brain Tumor
ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids
ARISTOCRAT is a phase II, multi-centre, double-blind, placebo-controlled, randomised trial to compare the cannabinoid Nabiximols with placebo in patients with recurrent MGMT methylated glioblastoma (GBM) treated with temozolomide…
- Conditions
- Glioblastoma, Brain Tumor, Cannabis, Brain Tumor, Recurrent
- Trial name
- ARISTOCRAT (NCT05629702)
- Testing
- Nabiximols, Temozolomide
- Where
- 17 sites in United Kingdom
- Volunteers
- 122 people
- Sponsor
- University of Birmingham
Opioid-use Disorder
Facilitating the Implementation of Interim Methadone to Increase Treatment Access
The primary aim of this study is to evaluate the effectiveness of Implementation Facilitation (IF) in promoting increased accessibility to methadone treatment.
- Trial name
- NCT04188977
- Testing
- Usual Practice, Implementation Facilitation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Self Harm, Substance-Related Disorders
CMAP Plus Intervention for Self-harm in Individuals With Substance Use Disorder in Pakistan
Objectives: To determine the feasibility and acceptability of the culturally adapted CMAP Plus CBT based Motivational Interviewing (MICBT) called CMAP Plus for self-harm in individuals with substance use disorder (SUD) in a…
- Trial name
- CMAP Plus (NCT05476601)
- Testing
- CMAP Plus
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Pakistan Institute of Living and Learning
Alcohol Use Disorder
Mobile Phone-Based Motivational Interviewing in Kenya
The primary objective of this study was to test whether motivational interviewing (MI) provided over the mobile phone would reduce alcohol use among adults, including people living with HIV/AIDS, visiting primary care in Kenya.
- Trial name
- NCT03573167
- Testing
- In-Person Motivational Interviewing (MI), Mobile Motivational Interviewing (MI)
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Alcohol Abuse, Tobacco Dependence
cSBI-M for Young Military Personnel
The goal of this project is to test the efficacy of a computer-facilitated Screening and Brief Intervention system adapted for Military use (cSBI-M) in reducing substance use among 18- to 25-yr-old U.S. Navy and U.S.
- Conditions
- Alcohol Abuse, Tobacco Dependence, Substance Abuse
- Trial name
- NCT01847300
- Testing
- cSBI-M
- Where
- United States
- Sponsor
- Boston Children's Hospital
Substance Abuse
Contingency Management for Attendance - 2
The purpose of this study is to evaluate the effectiveness of a low-cost contingency management procedure as compared to standard treatment.
- Trial name
- NCT00249639
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Post Traumatic Stress Disorder, Alcohol Use Disorder
MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder
The study investigators are conducting the first randomized placebo-controlled trial of MDMA-assisted therapy with a comorbid sample of military Veterans with a co-occurring diagnosis of Alcohol Use Disorder (AUD) and…
- Trial name
- MAP VETS (NCT07118839)
- Testing
- Full Dose MDMA, MDMA-Assisted psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
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