Clinical trials: Sudden Unexpected Death in Epilepsy
Sleep Disordered Breathing, Apnea of Prematurity
The PARS Study: Paediatric Advanced Respiratory Service Study - An Observational Diagnostic Feasibility Study
Diagnostic investigations in paediatric respiratory and sleep medicine are often challenging due to patient size (due to prematurity), tolerability, and compliance with "gold standard equipment".
- Conditions
- Sleep Disordered Breathing, Apnea of Prematurity, Respiratory Rate, Sudden Unexpected Death in Epilepsy
- Trial name
- PARS (NCT06292299)
- Testing
- Pneumowave
- Where
- 2 sites in United Kingdom
- Volunteers
- 225 people
- Sponsor
- NHS Greater Clyde and Glasgow
Epilepsy
Risk Factors of SUDEP
Numerous studies over the past decade have shown without any doubt that there is a higher mortality risk in patients with epilepsy than in the general population.
- Trial name
- PRERIES (NCT03074279)
- Testing
- Interview with a psychologist and self-reported questionnaires
- Where
- France
- Volunteers
- 408 people
- Sponsor
- University Hospital, Montpellier
Epilepsy
Caracterization of the Combined Alterations in Respiration and aROUSal in Patients With Drug-resistant EpiLepsy
30% of patients with epilepsy suffer from drug-resistant seizures and are at risk of epilepsy-related complications, from cognitive dysfunctions to premature mortality.
- Trial name
- CARROUSEL (NCT06545214)
- Testing
- Video-EEG monitoring, Respiratory monitoring and polysomnography, 1 Hypercapnic challenge while participant is awake
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Sudden Unexpected Death in Epilepsy (SUDEP)
Serotoninergic Pathways in Sudden and Unexpted Death in Epilepsy (SUDEP)
The mortality rate is increased in patients with epilepsy, and especially among patients with drug-resistant epilepsy. This increased mortality is mainly related to the risk of SUDEP whose incidence is between 3.5 and 9 per 1,000…
- Trial name
- SUDEP (NCT02788318)
- Testing
- Brain samples, Skin samples
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Hospices Civils de Lyon
Epilepsy, SUDEP
Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI
Sudden unexpected death in epilepsy patients (SUDEP) is devastating outcome for some patients with epilepsy. It ranks second only to stroke among neurological diseases in years of potential life lost.
- Trial name
- NCT02929667
- Testing
- Fluoxetine
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rup Kamal Sainju