Clinical trials: Subthalamic Nucleus
Parkinson Disease
Longitudinal Outcomes of DBS in PD
Vanderbilt University Medical Center is one of the largest-volume DBS centers in the country. From 2007 through October 2017, 265 Parkinson's disease (PD) patients underwent deep brain stimulation (DBS), 168 of those implanted in…
- Trial name
- NCT03582163
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson Disease
Weight Changes in Parkinsonian Patients, Treated With Deep Brain Stimulation
The aim of this trial is to verify that neurostimulated parkinsonian patients gain weight and to study its link with an energetic balance change.
- Trial name
- NCT00221793
- Testing
- Deep brain stimulation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Parkinson's Disease
Phase I Deep Brain Stimulation (DBS) vs. Best Medical Therapy (BMT) Trial
The goals of this study are to determine if simultaneous bilateral subthalamic nucleus stimulation or simultaneous bilateral globus pallidus stimulation is more effective in reducing symptoms of Parkinson's disease, and if deep…
- Trial name
- NCT00056563
- Testing
- Bilateral Deep Brain Stimulation, best medical therapy
- Where
- 14 sites in United States
- Volunteers
- 255 people
- Sponsor
- US Department of Veterans Affairs
Epilepsy, Drug Resistant
Subthalamic Nucleus Electrical Stimulation for Drug-resistant Focal Motor Epilepsy
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of subthalamic nucleus (STN) as adjunctive therapy for reducing the frequency of seizures in drug-resistant focal motor…
- Trial name
- STEM (NCT06248333)
- Testing
- STN-DBS ON, STN-DBS OFF
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson's Disease
Intravenous Versus Inhalational Anesthesia in Parkinson's Disease
Parkinson's disease is a common progressive degenerative disease affecting 3% of all patients over the age of 65. Given their age and frailty, these patients frequently require surgical procedures with general anesthesia.
- Trial name
- NCT00615472
- Testing
- Isoflurane, Remifentanil, Propofol
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Columbia University
Deep Brain Stimulation, Telemedicine
Evaluation of Remote DBS Programming.
Deep brain stimulation (DBS) represents the treatment of choice for advanced stages of Parkinson's disease (PD). Currently, adaptive closed-loop stimulation systems that apply disease-specific biomarkers, such as local field…
- Conditions
- Deep Brain Stimulation, Telemedicine, Parkinson Disease
- Trial name
- REMOTE (NCT05193825)
- Testing
- Remote Programming, Standard Programming
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Thomas Köglsperger
Parkinson's Disease, Magnetic Resonance Imaging
Predictive Value of Multimodal MRI in Parkinson's Disease
Deep brain stimulation (DBS) is recognized as the most safe and effective neurosurgical method for the treatment of advanced Parkinson's disease.
- Conditions
- Parkinson's Disease, Magnetic Resonance Imaging, Deep Brain Stimulation
- Trial name
- NCT05003206
- Testing
- Functional magnetic resonance imaging, Deep Brain Stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Parkinson's Disease, Depression
Mapping Mood in the Subthalamic Nucleus in Parkinson's Disease (PD)
The goal of this study is to determine the vulnerability of mood-related neurocircuitry in Parkinson Disease (PD) using deep brain stimulation of the subthalamic nucleus (STN DBS).
- Conditions
- Parkinson's Disease, Depression, Anxiety
- Trial name
- MOOD-D (NCT00847431)
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Washington University School of Medicine
Parkinson Disease, Deep Brain Stimulation
The Impact of Exercise on Subthalamic Nucleus Neural Activity in Parkinson's Disease
Fifteen PwPD who have undergone DBS surgery and utilize the Percept system will complete a FE and VE exercise session on a stationary cycle while Off antiparkinsonian medication.
- Trial name
- NCT05905302
- Testing
- Forced and Voluntary Exercise
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Jay Alberts
Obsessive Compulsive Disorder
SONATA LIFU for OCD
The study tests ATTN201, an investigational non-invasive headband that delivers low-intensity focused ultrasound (LIFU) to the subthalamic nucleus (STN) as a treatment for obsessive-compulsive disorder (OCD).
- Trial name
- NCT07728994
- Testing
- Low Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania