Clinical trials: Substance-Related Disorder
Substance Use
Substance Abuse Treatment to HIV Care (SAT2HIV): The Implementation & Sustainment Facilitation Experiment
A cluster randomized experiment focused on testing the extent to which the organization-focused Implementation \& Sustainment Facilitation (ISF) strategy is an effective adjunct to the staff-focused Addiction Technology Transfer…
- Trial name
- NCT03120598
- Testing
- ATTC strategy, ISF strategy
- Where
- 39 sites in United States
- Volunteers
- 190 people
- Sponsor
- RTI International
Alcohol Dependence
Telephone-Based Continuing Care for Alcohol Dependence
Alcohol dependency is the second most common psychiatric disorder and a major public health concern. As addictive disorders and now thought to be chronic disorders for many patients there is a need for the development of expanded…
- Trial name
- NCT02030093
- Testing
- Telephone-based counseling
- Where
- Switzerland
- Volunteers
- 317 people
- Sponsor
- University of Bern
Opioid-Refractory Chronic Cancer-Related Pain
The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.
This is a randomized, double-blinded, placebo-controlled, cross-over trial examining the effect of a series of two weekly intravenous infusions of lidocaine 4 mg/kg and ketamine 0.2 mg/kg in patients with moderate to severe…
- Trial name
- NCT07408193
- Testing
- Lidocaine and Ketamine Infusion
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- National and Kapodistrian University of Athens
Sexual Violence, Posttraumatic Stress Disorder (PTSD)
Testing STAR and TextSTAR: A Randomized Controlled Trial
The goal of this clinical trial is to learn whether a video given for recent sexual assault survivors and/or a 3-week text messaging intervention with similar content is effective at reducing mental health problems and substance…
- Conditions
- Sexual Violence, Posttraumatic Stress Disorder (PTSD), Opioid Misuse
- Trial name
- NCT07630428
- Testing
- Skills Training in Active Recovery (STAR) Video, Text Skills Training in Active Recovery (TextSTAR) program
- Where
- 3 sites in United States
- Volunteers
- 394 people
- Sponsor
- University of Wisconsin, Madison
Opioid-Induced Constipation
Assessment of Efficacy and Safety in Relieving Opioid-induced Constipation in Patients With Cancer-related Pain
The purpose of this study is to compare the effect of NKTR-118 with placebo in the treatment of opioid-induced constipation (OIC) in patients with cancer-related pain, including those patients that have inadequate response to…
- Trial name
- NCT01384292
- Testing
- NKTR-118
- Where
- 140 sites in United States, Australia and 12 more
- Volunteers
- 14 people
- Sponsor
- AstraZeneca
Substance-related Disorders
Medical Office Intervention for Adolescent Drug Use - Attention Study Supplement
This study will use the CCPT II to assess attention in 12-21 year olds enrolled in a randomized controlled trial of a brief behavioral treatment for substance abuse.
- Trial name
- NCT00593034
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Boston Children's Hospital
Cannabis Dependence
Quetiapine Pharmacotherapy for Cannabis Dependence
Despite a benign public perception, marijuana use disorders represent a significant public health problem. The development of safe and effective pharmacotherapies for marijuana dependence is an important unmet public health need.
- Trial name
- QUEST (NCT01697709)
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Chronic Pain, Back Pain
CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial
The goal of this clinical trial is to learn whether a combined behavioral and pharmacologic intervention can help reduce opioid use, improve pain recovery, and prevent opioid misuse after surgery in adults undergoing elective…
- Conditions
- Chronic Pain, Back Pain, Neck Pain, Opioid Misuse
- Trial name
- CARES (NCT06027099)
- Testing
- Tizanidine, MI-Opioid Taper, Enhanced Usual Care
- Where
- 4 sites in United States
- Volunteers
- 375 people
- Sponsor
- Stanford University
Nightmare
Treating Nightmares Among Domiciliary Patients
The purpose of the study is to assess the efficacy of a 2-session intervention to reduce nightmares among Veterans admitted VA mental health residential rehabilitation treatment programs.
- Trial name
- NCT04341987
- Testing
- brief Imagery Rehearsal Therapy, Treatment As Usual
- Volunteers
- healthy volunteers welcome
- Sponsor
- Canandaigua VA Medical Center
Housing Problems, Pregnancy Related
Evaluating the Impact of Emergency Maternity Housing
Moms will call and agencies will determine if she is eligible based on basic criteria. If she is eligible, the agency will send her an intake application link to complete, which includes a consent form.
- Trial name
- NCT05428514
- Testing
- Maternity Housing
- Where
- United States
- Volunteers
- 1,048 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
HIV Infections, Depression
Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)
The primary purpose of this study was to test the whether high-risk, HIV-seronegative persons with mild-to-moderate depression would be more likely to adopt protective behavior change when provided with pharmacotherapy for their…
- Trial name
- NCT00285584
- Testing
- Bupropion
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- NYU Langone Health
HIV Infections, Substance Use
Peer Behavioral Activation Utilization to Improve Substance Use and HIV Outcomes in People Receiving Long Acting Injectable-PrEP/ART (PUSH)
This randomized Type 1 hybrid effectiveness-implementation trial (N=186) will evaluate the effectiveness and implementation of a peer-delivered problem solving and behavioral activation intervention for adherence to LAI-PrEP/ART…
- Trial name
- PUSH (NCT06501781)
- Testing
- Peer Activate-LAI, Standard of Care HIV treatment or prevention with LAI-PrEP/ART
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Alcoholism
Baclofen for the Treatment of Alcohol Drinkers
The main objective of this study is to show the effectiveness to a year of baclofen compared to placebo, on the proportion of patients with a low risk alcohol consumption or no, according to the WHO standards.
- Trial name
- BACLOVILLE (NCT01604330)
- Testing
- Baclofen
- Where
- France
- Volunteers
- 323 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
PTSD, Suicidal Thoughts and Behaviors
Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study
This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD.
- Conditions
- PTSD, Suicidal Thoughts and Behaviors, PTSD Symptoms, Depressive Symptoms
- Trial name
- CNS (NCT07222306)
- Testing
- 1-(2-[+F]fluoroethyl)-L-tryptophan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wayne State University
PTSD, Alcohol Use Disorder
BioWare for AUD and PTSD
This study examines the ability of an innovative telehealth technology system to enhance Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure (COPE) talk-therapy for individuals with posttraumatic…
- Trial name
- NCT05187364
- Testing
- COPE
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medical University of South Carolina
Self Efficacy
Substance Use Risk and Solution-Focused Approach
Although substance abuse is the subject of serious struggles on the basis of individuals and countries, its rate of spread cannot be stopped and it creates an agenda with new people added every day.
- Trial name
- NCT06732206
- Testing
- Short Solution Focused Approach Program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ufuk DOĞAN
Malnutrition, Liver Diseases, Alcoholic
Gastric- Versus Jejunal Feeding Tubes in Alcoholic Liver Diseases
The study is an unblinded randomized trial, designed to examine whether gastric- or jejunal feeding tubes are the most effect full to feed patients with alcoholic liver diseases and non-sufficient oral intake.
- Trial name
- NCT02319252
- Testing
- Gastric tube (Nutricia Flocare® Pur Tube Enlock), Jejunal tube (Nutricia Flocare® Bengmark®)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Liver Failure, Liver Diseases, Alcoholic
BRIDGE Device for Post-operative Pain Control
Auricular neurostimulation is a potential novel and non-invasive method of pain control following liver transplantation in a growing patient population with the probability of significant impact on economics and morbidity.
- Conditions
- Liver Failure, Liver Diseases, Alcoholic, Liver Diseases, Pain, Postoperative
- Trial name
- BRIDGE (NCT03265249)
- Testing
- BRIDGE device
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Duke University
Opioid Use, Opioid-Related Disorders
Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients
Risk of long-term opioid dependence increases with initial opioid dose/duration, but despite recent Centers for Disease Control and Prevention (CDC)-endorsed minimum doses for initial opioid prescription, primary care providers…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Abuse, Prescription Drug Abuse and Dependency
- Trial name
- NCT03377855
- Testing
- Default Prescribing Change
- Where
- 2 sites in United States
- Volunteers
- 948 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Cocaine Dependence
Clinical Trial of Topiramate for Cocaine Addiction
This is an outpatient clinical trial of topiramate for addressing cocaine dependence and reduction of cocaine associated behaviors in opiate dependent drug users maintained on methadone treatment.
- Trial name
- NCT00685178
- Testing
- topiramate, Contingency Reinforcement
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
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