Clinical trials: Substance-Related Disorder
Substance Use Disorder (SUD), Anxiety
Effects of Qigong Exercise on Anxiety and Depression in Patients Receiving Inpatient Treatment for Substance Use Disorder
Patients receiving inpatient treatment for substance use disorder may experience anxiety and depressive symptoms. Qigong is a mind-body exercise that combines gentle movements, breathing techniques, and relaxation.
- Conditions
- Substance Use Disorder (SUD), Anxiety, Depression
- Trial name
- NCT07909447
- Testing
- Qigong Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Uskudar University
Cocaine-Related Disorders
Tiagabine for the Treatment of Cocaine Dependence - 1
The purpose of this study is to assess tiagabine for the treatment of cocaine dependence.
- Trial name
- NCT00086255
- Testing
- Tiagabine
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cannabis Intoxication
Cannabis Impairment Detection Device Study
The goal of this study is to develop a cannabis impairment detection device in adult cannabis users. The main question[s] it aims to answer are: Is the investigational device accurate and reliable at detecting cannabis…
- Trial name
- NCT07122349
- Testing
- Cannabis Impairment Test
- Where
- Canada
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Gaize
Alcohol Use Disorder, Alcoholism
Effect of Social Isolation on the Role of Pavlovian Mechanisms for Control Over Alcohol Use
During the first funding period (1st FP) we investigated the impact of acute and chronic stress (Trier Social Stress Test, TSST) on Pavlovian-to-instrumental transfer (PIT).
- Conditions
- Alcohol Use Disorder, Alcoholism, Stress Reaction, Ostracism
- Trial name
- ReCoDe (NCT06256952)
- Testing
- PIT paradigm, social exclusion (Cyberball task), Saliva samples
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Cannabis Use Disorder, Repetitive Transcranial Magnetic Stimulation
Repetitive Transcranial Magnetic Stimulation to People With Cannabis Use Disorder (SToP-C-rTMS x CUD)
This study is to explore if repetitive transcrinal magnetic stimulation (rTMS) with different stimulation schedules will be equally effective in reducing carving, frequency of cannabis use, and the severity of cannabis use…
- Trial name
- NCT05292547
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Alcohol Use Disorder (AUD)
Multimodal Intervention for GGT Reduction in Alcohol Use Disorder (GGT-AUD)
The aim of this clinical trial is to evaluate whether a combined nutraceutical and psychological intervention can reduce gamma-glutamyl transferase (GGT) levels in individuals with Alcohol Use Disorder (AUD).
- Trial name
- GGT-AUD (NCT07603726)
- Testing
- Alcohol Reduction Counseling, Nutraceutical Treatment, Psychological Intervention
- Where
- Romania
- Volunteers
- 197 people
- Sponsor
- Medical Center TOPMED
Substance Abuse, Substance Dependence
Improving Outcomes in Psychosis Associated With Substance Use Using Aripiprazole
This project focuses on the under-researched group of individuals who develop psychotic episodes of short duration (less than four weeks) while using substances.
- Trial name
- SIP (NCT01155544)
- Testing
- Behavioral Intervention
- Where
- 2 sites in United States
- Sponsor
- Northwell Health
Alcoholic Liver Disease, Chronic Hepatitis C Virus Infection
sgp130 in Chronic Human Liver Disease
Chronic liver disease are characterized by increased levels of plasma IL-6, but the bioactivity of this cytokine in this disease is not well known.
- Trial name
- NCT00770198
- Where
- Belgium
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Tobacco Dependence
UW Quitting Using Intensive Treatment Study (QUITS)
This research will determine whether two highly promising modifications to varenicline treatment (i.e. use of a nicotine patch adjuvant and extended 24-week duration) produce superior smoking outcomes when they are either used…
- Trial name
- QUITS (NCT03176784)
- Testing
- Varenicline, Nicotine patch
- Where
- 2 sites in United States
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alcohol Abuse
Project Health Link: Connecting Patients With Services
This study will compare three alternative interventions in the emergency department (ED) to promote substance abuse assessment, referral, and treatment entry: 1) a 5 session strengths-based case management model (SBCM); 2) a…
- Trial name
- NCT00234221
- Testing
- Strengths Based Case Management, Motivational Enhancement Therapy, Brief Informational Feedback
- Where
- United States
- Volunteers
- 686 people
- Sponsor
- University of Michigan
Alcohol Use Disorder (AUD)
Connecting Online Military Personnel to Alcohol Harm-reducing Smartphone Support Study
The purpose of this research is to test the effectiveness of a free mobile phone app designed to help veterans improve their relationship with alcohol and reduce alcohol-related harms.
- Trial name
- COMPASS (NCT07911345)
- Testing
- VetChange (Explorer/Research version) Mobile App, Sober Time
- Volunteers
- 150 people
- Sponsor
- University of New Mexico
Opioid Use Disorder
Integrating Brain, Neurocognitive, and Computational Tools in OUD
The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on…
- Trial name
- NCT06136247
- Testing
- Neurocognitive battery, fNIRS
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Pennsylvania
Nicotine Addiction, E-Cig Use
Quit Smoking Study for People Who Use E-Cigarettes
The overarching aim of this proposed randomized controlled trial (RCT) is to test nicotine replacement therapy (NRT) with text message support for two smoking cessation approaches among young adult dual users of combustible…
- Conditions
- Nicotine Addiction, E-Cig Use, Quitting Smoking
- Trial name
- NCT04946825
- Testing
- Nicotine replacement therapy patch, Nicotine replacement therapy lozenge, Quit electronic cigarettes
- Where
- United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Substance Use Disorders
Feasibility of Music Therapy in Community Substance Misuse Treatment Services
Music Therapy (MT) has been shown to improve several symptoms experienced by people with Substance Use Disorder (SUD), such as depressive and anxiety symptoms, as well as negative emotions.
- Trial name
- CRAVEMT (NCT05180617)
- Testing
- Music Therapy
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Anglia Ruskin University
Cannabis, HIV
Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the…
- Conditions
- Cannabis, HIV, Inflammation, Cognition
- Trial name
- CHI (NCT04810858)
- Testing
- Multimodal, multi-parametric MRI, Immune and cytokine profiling, Neuropsychological testing
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Drug Use Disorders, Drug Abuse
Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks
Background: Sixty million American adults suffer from moderate to severe chronic pain. Of these, 5 to 8 million currently use opioids long-term.
- Conditions
- Drug Use Disorders, Drug Abuse, Drug Addiction, Drug Dependence
- Trial name
- CARE (NCT02224508)
- Volunteers
- 1,588 people
- Sponsor
- Kaiser Permanente
Heroin Dependence, Opioid Dependence
Biomarkers of Injectable Extended Release Naltrexone Treatment
This study evaluates the biological markers of treatment of opioid dependent individuals with an extended release formulation of the opioid antagonist naltrexone.
- Trial name
- NCT02324725
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pennsylvania
Opioid-Induced Constipation (OIC)
Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation
The purpose of this study is to evaluate the effect and safety of NKTR-118 treatment of opioid-induced constipation in patients with non-cancer-related pain, including those patients that have inadequate response to laxative…
- Trial name
- NCT01323790
- Testing
- NKTR-118
- Where
- 120 sites in United States, Belgium and 6 more
- Volunteers
- 700 people
- Sponsor
- AstraZeneca
HIV
Long-acting Injectable Antiretroviral Treatment to Improve HIV Treatment Among Justice-involved Persons Being Released to the Community
The federal research award entitles "Long-acting injectable antiretroviral treatment to improve HIV treatment among justice-involved persons being released to the community" aims to Conduct interviews with justice and treatment…
- Trial name
- NCT06704204
- Testing
- The first FDA-approved LAI ART regimen includes an integrase inhibitor, cabotegravir (CAB), and a non-nucleoside reverse transcriptase inhibitor, rilpivirine (RPV) combined 4 wks
- Volunteers
- 20 people
- Sponsor
- The Miriam Hospital
TBI, Anxiety
Cranial Electrotherapy Stimulation (CES) Therapy
The primary aim of this proposed study is to gather preliminary data for CES use in treating PTSD and anxiety symptoms in OEF/OIF Veterans with PTSD and a history of TBI.
- Conditions
- TBI, Anxiety, PTSD, Depression
- Trial name
- CES (NCT02453347)
- Testing
- CES Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
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