Clinical trials: Substance-Related Disorder
Cannabis, Alcohol Drinking
Effects of THC and Alcohol on Driving Performance
Low blood concentrations of THC and alcohol appear to have a minimal effect on driving performance.However, there is a gap in the literature about the combined effects of THC and alcohol.
- Conditions
- Cannabis, Alcohol Drinking, Accident, Traffic
- Trial name
- NCT03555968
- Testing
- THC 0, THC 5, THC 10
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lakehead University
Cannabis, Pregnancy
Duration of Marijuana Concentration in Breast Milk- A Pilot Study
Legalization of marijuana in Colorado for both medicinal and recreational purposes has led to a perception of its safety, which has not been well studied in pregnant or lactating women.
- Conditions
- Cannabis, Pregnancy, Breast Feeding
- Trial name
- NCT02635568
- Testing
- Cannabis Use
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Substance Abuse, Post-partum Depression
Cradling Our Future Through Family Strengthening Study
The purpose of this study is to determine whether an in-home, paraprofessional-delivered family strengthening curriculum entitled Family Spirit is effective at increasing parental competence, improving maternal outcomes and…
- Conditions
- Substance Abuse, Post-partum Depression, Depression
- Trial name
- NCT00373750
- Testing
- Family Spirit Intervention
- Where
- 5 sites in United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Alcohol Use Disorder, Post Traumatic Stress Disorder
Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma
The U.S. Deaf community - more than 500,000 Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure as compared to the…
- Trial name
- NCT03845985
- Testing
- Seeking Safety + Signs of Safety toolkit
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
Nicotine Dependence
Extended Varenicline Treatment for Smoking Among Cancer Patients
Upwards of 33-50% of cancer patients who smoked prior to diagnosis continue to smoke following diagnosis and treatment. With medical advances in cancer care yielding a growing constituency of cancer survivors, addressing nicotine…
- Trial name
- NCT01756885
- Testing
- Varenicline, Smoking Cessation Counseling
- Where
- 2 sites in United States
- Volunteers
- 207 people
- Sponsor
- University of Pennsylvania
PTSD, Substance Use Disorder (SUD)
Adolescent Stress and Substance Intervention Subsequent to Trauma
The long-term goal of this study is to address the adoption of the new trauma center requirement to establish best practices of screening for acute stress with an intervention to prevent both adolescent PTSD and substance use.
- Conditions
- PTSD, Substance Use Disorder (SUD), Acute Stress Disorder
- Trial name
- ASSIST (NCT07197476)
- Testing
- ASSIST Video Intervention
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Methamphetamine Dependence
A Cognitive Behavioral Therapy-Based Text Messaging Intervention for Methamphetamine Dependence
This Phase I, randomized, 22-day crossover study seeks to improve treatment outcomes for methamphetamine-dependent subjects by developing a cognitive behavioral therapy (CBT)- based short message service (SMS) text messaging…
- Trial name
- NCT01577797
- Testing
- Text messages
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New Leaf Treatment Center
Opioid-Related Disorders
Alternate-Day Buprenorphine Administration. Phase I - 3
The purpose of this study is to determine if two times a subject's daily maintenance dose will hold for 48 hours without changes in agonist and antagonist effects.
- Trial name
- NCT00000221
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
Pharmacotherapy and Intensive Treatment - 2
The purpose of this study is to evaluate desipramine and carbamazepine in reducing cocaine craving; increase outpatient treatment capacity and evaluate their incidence of psychiatric disorders.
- Trial name
- NCT00000218
- Testing
- Carbamazepine
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Posttraumatic Stress Symptoms, Heavy Alcoholic Consumption
Self-administered Neurostimulation Intervention for Firefighter Traumatic Stress to Reduce Alcohol Use: Pilot Study
The goal of this clinical trial is to evaluate the feasibility, acceptability, and appropriateness of a transcutaneous auricular neurostimulation (tAN) protocol in firefighters who engage in heavy drinking, have at least a mild…
- Conditions
- Posttraumatic Stress Symptoms, Heavy Alcoholic Consumption, Alcohol Use Disorder (AUD)
- Trial name
- SANI-T (NCT07868055)
- Testing
- Transcutaneous auricular neurostimulation (tAN)
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Substance Use
Test of the Better Together Intervention
Better Together (BT) is a novel, culturally relevant library-based intervention designed to prevent substance use among Black youth (ages 11-13) affected by household challenges (i.e., parental substance use, parental…
- Trial name
- BT Pilot (NCT06594835)
- Testing
- Better Together, Youth In the Media (YM)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Pain, Insomnia
Effect of Medical Marijuana on Neurocognition and Escalation of Use
This study will use a randomized controlled design to test whether patients who use medical marijuana, compared to a waitlist control group, experience a change in health outcomes (relief of symptoms, or adverse health outcomes…
- Conditions
- Pain, Insomnia, Depression, Anxiety
- Trial name
- MMNE (NCT03224468)
- Testing
- Medical Marijuana
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV Infections, Substance Use Disorders
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users (PrEPSteps)
This study will deploy a novel, personalized, smartphone-based intervention (PrEPSteps) that responds to real-time PrEP adherence and nonadherence detected through the use of a digital pill.
- Trial name
- PrEPSteps (NCT03512418)
- Testing
- PrEPsteps, Digital pill, Truvada
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Substance Use Disorder, Opioid Use Disorder, Moderate
EXHIT ENTRE Comparative Effectiveness Trial
This study is a multi-site open-label randomized comparative effectiveness trial of a 28-day formulation of extended-release buprenorphine (XR-BUP) versus treatment as usual (TAU) for hospitalized patients with a moderate or…
- Conditions
- Substance Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
- Trial name
- EXHITENTRE (NCT04345718)
- Testing
- Extended Release Buprenorphine, Treatment as Usual
- Where
- 6 sites in United States
- Volunteers
- 344 people
- Sponsor
- Gavin Bart
Chronic Hepatitis C, Illicit Drug Use
Hepatitis C Treatment in Underserved Populations
The purpose of this study is to examine the feasibility, safety, and effectiveness of treating persons who are actively using illicit drugs for hepatitis C using a collaborative, multidisciplinary, integrated care model.
- Trial name
- NCT01717560
- Testing
- Collaborative, multidisciplinary, integrated care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brian Edlin
Adolescent Psychiatry, Antisocial Personality Disorders
Impaired Decision-making in Adolescents
There is clear evidence that aggressive behavior and disruptive behavior disorders (DBD) in middle childhood are associated with an increased risk for substance abuse in adolescence.
- Conditions
- Adolescent Psychiatry, Antisocial Personality Disorders, Substance-Related Disorders
- Trial name
- NCT01253993
- Where
- Netherlands
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Marijuana Abuse
INCA - Intervention and Neuropsychology in Cannabis Abuse
INCA (Intervention and Neuropsychology of Cannabis Abuse) is a study combining two research goals. One is to study efficacy of a short intervention the 'Problem Profile Intervention', which utilizes individual feedback from a…
- Trial name
- NCT00279604
- Testing
- 'Problem Profile Intervention' vs. WHO-Brief Intervention
- Where
- 2 sites in Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Substance Abuse, Offenders
Effects of Manualized Treatment in a Seamless System
The specific aims of this project are: 1. To conduct a randomized block experiment to test the effectiveness of different models of the seamless supervision/treatment system and traditional criminal justice supervision on…
- Conditions
- Substance Abuse, Offenders, Criminal Thinking, HIV Risk Behaviors
- Trial name
- Man Tx (NCT01372033)
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- George Mason University
Umbilical Cord Issue, Nicotine Addiction
Nicotine's Effect on Cancer Stem Cell Markers in Human Umbilical Cord Tissue
The umbilical cord is generally an organ that clinicians and pathologists do not pay sufficient attention to. The absence of significant pathology in the umbilical cords, along with the lack of association between certain…
- Conditions
- Umbilical Cord Issue, Nicotine Addiction, Pregnancy Related, Cancer
- Trial name
- NCT06678152
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Marijuana Dependence
Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management
Cognitive-behavioral coping skills therapy (CBT) is a widely used and recognized treatment that has been empirically validated for a range of substance use disorders, often with emergent effects and continuing improvement even…
- Trial name
- NCT00350649
- Testing
- Standard CBT, CBT+CM/adherence, CM/abstinence
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Yale University
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