Clinical trials: Substance-Related Disorder
Opioid-use Disorder
CBT4CBT for Office Based Buprenorphine
In this Phase II SBIR/STTR project, our Specific Aim will be to determine if the use of CBT4CBT-Buprenorphine leads to clinically significant improved outcomes and increased retention for buprenorphine maintenance patients in a…
- Trial name
- NCT03580902
- Testing
- CBT4CBT-Buprenorphine, Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- CBT4CBT, LLC
Substance Use Disorder
Personalized Approach to Healthy Use and Recovery (PATH) Trial
An important part of substance use treatment for many people is learning what triggers their substance use and urges, and how they can better manage those triggers.
- Trial name
- PATH (NCT06580457)
- Testing
- Personal Causal Model + Personalized Feedback
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- VA Office of Research and Development
Drug Dependence
Behavioral Economics of Human Drug Self-Administration
The objective of this protocol is to examine the utility of behavioral economics for understanding reinforcer interactions as they pertain to drug self-administration.
- Trial name
- NCT00005765
- Testing
- nicotine, alcohol
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06072001
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Nicotine Dependence, Alcohol Use
Pilot Study on Mindfulness for Tobacco and Alcohol in University Students
A. The study follows a randomized controlled design with approximately 60 smokers with a history of alcohol abuse age 18-29. The study will compare a 7-week mindfulness intervention to a matched 7-week education intervention to…
- Trial name
- NCT01679236
- Testing
- Mindfulness Training for Smokers, Interactive Learning for Smokers
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Wisconsin, Madison
Marijuana Smoking
Nabilone & Marijuana Addiction
Safety of Nabilone in reducing marijuana craving
- Trial name
- NCT01025700
- Testing
- Cesemat
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of British Columbia
Alcohol Intoxication
Accuracy of Self-estimation of Blood Alcohol Concentration Compared to Object Values
This will be a prospective survey study. The participants will all be volunteers of legal drinking age. Each participant will consume one alcoholic beverage (beer) at a time and then will be asked to verbally estimate their…
- Trial name
- NCT02722564
- Testing
- self estimation of breath alcohol content, breath alcohol content as measured by Alco Sensor IV device, drink a beer
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital and Health Network, Pennsylvania
Substance Abuse, Opioid Dependence
Methadone Oxytocin Option
The purpose of the study is to examine the effects of intranasal oxytocin administration on social cognition in patients receiving methadone maintenance treatment (MMT), examine the effects of intranasal oxytocin administration…
- Conditions
- Substance Abuse, Opioid Dependence, Methadone Treatment
- Trial name
- MOO (NCT01728909)
- Testing
- Oxytocin, Saline Nasal Spray
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol-Related Disorders, Opioid-Related Disorders
Effects of Alcohol History on Effects of Nitrous Oxide - 9
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Conditions
- Alcohol-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00000257
- Testing
- 0% N2O and 10% N2O, 0% N2O and 20% N2O, 0% N2O and 30% N2O
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Substance Use Disorders
Exercise Training as Medicine for Substance Use Disorder Patients
This study compares the effects of high dose and low dose, high intensity, endurance training and strength training in substance use disorder patients.
- Trial name
- NCT04065334
- Testing
- High dose training, low dose training
- Where
- Norway
- Volunteers
- 171 people
- Sponsor
- St. Olavs Hospital
Opioid-use Disorder, Opioid-Related Disorders
Harnessing Placebo Effects in Methadone Treatment
More than 2 million individuals in the United States have an Opioid Use Disorder (OUD). Methadone maintenance treatment is the gold standard of medication-assisted treatment for OUD, but high-dose methadone is associated with…
- Trial name
- NCT02941809
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- University of Maryland, Baltimore
Substance Use, Mental Health Issue
Gii'Igoshimong: Sitting With Your First Family
The goal of this randomized wait-list control study is to understand the relationship between ceremony and substance use (SU), SU risk (e.g., SU severity, depressive symptoms) and protective factors (e.g., spirituality, community…
- Trial name
- NCT07075081
- Testing
- Ceremony
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Substance Use Disorders
Facilitating Treatment Entry and Family Planning in Substance-using Neonatal Intensive Care Unit (NICU) Mothers
The purpose of this pilot study is to assess whether the hospital-based, adaptive behavioral intervention strategy promotes treatment entry and reduces risk of additional substance-exposed pregnancies (SEPs), as well as HIV and…
- Trial name
- NCT03165565
- Testing
- Motivational Interviewing (MI) and Acceptance and Commitment Therapy (ACT), Conventional Care
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The University of Texas Health Science Center, Houston
Opioid-Related Disorders
Multicenter Clinical Trial of Buprenorphine - 3
The purpose of this study is to test the efficacy and safety of buprenorphine.
- Trial name
- NCT00000207
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- University of California, Los Angeles
Cannabis, Pain
Impact of Repeatedly-Administered THC-cannabis on Experimental Pain and Abuse Liability in Humans
Chronic pain is a significant public health concern in the U.S., for which prescription opioids have historically been the standard treatment. This has resulted in striking rates of opioid use disorders and fatal overdoses.
- Conditions
- Cannabis, Pain, Tolerance, Hyperalgesia
- Trial name
- NCT04596644
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Acute Alcohol Intoxication
Evaluation of a Personalized Normative Feedback Repeatedly Delivered Via a Mobile Application After a Brief Therapeutic Intervention on Alcohol-related Risks:
BTI (Brief Therapeutic Intervention) motivates individuals admitted to ED (Emergency Department) for acute intoxication to take actions to prevent further alcohol-related issues.
- Trial name
- IFACAP (NCT03059628)
- Testing
- Personalized Normative Feedback, Brief Therapeutic Intervention, Evaluation questionnaire
- Where
- 5 sites in France
- Volunteers
- 222 people
- Sponsor
- Rennes University Hospital
Alcohol Dependence
Cerebral Hemodynamics With rTMS in Alcohol Dependence
The present study measures the cerebral hemodynamic indices of alcohol dependent patients and observe the relative changes in these parameters with rTMS application.
- Trial name
- NCT02446067
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Central Institute of Psychiatry, Ranchi, India
Alcohol Use Disorder
Effect of GET73 on MRS Measures of Central Glutamate and GABA in Individuals With Alcohol Use Disorder
This study is aimed at examining whether GET73 modulates the indices of central glutamate and γ-aminobutyric acid (GABA) levels in recently abstinent subjects that meet Alcohol Use Disorder (AUD) criteria, as measured by proton…
- Trial name
- NCT03418623
- Testing
- GET73
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Laboratorio Farmaceutico Ct S.r.l.
Substance Abuse, Juvenile Delinquency
The Community Youth Development Study: A Test of Communities That Care
The Community Youth Development Study is an experimental test of the Communities That Care (CTC) prevention planning system. It has been designed to find out if communities that were trained to use the CTC system improved public…
- Conditions
- Substance Abuse, Juvenile Delinquency, Sexual Behavior, Criminal Behavior
- Trial name
- CYDS IV (NCT01088542)
- Testing
- Communities That Care
- Where
- United States
- Volunteers
- 52,323 people, healthy volunteers welcome
- Sponsor
- University of Washington
Addiction, Alcohol, Addiction, Substance
Efficiency of Prevention Program Dedicated to Addictive Behaviors (PREVENTURE) of Vulnerable Teenagers
At the age of 17, in Brittany, 94.9% of adolescents have experimented alcohol consumption 78.1% within a month and 25.5% report repeated episodes of Intensive Punctual Alcohol.
- Trial name
- PREVADO (NCT04599270)
- Testing
- PREVENTURE Program, Routine care
- Where
- 5 sites in France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Brest
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