Clinical trials: Substance-Related Disorder
Lung Cancer, Squamous Lung Dysplasia
Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer
This clinical trial studies deuterated phenanthrene tetraol in smokers who are at high risk for lung cancer. Studying samples of urine in the laboratory from smokers who are at high risk for lung cancer may help doctors learn…
- Conditions
- Lung Cancer, Squamous Lung Dysplasia, Tobacco Use Disorder
- Trial name
- NCT01673711
- Testing
- deuterated phenanthrene tetraol, pharmacological study, laboratory biomarker analysis
- Where
- 3 sites in United States, Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Opioid-use Disorder
Frontoparietal Synchronization to Modulate Drug Craving in Opioid Use Disorder
Opioid use disorder (OUD) is among the costliest and deadliest substance use disorders (SUDs) in the US and world-wide. Opioids were involved in 42,249 deaths in the US in 2016, which were more than deaths due to road accidents…
- Trial name
- FPS_Opioid (NCT03907644)
- Testing
- Transcranial Alternating Current Stimulation (tACS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Tobacco Dependence
Direct to Smoker Outreach in a Health Care Setting
Tobacco use is the leading preventable cause of death in the United States. Effective treatment for tobacco dependence exists and includes counseling and pharmacotherapy with nicotine replacement, bupropion, or varenicline.
- Trial name
- DTS (NCT01321944)
- Testing
- Direct to Smoker Outreach Program
- Where
- United States
- Volunteers
- 590 people
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder
Deep Brain Stimulation to Understand and Treat Addiction
This study is testing whether deep brain stimulation (DBS) can safely help people with severe alcohol use disorder who have not improved with standard treatments.
- Trial name
- Brain-PACER (NCT07341230)
- Testing
- Dual-Target Deep Brain Stimulation, Nucleus Accumbens Deep Brain Stimulation, Ventral Internal Capsule Deep Brain Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Cambridge
Nicotine Dependence, Smoking
Varenicline for Smoking Cessation in Heavy Drinking Smokers
The purpose of this study is to determine whether extended pretreatment with varenicline (Chantix) is more efficacious for smoking cessation than standard pretreatment, how well varenicline is tolerated in heavy drinking smokers…
- Conditions
- Nicotine Dependence, Smoking, Heavy Drinking
- Trial name
- NCT00860028
- Testing
- Extended Varenicline Pretreatment, Short-term Varenicline Pretreatment
- Volunteers
- 30 people
- Sponsor
- Yale University
Opioid-use Disorder
Treatment Navigation for Opioid Use Disorder
The investigators will conduct a pilot randomized controlled trial (RCT) study of 100 people with a history of opioid use disorder releasing to WA Department of Corrections (DOC) community corrections supervision in King County.
- Trial name
- NCT03398265
- Testing
- Treatment Navigation (Intervention), Control
- Where
- 5 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Washington
Alcohol Use Disorder, Alcohol-associated Liver Disease
Pomegranate Dietary Supplements in AUD and ALD
The goal of this project is to determine an individual's ability to generate active gut microbial metabolites called urolithins upon consumption of pomegranate dietary supplements.
- Conditions
- Alcohol Use Disorder, Alcohol-associated Liver Disease, Alcoholic Cirrhosis, Healthy
- Trial name
- NCT07678567
- Testing
- Pomegranate Dietary Ssupplement
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Healthy Volunteers
Vaporization as a Smokeless Cannabis Delivery System
A study to evaluate the use of a vaporization system as a smokeless delivery system for inhaled marijuana.
- Trial name
- NCT00241592
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Center for Medicinal Cannabis Research
Cannabis Abuse, Cannabis Dependence
Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
Cannabis use is a significant public health concern that disproportionately affect youth. Although promising psychosocial interventions are being developed, most youth do not benefit from these interventions alone.
- Trial name
- NCT01110434
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Brown University
Opioid-use Disorder
Buprenorphine as Adjunct to Outpatient Induction Onto Vivitrol
The study will enroll 30 opioid-dependent participants into an open-label pilot outpatient study of methods to facilitate induction and stabilization onto XR-NTX.
- Trial name
- NCT03113409
- Testing
- Buprenorphine, Naltrexone, Vivitrol
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Mood Disorders
Behavioral Treatment of Drug Abuse in Severe and Persistent Mental Illness (SPMI) Patients
The main purpose of this study is to determine if the multifaceted treatment for substance abuse in dual disordered patients is more effective in reducing drug use than a supportive control treatment.
- Conditions
- Schizophrenia, Mood Disorders, Substance Dependence
- Trial name
- NCT00295139
- Testing
- Behavioral Treatment for Substance Abuse in SPMI (BTSAS), Supportive Treatment in Addiction Recovery (STAR), Critical Time Intervention (CTI)
- Where
- 4 sites in United States
- Volunteers
- 293 people
- Sponsor
- University of Maryland, Baltimore
Anxiety Depression, Alcohol Abuse
CBD Oil for Reducing Emotional Impact of COVID-19
Our purpose is to conduct a 4-arm placebo-controlled clinical trial to investigate the relative clinical efficacy of 300 mg. of pure hemp-derived CBD isolate, 300 mg. of full spectrum CBD oil, 300 mg.
- Conditions
- Anxiety Depression, Alcohol Abuse, Substance Abuse, Anger
- Trial name
- CBDOIL (NCT04603781)
- Testing
- CBD Isolate, Full Spectrum CBD Oil, Broad-Spectrum CBD Oil
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Alcohol Use Disorder, Attention Deficit Hyperactivity Disorder
Methylphenidate and Response to Alcohol Cues Pilot Study
The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues.
- Trial name
- NCT06063200
- Testing
- Methylphenidate Pill
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Florida
See One, Do One
Three Strategies for Implementing Motivational Interviewing on Medical Inpatient Units
General medical hospitals provide care for a disproportionate share of patients who misuse substances. Motivational interviewing (MI) is a well-recognized, evidenced-based substance use treatment.
- Conditions
- See One, Do One, Order One
- Trial name
- NCT01825057
- Testing
- See One, Do One, Order One
- Where
- United States
- Volunteers
- 1,211 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence
Efficacy of Topiramate for Hospitalized Patients With Alcoholism
This is a 12-Week, randomized controlled study of topiramate in hospitalized patients with alcoholism
- Trial name
- ETHoPA-R (NCT01145677)
- Testing
- Topiramate
- Where
- 4 sites in Thailand
- Volunteers
- 90 people
- Sponsor
- Chiang Mai University
Tobacco Dependence
Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes
Project 1, Study 1 will evaluate the relationship between nicotine yield of very low nicotine content cigarettes and cigarettes smoked per day, nicotine exposure, discomfort/dysfunction, other health-related behaviors…
- Trial name
- P1S1 (NCT01681875)
- Testing
- very low nicotine content cigarettes
- Where
- 9 sites in United States
- Volunteers
- 839 people
- Sponsor
- Wake Forest University Health Sciences
Healthy
A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers
The main purpose of this study is to determine if oxycodone and naltrexone combination capsules (ALO-02) have the potential to be abused.
- Trial name
- NCT01746901
- Testing
- intact ALO-02 60 mg/7.2 mg, crushed ALO-02 60 mg/7.2 mg, crushed oxycodone IR 60 mg
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cocaine Dependence
Cocaine Use Reduction With Buprenorphine
The aim of this study is to investigate the safety and effectiveness of buprenorphine in the presence of naltrexone for the treatment of cocaine dependence.
- Trial name
- CURB (NCT01402492)
- Testing
- Buprenorphine + Naltrexone
- Where
- 11 sites in United States
- Volunteers
- 302 people
- Sponsor
- University of California, Los Angeles
Substance Use Disorders, Criminal Behavior
Feasibility, Acceptability and Preliminary Treatment Effects of A-CRA for Youth in Compulsory Institutional Care
Substance abuse and criminal behavior are increasing among adolescents in Sweden. The Swedish National Board of Institutional Care, SiS, provides institutional care on basis of the Swedish laws Care of Young Persons (Special…
- Trial name
- NCT05081934
- Testing
- A-CRA, TAU
- Where
- Sweden
- Volunteers
- 42 people
- Sponsor
- Karolinska Institutet
Substance Use, Psychopathy
The Impact of Psychopathic Traits on the Efficacy of a Substance Use Intervention
Substance use among criminal offenders constitutes a major public health problem and is tied to negative consequences for offenders, their families, and their communities.
- Trial name
- NCT01532934
- Testing
- motivational enhancement therapy, standard care
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Rochester
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