Clinical trials: Substance-Related Disorder
Binge Drinking
Binge Drinking Among Youngs is a Risk Factor for Alcohol Use Disorders
The purpose of this study was to assess drinking habits and patterns of alcohol consumption, smoking habits, use of illicit drugs and the prevalence of binge drinking and alcohol use disorders among Italian young students.
- Trial name
- NCT03062189
- Volunteers
- 2,704 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Opioid-induced Constipation
Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation
The research objective is to characterize the risk of a major adverse cardiovascular event (MACE) among new users of naldemedine versus new users of lubiprostone and new users of naloxegol as comparator opioid induced…
- Trial name
- NCT03720613
- Testing
- Naldemedine, Lubiprostone, Naloxegol
- Where
- United States
- Volunteers
- 34,532 people
- Sponsor
- BioDelivery Sciences International
Substance-Related Disorders
Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace
Tobacco regulatory policies can have unanticipated consequences; therefore, methods that would permit prospective estimates of the effects of potential tobacco regulations are necessary for the development of tobacco regulatory…
- Trial name
- NCT02951143
- Testing
- SPECTRUM cigarettes, SPECTRUM cigarettes between
- Where
- United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Alcohol Dependence
Network Support for Treatment of Alcohol Dependence
Relapse is the most serious problem in alcoholism treatment. The overall aim of the present study was to determine if a treatment directed at changing the patient's social network, from one that reinforces drinking behavior to…
- Trial name
- NCT00845208
- Testing
- Network Support
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- UConn Health
Neonatal Abstinence Syndrome
Buprenorphine for Treatment of Neonatal Abstinence Syndrome in Infants With In Utero Exposure to Benzodiazepines
The opioid neonatal abstinence syndrome (NAS) is a condition of withdrawal symptoms after utero exposure to opioids. Sublingual buprenorphine shows promise as a new treatment in NAS.
- Trial name
- MOPPlus (NCT01671410)
- Testing
- oral morphine, sublingual buprenorphine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Thomas Jefferson University
Heroin Dependence
Naltrexone and Adrenergic Agents to Reduce Heroin Use in Heroin Addicts
Naltrexone is a medication that is currently used to treat drug and alcohol addiction. Guanfacine is a medication that is currently used to manage the withdrawal symptoms in individuals undergoing opioid detoxification.
- Trial name
- NCT00142948
- Testing
- Naltrexone
- Where
- Russia
- Volunteers
- 301 people
- Sponsor
- Baylor College of Medicine
Opioid-Related Disorders
Assessment of Tramadol as a Treatment for Opioid Addiction
Opioids are one of the most commonly abused drugs among individuals who seek treatment for drug abuse. Thus, it is necessary to develop new treatments for opioid addiction.
- Trial name
- NCT00301210
- Testing
- Tramadol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Johns Hopkins University
Liver Disease, Alcoholic
Effects of SAMe in Patients With Alcoholic Liver Disease
Prior studies in animal models have established that the pathogenesis of alcoholic liver disease (ALD) is regulated in part by the effects of chronic alcohol abuse on hepatic methionine metabolism.
- Trial name
- NCT00573313
- Testing
- S-adenosylmethionine
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Nicotine Dependence
Selegiline for Smoking Cessation - 1
The purpose of this study is designed to examine the effects of Selegiline Transdermal System and behavioral intervention in smoking cessation as compared to behavioral intervention alone.
- Trial name
- NCT00439413
- Testing
- Selegiline Transdermal Patch, Smoking Cessation Counseling
- Where
- 4 sites in United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cannabis Use Disorder, Anxiety
Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use
The goal of this clinical trial is to learn if Therabot-CALM (Cannabis, Anxiety, Low Mood) has acceptability among users and could work to improve the symptoms of persons with cannabis use disorder and anxiety and/or depression.
- Conditions
- Cannabis Use Disorder, Anxiety, Depression, Anxiety, Depression - Major Depressive Disorder
- Trial name
- NCT06920238
- Testing
- Therabot-CALM
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Trustees of Dartmouth College
Neonatal Abstinence Syndrome
Clinical Trial to Decrease Length of Stay in Infants With Neonatal Abstinence Syndrome With an Exclusive Human Milk Diet
A clinical trial to evaluate length of stay, growth velocity and clinical outcomes in infants with neonatal abstinence syndrome receiving an exclusive human milk diet.
- Trial name
- NCT04508348
- Testing
- Human Milk, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Opioid Use, Opioid Use Disorder
Enhancing Prospective Thinking in Early Recovery (PARK)
The goal of this clinical trial is to demonstrate the commercial potential for a novel virtual reality (VR) intervention in preparation for Phase II development.
- Conditions
- Opioid Use, Opioid Use Disorder, Substance Use Disorders
- Trial name
- PARK (NCT05908097)
- Testing
- Virtual Reality Avatar Intervention, Virtual Reality Empty Park
- Where
- 2 sites in United States
- Volunteers
- 104 people
- Sponsor
- Indiana University
Opiate-Related Disorders, Opiate Substitution Treatment
A Chatbot To Support Substance Use Recovery
The goal of this clinical trial is to learn if/how an AI chatbot can support patients who in recovery for substance use, specifically those who are receiving medication for opioid use disorder.
- Trial name
- NCT06845878
- Testing
- chatbot
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Dimagi Inc.
Tobacco Use Disorder
Comparative Acceptability of Tobacco and Menthol Flavored E-cigarettes
The study is a randomized crossover trial. Current menthol smokers will complete a session with each flavor of an electronic cigarette: menthol and tobacco. The objective of this survey is to assess for flavor preference.
- Trial name
- NCT04996940
- Testing
- E-cigarette product
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Nicotine Dependence
IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate
This project will examine the impact of the nicotine dose and delivery rate on nicotine's abuse potential, versus its potentially beneficial effects on smoking urges and withdrawal.
- Trial name
- NCT05176418
- Testing
- low dose Nicotine, high dose Nicotine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
HIV-associated Neuropathy, Polyneuropathy
Combination of an Investigational Cannabinoid and Methadone for HIV-associated Neuropathy
The purpose of this study is to evaluate the effectiveness of methadone alone and in combination with SAB378 for the treatment of painful HIV-associated neuropathy.
- Trial name
- NCT00723918
- Testing
- SAB378, methadone
- Where
- 3 sites in United States
- Sponsor
- Washington University School of Medicine
Hepatitis C, Opiate Dependence
Effective Treatment of Hepatitis C in Substance Users
We hypothesize that integrating Hepatitis C into methadone and buprenorphine treatment will improve Hepatitis C outcomes as well as drug treatment outcomes in patients who are addicted to opiates.
- Trial name
- NCT00633243
- Testing
- Modified Directly Observed Therapy (mDOT), Self-Administered Therapy (SAT)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Opioid Use Disorder
Wellcome Leap Psilocybin for OUD
Investigators will recruit 36 individuals on MAT for OUD for a double-blind, placebo-controlled design to determine whether PEX010 (25-mg/d) shows preliminary efficacy on neural correlates of neurocognition and on clinical…
- Trial name
- NCT06786325
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Anna Rose Childress, Ph.D.
Drug Abuse
Youth Drug Abuse Family and Cognitive-Behavioral Therapy
This Stage II study is in response to NIDA's Behavioral Therapies Development Program (PA-99-107). A randomized clinical trial is proposed to evaluate the direct, mediated, and moderated effects of Integrated Family and…
- Trial name
- NCT00198874
- Testing
- Integrated Family and Cognitive-Behavioral Therapy, Education
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- University of Florida
Alcoholic, Marijuana Misuse
Skills and Motivation at the Rhode Island Training School (Project SMART) - 1
This study will focus on treating substance abusing incarcerated teens using individually administered Motivational Interviewing (MI) followed by group Cognitive Behavior Therapy (CBT).
- Trial name
- NCT00227890
- Testing
- MI/CBT, RT/TU
- Where
- 2 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
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