Clinical trials: Substance-Related Disorder
Tobacco Use Disorder, Schizophrenia
Combining rTMS With Varenicline to Prevent Smoking Lapse in Schizophrenia
Tobacco smokers with schizophrenia are known to be resistant smokers, with high rates of smoking and inability to quit in the long-term, often related to smoking relapse.
- Conditions
- Tobacco Use Disorder, Schizophrenia, Cognitive Functioning, Craving
- Trial name
- NCT03497299
- Testing
- Active rTMS (20Hz)
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation, Tobacco Dependence
De-nicotinised Cigarettes Study
The aim of this study is to determine if using a behavioural replacement for smoking (de-nicotinised cigarettes; DNCs), in addition to standard treatment during the first two weeks after the target quit date, can reduce urges to…
- Trial name
- Denic (NCT01250301)
- Testing
- De-nicotinised cigarettes + standard treatment, Standard Treatment
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Cocaine-Related Disorders
Cocaine Effects in Humans: Physiology and Behavior - 1
The purpose of this study is to compare the effects of buprenorphine or methadone maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving, in opiate-dependent cocaine…
- Trial name
- NCT00000200
- Testing
- Methadone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol-Related Disorders
Alcohol & Exercise Study
The goal of this clinical trial is to learn if exercise can reduce alcohol craving in heavy social alcohol drinkers. The main questions this project aims to answer are 1) compared to a distraction activity (i.e., coloring), will…
- Trial name
- Alc-Excr (NCT05955911)
- Testing
- Exercise, Coloring
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Western University, Canada
Sleep, THC
Tetrahydrocannabinol (THC) and Sleep
The investigators will test the effects of 10-60mg dronabinol (oral THC) on sleep in non-frequent and frequent cannabis users.
- Conditions
- Sleep, THC, Marijuana, Cannabis
- Trial name
- NCT03560934
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Opioid-use Disorder, Substance Use Disorders
Physical Activity as Adjunct Treatment for Opioid Substitution Therapy
In terms of research, it is documented that exercise has a positive effect on mental disorders. Studies have shown positive correlations between physical and mental health, also among substance users.
- Conditions
- Opioid-use Disorder, Substance Use Disorders, Opioid Dependence
- Trial name
- NCT04496934
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- Haukeland University Hospital
Tobacco Abstinence
Varenicline For Smokers In Recovery From Alcohol Dependence
The goal of this proposal is to explore the potential effectiveness of varenicline to treat tobacco dependence among recovering alcoholic smokers who, as a group, are at high risk for tobacco-caused morbidity and mortality.
- Trial name
- NCT01092702
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cocaine Dependence
Complementary Combination Therapy for Cocaine Dependence
The investigators will assess the impact of treatment with doxazosin and modafinil, alone and in combination, on the subjective and reinforcing effects of cocaine in non-treatment-seeking, cocaine-dependent volunteers.
- Trial name
- NCT02538744
- Testing
- Doxazosin, Modafinil, cocaine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Baylor College of Medicine
Alcohol Use Disorder, Cigarette Smoking
Semaglutide for Alcohol Use Disorder
This is an early-Phase II human laboratory trial using a randomized, placebo-controlled, dose-ranging design to investigate the effects of semaglutide, a GLP-1 receptor agonist, on alcohol-related outcomes in adults with alcohol…
- Trial name
- NCT05520775
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Substance Use Disorders, Hiv
HIV, Equity, and Addiction Training (HEAT) Program
This project is a pilot study to determine the feasibility and acceptability of a telemedicine intervention for substance use disorder service delivery in diverse people living with HIV in Alabama.
- Conditions
- Substance Use Disorders, Hiv, Opioid Use Disorder, Stimulant Use (Diagnosis)
- Trial name
- HEAT (NCT06370481)
- Testing
- Telemedicine, Standard of care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Parenting, Parent-Child Relations
Parenting Young Children in Pediatrics
In this study, investigators will partner with pediatric primary care providers to recruit parent participants, then evaluate feasibility and acceptability by systematically assessing parents' engagement with the FCU Online app.
- Conditions
- Parenting, Parent-Child Relations, Substance Use Disorders, Stress
- Trial name
- NCT06273228
- Testing
- Family Check-Up Online
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Oregon
Amphetamine-Related Disorders
Extended-Release Naltrexone to Treat Methamphetamine Dependence in Men Who Have Sex With Men (MSM)
Extended-release naltrexone (XR-NTX, VIVITROL) is an FDA-approved medication with efficacy in treating alcohol dependence and prevention of relapse to opioid dependence.
- Trial name
- TREX (NCT01449565)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- San Francisco Department of Public Health
Alcoholism
To Evaluate the Influence of the A118G Polymorphism in the mu Opioid Receptor Gene (OPRM1) on Effects of GSK1521498 and Naltrexone on Physiological and Behavioural Markers of Brain Function in Healthy Social Drinkers
A total of at least 48 healthy subjects with a history of social drinking will be recruited into this single-centre, randomized, double-blind, cross-over study.
- Trial name
- NCT01738867
- Testing
- GSK1521498, Naltrexone (NTX)
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Opioid-Related Disorders
Buprenorphine/Naloxone for Treatment of Opiate Dependence - 9
The purpose of this study is to determine the efficacy and safety of a buprenorphine/naloxone sublingual tablet formulation as an office-based therapy for opiate-dependence treatment.
- Trial name
- NCT00000344
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Marijuana Dependence
Effect of Baclofen on Marijuana Withdrawal and Relapse
The purpose of this study is to determine if baclofen dose-dependently decreases marijuana's direct effects and symptoms of marijuana withdrawal and thus decreases marijuana relapse.
- Trial name
- NCT00373295
- Testing
- Baclofen, Marijuana
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Substance Withdrawal Syndrome, Opiate Addiction
Study to Evaluate the Exposures of Lofexidine and Its Major Metabolites in Subjects Seeking Buprenorphine Dose Reduction
The purpose of this study is to evaluate the relative exposures of lofexidine and its major metabolites in subjects seeking buprenorphine dose reduction.
- Conditions
- Substance Withdrawal Syndrome, Opiate Addiction, Opiate Dependence
- Trial name
- NCT02801357
- Testing
- lofexidine administration in subjects seeking buprenorphine dose reduction
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- USWM, LLC (dba US WorldMeds)
Alcohol Dependence
Neurofeedback & Alcohol Dependence
The study aims to examine whether the neurofeedback method (based on functional magnetic resonance imaging [fMRI]) can help patients with alcohol dependence to control their urges to drink alcohol and thus to remain abstinent.
- Trial name
- NCT02486900
- Testing
- fMRI-based neurofeedback
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- Cardiff University
Tobacco Use Disorder, Smoking
Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy
The purpose of this study is to examine the feasibility of using e-cigarettes as a method for harm reduction and the effects of providing e-cigarettes (or placebo e-cigarettes) on smoking outcomes.
- Trial name
- NCT02628964
- Testing
- e-cigarettes
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD
The current study will modify an already existing therapy for individuals with substance use disorders to address Post Traumatic Stress Disorder (PTSD) in women enrolled in substance use disorders (SUD) treatment who suffer with…
- Trial name
- NCT02755103
- Testing
- Mindfulness Based Relapse Prevention (MBRP)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Flushing, Alcohol-Related Disorders
Treatment of Asian Flushing Syndrome With Topical Alpha Agonists
Asian Flushing Syndrome (AFS) is a genetic disease affecting approximately 70% of patients of East Asian descent characterized by severe flushing with minimal ethanol consumption.
- Conditions
- Flushing, Alcohol-Related Disorders, Aldehyde Dehydrogenase Deficiency
- Trial name
- NCT03497442
- Testing
- Brimonidine Tartrate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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