Clinical trials: Substance-Related Disorder
Alcoholism, Alcohol Dependence
Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone)
This study will evaluate naltrexone and cognitive-behavioral therapy treatments for alcohol dependence and post-traumatic stress disorder (PTSD).
- Conditions
- Alcoholism, Alcohol Dependence, Post-Traumatic Stress Disorder
- Trial name
- NCT00006489
- Testing
- Cognitive-Behavioral Therapy, Naltrexone
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- University of Pennsylvania
HIV/AIDS, Alcohol Abuse
Couple-Based Motivational Interviewing With Mobile Breathalyzers to Reduce Alcohol Use in South Africa
This project aims to develop and pilot test an intervention using couple-based motivational interviewing (MI) and mobile breathalyzers to reduce heavy alcohol use with couples living with HIV in South Africa.
- Trial name
- NCT05756790
- Testing
- Motivational Interviewing, Motivational Interviewing plus Breathalyzer
- Where
- South Africa
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Unemployment, Mental Illness
Assessing the Effect of Distance Learning Vocational Rehabilitation on Employment Outcomes of Veterans With Psychiatric Illness and Histories of Legal Convictions
64,000 Veterans are released annually from jails and prisons. These Veterans have a weekly unemployment rate of up to 40-55%. However, many are unable to access traditional vocational rehabilitation, not to mention specialized…
- Conditions
- Unemployment, Mental Illness, Substance Use Disorder, Legal History
- Trial name
- NCT03331354
- Testing
- Distant vocational learning, Basic vocational services
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Nicotine Dependence, Smoking Cessation
Accelerated iTBS in Smoking Cessation
Cigarette smoking is one of the foremost causes of preventable disease and premature death. In 2014, 68% of adult smokers wanted to quit smoking and in 2017, 55.1% of adult smokers had made a quit attempt.
- Trial name
- NCT05271175
- Testing
- Active intermittent theta burst stimulation
- Where
- Cyprus
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Cyprus rTMS Center
Pregnancy, High Risk, Opioid-Related Disorders
Optimizing Pregnancy and Treatment Interventions for Moms 2.0
The US opioid epidemic continues to result in serious health consequences for pregnant and postpartum women. In the US from 2007 to 2012, an average of 21,000 pregnant women each year reported past month opioid misuse.
- Conditions
- Pregnancy, High Risk, Opioid-Related Disorders, Pregnancy Related
- Trial name
- NCT03833245
- Testing
- Patient Navigation
- Where
- 2 sites in United States
- Volunteers
- 102 people
- Sponsor
- University of Utah
Alcohol Use Disorder (AUD)
AAT-App Outpatient Trial
Cognitive biases contribute to the difficulty experienced by heavy drinkers wishing to reduce their alcohol use. Recent interventions designed to reduce cognitive biases demonstrate efficacy for Approach Bias Modification (ApBM).
- Trial name
- AAT-App (NCT05120856)
- Testing
- AAT-App, Minimal AAT-App
- Where
- 6 sites in Australia
- Volunteers
- 82 people
- Sponsor
- Turning Point
Cannabis Use Disorder
N-Acetylcysteine for Youth Cannabis Use Disorder
This is a 12-week randomized, placebo-controlled trial of N-acetylcysteine for cannabis use disorder (CUD) in youth (N=192). Participants will be randomized to double-blind NAC or PBO, yielding two equally-allocated treatment…
- Trial name
- NCT03055377
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Medical University of South Carolina
Nicotine Addiction
Pharmacogenetics of Nicotine Addiction Treatment
The purpose of this research program is to understand how a biomarker called the "nicotine metabolite ratio" (also referred to as NMR) may influence a smoker's ability to quit smoking.
- Trial name
- NCT01314001
- Testing
- Varenicline, Transdermal Nicotine
- Where
- 4 sites in United States, Canada
- Volunteers
- 1,246 people
- Sponsor
- University of Pennsylvania
Alcohol Dependence
Oxytocin Treatment of Alcohol Dependence
Purpose: Test whether oxytocin treatment decreases drinking in people who have been consuming alcohol heavily for long periods and are physically and psychologically dependent on alcohol.
- Trial name
- OTETOH-3 (NCT02251912)
- Testing
- Intranasal Oxytocin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Substance Use Disorders, Bipolar Disorder
Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation
This study proposes to use quetiapine as an adjunct treatment to treatment as usual to improve both substance use disorder (SUD) and mood symptoms in youth with SUD and severe mood dysregulation (SMD).
- Conditions
- Substance Use Disorders, Bipolar Disorder, Mood Disorders
- Trial name
- NCT02845453
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston Medical Center
Smoking, Nicotine Dependence
Message Framing for Telephone Quitline Callers
The purpose of this study is to compare gain-framed counseling + gain-framed materials" to standard care Quitline counseling + standard print materials.
- Trial name
- NCT00589277
- Testing
- Gain-Framed counseling & Gain-framed materials, Standard care counseling + standard materials
- Where
- United States
- Volunteers
- 2,032 people
- Sponsor
- Yale University
Fetal Alcohol Spectrum Disorder, Attachment Disorders
Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With FASD
Study Summary: This study is being conducted in order to rigorously evaluate the real-world effectiveness of a publicly-funded, home-based, attachment-focused intervention Circle of Security (COS) Family Intervention Model…
- Trial name
- NCT01536184
- Testing
- Circle of Security (COS)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Manitoba
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development
Maternal Adversity, Vulnerability and Neurodevelopment
Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) project is a prospective community-based, pregnancy and birth cohort of Canadian mother-child dyads.
- Conditions
- Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development, Infant Behavior
- Trial name
- MAVAN (NCT03434457)
- Where
- Canada
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Tobacco Dependence
UW Withdraw From Tobacco Study
It is of considerable scientific and clinical importance to assess tobacco withdrawal accurately since withdrawal severity is highly determinant of smoking cessation success.
- Trial name
- NCT04969198
- Testing
- Combination nicotine replacement therapy (Nicotine patch + nicotine mini-lozenge)
- Where
- United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alcohol Use Disorder
Ibudilast and Withdrawal-Related Dysphoria
Alcohol use disorder (AUD) is a prevalent and disabling psychiatric disorder with few, and only moderately efficacious, treatment options.
- Trial name
- NCT03489850
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, Los Angeles
Stimulant Use Disorder, Substance-related Disorders
Treating Stimulant Addiction With Repetitive Transcranial Magnetic Stimulation
The purpose of this study is to establish a new treatment (repetitive transcranial stimulation (rTMS)) for Veterans with stimulant use disorder (SUD).
- Trial name
- VA-StARTS (NCT04228276)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
HIV/AIDS, HIV Infections
Health and Justice: A Continuum of Care for HIV and SU for Justice-Involved Young Adults (PHASE 2)
This research study proposes to embed HIV testing outreach workers from a young adult focused medical and HIV treatment program into an alternative sentencing program to deliver a new service delivery model (Link2CARE) that…
- Conditions
- HIV/AIDS, HIV Infections, Substance Use, Substance Abuse
- Trial name
- NCT03369249
- Testing
- Link2CARE
- Where
- United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Dual Diagnosis
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment
The first aim of this study is to determine whether a brain reward center (BRC) deficiency in patients with schizophrenia (SCZ) and cannabis use disorder (CUD) will be normalized when patients are given cannabis or dronabinol.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00946348
- Testing
- Dronabinol, Cannabis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Posttraumatic Stress Disorder
Pilot Study of the Safety and Efficacy of Four Different Potencies of Smoked Marijuana in 76 Veterans With PTSD
This pilot study gathered preliminary evidence of the safety and efficacy of four potencies of smoked cannabis to manage chronic, treatment-resistant PTSD among veterans: (1) High THC/ Low CBD (High THC), (2) Low THC/High CBD…
- Trial name
- NCT02759185
- Testing
- High THC cannabis, High CBD cannabis, THC/CBD cannabis
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Multidisciplinary Association for Psychedelic Studies
Cocaine Dependence
A Phase II Trial of Varenicline for the Treatment of Cocaine Dependence
This is a double-blind placebo-controlled clinical trial (n = 156) of varenicline for the treatment of cocaine dependence that utilizes contingency management to promote treatment attendance.
- Trial name
- NCT01680887
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pennsylvania
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.