Clinical trials: Substance-Related Disorder
HIV, Opioid Use Disorder
Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women
The purpose of this 2-site (CT, AL) study is to test innovative interventions to reduce stigma and improve the pre-exposure prophylaxis (PrEP) and opioid use disorder (OUD) care continua in women involved in the criminal justice…
- Conditions
- HIV, Opioid Use Disorder, eHealth
- Trial name
- NCT05547048
- Testing
- Decision Aid, Athena strategy
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder (AUD)
Renewed Recovery: a Pilot Test of a Web-Based Mindfulness-Based Relapse Prevention Continuing Care Intervention for Alcohol Use Disorder
This study aims to design, implement, and evaluate a pilot test of a web-based Mindfulness-Based Relapse Prevention (MBRP) continuing care intervention to support individuals with alcohol use disorder (AUD) exiting standard…
- Trial name
- NCT06987526
- Testing
- Mindfulness-Based Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Georgia
Fetal Alcohol Spectrum Disorders
Fetal Alcohol Spectrum Disorder : Clinical Description and Search for Epigenetic Biomarker (EPI-TSAF)
The goal of this clinical trial is to carry out a clinical description of a Reunionese series of patients (aged 0 to 18 inclusive) with Fetal Alcohol Spectrum Disorders followed up in the Genetics Department of the University…
- Trial name
- EPI-TSAF (NCT06471335)
- Testing
- Extraction of microRNAs extracted from plasma (4 ml recovered as part of treatment), Extraction of microRNAs extracted from bucal swabs (act added for research).
- Where
- France
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Tobacco Use Disorder
Comparative Acceptability of Tobacco and Menthol Flavored E-cigarettes
The study is a randomized crossover trial. Current menthol smokers will complete a session with each flavor of an electronic cigarette: menthol and tobacco. The objective of this survey is to assess for flavor preference.
- Trial name
- NCT04996940
- Testing
- E-cigarette product
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Substance Dependence, HIV (Human Immunodeficiency Virus)
Pre-exposure Prophylaxis (PrEP) for Health
This randomized controlled trial will test the efficacy of "PrEP for Health," a behavioral intervention to improve the use of antiretroviral pre-exposure prophylaxis (PrEP) among at-risk people who inject drugs (PWID) in two…
- Trial name
- PrEP (NCT04430257)
- Testing
- HIV and PrEP education, Motivational interviewing, Problem-solving and planning
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Brown University
Poly Drug Exposed Pregnancies
Fetal Neurobehavior in Poly-drug Dependent Women
This project examines fetal neurobehavior and maternal physiology in poly-drug dependent women. This study also evaluates infant neonatal abstinence syndrome, infant neurobehavior and vagal tone in the post-partum period.
- Trial name
- NCT00653692
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Johns Hopkins University
Alcohol Drinking, Alcohol Use Disorder
Ketone Ester Intervention in Alcohol Use Disorder
The purpose of this research is to study how a nutritional ketone ester may effect brain function and alcohol consumption in regular alcohol users.
- Trial name
- NCT04616781
- Testing
- Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", Alcohol drinks
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Bipolar Disorder, Alcohol Drinking
Familial Risk for Bipolar Disorder and Alcohol Sensitivity
Early identification in individuals with bipolar disorder who are at risk for AUDs could inform novel intervention strategies and improve life-long outcomes.
- Conditions
- Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
- Trial name
- FACS (NCT04716036)
- Testing
- Alcohol beverage
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Substance Use
Pre-exposure Prophylaxis (PrEP) Adherence Intervention for Women with Substance Use Disorders
The goal of this clinical trial is to test an addiction-clinic based behavioral intervention for increasing PrEP uptake and adherence among women who engage in high-risk sexual behaviors and problematic substance use.
- Trial name
- NCT06158607
- Testing
- Addiction Clinic-Based PrEP Adherence Intervention for Women with Substance Use Disorders, Standard of care treatment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Substance-Related Disorders, Mental Disorders
Performance-based Reinforcement to Enhance Cognitive Remediation Therapy
The purpose of this study is to investigate whether monetary reinforcement for performance will enhance the effects of cognitive remediation therapy for substance users seeking treatment at an outpatient facility.
- Trial name
- NCT01633138
- Testing
- Cognitive Remediation Therapy - Standard, Cognitive Remediation Therapy plus Contingency Management
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Opioid Use, Opioid Use Disorder
Increasing Access to Evidence-based Treatment for Chronic Pain and Opioid Use Disorder: Adapting Acceptance and Commitment Therapy for Opioid Treatment Programs
The overarching goal of this study was to provide patient-centered treatment for chronic pain in opioid treatment programs (OTPs).
- Conditions
- Opioid Use, Opioid Use Disorder, Chronic Pain
- Trial name
- OTP-ACT (NCT06581276)
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Montefiore Medical Center
Marijuana Abuse
The Effect of Food on the Oral Bioavailability of AEF0117 in Healthy Volunteers
Cannabis use is increasing and will only further escalate with legalization of recreational and medical cannabis use in western countries , with a prevalence greater than 30 % in the US and most European countries for individuals…
- Trial name
- NCT05451017
- Testing
- 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fed condition, 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fasting condition
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aelis Farma
Cocaine-Related Disorders
Dextroamphetamine-Cocaine Behavioral Intervention - 5
The purpose of this study is to examine dextroamphetamine-cocaine behavioral intervention in cocaine dependent patients.
- Trial name
- NCT00000308
- Testing
- Dextroamphetamine, D-amphetamine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence
Study of 18 mg Selincro® As-needed Use, in the Treatment of Patients With Alcohol Dependence in Primary Care
To determine the reduction in alcohol consumption in patients with alcohol dependence treated with 18 mg Selincro® as-needed use, in conjunction with continuous psychosocial support in primary care
- Trial name
- NCT02195817
- Testing
- Selincro® 18 mg with continuous psychosocial support: Cohort A, Initial psychosocial support: Cohort B
- Where
- 48 sites in France, Germany and 2 more
- Volunteers
- 378 people
- Sponsor
- H. Lundbeck A/S
Cannabis Use, Impaired Driving
Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance
The purpose of this research is to determine the extent to which oculomotor function accurately detects THC-impairment, if cannabis use experience impacts this detection threshold, and to examine how the oculomotor index…
- Conditions
- Cannabis Use, Impaired Driving, Cognitive Impairment
- Trial name
- NCT06351540
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Schizophrenia, Schizotypal Disorder
The OPUS YOUNG Trial. Early Intervention Versus Treatment as Usual for Adolescents With First-episode Psychosis
The OPUS YOUNG (OY) study investigates the efficacy of early intervention service versus treatment as usual (TAU) for adolescents aged 12-17 years with a first-episode psychosis.
- Conditions
- Schizophrenia, Schizotypal Disorder, Delusional Disorder, Acute and Transient Psychotic Disorder, Unspecified
- Trial name
- OPUS-YOUNG (NCT04916626)
- Testing
- OPUS YOUNG, Treatment as Usual
- Where
- Denmark
- Volunteers
- 284 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Opioid Induced Constipation
Real World Observational Study of Naloxegol for Patients With Cancer Pain Diagnosed With OIC.
This is a single-arm, open label, multinational, multicentre, prospective, real world observational study of Naloxegol in adult subjects with Opioid Induced Constipation (OIC) in patients receiving Naloxegol in routine clinical…
- Trial name
- NACASY (NCT03638440)
- Testing
- Naloxegol
- Where
- 10 sites in Denmark, Finland and 8 more
- Volunteers
- 183 people
- Sponsor
- Kyowa Kirin Pharmaceutical Development Ltd
Drug Addiction
Four Models of Telephone Support for Stimulant Recovery
The overall objective of this research is to develop and refine empirically supported continuing care interventions that promote healthy behavior and sustained abstinence from illicit drug use.
- Trial name
- NCT00744068
- Testing
- Continuing Care Telephone Support
- Where
- 6 sites in United States
- Volunteers
- 302 people
- Sponsor
- University of California, Los Angeles
Opioid Use Disorder
Changing Opioid Users' Negative Attitudes Toward Medication Assisted Treatment
In this treatment development project, the investigators propose to develop and assess the feasibility and acceptability of a narrative-based video intervention and accompanying workbook (entitled MATTeRS: Medication Assisted…
- Trial name
- NCT03151655
- Testing
- MATTeRS Video, Didactic Video
- Where
- United States
- Sponsor
- Butler Hospital
Cocaine-Related Disorders, Opioid-Related Disorders
Combined Buprenorphine and Behavioral Treatment With and Without Contingent Reinforcement on Opioid and Cocaine Abstinence. - 22
The purpose of this study is to test combined buprenorphine and behavioral treatment with and without contingent reinforcement on opioid and cocaine abstinence.
- Trial name
- NCT00000240
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- University of Vermont
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.