Clinical trials: Substrate Ablation
Cardiovascular Diseases
The STandard Versus ImAging SuBstrate Aided Ablation in Severe Left VEntricular Dysfunction VT.
The STABLE-VT trial aims to determine the safety profile and clinical efficacy of a modified approach to ventricular tachycardia (VT) ablation that integrates myocardial scar as visualized on cardiac magnetic resonance (c-MRI) or…
- Trial name
- STABLE-VT (NCT05828667)
- Testing
- Incorporation of CT and/or c-MRI derived myocardial scar with 3D electroanatomical mapping (EAM).
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Atrial Fibrillation, Catheter Ablation
Randomized Controlled Trial- Ablation Strategy for Paroxysmal Atrial Fibrillation - Trigger and Substrate Guided Wide Area Radiofrequency Ablation Compared to Pulsed Field Ablation Pulmonary Vein Isolation
Atrial fibrillation (AF) is a common heart rhythm disorder affecting over a million people in North America and is associated with serious complications including stroke, heart failure, reduced quality of life, and premature…
- Conditions
- Atrial Fibrillation, Catheter Ablation, Radiofrequency Catheter Ablation
- Trial name
- AWARE-2 (NCT04823299)
- Testing
- PVI-ONLY, CONTROL ARM, PVI-PLUS ARM, INTERVENTIONAL ARM
- Where
- 2 sites in Canada
- Volunteers
- 556 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Ventricular Tachycardia
"Ventricular Tachycardia Ablation Registry".
Catheter ablation of Ventricular Tachycardias is a well-established approach in clinical practice in patients with Implantable Cardioverter Defibrillator (ICD) implanted.
- Trial name
- NCT03649022
- Testing
- Catheter ablation
- Where
- Italy
- Volunteers
- 312 people
- Sponsor
- Paolo Della Bella
Atrial Fibrillation
Substrate Ablation Guided by High Density Mapping in Atrial Fibrillation
To evaluate a new AF Substrate mapping method based on automatic high density CFAE detection with a multipolar catheter (Pentaray) and the " SCI 30-40 " setting of CARTO CFAE algorithm.
- Trial name
- SUBSTRATE-HD (NCT02093949)
- Testing
- Routine substrate ablation without pulmonary vein Isolation, Routine conventional ablation with pulmonary vein Isolation
- Where
- 3 sites in France
- Volunteers
- 152 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Ventricular Tachycardia
Modification of the Local Abnormal Ventricular Activity Only
Local abnormal ventricular activity (LAVA) is composed of high-frequency, mainly low voltage signals that represent near-field signals from slow-conducting tissue and thus potential VT isthmuses.
- Trial name
- LAVAONLY (NCT05331716)
- Testing
- Cardiac ablation therapy
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- University of Kiel
Heart Failure, Myocardial Infarction
Prophylactic Substrate Ablation in Post-myocardial Patients Undergoing Defibrillator Implantation.
Prophylactic substrate ablation in post-MI patients undergoing defibrillator implantation reduces appropriate defibrillator therapies.
- Conditions
- Heart Failure, Myocardial Infarction, Ventricular Tachycardia
- Trial name
- NCT02780947
- Testing
- Ventricular tachycardia substrate ablation
- Volunteers
- 40 people
- Sponsor
- Spyridon Deftereos
Atrial Fibrillation (AF)
Non-invasive Mapping-Guided Atrial Fibrillation Ablation
The goal of this pilot study is to test if noninvasive global mapping can guide catheter ablation defining personalized targets and improve the therapy of atrial fibrillation. It will also test the safety of such an approach.
- Trial name
- ELISA-AF (NCT07358611)
- Testing
- Non-invasive mapping-guided ablation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Clinic of Barcelona
Atrial Fibrilation Termination Endpoint
Crucial Areas on AF Termination
Recent data has demonstrated that focal sources are determinant in human atrial fibrillation (AF) perpetuation. The investigators sought to identify crucial areas for AF perpetuation during our routine electrogram (EGM)-based…
- Trial name
- NCT02099643
- Where
- 4 sites in France, United Kingdom
- Volunteers
- 113 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Ventricular Tachycardia
Ventricular Tachycardia Mechanisms
The purpose of this study is to understand why certain hearts have ventricular arrhythmias and help identify areas of the heart that cause arrhythmias.
- Trial name
- NCT05478213
- Testing
- Monophasic Action Potential (MAP) Catheter
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Atrial Fibrillation
Use of Volta Medical AI-software During Atrial Fibrillation Ablation to Identify Patients Who May Need More Than Pulmonary Vein Isolation.
DISPLAY-AF is a prospective, multicenter, single-arm post-market clinical follow-up investigation designed to evaluate whether spatiotemporal dispersion areas identified by the Volta AF-Xplorer II artificial intelligence (AI)…
- Trial name
- DISPLAY-AF (NCT07807423)
- Testing
- Complete biatrial mapping
- Where
- 5 sites in France
- Volunteers
- 125 people
- Sponsor
- Volta Medical
Ventricular Tachycardia, Coronary Artery Disease
Substrate Modification in Stable Ventricular Tachycardia in Addition to Implantable Cardioverter Defibrillator (ICD) Therapy
The main objective of this study is to compare the time from randomization to the first recurrence of any ventricular tachycardia (VT) in patients undergoing VT ablation (for stable VTs) and substrate ablation (for unstable VTs)…
- Conditions
- Ventricular Tachycardia, Coronary Artery Disease, Left Ventricular Dysfunction
- Trial name
- VTACH (NCT00919373)
- Testing
- Substrate modification, VT ablation, ICD Implantation
- Where
- 16 sites in Czechia, Denmark and 2 more
- Volunteers
- 110 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation (AF)
Pulsed Field Ablation in Three Different Substrate Ablation Strategies for Persistent Atrial Fibrillation
This multicenter, randomized, controlled trial aims to evaluate the efficacy and safety of pulsed field ablation (PFA) in patients with persistent atrial fibrillation (PeAF).
- Trial name
- NCT06739512
- Testing
- Extensive Electro-Anatomical Guided Ablation, Anatomical Guided Ablation, Electrogram Guided Ablation
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Atrial Substrate Modification With Aggressive Blood Pressure Lowering to Prevent AF
Atrial fibrillation (AF) is a very common arrhythmia causing many symptoms resulting in numerous hospitalizations. Catheter ablation is a technique that has evolved significantly to improve symptomatic recurrences, but does not…
- Trial name
- SMAC AF (NCT00438113)
- Testing
- Aggressive Blood Pressure control
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- Nova Scotia Health Authority
Atrial Fibrillation
Substrate Versus Trigger Ablation for Paroxysmal Atrial Fibrillation
This is a prospective randomized study to assess the safety and efficacy of FIRM (Focal Impulse and Rotor Modulation)-guided ablation for the treatment of symptomatic atrial fibrillation (AF).
- Trial name
- SUBSTRATE (NCT02169037)
- Testing
- FIRM Ablation, Conventional AF ablation with PVI
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Atrial Fibrillation
Left Atrium Substrate Based Ablation Plus Circumferential Pulmonary Vein Isolation to Treat Chronic Atrial Fibrillation
The purpose of this study is to determine whether left atrium substrate based ablation plus circumferential is effective in the treatment of persistent and long-standing atrial fibrillation.
- Trial name
- NCT01716143
- Testing
- radiofrequency catheter ablation
- Where
- China
- Volunteers
- 87 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Ventricular Tachycardia, Ischemic Cardiomyopathy
The SoundScar Study The SOUNDSCAR Study
Prospective, Non-randomized, Single-arm Study to assess the accuracy of intracardiac echocardiography (ICE) for characterization of arrhythmogenic substrate in patients with ischaemic cardiomyopathy undergoing ventricular…
- Trial name
- SoundScar (NCT03862339)
- Where
- 2 sites in Australia, United Kingdom
- Volunteers
- 38 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Atrial Fibrillation, Atrial Remodeling
High-density Mapping-guided bOx Isolation and subsTrate Ablation
This study evaluates the efficacy of high-density mapping guided atrial substrate ablation for persistent atrial fibrillation. 1/5 of the patients with persistent atrial fibrillation undergo pulmonary veins isolation, 2/5 of them…
- Trial name
- HOT (NCT03998956)
- Testing
- CPVI, CPVI+BOX, CPVI+BOX+SUB
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Ventricular Tachycardia, Sudden Cardiac Death
Functional Substrate-Only Guided VT Ablation
Ventricular tachycardia (VT) is a leading cause of death and suffering in the Veteran population. Currently, ablation procedures are performed to destroy the diseased tissue that causes this problem.
- Trial name
- SLO-VT (NCT06464315)
- Testing
- Functional Substrate-Only Mapping without VT Induction, Standard-of-Care Mapping/Imaging
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Tachycardia, Ventricular
Comparison of VT Ablation Outcomes Using Remote MAGNETIC Navigation Versus Manual Approach in a Low LVEF Population
The study purpose is to demonstrate that ventricular tachycardia (VT) ablation using the Niobe™ ES system results in superior outcomes compared to a manual approach in subjects with ischemic scar VT in a low ejection fraction…
- Trial name
- MAGNETIC-VT (NCT02637947)
- Testing
- catheter ablation using magnetic navigation, catheter ablation using manual navigation
- Where
- 16 sites in United States, Australia and 5 more
- Volunteers
- 182 people
- Sponsor
- Stereotaxis
Ventricular Tachycardia Ablation
Repolarization and Activation Mapping in Ventricular Tachycardia Ablation: the REDEMPTION Study
The aim of this study is to prospectively evaluate a novel sinus rhythm mapping strategy for ventricular tachycardia (VT) ablation based on combined ventricular repolarization and activation (depolarization) mapping…
- Trial name
- REDEMPTION (NCT06765746)
- Testing
- Ventricular tachycardia ablation
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel