Clinical trials: Substance-Related Disorder
Marijuana Dependence
Buspirone Treatment for Marijuana Dependence
Marijuana is the most commonly used illicit drug, yet few clinical trials have evaluated pharmacotherapy treatments for marijuana dependence.
- Trial name
- NCT00875836
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Medical University of South Carolina
Attention Deficit Hyperactivity Disorder, Cannabis Abuse
Pilot Evaluation of Atomoxetine on Attention Deficit Hyperactivity Disorder (ADHD) Symptoms in Adolescents With Cannabis abusE
The purpose of this study is to determine whether atomoxetine is effective in reducing ADHD (Attention Deficit/Hyperactivity Disorder) symptoms in adolescents with ADHD and comorbid cannabis abuse.
- Trial name
- PEACE (NCT00687609)
- Testing
- Atomoxetine
- Where
- Netherlands
- Volunteers
- 7 people
- Sponsor
- Eli Lilly and Company
Marijuana Abuse, Sleep Initiation and Maintenance Disorders
CBT-I for Cannabis Use
The purpose of this study is to investigate the efficacy of a group-based behavioral sleep intervention, and the incremental benefit provided by an adjunct sleep mobile app, on cannabis and sleep outcomes among cannabis dependent…
- Trial name
- CBT-I-CU (NCT02102230)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Cognitive Behavioral Therapy for Insomnia Plus Mobile App (CBT-I-MA), Desensitization Treatment for Insomnia
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- VA Office of Research and Development
Cannabis Use Disorder, Tobacco Use Disorder
Clinical Trial Tobacco Marijuana
Approximately 50% of persons seeking treatment for cannabis-use disorders (CUDs) regularly smoke tobacco. Combining tobacco with cannabis has become a common method of smoking cannabis.
- Trial name
- RCTTM (NCT02277665)
- Testing
- CUD Treatment, Tobacco Treatment
- Where
- 3 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Alcohol Abuse
Computer-delivered Screening and Brief Intervention for Alcohol Use in Pregnancy
The purpose of this study is to lay the ground work for a fully powered clinical trial of a computer-delivered screener and intervention for alcohol use during pregnancy. The pilot study will include: 1.
- Trial name
- NCT01643044
- Testing
- Computer-delivered, brief intervention on alcohol use
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Wayne State University
Substance-Related Disorders
Functional Magnetic Resonance Imaging of Opioid Withdrawal in Healthy Human Volunteers
Opioid medications are commonly used for pain relief. When given over time, physical dependence can occur. This results in unpleasant side effects--such as agitation and nausea--if opioid medications are suddenly stopped.
- Trial name
- NCT01006707
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stanford University
Opioid Use, Opioid-Related Disorders
Comparing State Payer Strategies to Prevent Unsafe Opioid Prescribing
This study examines the comparative effectiveness of opioid review programs in reducing unsafe opioid prescribing in two states: prospective prior authorization (PA) with hard stops in Washington and retrospective review (RR)…
- Trial name
- NCT03932799
- Testing
- Prospective prior authorization (PA) with hard stops in Washington, Retrospective review (RR) with prescriber notification in Ohio
- Where
- 2 sites in United States
- Volunteers
- 5,411 people
- Sponsor
- University of Washington
Cannabis Use Disorder
Buspirone, Stress, and Attentional Bias to Marijuana Cues
This project has two primary goals. The first goal is to further scientific understanding about marijuana abuse by examining two recognized factors in marijuana use and relapse: (1) stress/anxiety and (2) atypical reactivity to…
- Trial name
- NCT02132832
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The University of Texas Health Science Center, Houston
Heroin Dependence
Reinforcing Effects of Intranasal (IN) Buprenorphine Versus Buprenorphine/Naloxone
The study is designed to compare the abuse liabilities of intranasal buprenorphine and buprenorphine/naloxone in individuals who are physically dependent on sublingual buprenorphine.
- Trial name
- NCT01760473
- Testing
- Intranasal challenge drug
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Alcohol Dependence
Effects and Therapeutic Potential of Psilocybin in Alcohol Dependence
This trial is an open-label pilot study (N = 10) designed to assess the effects of psilocybin in alcohol dependent participants, demonstrate the feasibility of the integrated behavioral/pharmacologic intervention, and provide…
- Trial name
- NCT01534494
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of New Mexico
Cigarette Smoking, Nicotine Addiction
STOP Study: Effectiveness of Zyban in a Clinical Population
Despite the significant health, social and economic costs of cigarette smoking, 17% of Ontarians still currently smoke. Use of smoking cessation pharmacotherapy such as Zyban (bupropion HCl) has been shown to double quit rates…
- Conditions
- Cigarette Smoking, Nicotine Addiction, Smoking Cessation
- Trial name
- NCT01015170
- Testing
- bupropion HCl
- Where
- 24 sites in Canada
- Volunteers
- 454 people
- Sponsor
- Centre for Addiction and Mental Health
Risk Reduction Behavior, Health Behavior
Alcohol, Marijuana, and Risky Sex: Group Interventions With Detained Adolescents
This research is studying behaviors that young people engage in that may place them at risk for contracting a sexually transmitted disease like HIV/AIDS, and what kind of educational program works best to reduce these risky…
- Conditions
- Risk Reduction Behavior, Health Behavior, Sexual Behavior, Adolescent Behavior
- Trial name
- MARS (NCT01170260)
- Testing
- INFORMATION-ONLY SEXUAL RISK REDUCTION (INFO-ONLY), SEXUAL PLUS ALCOHOL RISK REDUCTION (SRRI+ETOH), SEXUAL + ALCOHOL + MARIJUANA RISK REDUCTION
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Social Skills, Self-Criticism
Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
The purpose of this randomized controlled trial is to evaluate an intervention, Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS).
- Conditions
- Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression
- Trial name
- NCT03488927
- Testing
- Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
- Where
- United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Bladder Cancer, Cervical Cancer
Acceptability of Less Harmful Alternatives to Cigarettes
RATIONALE: A study that evaluates participants' beliefs about smokeless tobacco products and nicotine replacement therapy may be useful in helping smokers stop smoking.
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00957424
- Testing
- telephone-based intervention, nicotine replacement therapy, informational intervention
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Roswell Park Cancer Institute
HIV/AIDS, Substance Use Disorders
HIV+ Substance Users Released From Jail
The long-term goal of this project is to improve HIV and substance use outcomes and reduce recidivism for HIV+ substance users released from jail.
- Trial name
- NCT03834779
- Testing
- DOORS-CHW Intervention
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Texas Southwestern Medical Center
Opioid-induced Constipation
Study of Subcutaneous Methylnaltrexone (MNTX) in the Treatment of Opioid-Induced Constipation During Rehabilitation After Orthopedic Procedures
The purpose of this study is to examine the safety and activity of MNTX in relieving opioid-induced constipation following orthopedic procedures.
- Trial name
- NCT00640146
- Testing
- Methylnaltrexone bromide
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Bausch Health Americas, Inc.
Tobacco Dependence
Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1
Schizophrenia is associated with high rates of cigarette smoking and associated morbidity and mortality. In this study, smokers with schizophrenia will complete a baseline session and then randomized to varenicline (VAR) or…
- Trial name
- NCT03507127
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brown University
Substance-related Disorders, Violence
Treating Violence-Prone Substance Use Disorder Patients
This project is intended to help substance use disorder patients who perpetrate interpersonal violence against other adults.
- Trial name
- NCT00700973
- Testing
- Interpersonal Violence Prevention Intervention, Usual care
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- US Department of Veterans Affairs
Nicotine Dependence
Varenicline for Nicotine Dependence Among Those With HIV/AIDS
Among people diagnosed with HIV/AIDS, the widespread use of highly active antiretroviral therapy (HAART) has greatly improved survival rates and changed the leading causes of death, from AIDS-related diseases to cardiovascular…
- Trial name
- NCT01710137
- Testing
- Varenicline, Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- University of Pennsylvania
Cannabis Dependence, Alcohol Dependence
Pharmacological Treatment of Comorbid Alcohol and Marijuana Withdrawal and Dependence
The primary aim of the supplemental study is to provide POC testing of aprepitant as a treatment for comorbid alcohol and cannabis dependence.
- Conditions
- Cannabis Dependence, Alcohol Dependence, Cannabis Use Disorder, Alcohol Use Disorder
- Trial name
- NCT02210195
- Testing
- aprepitant, Manual-guided behavioral counseling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Scripps Research Institute
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