Clinical trials: Success
Thoracic Epidural Anesthesia
CompuFlo Thoracic Epidural Study
Traditionally, loss-of-resistance (LOR) to air or saline with a special ground-glass syringe is the technique used to identify epidural space, but failure rates up to 30% have been reported using this technique for thoracic…
- Trial name
- NCT03826186
- Testing
- Traditional (loss-of-resistance technique) thoracic epidural placement, CompuFlo thoracic epidural placement
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- YATISH SIDDAPURA RANGANATH
Analgesia
Rivanna Ultrasound for Neuraxial Block
We hypothesize that the Rivanna Accuro or similar U/S device would reduce time to success of identifying epidural and/or intrathecal spaces as compared to conventional palpation method.
- Trial name
- NCT03214640
- Testing
- Rivanna Accuro US Device, Palpation, Neuraxial Analgesia
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Wake Forest University Health Sciences
Trichiasis, Surgery
Maximizing Trichiasis Surgery Success
The purpose of this study is to determine whether the rate of post-operative trachomatous trichiasis differs significantly between bilamellar tarsal rotation surgery with an incision height of 3 mm, bilamellar tarsal rotation…
- Trial name
- MTSS (NCT03100747)
- Testing
- Bilamellar 3 mm, Bilamellar 5 mm, Trabut 3 mm
- Where
- Ethiopia
- Volunteers
- 4,914 people
- Sponsor
- University of North Carolina, Chapel Hill
Stress
Impact of a Financial Success Education Program in Women and Children
Many Americans are living paycheck to paycheck. This may lead to financial stress and an increase in overall stress. People under stress are more likely to smoke, consume alcohol, eat a poor diet, and experience depression or…
- Trial name
- NCT01409291
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Creighton University
Ischemic Stroke
ASSIST Registry Studying Various Operator Techniques
The purpose of this Registry is to assess the procedural success and clinical outcomes associated with various operator techniques for mechanical thrombectomy in large vessel occlusions (LVO).
- Trial name
- NCT03845491
- Testing
- Mechanical Thrombectomy
- Where
- 72 sites in United States, Belgium and 9 more
- Volunteers
- 1,492 people
- Sponsor
- Stryker Neurovascular
Tracheal Intubation
Randomised Controlled Trial of Intubation With the McGrath Series 5 Video Laryngoscope vs the Macintosh Laryngoscope
The simplicity of use and intuitive function of the McGrath video-laryngoscope suggests it may have a bigger role than as a back-up to conventional direct laryngoscopy and could possibly be the first-line laryngoscope for…
- Trial name
- NCT00633867
- Testing
- McGrath, Tracheal intubation using Macintosh Laryngoscope
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- NHS Grampian
Opioid-use Disorder
A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders
This study is an open--label randomized outpatient trial to evaluate feasibility and efficacy of rapid buprenorphine (BUP) discontinuation followed by brief course of treatment with long--acting naltrexone (XR--NTX) and to…
- Trial name
- NCT03232346
- Testing
- Vivitrol, Buprenorphine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Vascular Access
Comparison of Different Techniques on First Attempt Success in Difficult Vascular Access Patients
The aim of this study is to investigate whether there is any difference between the use of standard techniques, ultrasonography and infra-red light for the success of the first attempt in difficult peripheral vascular access…
- Trial name
- NCT04821362
- Testing
- Ultrasound group, Near Infrared Device Group
- Where
- Turkey (Türkiye)
- Volunteers
- 270 people
- Sponsor
- Ege University
Overactive Bladder Syndrome
Validation of a Real-time Urodynamic Measure of Urinary Urgency
Urinary urgency is a key symptom of overactive bladder syndrome (OAB) and may be more bothersome to a patient than the symptom of urinary frequency.
- Trial name
- NCT00909428
- Testing
- Solifenacin Succinate
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Loyola University
Major Depressive Disorder (MDD)
Preventing Relapse After Successful Electroconvulsive Therapy for Depression
The present project is designed to study two promising relapse prevention strategies in an RCT. This will be the first project worldwide to study the effects of a personalized ECT treatment algorithm in the continuation phase of…
- Trial name
- PRASED (NCT06751875)
- Testing
- Lithium
- Where
- Belgium
- Volunteers
- 96 people
- Sponsor
- Universiteit Antwerpen
Peanut Allergy
ARTEMIS Peanut Allergy In Children
The purpose of this study is to demonstrate the efficacy and safety of AR101 through oral immunotherapy (OIT) in peanut-allergic children.
- Trial name
- ARTEMIS (NCT03201003)
- Testing
- AR101 powder provided in capsules & sachets
- Where
- 18 sites in France, Germany and 5 more
- Volunteers
- 175 people
- Sponsor
- Aimmune Therapeutics, Inc.
Autism Spectrum Disorder
Teaching Academic Success Skills to Students With Autism Spectrum Disorders in Clinical Setting
The goal of the study is to develop an academic EF intervention, Teaching Academic Skills to Kids (TASK), for high functioning (i.e., IQ score ≥80) middle-school youth with ASD and EF deficits.
- Trial name
- TASK-R21 (NCT03606343)
- Testing
- Teaching Academic Skills to Kids
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bleeding Peptic Ulcer
High Dose Esomeprazole Na for Prevention of Rebleeding After Successful Endoscopic Therapy of a Bleeding Peptic Ulcer
To describe the rate of clinically significant rebleeding during 72 hours continuous i.v. infusion of high dose esomeprazole Na in patients in China with primary successful endoscopic haemostatic therapy of a bleeding peptic…
- Trial name
- NCT01757275
- Testing
- Esomeprazole Na, Cimetidine, Esomeprazole Mg
- Where
- 12 sites in China
- Volunteers
- 239 people
- Sponsor
- AstraZeneca
Left Atrail Appendage Closure: Peri-device Leaks
Multimodality Evaluation of LAA Leaks Arising After Incomplete LAAC: Insights From the LAA-Leak Registry
Closure of peri-device leaks (PDL) after incomplete LAAC have shown early feasibility, however no comparison study of all the leak closure modalities exists.
- Trial name
- NCT05131308
- Testing
- leak closure with either detachable embolization coils, vascular plugs/CSO, or RFA
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest
Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )
To establish whether a pre-hospital advanced physician/ paramedic cardiac arrest team that is ECMO capable can establish ECMO flow within 30 minutes of collapse.
- Conditions
- Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation, Cardiopulmonary Arrest With Successful Resuscitation
- Trial name
- SUB30 (NCT03700125)
- Testing
- ECMO resuscitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- Barts & The London NHS Trust
Dental Implantation
Immediate Loading Of Dental Implants: A Pilot Clinical Study
Objective: To provide 2-year clinical- and patient-oriented data with regard to mandibular overdenture assisted by 2 immediately loaded unsplinted implants.
- Trial name
- NCT01644058
- Testing
- Immediate loading
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Anterior Wall Acute Myocardial Infarction
Evaluation of Intracoronary Hyperoxemic Oxygen Therapy in Anterior Acute Myocardial Infarction Patients (IC-HOT)
The primary objective of the study is to collect confirmatory data supporting the safety and effectiveness of SSO2 Therapy in treatment of anterior acute myocardial infarction (AMI) patients who have undergone successful…
- Trial name
- IC-HOT (NCT02603835)
- Testing
- SSO2 Therapy
- Where
- 15 sites in United States
- Volunteers
- 100 people
- Sponsor
- TherOx
Opioid Withdrawal
Combining Pregabalin (LYRICA®) With Lofexidine (LUCEMYRATM) to Treat OPIOID Withdrawal
A phase II double-blind placebo-controlled parallel group clinical trial that will randomize 90 subjects to investigate whether pregabalin (PGB) combined with Lofexidine (LFX) can reduce opioid withdrawal-related subjective…
- Trial name
- PGB-LOF (NCT04218240)
- Testing
- Pregabalin 200 MG capsules, Lofexidine 0.18Mg Tab
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Pennsylvania
Presbyopia
Evaluating the Success of Habitual Multifocal Wearers When Refit With a New Lens Design
The objective of the study was to adapt existing multifocal soft lens wearers to a CONTROL lens for 2 weeks and then evaluate the success of switching them to the TEST lens, with a review after 2 weeks.
- Trial name
- NCT04952701
- Testing
- Control lenses, Test lenses
- Where
- 5 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Mechanical Ventilation Complication
Change In Diaphragmatic Thickness Predicts Extubation Success
We will investigate whether measurement of the change in thickness of the diaphragm during the respiratory cycle by ultrasound can predict extubation success in a 48 hour window.
- Trial name
- NCT02656199
- Testing
- Diaphragm Ultrasound
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Albert Einstein Healthcare Network