Clinical trials: Substance-Related Disorder
Anxiety Disorders, Mood Disorders
Mental Health Related to School Dropout in Luxembourg
This study aims to investigate psychosocial risk- and protective factors such as psychiatric disorder, socio-economic background and family functioning among school dropouts and to compare the findings with those by a matched…
- Conditions
- Anxiety Disorders, Mood Disorders, Eating Disorders, Substance-related Disorders
- Trial name
- NCT01354236
- Where
- Luxembourg
- Volunteers
- 200 people
- Sponsor
- Public Research Centre Health, Luxembourg
Suicide, Alcohol Abuse
Alcohol, Suicide and HIV Prevention for Teens in Mental Health Treatment
This study examines whether an integrated alcohol/substance abuse, suicide, and HIV prevention protocol is associated with lower onset and frequency of alcohol and other drug use, suicidal behavior, and high risk sexual behavior…
- Conditions
- Suicide, Alcohol Abuse, Drug Abuse, HIV
- Trial name
- NCT02228044
- Testing
- Prevention program
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- George Mason University
Alcohol Use Disorder, Insomnia
Mobile App Intervention for Sleep Problems and Alcohol Use Among Veterans
The goal of this clinical trial is to test the preliminary efficacy of a brief mobile app targeting insomnia symptoms among veterans.
- Trial name
- NCT06487793
- Testing
- Enhanced Insomnia Coach, Sleep hygiene comparator
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Bipolar Disorder, Substance Use Disorders
Post-Hospital Intervention for Veterans With Comorbid Bipolar and Substance Use Disorders
This trial aims to evaluate the effectiveness of a novel intervention for Veterans with co-occurring bipolar and substance use disorders following a psychiatric hospitalization.
- Trial name
- NCT04127604
- Testing
- Integrated Treatment Adherence Program for Veterans (ITAP-VA), Safety Assessment and Follow-up Evaluation (SAFE)
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence
Aripiprazole and Topiramate on Free-Choice Alcohol Use
The current study investigates the effects of two potential alcohol treatment medications on drinking in a laboratory setting. Aripiprazole (APZ), effects dopamine and serotonin receptors with fewer limiting side effects seen…
- Trial name
- AT (NCT00884884)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
PTSD - Post Traumatic Stress Disorder, Substance Use
CBITS-RTM Pilot Study
This pilot study, conducted in partnership with juvenile detention centers, evaluates an adapted CBITS-RTM intervention delivered in a detention school setting.
- Trial name
- NCT07682441
- Testing
- Adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS) with a Racial Trauma Module (RTM)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Francisco
Tobacco Dependence
C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics
In a residency clinic in Baltimore, the investigators propose to conduct a pilot RCT comparing a) an avatar-delivered computerized intervention (CI) for tobacco cessation augmented with CHW support and navigation to lung cancer…
- Trial name
- NCT07220356
- Testing
- C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Drug Use, Alcohol Use
Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions
This study will assess Specialized Community Disease Management (SCDM), an intervention which employs various evidence-based strategies to engage substance using co-morbid patients while in the hospital and follow them into the…
- Conditions
- Drug Use, Alcohol Use, Congestive Heart Failure, Pneumonia
- Trial name
- NCT02059005
- Testing
- Specialized Community Disease Management, Treatment As Usual
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Treatment Research Institute
HIV Infections, HCV
The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York City
The goal of this pilot clinical trial is to learn if an intervention that trains Gancheros (people who provide injection services in exchange for drugs or money) to conduct risk-reduction outreach could help lower risk for human…
- Conditions
- HIV Infections, HCV, Overdose
- Trial name
- NCT06316739
- Testing
- Ganchero intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI)
AMD, nAMD
Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD
ABBV-RGX-314 (also known as RGX-314 and surabgene lomparvovec (sura-vec)) is being developed as a novel one-time gene therapy for the treatment of neovascular (wet) age-related macular degeneration (wet AMD).
- Conditions
- AMD, nAMD, Wet Age-related Macular Degeneration, wAMD
- Trial name
- ASCENT (NCT05407636)
- Testing
- ABBV-RGX-314 Dose 1, ABBV-RGX-314 Dose 2, Aflibercept (EYLEA®)
- Where
- 181 sites in United States, Canada and 8 more
- Volunteers
- 735 people
- Sponsor
- AbbVie
Opioid Use Disorder, Pregnancy
Technology-Enhanced Therapy vs. Medication Monitoring for Buprenorphine Retention in Pregnant Persons
This study involves testing how useful a technology-enhanced therapy is for pregnant people prescribed buprenorphine for the treatment of opioid use disorder, compared to medication monitoring.
- Trial name
- NCT06999811
- Testing
- Empowering Pregnant Women and People Receiving medications for opioid use disorder (EMPWR), Medication monitoring (control)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Medical University of South Carolina
Substance Use Disorders
A Therapeutic Workplace to Address Poverty and Substance Use
Addiction is a chronic relapsing disorder. High magnitude and long-duration voucher-based abstinence reinforcement is one of the most effective treatments for alcohol and drug addiction and can maintain abstinence over extended…
- Trial name
- NCT03519009
- Testing
- IPS Plus Abstinence-Contingent Wage Supplement
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Nicotine Dependence, Drug Abuse
Effects of Nicotine on Cognitive Task Performance and Brain Activity as Measured by fMRI
Background: Many cigarette smokers claim that smoking improves their ability to think and concentrate, and have reported problems in thinking and concentration after quitting smoking.
- Trial name
- NCT01036711
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Anxiety Disorders, Substance Use Disorders
Delivery of Anxiety Disorder Treatment in Addictions Centers
Anxiety disorders are highly prevalent among those with substance use disorders, but the majority of addictions treatment centers provide little to no evidence-based treatment for anxiety disorders.
- Trial name
- NCT01764698
- Testing
- CALM-SUD, Treatment as usual
- Where
- 2 sites in United States
- Volunteers
- 98 people
- Sponsor
- University of California, Los Angeles
Chronic Obstructive Pulmonary Disease (COPD), Breathlessness
CAN BREATHE in COPD Trial
A growing body of physiological evidence now exists to support a potential role for inhaled cannabis in the medical management of adults with chronic obstructive pulmonary disease (COPD), particularly as it may related to…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Breathlessness, Exercise Intolerance
- Trial name
- NCT03060993
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- McGill University
Prevention, Family Function
Familias Unidas: Preventing Substance Abuse in Hispanic Youth
The focus of this study will be to test the Familias Unidas Intervention program among Hispanic 8th graders in the Miami-Dade County Public School System.
- Conditions
- Prevention, Family Function, Substance Use, Sexual Behavior
- Trial name
- NCT01038206
- Testing
- Familias Unidas
- Where
- United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of Miami
Opioid Use Disorder, Polysubstance Addiction
The Feasibility of the OpiVenture Program for Clients Undergoing Opioid Agonist Therapy
The opioid crisis continues its devastating impact on Canada, with over 13,900 deaths recorded between 2016 and 2019. Dangerous prescription opioid usage persists, affecting 12.3% of Canadians in 2018.
- Conditions
- Opioid Use Disorder, Polysubstance Addiction, Substance Use
- Trial name
- NCT06211972
- Testing
- OpiVenture
- Volunteers
- 96 people
- Sponsor
- Dalhousie University
Alcohol Use Disorder, Mild Cognitive Impairment
The Combination of Donepezil and Cognitive Training for Treating Alcohol Use Disorder
This is an open label feasibility trial to learn whether the combination of donepezil and cognitive remediation therapy (Donepezil + CRT) may improve neurocognitive functioning and decreasing alcohol use in Veterans with alcohol…
- Trial name
- NCT04318639
- Testing
- Donepazil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Connecticut Healthcare System
Contraceptive Usage, Opioid Dependence
Improving Effective Contraceptive Use Among Opioid-maintained Women: Stage II
Nearly 9 of every 10 pregnant opioid-dependent women report that the current pregnancy was unintended and the majority of non-pregnant opioid-maintained women do not use contraception or use less effective methods like condoms.
- Trial name
- NCT02411357
- Testing
- Treatment as usual, WHO contraception protocol, Incentives
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- University of Vermont
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06072001
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
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