Clinical trials: Substance-Related Disorder
Nicotine Addiction
Comparative Effectiveness of Cystine Versus Nicotine Replacement Therapy
A pragmatic, single blinded, randomized, controlled non-inferiority trial of Cytisine versus Nicotine Replacement Therapy for continuous abstinence is conducted in the government run primary health hospitals in Mongolia.
- Trial name
- NCT04126135
- Testing
- Cytisine, Nicotine Replacement Therapy (NRT)
- Where
- Mongolia
- Volunteers
- 1,307 people
- Sponsor
- Loma Linda University
Abuse, Drug
Abuse Potential of Intravenous Remimazolam Compared to Midazolam and Placebo in Recreational CNS Depressant Users
A double-blind, randomized crossover study to assess the subjective abuse potential of intravenous remimazolam compared to midazolam and placebo in recreational CNS depressant users
- Trial name
- NCT04110535
- Testing
- Remimazolam, Midazolam, Saline
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Paion UK Ltd.
Alcohol-Related Disorders, Alcohol Use Disorders
Tailored Mobile Text Messaging to Reduce Problem Drinking
This study is designed to develop and test a tailored adaptive text messaging/short message service (SMS) intervention for individuals interested in stopping or reducing their alcohol consumption; and test and compare it to…
- Conditions
- Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism
- Trial name
- NCT01885312
- Testing
- Adaptive Tailored Intervention, Consequence-based Intervention, Tailored, not adaptive, based Intervention
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Alcohol Dependence
Computer-Based Alcohol Use Disorder Recovery System
The purpose of this grant is to develop and test a proven computer based quality improvement/behavior change e-Health system (CHESS--Comprehensive Health Enhancement Support System) to help prevent relapse in alcohol dependent…
- Trial name
- NCT01003119
- Testing
- Addiction CHESS
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Wisconsin, Madison
Alcohol Use Disorder
HLAB-002 of ANS-6637 for Alcohol Use Disorder
Primary: The primary objective of this study was to evaluate the effects of 2 different doses of ANS-6637, 200 mg (given as 2 x 100 mg tablets) and 600 mg (given as 2 x 300 mg tablets) once a day, and matched placebo, on alcohol…
- Trial name
- NCT03970109
- Testing
- ANS-6637
- Where
- 3 sites in United States
- Volunteers
- 43 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Heroin Dependence, Sleep Impairment
Methadone Maintenance Outcome Study in Taiwan: 5-year Follow-up
Methadone maintenance treatment (MMT) has been one of the most effective treatment choices for opioid addicts to reduce their heroin use, criminality and spread of HIV. In Taiwan, MMT has been introduced since 2006.
- Conditions
- Heroin Dependence, Sleep Impairment, Mortality, Quality of Life
- Trial name
- NCT02524912
- Volunteers
- 1,200 people
- Sponsor
- National Health Research Institutes, Taiwan
Autism Spectrum Disorder
The Effects of Medical Cannabis in Children With Autistic Spectrum Disorder
Children with autism spectrum disorder (ASD) commonly exhibit comorbid symptoms such as aggression, hyperactivity and anxiety. Data on the effects of cannabidiol rich cannabis extract use for ASD is promising but still limited.
- Trial name
- NCT05212493
- Testing
- Cannabis oil
- Where
- Israel
- Volunteers
- 128 people
- Sponsor
- Assaf-Harofeh Medical Center
HIV, AIDS
Personalized Text Messages to Improve Antiretroviral Treatment (ART) Adherence in HIV+ Methamphetamine Users
Methamphetamine (METH) is a debilitating and frequently abused substance that is often comorbid with HIV infection. HIV+ persons with current METH abuse or dependence (HIV+/METH+) have several characteristics, in addition to…
- Trial name
- iTAB (NCT01317277)
- Testing
- individualized Texting for Adherence Building (iTAB), Psychoeducation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, San Diego
Substance Withdrawal Syndrome, Opiate Addiction
Study to Evaluate the Exposures of Lofexidine and Its Major Metabolites in Subjects Seeking Buprenorphine Dose Reduction
The purpose of this study is to evaluate the relative exposures of lofexidine and its major metabolites in subjects seeking buprenorphine dose reduction.
- Conditions
- Substance Withdrawal Syndrome, Opiate Addiction, Opiate Dependence
- Trial name
- NCT02801357
- Testing
- lofexidine administration in subjects seeking buprenorphine dose reduction
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- USWM, LLC (dba US WorldMeds)
Bladder Cancer, Cervical Cancer
Bupropion in Helping Adults Stop Smoking
RATIONALE: Bupropion may help people stop smoking by decreasing the symptoms of nicotine withdrawal. Giving bupropion over a longer period of time may be effective in helping people stop smoking.
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00534001
- Testing
- bupropion hydrochloride
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Roswell Park Cancer Institute
Alcohol Use Disorder
Compensatory Cognitive Training Via Telehealth for Veterans With Alcohol Use Disorders
Most individuals entering treatment for alcohol use disorders (AUDs) present with cognitive deficits across a range of cognitive domains, and these deficits frequently persist for six months or longer following remission.
- Trial name
- CCT-A (NCT06134128)
- Testing
- Motivationally Enhanced Compensatory Cognitive Training for Addictions Group
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Portland VA Medical Center
Alcohol Use Disorder, Insomnia
Daridorexant for People With Insomnia and Alcohol Use Disorder Study
The goal of this clinical trial is to see if a sleep medication, daridorexant (DTX), can help decrease drinking in people who have alcohol use disorder (AUD) and insomnia.
- Trial name
- DIAS (NCT07701928)
- Testing
- Daridorexant, Brief Counseling, MEMS and Medication Accounting
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Sterling McPherson
Cocaine-Related Disorders, Substance-Related Disorders
New Approaches to Cocaine Abuse Medications (A) - 6
The purpose of this study is to measure the effect of desipramine in cocaine abusers selected for major depression or dysthymia.
- Trial name
- NCT00000271
- Testing
- Desipramine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- New York State Psychiatric Institute
Opioid Use Disorder
LIFU for Treatment for Refractory Opioid Use Disorder
This is a randomized, double-blind, sham-controlled, partial crossover study investigating LIFU targeting the NAc and VC for participants with severe, treatment refractory OUD.
- Trial name
- NCT06218706
- Testing
- Low Intensity Focussed Ultrasound
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Ali Rezai
Methamphetamine Dependence, Substance Abuse
Varenicline for Methamphetamine Dependence
Methamphetamine (MA) dependence is a source of continuing danger for both individuals and society. While there are some behavioral treatments, they are not always effective.
- Conditions
- Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
- Trial name
- NCT01365819
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, Los Angeles
Metabolic Alcohol-associated Liver Disease, Alcohol Use Disorder
Tirzepatide in MetALD
Background: People with alcohol use disorder (AUD) often develop metabolic alcohol-associated liver disease (MetALD). MetALD is a term for the heart, liver, obesity, and other issues that can accompany AUD. MetALD can be fatal.
- Trial name
- NCT07046819
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
Study of Retinal Function Using Electroretinogram in Regular Alcohol Users
Alcohol is a major public health problem and its neurotoxic effects are, among other things, responsible for altering the functioning of cerebral neurotransmission pathways.
- Trial name
- ERICA (NCT03818971)
- Testing
- electroretinogram (flash, pattern and multifocal)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Psychothérapique de Nancy
Substance Dependence
EtOH Interaction Study
This study will investigate the possible effects of alcohol in combination with GSK598809 on the central nervous system in 20 healthy male and female volunteers, between 18 and 65 years of age.
- Trial name
- NCT00887367
- Testing
- GSK598809, Ethanol
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alcoholic Hepatitis
Utility of the Use of N-acetylcysteine Associated With Conventional Treatment in Patients With Severe Acute Alcoholic Hepatitis (Maddrey> 32)
This study is designed to evaluate the hypothesis that patients with severe acute alcoholic hepatitis have lower morbi-mortality if the patients receive treatment with corticosteroids + NAC, compared to patients that only receive…
- Trial name
- NCT05294744
- Testing
- N-acetylcysteine
- Where
- Spain
- Volunteers
- 390 people
- Sponsor
- Bioaraba Health Research Institute
Alcohol Addiction
Disulfiram as a Modulator of Amyloid Precursor Protein-processing
A causal therapeutic approach for treatment of Alzheimer's disease has not been established so far. The protein ADAM10 represents a promising target for an A-beta peptide preventing strategy.
- Trial name
- DIMAP (NCT03212599)
- Testing
- Disulfiram
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.