Clinical trials: Substance-related Disorders
Mental Health, Depression
Designing a Mobile App to Support Academic Success for Student Veterans
Compared to civilian students in higher education, student Veterans have high rates of mental health disorders (e.g., Depression: 24% vs 12.1%).
- Conditions
- Mental Health, Depression, Post-Traumatic Stress Disorder, Anxiety
- Trial name
- NCT05344092
- Testing
- VetEd Mobile Application
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Drug Use, Substance Use
Organization-level Youth Engagement Approach for Substance Misuse Prevention
This study will consist of a small pilot Randomized Controlled Trial (RCT). Four prevention organizations will be randomized either to include Youth Engagement in prevention efforts (treatment) or not (control).
- Conditions
- Drug Use, Substance Use, Opioid Use, Substance Misuse
- Trial name
- NCT05736211
- Testing
- Organization-level Youth Engagement prevention strategy
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Post-traumatic Stress Disorder, Traumatic Brain Injury
Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop
In this proposal, the investigators extend their previous SPiRE feasibility and preliminary effectiveness study to examine STEP-Home efficacy in a RCT design.
- Conditions
- Post-traumatic Stress Disorder, Traumatic Brain Injury, Substance Related Disorders, Depression
- Trial name
- STEP-Home (NCT03868930)
- Testing
- STEP-Home, PCGT
- Where
- 2 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Substance Use, Substance Abuse
Data-driven Identification for Substance Misuse
The investigators propose to develop an open-source, publicly available machine learning model that health systems could download and apply to their electronic health record data marts to screen for substance misuse in their…
- Conditions
- Substance Use, Substance Abuse, Substance-Related Disorders
- Trial name
- NCT03833804
- Testing
- Processing of clinical notes in the EHR data collected during routine care
- Where
- United States
- Volunteers
- 64,996 people
- Sponsor
- University of Wisconsin, Madison
Substance Use Disorders, HIV
Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care
Substance use disorders (SUDs), depression and anxiety in HIV-infected patients result in poor HIV outcomes, yet are often unrecognized and untreated.
- Conditions
- Substance Use Disorders, HIV, Depression, Anxiety
- Trial name
- PACE (NCT03217058)
- Testing
- Clinic-based screening and behavioral interventions
- Where
- United States
- Volunteers
- 10,821 people
- Sponsor
- University of California, San Francisco
Substance-Related Disorders
COMET Study 1: Filter Ventilated Cigarette Substitution in the ETM
Early attempts by the tobacco industry to develop "safer" cigarettes led to the widespread introduction of ventilation holes in cigarette filters; however, this design feature may instead increase smoking-related harm and make…
- Trial name
- NCT03306173
- Testing
- Commercially available cigarette
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
HIV Infections, Substance Use Disorders
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users (PrEPSteps)
This study will deploy a novel, personalized, smartphone-based intervention (PrEPSteps) that responds to real-time PrEP adherence and nonadherence detected through the use of a digital pill.
- Trial name
- PrEPSteps (NCT03512418)
- Testing
- PrEPsteps, Digital pill, Truvada
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Medication Abuse
A Health System Wide Evaluation of Clinical Decision Support Tools to Improve PDMP Utilization and Patient Outcomes
This is a study comparing three clinical decision support (CDS) tools to enhance care by easing health care provider review of the Colorado prescription drug monitoring program (PDMP) prior to prescribing opioids (pain…
- Trial name
- NCT04918355
- Testing
- Clinical Decision Support (CDS) alerts
- Where
- United States
- Volunteers
- 3,635 people
- Sponsor
- University of Colorado, Denver
Substance Use
Prevention of OUD: The HOME Project (Housing, Opportunities, Motivation and Engagement)
Homeless youth have a much higher rate of substance use than non-homeless peers with evidence suggesting that homeless youth have the highest rates of opioid use among youth subgroups in the country (Brands et al., 2005); heroin…
- Trial name
- HOME (NCT04135703)
- Testing
- Risk Prevention Services + Housing, Risk Prevention Services Only
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Stimulant Use Disorder, Substance-related Disorders
Treating Stimulant Addiction With Repetitive Transcranial Magnetic Stimulation
The purpose of this study is to establish a new treatment (repetitive transcranial stimulation (rTMS)) for Veterans with stimulant use disorder (SUD).
- Trial name
- VA-StARTS (NCT04228276)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Delayed Sleep Phase
Delayed Sleep Timing in Teens Study
This study will (1) comprehensively characterize the substance use disorder (SUD) risk profile associated with adolescent Delayed Sleep Phase (DSP), and (2) probe whether SUD risk is diminished by altering sleep/circadian timing.
- Trial name
- NCT03806296
- Testing
- Increase morning bright light, Decrease evening blue light, Sleep scheduling
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Substance Abuse
Preventing Drug Abuse Among Sexual Minority Youth
The planned randomized clinical trial will longitudinally test a tailored, web-based drug abuse prevention program with a nationwide sample of 15- to 17-year-old sexual minority youth (youth who identify as gay, lesbian…
- Trial name
- NCT03954535
- Testing
- Free2b
- Where
- United States
- Volunteers
- 1,216 people, healthy volunteers welcome
- Sponsor
- Columbia University
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Risk Behavior, HIV/AIDS
Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use Drugs
This study will evaluate the efficacy and cost-effectiveness of CHRP-BB - an integrated bio-behavioral approach that incorporates the use of PrEP - with an evidence-based behavioral approach aimed at enhancing PrEP adherence and…
- Conditions
- Risk Behavior, HIV/AIDS, Medication Adherence, Substance Abuse
- Trial name
- CHRP-BB (NCT03282890)
- Testing
- CHRP-BB
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- University of Connecticut
Suicide, Substance-Related Disorders
Preventing Addiction Related Suicide (PARS)
The goal of this study is to evaluate the effectiveness and utility of the investigator's National Institute on Drug Abuse (NIDA) R21 developed "Preventing Addiction Related Suicide" (PARS) program by utilizing a novel stepped…
- Trial name
- PARS (NCT03166709)
- Testing
- Preventing Addiction Related Suicide (PARS), Intensive Outpatient Program standard session
- Where
- 16 sites in United States
- Volunteers
- 906 people, healthy volunteers welcome
- Sponsor
- University of Washington
Risk Behavior, Medication Adherence
Secondary HIV Prevention and Adherence Among HIV-infected Drug Users
This study will test whether 3H+ (Holistic Health for HIV) is comparable to the original HHRP+ (Holistic Health Recovery Program) in reducing HIV risk behaviors and improving ART (Antiretroviral Therapy) adherence in a randomized…
- Conditions
- Risk Behavior, Medication Adherence, HIV
- Trial name
- NCT01741311
- Testing
- 3H+ (Holistic Health for HIV), HHRP+ (Holistic Health Recovery Program)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Connecticut
Drug Use Disorders, Illicit Drug Use
An Initial Study of the Implementation of Digital Therapeutics for Substance Use Disorders in Primary Care
The DIGITS Trial addresses a critical knowledge gap: How to best implement digital treatments for opioids and other substance use disorders in primary care.
- Conditions
- Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
- Trial name
- DIGITS Pilot (NCT04907045)
- Testing
- Health Coaching, Practice Facilitation, Standard Implementation
- Where
- United States
- Volunteers
- 1,552 people
- Sponsor
- Kaiser Permanente
Opioid-use Disorder
Mindful Moms in Recovery
The purpose of this study is to evaluate the initial efficacy of a yoga-mindfulness intervention to promote ongoing recovery for pregnant and parenting women with Opioid Use Disorder (OUD) receiving perinatal services and…
- Trial name
- MMORE (NCT04584502)
- Testing
- Mindful Moms Yoga Mindfulness Intervention
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Trustees of Dartmouth College
Cocaine Use Disorder, Substance Use Disorders
Multiple Ascending Dose Study of TMP-301 in Healthy Subjects
A PHASE 1, RANDOMIZED, PLACEBO CONTROLLED, MULTIPLE ASCENDING DOSE (MAD) STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF TMP-301 IN HEALTHY SUBJECTS.
- Conditions
- Cocaine Use Disorder, Substance Use Disorders, Healthy Volunteers
- Trial name
- NCT06025396
- Testing
- Cohort 1 - TMP-301, Cohort 2 - TMP-301, Cohort 3 - TMP-301
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tempero Bio, Inc.
Substance-Related Disorders, Underage Drinking
Testing a Brief Substance Misuse Preventative Intervention for Parents/Guardians of 5th-7th Grade Students
The current study aims to test the efficacy of a family communication-based, novel, adaptable, and resource-efficient substance misuse preventive intervention for parents/guardians of pre/early adolescents (grades 5-7).
- Conditions
- Substance-Related Disorders, Underage Drinking, Drug Use
- Trial name
- NCT03925220
- Testing
- The SUPPER Project, Improving nutrition and physical activity among youth
- Where
- United States
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Tufts University