Clinical trials: Substance-Related Disorder
Alcohol Abuse/Dependence, Alcohol Use Disorder (AUD)
Ketamine and Neurofeedback as Combined Therapeutic Interventions to Target Glutamatergic Neurotransmission in Alcohol Use Disorder
The goal of this clinical trial is to learn about the effects of the combination of ketamine and realtime functional magnetic resonance imaging (fMRI) neurofeedback training on the treatment of individuals with alcohol use…
- Conditions
- Alcohol Abuse/Dependence, Alcohol Use Disorder (AUD), Alcoholism
- Trial name
- Nektar (NCT06969937)
- Testing
- Ketamine, Real-time fMRI Neurofeedback Training
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- Dr. med. Marcus Herdener
Substance-Related Disorders
Phase 1 Study to Evaluate RDC-0313 Coadministered With Buprenorphine to Opioid-Experienced Healthy Adults
This is a single site, double-blind, randomized, placebo-controlled, crossover study to assess the pharmacodynamics (PD) of RDC-0313 coadministered with buprenorphine in 12 healthy, opioid-experienced, non-treatment-seeking…
- Trial name
- NCT01046539
- Testing
- RDC-0313 + Buprenorphine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Use
Gender-Responsive Drug Use Treatment for Juvenile Justice Girls
Girls in the juvenile justice system have unique developmental pathways to drug use and co-occurring risk (e.g., HIV/STI) behaviors that have typically not been considered or tested in order to identify evidence-based…
- Trial name
- NCT02293057
- Testing
- VOICES Group, Girl Health Group
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder
Tobacco Approach Avoidance Training for Adolescent Smokers-2
This is a two part study. In Study 2, smokers who want to quit smoking will participate in a 4 week smoking cessation program combining weekly cognitive behavioral therapy (CBT) with weekly regular-AAT or placebo-AAT training.
- Trial name
- AAT-2 (NCT01625637)
- Testing
- AAT-experiment
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Yale University
Cocaine Dependence
A Sequenced Behavioral and Medication Intervention for Cocaine Dependence
This study will investigate a treatment strategy in which a computer-assisted behavioral intervention will be used to help individuals stop their use of cocaine.
- Trial name
- NCT01986075
- Testing
- Computer-assisted behavior therapy, Mixed-Amphetamine Salts- Extended Release (MAS-ER)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- New York State Psychiatric Institute
Medication Abuse
A Prospective Evaluation of Colorado's New Statutory PDMP Mandates: Compliance and Patient Outcomes
The goal of this study is to test the impact of a clinical decision support (CDS) tool to improve health care provider practices in line with state law requiring review of the Colorado prescription drug monitoring program (PDMP)…
- Trial name
- NCT06215560
- Testing
- PDMP Check CDS
- Where
- United States
- Volunteers
- 89,871 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcohol Use Disorder
Intensive Virtual Treatment With Remote Abstinence Monitoring for Alcohol Use Disorder
This single-arm pilot study will recruit participants with moderate to severe alcohol use disorder for a 4-week virtual intensive outpatient program (IOP).
- Trial name
- NCT05722483
- Testing
- Virtual Intensive Outpatient Program
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- Centre for Addiction and Mental Health
Cannabis
Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users
The growing legalization of cannabis across the U.S. is associated with increases in cannabis use, and accordingly, an increase in the number of individuals with cannabis use problems, including cannabis use disorder (CUD).
- Trial name
- iCURE (NCT05401929)
- Testing
- iTBS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Drug Use, Alcohol Use
Integrating Substance Abuse Assessment & Intervention in Primary Care Settings
The purposes of this study are to: 1) implement a high fidelity Screening, Brief Intervention and Referral to Treatment (SBIRT) protocol with computerized screening technology into three primary care clinics in urban…
- Trial name
- NCT01751672
- Testing
- SBIRT, SBIRT+
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- Treatment Research Institute
Obesity, Substance Abuse
Health Behaviors in School-age Children: 2009-2010
The Health Behaviors in School-age Children (HBSC) study is a consortium of investigators from 40 predominantly European and North American countries who conduct a common survey of early adolescent health behaviors every 4 years.
- Conditions
- Obesity, Substance Abuse, Violence, Mental Health
- Trial name
- NCT00797095
- Where
- United States
- Volunteers
- 12,651 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Tobacco Smoking, Tobacco Withdrawal
Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects
In the 20th century, tobacco caused the death of 100 million people worldwide and it is estimated that it will be responsible for 1 billion deaths in the 21st century.
- Conditions
- Tobacco Smoking, Tobacco Withdrawal, Nicotine Addiction, Nicotine Withdrawal
- Trial name
- NCT06254001
- Testing
- Bupropion, Nicotine replacement therapy (Nicotine patches)
- Where
- Mexico
- Volunteers
- 134 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
HIV Prevention, Substance Use
Integrating Sexual Pleasure Into Harm Reduction Services for Men Who Have Sex With Men and Transgender Persons Who Engage in Chemsex or Substance Use in Thailand
The study evaluates the integration of a sexual pleasure-based approach into harm reduction services for MSM and transgender persons engaging in chemsex or substance use in Thailand, using the "Pleasuremeter" tool to improve…
- Conditions
- HIV Prevention, Substance Use, Mental Health, Sexually Transmitted Infections (STIs)
- Trial name
- PLEASURE (NCT07509853)
- Testing
- Pleasuremeter-guided qualitative interview, Pleasuremeter-based sexual pleasure discussion integrated with harm reduction services
- Where
- Thailand
- Volunteers
- 300 people
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
Alcoholic Liver Disease
THE IMMUNOLOGICAL EFFECTS AND METABOLIC TOLERANCE OF LIPID INFUSION IN PATIENTS WITH CIRRHOSIS.
The study will be an experimental pre-post trial in which patients with ethanol related liver disease (both severe alcoholic hepatitis and decompensated ) admitted in our institute from Jun 2013-Dec 2014 will be enrolled in the…
- Trial name
- NCT02381769
- Testing
- Soybean based lipid emulsion
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcohol Use Disorder
Study of Mechanisms of Emotion Regulation in Alcohol-abstinent Patients
Background: Difficulties in assigning and identifying emotional states, or to regulate the emotional costs are recognized as one of the major factors of relapse.
- Trial name
- REAL (NCT02881983)
- Testing
- the presentation of pictures (static stimuli) or videos (dynamic stimuli)
- Where
- 2 sites in France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Cannabis Use Disorders
Stress and Marijuana Cue-elicited Craving and Reactivity
The purpose of this study is to explore the interaction between stress and marijuana cues, in hopes that it may lead to the development of new treatments for marijuana dependence.
- Trial name
- NCT00613405
- Testing
- Stress + cue exposure, No stress + cue exposure
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1
The purpose of this study is to evaluate the Selegiline Transdermal System for the treatment of cocaine dependence.
- Trial name
- NCT00032929
- Testing
- Selegiline
- Where
- 16 sites in United States
- Volunteers
- 269 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder, Depression
aTBS for Treatment of Depression in AUD
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for improvement of depressive symptoms and drinking behavior in individuals with alcohol dependence.
- Trial name
- NCT03981185
- Testing
- Accelerated theta burst treatment
- Sponsor
- Stanford University
Opioid Use, Cognitive Change
Cognitive Functioning in Opioid Use Disorder
This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose and cognitive functioning.
- Conditions
- Opioid Use, Cognitive Change, Opioid-use Disorder
- Trial name
- NCT05001789
- Testing
- CogMed
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute
HIV, Opioid Dependence
Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users
To conduct a randomized clinical trial (RCT) of a community-friendly behavioral intervention designed to reduce HIV risk behavior among injection drug users (IDUs) in drug treatment by comparing risk-behavior outcomes of four…
- Trial name
- NCT01741350
- Testing
- Community-friendly Health Recovery Program, Time-and-Attention-Matched Control Condition
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Connecticut
Opioid Dependence
Utilizing Helpline for Opioid Dependence Treatment
The investigator propose to develop an opioid telephone helpline, where trained counselors and educators provide referral, educational and targeted interventions and support to individuals interested in addressing their addiction…
- Trial name
- NCT03969238
- Testing
- Helpline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
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