Clinical trials: Sudden Loss of Hearing
Obstructive Sleep Apnea, Sudden Hearing Loss
OSA and Sudden Sensorineural Hearing Loss
This study studies the prevalence between obstructive sleep apnea syndrome and sensorineural hearing loss. We recruit patients who have been treated for sudden sensorineural hearing loss in Poitiers' University Hospital between…
- Trial name
- SAS-SB (NCT03747874)
- Testing
- ventilatory polygraphy
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Poitiers University Hospital
Vestibular Disorder
Vestibular Function and Vestibular Rehabilitation in SSHL With Vertigo
To evaluate the vestibular function and vestibular rehabilitation in sudden sensorneural hearing loss(SSHL) with vertigo
- Trial name
- NCT03431506
- Testing
- Vestibular rehabilitation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Sensorineural Hearing Loss, Tinnitus
Regenerative Medicine and Stem Cell-Based Interventions for Inner Ear Trauma, Tinnitus, and Sensorineural Hearing Loss
The HEAR-RESTORE study is an exploratory clinical research program designed to evaluate new diagnostic and regenerative approaches for individuals experiencing inner ear injury, tinnitus, and temporary or permanent hearing loss.
- Conditions
- Sensorineural Hearing Loss, Tinnitus, Acoustic Trauma, Inner Ear Injury
- Trial name
- HEAR-RESTORE (NCT07472023)
- Testing
- Audiologic Monitoring, Investigational Regenerative Pharmacologic Therapy, Stem Cell Regenerative Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Truway Health, Inc.
Hearing Loss, Deafness
Efficacy, Safety, and Tolerability of Ancrod in Patients With Sudden Hearing Loss
The purpose of this study is to determine whether ancrod is effective and safe in the treatment of sudden sensorineural hearing loss (SSHL).
- Conditions
- Hearing Loss, Deafness, Hearing Loss, Sensorineural, Hearing Disorders
- Trial name
- NCT01621256
- Testing
- Ancrod, Saline solution
- Where
- 7 sites in Czechia, Germany
- Volunteers
- 31 people
- Sponsor
- Nordmark Arzneimittel GmbH & Co. KG
Seneorineural Deafness, Sudden Sensorineural Hearing Loss
A Phase 1b/2a, Study Evaluating the Safety, PK/PD and Efficacy of NS101 in Healthy Volunteers and SSNHL Patients
The goal of this 2 step-up, exploratory study is to test safey, tolerability and PK/PD profiles in healthy volunteers and safety, tolerability and efficacy in sudden sensorineural hearing loss patients as an early salvage…
- Trial name
- NCT06249919
- Testing
- NS101
- Where
- 16 sites in South Korea
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Neuracle Science Co., LTD.
Sudden Hearing Loss
Efficacy and Safety of Hydroxychloroquine in the Treatment of Sudden Sensorineural Hearing Loss
Sudden sensorineural hearing loss (SSNHL) is diagnosed when there's a sudden drop in hearing of at least 30 decibels across three consecutive frequencies, emerging within up to 72 hours.
- Trial name
- NCT06467526
- Testing
- Hydroxychloroquine, Steroid
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Chang Gung Memorial Hospital
Sensorineural Hearing Loss, Autoimmune Inner Ear Disease
A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease
The purpose of this study is to determine if Anakinra (an interleukin-1 receptor antagonist) can improve hearing thresholds in those patients with Autoimmune Inner Ear Disease (AIED) that did not respond to oral steroid therapy…
- Trial name
- NCT01267994
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Andrea Vambutas
Idiopathic Sudden SNHL
Predictive Factors for Recovery in Idiopathic Sensory Neural Hearing Loss
Sudden sensorineural hearing loss (SSNHL) is an otological emergency that is defined as a hearing loss greater than 30 dB over three consecutive frequencies within 72 hours, with abnormalities of the cochlea, auditory nerve, or…
- Trial name
- NCT05112354
- Testing
- systemic and intratympanic injection of steoid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Sudden Deafness, Sudden Sensorineural Hearing Loss
The Role of Migraine Prophylaxis Agent Topiramate in Treating Patients With Sudden Sensorineural Hearing Loss
Migraine and sudden sensorineural hearing loss(SSNHL) are two related disorders. A systemic steroid is usually used to treat SSNHL but the role of migraine prophylaxis medication remained unknown. Mehdi Abouzari et al.
- Trial name
- NCT05403229
- Testing
- Topiramate, Systemic Steroids
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Chang Gung Memorial Hospital
Sudden Sensorineural Hearing Loss, Hearing Loss, Sensorineural
Multi-omics Characteristics and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss
The goal of this observational study is to describe the multi-omics characteristics and to learn about the prognostic factors in patients with idiopathic sudden sensorineural hearing loss (SSNHL).
- Conditions
- Sudden Sensorineural Hearing Loss, Hearing Loss, Sensorineural, Hearing Loss, Sudden
- Trial name
- NCT06365775
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Dan Bing
Sudden Sensorineural Hearing Loss (SSNHL), Tinnitus
'Inner Ear Support' Oral Capsule in Patients With Sudden Sensorineural Hearing Loss
Sudden sensorineural hearing loss (SSNHL) is a medical condition where people experience rapid hearing loss, usually in one ear, over a short period of time (typically within 72 hours).
- Trial name
- NCT06997406
- Testing
- Inner ear support
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Far East Bio-Tec Co., Ltd
Sudden Sensorineural Hearing Loss, Tinnitus
The Development of Tinnitus in Patients With SSNHL: Insights From fMRI and Metabolomics
The goal of this clinical trial is to investigate the factors and mechanisms underlying tinnitus generation and chronification in patients with sudden sensorineural hearing loss (SSNHL) .
- Trial name
- NCT06355102
- Testing
- Conventional treatment and care
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Sudden Sensorineural Hearing Loss
Phase I Clinical Study of HY01 in Patients
Phase I clinical study on the safety, tolerance, efficacy and pharmacokinetics of repeated intratympanic HY01 in patients with sudden sensorineural hearing loss.
- Trial name
- NCT04961099
- Testing
- HY01
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Heyu (Suzhou) Pharmaceutical Technology Co., Ltd
Sudden Hearing Loss, Sensorineural Hearing Loss
Yiyuancong for the Treatment of Sudden Sensorineural Hearing Loss
This project aims to evaluate the clinical efficacy of Yiyuancong, an independently developed traditional Chinese medicine (TCM) formula based on the homology of medicine and food, in participants with sudden sensorineural…
- Trial name
- NCT07505667
- Testing
- Standard treatment combined with Yiyuancong, Standard treatment
- Where
- 5 sites in China
- Volunteers
- 128 people
- Sponsor
- Guangdong Provincial People's Hospital
Hearing Loss, Sudden Deafness
The Effect of Antiviral Therapy With Pegylated Interferon-alpha on Auditory Disability
The aim of the study is to assess the effect of antiviral therapy with pegylated interferon alpha for hepatitis C and B on auditory disability as there are reports in the English literature on auditory disability caused by…
- Trial name
- HLIPT2010 (NCT01265693)
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Carmel Medical Center
Sudden Deafness
Sudden Deafness Treatment Trial
This trial aims to compare the efficacy of oral prednisone vs. methylprednisolone injected into the middle ear for the treatment of moderate-to-severe, sudden sensorineural hearing loss (inner ear hearing loss affecting one ear…
- Trial name
- SSNHL (NCT00097448)
- Testing
- prednisone, methylprednisolone sodium succinate
- Where
- 14 sites in United States
- Volunteers
- 255 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Sudden Sensorineural Hearing Loss
Effect of Aspirin and Folic Acid for Sudden Sensorineural Hearing Loss
The annual incidence of sudden sensorineural hearing loss (SSNHL) is 5 to 20 per 100 000 persons. The pathophysiology of SSNHL and acute vestibulo-cochlear syndromes (VCS) is unknown in more than 70% of cases.
- Trial name
- SERORL (NCT07113158)
- Testing
- Aspirin + Acid folic
- Where
- France
- Volunteers
- 142 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sudden Sensorineural Hearing Loss
Oral Statins and Protection From Hearing Loss
A small clinical trial for idiopathic sudden sensorineural hearing loss (ISSNHL). Will the addition of an oral statin to the standard treatment (oral methylprednesolone and the salvage therapy of intratympanic dexamethasone)…
- Trial name
- NCT04826237
- Testing
- Statin, methylprednisolone, dexamethasone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Sensorineural Hearing Loss, Noise Induced Hearing Loss
FX-322 in Adults With Stable Sensorineural Hearing Loss
This is a phase 2a single and repeat dose exploratory efficacy study of intratympanic FX-322 compared to placebo in healthy male and female adults with stable sensorineural hearing loss.
- Conditions
- Sensorineural Hearing Loss, Noise Induced Hearing Loss, Sudden Sensorineural Hearing Loss
- Trial name
- NCT04120116
- Testing
- FX-322 (One Dose), FX-322 (Two Doses), FX-322 (Four Doses)
- Where
- 16 sites in United States
- Volunteers
- 95 people
- Sponsor
- Frequency Therapeutics
Sudden Hearing Loss
Effectiveness of Integrative Medical Treatment in Sudden Hearing Loss
Sudden hearing loss is an emergency in otolaryngology that requires diagnosis and treatment as soon as possible. The golden treatment period is two weeks since the onset of the disease.
- Trial name
- NCT07235488
- Testing
- Acupuncture, steroid therapy
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- China Medical University Hospital