Clinical trials: Substance-Related Disorder
Drug Use Disorders, Drug Abuse
Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks
Background: Sixty million American adults suffer from moderate to severe chronic pain. Of these, 5 to 8 million currently use opioids long-term.
- Conditions
- Drug Use Disorders, Drug Abuse, Drug Addiction, Drug Dependence
- Trial name
- CARE (NCT02224508)
- Volunteers
- 1,588 people
- Sponsor
- Kaiser Permanente
Social Anxiety Disorder
CHI-902 for Treatment of Social Anxiety Disorder
No substantial clinical trials of Cannabidiol (CBD) in Social Anxiety Disorder (SAD) have yet been conducted. This randomized doubleblind, placebo-controlled trial of CBD in adults with SAD will evaluate the efficacy…
- Trial name
- NCT04086342
- Testing
- CHI-902
- Where
- 2 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Canopy Growth Corporation
Alcoholism
Study of the Medication Prazosin for Alcohol Dependence
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency.
- Trial name
- NCT00762710
- Testing
- Prazosin medication
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Nicotine Dependence
Testing a Full Substitution Therapy Approach As Treatment of Tobacco Dependence
This study will test a new medication strategy designed to help smokers quit. It will combine selegiline, a drug currently approved and available for the treatment of Parkinson's disease, with a nicotine skin patch.
- Trial name
- NCT00390923
- Testing
- Selegiline + nicotine replacement therapy
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Opiate Dependence
Prospective Cohort of Opiate Dependent Patients on Buprenorphine/Naloxone for Maintenance
The purpose of this study was to expand access to buprenorphine using a mobile health care system among marginalized populations with or at high risk for HIV and observe longitudinal effects of treatment.
- Trial name
- Project BEST (NCT00622596)
- Testing
- Mobile Access
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Yale University
Drug Discontinuation, Substance Use Disorders
Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation
The goal of this clinical study with research procedures is to learn how stopping and restarting tirzepatide (a medication that helps regulate blood sugar and appetite) affects brain activity, behavior, and health in adults ages…
- Conditions
- Drug Discontinuation, Substance Use Disorders, Eating Behavior Changes, Tirzepatide
- Trial name
- CLIN-GLP1 (NCT07387796)
- Testing
- Discontinuation and Reinitiation of Tirzepatide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas at Dallas
Substance-Related Disorders
A Behavioral Trial for the Treatment of Methamphetamine Dependence. - 1
The purpose of this study is to examine behavioral treatment for methamphetamine dependence.
- Trial name
- NCT00033124
- Testing
- Behavior Therapy
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence
Safety and Pharmacodynamic Study of GET 73 in Alcohol Dependent
Examination of the effect of GET 73 on alcohol pharmacokinetics and pharmacodynamics (intoxication and sedation)and safety profile in alcohol-dependent individuals.To evaluate whether GET 73, as compared to placebo, results in…
- Trial name
- SPAD (NCT01842503)
- Testing
- GET 73, inactive ingredients capsule
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Laboratorio Farmaceutico Ct S.r.l.
Craving, Self Efficacy
CARESS: An Investigation of Effects of CARESS
The purpose of this research is to study the efficacy of an intervention that could interrupt the cycle of emotion dysregulation as it relates to cravings and negative emotions for those with problematic substance use behaviors.
- Conditions
- Craving, Self Efficacy, Affective; Reaction, Substance Abuse
- Trial name
- NCT03758027
- Testing
- CARESS, Isometric Exercise
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Morbid Obesity, Opioid-Related Disorders
Recovery of Ventilation After General Anesthesia in Morbidly Obese Patients
This is an observational study of morbidly obese patients recovering from general anesthesia after weight-loss surgery. The investigators aim to assess ventilatory function and how this is influenced by the diagnosis of…
- Conditions
- Morbid Obesity, Opioid-Related Disorders, Surgery--Complications, Sleep Apnea Syndromes
- Trial name
- NCT03925610
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Stanford University
Cocaine Abuse, Heroin Abuse
Effect of Clonidine on Responses to Imagery Scripts
Background: Research has shown that clonidine, a drug originally prescribed to treat high blood pressure and some symptoms of opioid withdrawal, can help block stress-induced relapse to heroin and cocaine seeking in rats.
- Trial name
- NCT00318760
- Testing
- Clonidine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Withdrawal, Tobacco Abstinence
Effects of Transcranial Direct Current Stimulation on Tobacco Withdrawal Symptoms
We hypothesize that transcranial direct current stimulation will reduce tobacco withdrawal symptoms of tobacco dependent smokers abstinent from smoking for more than 10 hours.
- Trial name
- tDCSsmokers (NCT01567982)
- Testing
- tDCS, prefrontal cortex and parietal cortex
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Addiction
Acute and Chronic Nicotine Modulation of Reinforcement Learning
The purpose of this study is to use functional magnetic resonance imaging (fMRI) to investigate the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation.
- Trial name
- NicLearning (NCT01830842)
- Testing
- Nicotine polacrilex, satiety, abstinence
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Alcohol Dependence
Contingency Management for Chronic Recidivist Alcohol-Dependent Patients
The purpose of this study is to evaluate the efficacy of prize contingency management (CM) in reducing in-patient detoxification services for chronic recidivist alcohol-dependent patients.
- Trial name
- NCT00408161
- Testing
- Contingency Management, standard case management treatment
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- UConn Health
HIV Infections
A Test of Behavioral Intervention for Women at High Risk for HIV Infection
The purpose of this study is to find out if it is possible to conduct a group counseling program for women at risk for HIV infection. Women have been the fastest-growing group with new AIDS diagnoses.
- Trial name
- NCT00006440
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Addiction
A Study to Assess 18-Methoxycoronaridine (18-MC HCl) in Healthy Volunteers
The primary objective of this study is to assess the safety and tolerability of a single day dosing and a separate multiple day dosing of 18-MC HCl administered orally, each part of the study having a different set of healthy…
- Trial name
- NCT04292197
- Testing
- 18-MC Compound
- Where
- Australia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Definium Therapeutics US, Inc.
Colorectal Disorders, Anorectal Disorder
A Multimodal Enhanced Recovery Program in Anorectal Surgery
The goal of this study is to establish whether an opioid-sparing Enhanced Recovery After Surgery (ERAS) program in ambulatory anorectal surgery can be safely introduced at a single tertiary referral center without an increase in…
- Conditions
- Colorectal Disorders, Anorectal Disorder, Patient Satisfaction, Pain, Postoperative
- Trial name
- ARSE (NCT03992079)
- Testing
- ReCOVER Enhanced Recovery Protocol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Alcohol Abuse
Delivering Treatment in DUI Programs to Reduce Alcohol-Related Disparities
The current study evaluates the efficacy of Cognitive Behavioral Therapy (CBT) in DUI programs for individuals with a first-time offense.
- Trial name
- NCT02588703
- Testing
- Cognitive Behavioral Therapy, Usual Care
- Volunteers
- 351 people
- Sponsor
- RAND
Opioid Use Disorder
Neurobehavioral Mechanisms of Choice in Opioid Use Disorder
The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making…
- Trial name
- NCT03958474
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Joshua A. Lile, Ph.D.
Alcohol Use Disorder
Intensive Referral to Al-Anon: Benefits to Concerned Others and Their Drinkers
This study is examining the effectiveness of Al-Anon Intensive Referral (AIR) with Concerned Others (COs) of individuals in treatment for alcohol use disorders ("drinkers").
- Trial name
- NCT04018560
- Testing
- Al-Anon Intensive Referral (AIR)
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- Palo Alto Veterans Institute for Research
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