Clinical trials: Substance-Related Disorder
Tobacco Use Cessation, Smoking Cessation
Treating Low-Income Smokers in the Hospital Emergency Department
This study will test the effectiveness of an Emergency Department (ED) initiated tobacco intervention which includes counseling and medication.
- Conditions
- Tobacco Use Cessation, Smoking Cessation, Smoking, Tobacco Use Disorder
- Trial name
- NCT01328431
- Testing
- Brief Intervention with NRT Initiation
- Where
- United States
- Volunteers
- 780 people
- Sponsor
- Yale University
Nicotine Dependence
An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence
The transdermal nicotine patch is the most widely used form of tobacco dependence treatment in the US and Europe, but most smokers are unable to successfully quit with this form of treatment.
- Trial name
- NCT01047527
- Testing
- Transdermal nicotine patch
- Where
- 2 sites in United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cigarette Smoking
Tailored Tobacco Quitline for Rural Veterans
The proposed work is designed to help increase access to tobacco cessation services among rural veterans and to develop more effective treatment services that better address comorbid issues commonly experienced by rural smokers.
- Trial name
- NCT01592695
- Testing
- Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Opioid-use Disorder
mHealth for Patient Self-Management of Opioid Use Disorder
Twenty individuals diagnosed with opioid use disorder (OUD) will be recruited to participate in a beta test to demonstrate feasibility of using an online tool to help them better self-manage their recovery.
- Trial name
- NCT03633929
- Testing
- KIOS OUD
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Biomedical Development Corporation
Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome
Scaling Up: A Multi-Site Trial of e-SBI for Alcohol Use in Pregnancy
The purpose of this research study is to find out if pregnant women screening positive for alcohol risk like the brief alcohol intervention application that the investigators have developed (called the MommyCheckup, which is a…
- Conditions
- Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome, Fetal Alcohol Effect
- Trial name
- e-Health (NCT04332172)
- Testing
- General information, Baseline brief intervention, Remote online booster sessions
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- Michigan State University
Cannabis Dependence, Marijuana Dependence
Combined Pharmacotherapy for Cannabis Dependency
The purpose of this study is to see if Lofexidine in combination with Marinol is superior to placebo in achieving abstinence, reducing cannabis use and reducing withdrawal in cannabis-dependent patients seeking treatment for…
- Trial name
- D-LUCS (NCT01020019)
- Testing
- Dronabinol, Lofexidine
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Use
A Trial of Guanfacine-er for Cannabis Use Disorder
The primary purpose of this study is to investigate the effect of guanfacine-ER on reductions in cannabis use and explore its effects on impulsivity and withdrawal through a hybrid in-person and virtual trial of treatment-seeking…
- Trial name
- NCT05273567
- Testing
- guanfacine-ER
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- New York State Psychiatric Institute
Tobacco Use Cessation, Tobacco Use Disorder
Text Messaging for Supporting Quit Attempts
This study is a preliminary research aimed to compare the feasibility and effectiveness of motivational interview (MI), Personalized text messages (TM) and usual care for outpatients, with focus on smoking cessation as the main…
- Trial name
- NCT02571244
- Testing
- Motivational Interview plus text message
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Federal University of Juiz de Fora
Nicotine Dependence, Nicotine Withdrawal
Progesterone and Brain Imaging Study
Male and female smokers were recruited to undergo 2 phases of smoking cessation. Each phase was 4 days long and involved 3 brain-imaging scans, blood draws and an intervention involving progesterone or a matched placebo.
- Trial name
- NCT01954966
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid-use Disorder
Surmounting Withdrawal to Initiate Fast Treatment With Naltrexone
This study compares two methods of initiating treatment with extended-release naltrexone (XR-NTX) when implemented at community-based inpatient or residential programs.
- Trial name
- SWIFT (NCT04762537)
- Testing
- Standard Induction Procedure (SP), Rapid Induction Procedure (RP)
- Where
- 6 sites in United States
- Volunteers
- 415 people
- Sponsor
- New York State Psychiatric Institute
Alcoholism
Medication Development in Alcoholism: Acamprosate Versus Naltrexone
The purpose of this study is to develop and validate a human laboratory model for prediction of medication efficacy in clinical trials for relapse prevention in alcohol dependence.
- Trial name
- NCT00656630
- Testing
- Acamprosate, Naltrexone
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- The Scripps Research Institute
Cannabis Dependence
A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana
This study is investigating how N-Acetylcysteine (NAC), an over-the-counter medication, will reduce marijuana use when combined with Contingency Management, a behavioral treatment.
- Trial name
- NCT01005810
- Testing
- N-Acetylcysteine, Contingency Management
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Medical University of South Carolina
Alcoholism
ALK21-010: Long-term Safety of Medisorb® Naltrexone (VIVITROL®) in Alcohol-dependent Adults
This was a Phase 3, multi-center extension of Alkermes' Study ALK21-003EXT (NCT01218971) to further assess the long-term safety of repeat monthly doses of Medisorb® naltrexone (VIVITROL®).
- Trial name
- NCT00156923
- Testing
- Medisorb naltrexone 380 mg, Medisorb naltrexone 190 mg
- Volunteers
- 108 people
- Sponsor
- Alkermes, Inc.
HIV Infections, Substance Use Disorders
Couples ART Adherence Intervention for PWID in Kazakhstan
The fastest growing HIV epidemics globally are driven by injection drug use, but only a small percentage of HIV-positive people who inject drugs (PWID) have achieved viral suppression.
- Trial name
- NCT03555396
- Testing
- SMART Couples 2, Standard of Care
- Where
- Kazakhstan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cocaine Abuse, Cocaine-Related Disorders
Medications for Stopping Cocaine Dependence and Preventing Relapse
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218023
- Testing
- Modafinil, Levodopa/Carbidopa, Naltrexone HCl
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Alcoholism, Alcohol Abuse
Dutasteride Treatment for the Reduction of Heavy Drinking in Men
This study will examine the safety and potential benefit of the medication dutasteride to help men reduce or stop drinking alcohol.
- Conditions
- Alcoholism, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01758523
- Testing
- Dutasteride, sugar pill
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- UConn Health
Cocaine Dependence
Treatment of Cocaine Dependence With Lisdexamfetamine
This protocol is a 2-group double-blind placebo-controlled outpatient study investigating lisdexamfetamine for treatment of cocaine dependence. The investigators plan to enroll 100 subjects in a 14-week trial.
- Trial name
- NCT00958282
- Testing
- lisdexamfetamine/Behavior Therapy
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
Alcoholic Liver Disease
Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease
Background/Aims: The investigators explored the therapeutic effects of probiotics in patients with AH. Methods: Between September 2010 and April 2012, the investigators conducted a 7-day, double-controlled, randomized…
- Trial name
- EPALD (NCT01501162)
- Testing
- hepatitis, alcohol, probiotics
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Opioid-Induced Bowel Dysfunction
Opioid-induced Bowel Dysfunction: Long-Term Assessment of Lubiprostone
The purpose of this study is to evaluate the long-term safety and efficacy of lubiprostone administration in participants with opioid-induced bowel dysfunction.
- Trial name
- NCT00620061
- Testing
- Lubiprostone 24
- Where
- 123 sites in United States, Canada
- Volunteers
- 439 people
- Sponsor
- Sucampo Pharma Americas, LLC
Alcohol Use Disorder
Deep Brain Stimulation for Alcohol Use Disorder
The purpose of this clinical study is to investigate the safety, tolerability, and feasibility of Deep Brain Stimulation (DBS) of the limbic pallidum in participants with severe alcohol use disorder (AUD) who have advanced but…
- Trial name
- NCT05522751
- Testing
- DBS
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Khaled Moussawi
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