Clinical trials: Substance-Related Disorder
Pregnancy, Substance Use Disorder (SUD)
Justice Core Trial
The goal of this clinical trial is to learn if Justice Core, an intervention that moves pregnant women with substance use disorder (SUD) from jail into community-based SUD treatment while awaiting trial, can improve the health of…
- Conditions
- Pregnancy, Substance Use Disorder (SUD), Prisoners
- Trial name
- NCT07911332
- Testing
- Jail Diversion into Treatment, Referral at Release
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of North Carolina, Chapel Hill
Heroin Dependence
University of Houston Drug Abuse Research Development Program II
The study is examining the impact of a Virtual Reality Cue Exposure Therapy intervention on heroin cravings compared to Relapse Prevention Drug Education.
- Trial name
- UHDARDP-II (NCT03557632)
- Testing
- Virtual Reality Cue Exposure Therapy, Relapse Prevention Drug Education
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Houston
Substance Use Disorders
Non-Invasive Brain Stimulation and Substance Use
The will investigate the feasibility and effectiveness and initial efficacy of non-invasive transcranial alternating current stimulation (tACS) on distress tolerance and inhibitory control among treatment seeking substance users.
- Trial name
- NCT03122587
- Testing
- Transcranial Alternating Current Stimulation at 10 Hz, Transcranial Alternating Current Stimulation at 40 Hz
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of North Carolina, Chapel Hill
Depression, Anxiety
A Virtual Navigation Intervention to Reduce Behavioral Health Admissions From Rural Emergency Departments
This research project is a pragmatic, randomized evaluation of a quality improvement initiative which seeks to evaluate the effects of standardizing the use of a BH-VPN program among patients with a telepsychiatric consult.
- Conditions
- Depression, Anxiety, Substance Use Disorders
- Trial name
- VIBRANT (NCT04148521)
- Testing
- Behavioral Health - Virtual Patient Navigation
- Where
- 9 sites in United States
- Volunteers
- 1,089 people
- Sponsor
- Wake Forest University Health Sciences
Healthy Volunteers
Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)
Background: Transcranial magnetic stimulation (TMS) uses magnetic pulses to affect brain activity. A type of TMS called theta burst stimulation (TBS) is approved to treat people with major depression.
- Trial name
- NCT06868914
- Testing
- TMS (MagVenture MagPro 100 with MagOption)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Abuse, Depression
Mindfulness-Based Recovery in Veterans
This study will provide important information concerning the used of mindfulness-based relapse prevention (MBRP) as a continuing care strategy for Veterans who have completed primary treatment for a SUD.
- Conditions
- Substance Abuse, Depression, Anxiety Disorder
- Trial name
- MBR-Veterans (NCT02326363)
- Testing
- Mindfulness Based Relapse Prevention (MBRP), Twelve-Step Facilitation Intervention (TSF)
- Where
- 2 sites in United States
- Volunteers
- 204 people
- Sponsor
- VA Office of Research and Development
Nicotine Dependence
Nicotinic Modulation of the Default Network of Resting Brain Function
Background: A brain circuit called the default network is the brain circuit that is active when the brain is at rest; that is, when individuals are not concentrating on specific tasks.
- Trial name
- NCT01240616
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Intoxication
Trials of Ventilation Assisted Substance Elimination Via the Lung - Ethanol (VASEL - Ethanol)
This prospective, randomized control trial will use passive, isocapnic hyperventilation, applied via the ClearMateTM device (Thornhill Medical, Inc) versus controls receiving standard of care supportive management for severe…
- Trial name
- NCT04229732
- Testing
- ClearMateTM
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Alcoholism, Alcohol Dependence
Usability Study for SOBERLINK System
The Soberlink Cellular device, in its original packaging, along with the QuickStart guide will be provided to the end user in a simulated home use environment or by Rx in clinic.
- Trial name
- NCT02650180
- Testing
- Soberlink Cellular Device
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Soberlink Healthcare LLC
Opiate Dependence, Human Immunodeficiency Virus
Opioid Relapse & HIV Risk: 48 Versus 24 Weeks of Injectable Extended Release Naltrexone
To address the question of the comparison of two courses of Vivitrol with differing lengths in 130 HIV negative, consenting, opioid addicted patients who have completed inpatient treatment.
- Trial name
- NCT01882361
- Testing
- injectable naltrexone
- Where
- Russia
- Volunteers
- 77 people
- Sponsor
- University of Pennsylvania
Attention Deficit Hyperactivity Disorder (ADHD), Substance-related Disorder
Deficit Hyperactivity Disorder / Substance Use Disorder Comorbidity in Integrated Treatment
Attention Deficit Hyperactivity Disorder (ADHD) and Substance Use Disorders (SUDs) is a highly common comorbid condition associated with serious medical and psychosocial consequences.
- Trial name
- ATTenTIFF (NCT06858527)
- Testing
- TAU+integrated group CBT
- Where
- France
- Volunteers
- 132 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071988
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Opioid Use Disorder
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Doses of ASP8062 With a Single Dose of Morphine in Recreational Opioid Using Participants
The primary purpose of this study was to assess the safety and tolerability of multiple doses of ASP8062 or placebo alone and in combination with a single dose of morphine.
- Trial name
- NCT04448561
- Testing
- ASP8082, morphine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Emotional Intelligence, Opioid Use Disorder
Impact Emotional Intelligence Program on Opioid Relapse
Addiction is the repeated and increased use of a substance, the deprivation of which gives rise to symptoms of distress and an irresistible urge to use the agent again and which leads also to physical and mental deterioration.
- Trial name
- NCT06207266
- Testing
- emotion intelligence program
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Alcohol Dependence
Effectiveness of Naltrexone and/or Ondansetron to Reduce Craving for Alcohol and Drinking
The purpose of this study is to determine whether naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence), ondansetron a serotonin 3 antagonist medication approved to treat nausea) or their…
- Trial name
- NCT00183222
- Testing
- naltrexone (up to 50 mg/day) for 8 days; ondansetron (0.25 mg twice a day) for 8 days
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine Abuse
Prize Contingency Management for Cocaine-Dependent Methadone Patients
The investigators will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a contingency management condition that arranges a 100% probability of winning a prize with each draw and…
- Trial name
- NCT01401270
- Testing
- prize contingency management
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- UConn Health
Opioid Use Disorder
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
This study will evaluate the safety, effectiveness and tolerance of low doses of oral naltrexone along with buprenorphine to treat opioid use disorder prior to the first injection of VIVITROL.
- Trial name
- NCT02537574
- Testing
- NTX/BUP, NTX/PBO-B, PBO-N/PBO-B
- Where
- 20 sites in United States
- Volunteers
- 380 people
- Sponsor
- Alkermes, Inc.
Tuberculosis, HIV Infections
Improving HIV/Tuberculosis Outcomes in Irkutsk
The investigators propose to examine the prospective influence of substance use patterns on HIV/tuberculosis adherence, pharmacokinetics and disease progression while developing novel methods for early detection and correction of…
- Conditions
- Tuberculosis, HIV Infections, Substance Use
- Trial name
- NCT03819374
- Where
- Russia
- Volunteers
- 53 people
- Sponsor
- University of Virginia
Nicotine Dependence
Improving the Efficacy of Anti-Nicotine Immunotherapy
The purpose of this study is to find out how vaccine-induced antibodies change the way the body processes nicotine from cigarettes. These antibodies absorb nicotine and can reduce nicotine levels in the brain.
- Trial name
- PETNic002 (NCT01280968)
- Testing
- NIC002 in Aluminum hydroxide (Alum)
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Alexey Mukhin
Substance Use Disorders
Eye Movement Desensitization and Reprocessing as a Treatment for Substance Use Disorders
Substance Use Disorders (SUD) are often comorbid with psychological trauma, however, the complex interaction between the two is not yet fully understood.
- Trial name
- NCT05488691
- Testing
- EMDR, TAU
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Hospital Clinic of Barcelona
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