Clinical trials: Substance-Related Disorder
Opioid-use Disorder
Harnessing Digital Health to Understand Clinical Trajectories of Opioid Use Disorder
The main objective of the study is to evaluate the feasibility of utilizing digital health technology with opioid use disorder (OUD) patients as measured by a 12-week period of continuous assessment using smartphone surveys and…
- Trial name
- D-TECT (NCT04535583)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Perinatal Depression, Substance Use
Sober Network IPT for Perinatal Women With Comorbid Substance Use and Depression
This study will evaluate the effectiveness of Sober Network Interpersonal Psychotherapy (IPT) in treating women with depression and comorbid substance abuse.
- Trial name
- NCT01550913
- Testing
- Sober Network Interpersonal Psychotherapy (IPT), Treatment as Usual
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Central Sleep Apnea, Secondary
Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption
Acetazolamide improves central sleep apnea related to opium consumption.
- Trial name
- NCT02371473
- Where
- Iran
- Volunteers
- 12 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Aggression, Substance-Related Disorders
Preventing Violence Among Veterans in Substance Use Disorder Treatment
The purpose of this study is to examine the impact on both clinical (violence and substance use) outcomes and health services use (substance use disorder and mental health treatment) compared to standard SUD treatment (enhanced…
- Trial name
- NCT01337973
- Testing
- MI-CBT, MI-CBT+CC, E-TAU
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- VA Office of Research and Development
Nicotine Dependence
Baclofen for Smoking Cessation in a Non-Psychiatric Population
The primary hypothesis for this study is that, in nicotine-dependent tobacco smokers, baclofen will be superior to placebo for smoking abstinence measures.
- Trial name
- Baclofen (NCT01228994)
- Testing
- Baclofen 30 mg/day, Baclofen 60 mg/day
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Substance Use Disorder, Motivation
Stop&Go: an Intervention Program to Promote Healthy and Active Lifestyles Among Patients With Substance Use Disorders
Stop\&Go is an intervention program aimed at promoting a healthy and physically active lifestyle for patients requiring inpatient detoxification treatment. The program includes two different phases.
- Trial name
- NCT03055351
- Testing
- Stop&Go Intervention
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Gambling Disorder, Substance Use Disorders
Integrative Couple Treatment for Gambling/Substance Use Disorder
The aim of the study is to compare couple-based treatment to individual treatment (treatment as usual) for addiction (gambling or substance use disorder).
- Trial name
- NCT05833503
- Testing
- Integrative Couple Treatment for Addiction (ICT-A), Treatment individual as usually offered
- Where
- 7 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Université du Québec à Trois-Rivières
Tobacco Use Disorder
Varenicline or Nicotine Patch in Promoting Smoking Cessation Among Current Smokers
This pilot clinical trial studies varenicline or nicotine patch in promoting smoking cessation among current smokers. Varenicline or nicotine patch may help people stop smoking
- Trial name
- NCT01771627
- Testing
- varenicline, nicotine patch
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Roswell Park Cancer Institute
Substance Use
Mindfulness-Based Substance Use Prevention (MINDS-UP)
The goal of this clinical trial is to test the feasibility, behavioral/neural mechanisms, and preliminary efficacy of "MINDfulness-based Substance Use Prevention Program," or "MINDS-UP", a novel substance use prevention…
- Trial name
- MINDS-UP (NCT06593470)
- Testing
- MINDS-UP, Prevention Plus Wellness
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Substance-Related Disorders
Effect of Fruit Smoothie Supplementation on Psychological Distress Among People Receiving Opioid Agonist Therapy
Background: People with substance use disorders generally have poor diets including limited intake of fruit and vegetables. Evidence shows substantial health benefits from increasing fruit and vegetable consumption on a variety…
- Trial name
- FruktBAR (NCT05229770)
- Testing
- Fruit smoothie
- Where
- 2 sites in Norway
- Volunteers
- 324 people
- Sponsor
- Haukeland University Hospital
Alcohol Drinking, Alcohol Problem Drinking
Parent Feedback Intervention Targeting Student Transitions and Alcohol Related Trajectories (+) Efficacy Study
FITSTART (Feedback Intervention Targeting Student Transitions and Risk Trajectories) is a parent-based social norms intervention that has been shown to reduce risky drinking in incoming first year students.This program uses…
- Conditions
- Alcohol Drinking, Alcohol Problem Drinking, Parenting
- Trial name
- FITSTART+ (NCT04549454)
- Testing
- FITSTART+ PBI, General Parenting Advice
- Where
- United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Loyola Marymount University
Nicotine Use Disorder
Identify the Optimal TMS Target to Modulate Reward Activity
Our primary goal will be to identify the optimal prefrontal-cingulate target by systematically measuring the efficacy of various image-based targeting techniques to increase the reward positivity using the 10-Hz TMS protocol in…
- Trial name
- NCT05766254
- Testing
- Active 10-Hz TMS to the DLPFC
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Rutgers, The State University of New Jersey
Cocaine Use Disorder, Tobacco Use Disorder
Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001)
This is a study of EMB-001 (a combination of two FDA-approved drugs, metyrapone and oxazepam) in otherwise healthy adults who are regular cigarette smokers.
- Trial name
- NCT02406066
- Testing
- metyrapone & oxazepam
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Embera NeuroTherapeutics, Inc.
Tobacco Use Disorder, Substance Use Disorders
A Digital Smoking Cessation Intervention for Adults With Substance Use Disorder
Adults with substance use disorder (SUD) tend to have started smoking at a younger age and are more likely to be heavy smokers. Due to the many conflicting priorities in this population, smoking cessation is often relegated and…
- Trial name
- NCT04419922
- Testing
- Smartphone Contingency Management Intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- BrightView LLC
Opioid Overdose, Drug Overdose
Preventing Overdose Using Information and Data From the Environment
The objectives of this project are to leverage surveillance data to predict future overdose outbreaks, and to evaluate the impact of a randomized, statewide, community-level intervention trial to target overdose prevention…
- Trial name
- PROVIDENT (NCT05096429)
- Testing
- PROVIDENT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Brown University
Opioid Use Disorder
Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder
This study will examine the effect of a single high dose of psilocybin therapy (30 mg) versus a very low dose (1 mg) as an adjunctive therapy to individuals undergoing standard-of-care outpatient buprenorphine treatment for…
- Trial name
- BIPOD-Out (NCT06067737)
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Substance Abuse
Telephone Coaching of Family Members of Veterans With Substance Abuse Problems
This project will develop and pilot test an enhanced, telephone "coaching" intervention to help family members concerned about a Veteran of the wars in Iraq or Afghanistan who needs to seek treatment for a substance abuse problem.
- Trial name
- VA-CRAFT (NCT03246646)
- Testing
- Coaching
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Risky Health Behavior
A Female-Specific CBT Group for Veteran Women With Alcohol Use Disorder in VA Primary Care Settings
The purpose of this study is to evaluate a Female-Specific Cognitive Behavioral Therapy (CBT) Group as treatment for Alcohol Use Disorder among Veteran women.
- Trial name
- NCT06118346
- Testing
- Female-Specific Cognitive Behavioral Therapy (FS-CBT), Usual Care
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Dependence, PTSD
Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence
Objective: To develop a detailed treatment manual that modifies the existing CPT-C treatment protocol to allow for concurrent treatment of PTSD and AD, and to obtain some pilot data regarding its efficacy.
- Trial name
- NCT00639288
- Testing
- modified CPT-C
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Yale University
Methamphetamine-dependence, Substance Abuse
Safety Interaction Trial Ibudilast and Methamphetamine
This study is designed to collect data to determine whether a medication, ibudilast, is safe for use as a potential treatment for methamphetamine-dependent people.
- Trial name
- NCT01217970
- Testing
- Ibudilast 20mg, Ibudilast 50mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
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