Clinical trials: Sudden Hearing Loss
Sudden Sensorineural Hearing Loss (SSNHL)
Autologous Circulating Extracellular Vesicles for Total-Type Sudden Sensorineural Hearing Loss
Total-type sudden sensorineural hearing loss (defined in this study as severe-to-profound sudden sensorineural hearing loss with pure-tone average (PTA) >70 dB HL) represents one of the poorer-prognosis subtypes of sudden…
- Trial name
- NCT07878559
- Testing
- autologous circulating extracellular vesicles, Glucocorticoids
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Idiopathic Sudden SNHL
Predictive Factors for Recovery in Idiopathic Sensory Neural Hearing Loss
Sudden sensorineural hearing loss (SSNHL) is an otological emergency that is defined as a hearing loss greater than 30 dB over three consecutive frequencies within 72 hours, with abnormalities of the cochlea, auditory nerve, or…
- Trial name
- NCT05112354
- Testing
- systemic and intratympanic injection of steoid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Sudden Sensorineural Hearing Loss, Hearing Loss, Sensorineural
Multi-omics Characteristics and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss
The goal of this observational study is to describe the multi-omics characteristics and to learn about the prognostic factors in patients with idiopathic sudden sensorineural hearing loss (SSNHL).
- Conditions
- Sudden Sensorineural Hearing Loss, Hearing Loss, Sensorineural, Hearing Loss, Sudden
- Trial name
- NCT06365775
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Dan Bing
Idiopathic SSNHL, Age Over 18
Blood Markers in Adult Patients With Sudden Sensorineural Hearing Loss (SSNHL)
The roles of thrombophilia and cardiovascular risk factors in sudden sensorineural hearing loss (SSNHL) remain controversial. Cochlear micro-thrombosis has been hypothesized as a possible pathogenic mechanism of SSNHL.
- Trial name
- SSNHL (NCT03919474)
- Testing
- microvascular markers
- Where
- France
- Volunteers
- 394 people
- Sponsor
- Hopital Lariboisière
Sudden Hearing Loss
The Effect of Patient's Position After Intra-tympanic Injection on the Amount of Fluid in the Middle Ear
During the regular protocol of Intra-tympanic injections of Dexamethasone to the middle ear due to Sudden Sensorineural Hearing Loss, the patients will be sitted once after the injection instead of lying down.
- Trial name
- NCT04449848
- Testing
- Sitting after intra tympanic injection
- Volunteers
- 20 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Vestibular Vertigo, Sudden Hearing Loss
Vestibular Prognosis Assessment of ISSNHL With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids
Idiopathic sudden sensorineural hearing loss (ISSNHL) is a complicated hearing impairment with unclear etiology and unsatisfying treatment effects.
- Trial name
- NCT03974867
- Testing
- Prednisone 5Mg Tab, Methylprednisolone 40 mg
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Sudden Sensorineural Hearing Loss (SSNHL)
Acupuncture Therapy for Sudden Sensorineural Hearing Loss
The goal of this multicenter, prospective, randomized controlled trial is to evaluate the efficacy and safety of acupuncture combined with corticosteroid therapy in treating sudden sensorineural hearing loss (SSNHL).
- Trial name
- SSNHL-Acu (NCT07575334)
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Sudden Hearing Loss
Effectiveness of Integrative Medical Treatment in Sudden Hearing Loss
Sudden hearing loss is an emergency in otolaryngology that requires diagnosis and treatment as soon as possible. The golden treatment period is two weeks since the onset of the disease.
- Trial name
- NCT07235488
- Testing
- Acupuncture, steroid therapy
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- China Medical University Hospital
Sudden Sensorineural Hearing Loss
Evaluation of Oral Corticosteroid Therapy in Idiopathic Sudden Unilateral Hearing Loss.
Context: Idiopathic Sudden Sensorineural Hearing Loss (ISSHL) is a rapid-onset, sensorineural hearing loss of unknown etiology. It is one of the most common ENT emergencies, with spontaneous recovery occurring in 32% to 65% of…
- Trial name
- ECOSUB (NCT07067801)
- Testing
- prednisone - oral corticosteroid 1mg/kg/D for 1 week
- Where
- France
- Volunteers
- 430 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Sudden Hearing Loss, Extracellular Vesicles
Study on the Safety and Efficacy of Intratympanic Injection of Small Extracellular Vesicles Derived From Mesenchymal Stem Cells in Severe and Profound Sudden Sensorineural Hearing Loss
The goal of this clinical trial is to learn if small extracellular vesicles derived from mesenchymal stem cells work to treat severe and above sudden sensorineural hearing loss.
- Trial name
- NCT07404709
- Testing
- Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at low doses, Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at moderate doses, Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at high doses
- Where
- 5 sites in China
- Volunteers
- 9 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Acute Hearing Loss
Safety and Efficacy of STR001-IT and STR001-ER in Patients With SSHL
a multicenter, double-blind, placebo-controlled study in patients with Sudden Sensorineural Hearing Loss (SSHL). Patients will be treated with STR001 thermogel (STR001-IT) / STR001 tablets (STR001-ER) and corresponding Placebo on…
- Trial name
- NCT03331627
- Testing
- STR001-IT and STR001-ER
- Where
- 3 sites in Czechia, Germany and 1 more
- Volunteers
- 165 people
- Sponsor
- Strekin AG
Autoimmune Inner Ear Disease
The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease
The purpose of this study is to determine if gevokizumab therapy may be an alternate therapy in patients with steroid resistant Autoimmune Inner Ear Disease.
- Trial name
- NCT01950312
- Testing
- gevokizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- XOMA (US) LLC
Sudden Sensorineural Hearing Loss (SSNHL)
Intracochlear Injection of Glucocorticoid
This study is a prospective, randomized pilot study. To verify safety and efficacy of intracochlear injection of glucocorticoid through the round window membrane in patients with total sudden sensorineural hearing loss safety and…
- Trial name
- NCT07134075
- Testing
- intracochlear triamcinolone acetonide injection, intracochlear injection of dexamethasone through the round window membrane, intracochlear dexamethasone injection and intratympanic dexamethasone injection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Sudden Deafness, Sensorineural Hearing Loss
Autologous Blood Monocyte Vesicles for the Treatment of Sudden Deafness
Sudden deafness is a common emergency in otorhinolaryngology. As the etiology and mechanism of sudden deafness remains unknown, there is no specific treatment.
- Trial name
- NCT06707389
- Testing
- autologous blood monocyte vesicles (lower dose), Methylprednisolone, autologous blood monocyte vesicles (higher dose)
- Volunteers
- 30 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Dexamethasone or Methylprednisolone; Sudden Hearing Loss; Intratympanic Steroid
Intratympanic Steroids for Sudden Hearing Loss
For patients with sudden hearing loss, the initial treatment is not usually effective. We use Dexamethasone or Methylprednisolone to be an Intratympanic steroid administration as a salvage treatment.
- Trial name
- NCT04129697
- Testing
- Dexamethasone or Methylprednisolone
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sudden Hearing Loss
Trans-round Window Membrane Intracochlear Steroid
Safety and efficacy of intracochlear injection of glucocorticoid through the round window membrane in patients with profound or complete sudden sensorineural hearing loss
- Trial name
- NCT07540728
- Testing
- Experimental: Group A: intracochlear triamcinolone acetonide injection, intracochlear injection of dexamethasone, intratympanic dexamethasone injection
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Hearing Loss
Efficacy of AM-111 in Patients With Acute Sensorineural Hearing Loss
The purpose of the study is to determine whether AM-111 is effective in the treatment of acute inner ear hearing loss (acute sensorineural hearing loss, ASNHL).
- Trial name
- NCT00802425
- Testing
- AM-111
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- Auris Medical AG
Hearing Loss, Sudden, Prednisone Acetate
Treatment of Sudden Deafness With Prednisone+Hyperbaric Oxygen and Prednisone+Somatosensory Stimulation
To study the effective treatment of sudden deafness by giving prednisone, hyperbaric oxygen and somatosensory stimulation to sudden deafness patients.
- Conditions
- Hearing Loss, Sudden, Prednisone Acetate, Hyperbaric Oxygen, Somatic Stimulus
- Trial name
- NCT04129983
- Testing
- Drugs and Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Dan Su
Air or Gas Embolism, Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy Registry
The purpose of the Hyperbaric Oxygen Therapy Registry (HBOTR) is to provide real world patient outcome and side effect information from electronic health records submitted to a specialty specific hyperbaric registry as part of…
- Conditions
- Air or Gas Embolism, Carbon Monoxide Poisoning, Clostridial Myositis and Myonecrosis (Gas Gangrene), Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias
- Trial name
- HBOTR (NCT02483650)
- Volunteers
- 5,000 people
- Sponsor
- U.S. Wound Registry
Hearing Loss
Hearing Aid Algorithms for Sudden Sounds
This study explores the impact of hearing aid settings for managing sudden sounds on speech comprehension and recall in individuals with hearing loss.
- Trial name
- NCT06340919
- Testing
- Sudden Sound Reduction Setting
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Purdue University