Clinical trials: Sudden Unexplained Death Syndrome
Brugada Syndrome 1
Brugada Syndrome and Artificial Intelligence Applications to Diagnosis
Aim of the project is the development of an integrated platform, based on machine learning and omic techniques, able to support physicians in as much as possible accurate diagnosis of Type 1 Brugada Syndrome (BrS).
- Trial name
- BrAID (NCT04641585)
- Testing
- Patients affected by Brugada Syndrome 1
- Where
- 6 sites in Italy
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Istituto di Fisiologia Clinica CNR
Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS)
Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias
Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and…
- Conditions
- Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS), Brugada Syndrome (BrS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- Trial name
- NCT02413450
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Brugada Syndrome (BrS), Breast Cancer Females
Analysis of the Presence and Cardiac Functional Effects of Anti-NaV1.5 Autoantibodies in Patients With Metastatic Tumors
The overall aim of this study is to identify and characterize anti-NaV1.5 autoantibodies in patients with metastatic breast and colorectal cancer.
- Conditions
- Brugada Syndrome (BrS), Breast Cancer Females, Colon Cancer, ECG Abnormalities
- Trial name
- NCT07364656
- Testing
- ECG
- Where
- Italy
- Volunteers
- 196 people
- Sponsor
- IRCCS Policlinico S. Donato
Channelopathies, Brugada Syndrome
Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies
Patients with cardiac channelopathies needing restorative dental treatment will be included in two sessions of the study, using local dental anesthetic: lidocaine 2% with epinephrine and lidocaine 2% without vasoconstrictor.
- Conditions
- Channelopathies, Brugada Syndrome, Long QT Syndrome, Ventricular, Tachycardia
- Trial name
- SLDAPCC (NCT03182777)
- Testing
- Dental restorative procedure
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo General Hospital
Brugada Syndrome
European Perioperative Brugada Survey
The aim of this survey is to assess the current perception and clinical practice of Resident and Board-certified Anaesthesiologists and Intensivists regarding perioperative care of patients burdened with the Brugada Syndrome.
- Trial name
- NCT04808193
- Testing
- Survey
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Brugada Syndrome
Ripple Mapping for Epicardial Mapping of Brugada Syndrome
Whether a mapping algorithm "Ripple-mapping" is able to rapidly identify the areas of long-duration multicomponent electrograms which constitute the targets for ablation for an automated strategy remains to be assessed.
- Trial name
- NCT03435393
- Testing
- Catheter ablation
- Where
- 3 sites in Brazil, Portugal and 1 more
- Volunteers
- 10 people
- Sponsor
- University College London Hospitals
Sudden Unexplained Death Syndrome, Sudden Unexplained Death in Childhood
Sudden Unexplained Death in Childhood (SUDC) Registry
The purpose is to increase the understanding of the characteristics, circumstances, medical histories and pathologies of children from ages 11 months through 18 years who have died suddenly and unexpectedly, and in some…
- Trial name
- SUDC (NCT03109197)
- Testing
- Biospecimin Collection
- Where
- United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Brugada Syndrome
DAPERB 3,4-DiAminoPyridine and Electrophysiological Response in Brugada Syndrome
The Brugada syndrome is a rare disease potentially leading to severe arrhythmic events in otherwise healthy subjects.In many patients an Implantable cardiovertor defibrillator (ICD) is implanted to prevent sudden cardiac death.
- Trial name
- DAPREB (NCT00701077)
- Testing
- 3,4-Di-amino-Pyridine
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brugada Syndrome
Epicardial Radiofrequency Catheter Ablation in Patients With Brugada Syndrome
This randomized, sham-controlled, and blinded clinical trial aims to evaluate the effects of radiofrequency catheter ablation on the phenotypic expression of patients with Brugada syndrome.
- Trial name
- NCT05685134
- Testing
- Radiofrequency catheter ablation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Long QT Syndrome, Brugada Syndrome
Physical Activity in Children With Inherited Cardiac Diseases
Use lay language. Current guidelines regarding physical activity in patients with inherited arrhythmia and cardiomyopathy are mostly dedicated to adult patients, with a special focus on sports competition.
- Conditions
- Long QT Syndrome, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Hypertrophic Cardiomyopathy
- Trial name
- NCT04650009
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Montpellier
Brugada Syndrome
UZ Brussel HRMC Registry of Brugada Syndrome
The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome at UZ Brussel hospital (UZB).
- Trial name
- HRMCBrS (NCT05283759)
- Testing
- No intervention because it is a patient registry
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- Universitair Ziekenhuis Brussel
Brugada Syndrome
Brugada Ablation of VF Substrate Ongoing MultiCenter Registry
Current treatment of high-risk Brugada Syndrome (BrS) patients (pts) with recurrent VF is limited. Catheter ablation (CA) has been performed for BrS but a large study with long-term outcomes of CA in BrS ablation are lacking.
- Trial name
- BRAVO (NCT04420078)
- Testing
- Catheter Ablation
- Where
- Thailand
- Volunteers
- 159 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Brugada Syndrome Type 1
Rhythmic Risk of Type 1 Brugada Syndrome and Pulmonary Infundibulum Mapping
Brugada syndrome has been described as the association of a right bundle block with ST segment elevation on the V1 to V3 electrocardiogram in patients with a structurally normal heart.
- Trial name
- SB-CARTO (NCT03572881)
- Testing
- Endocardial mapping
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Long QT Syndrome, Brugada Syndrome
Healthy-related Quality of Life and Physical Activity of Children With Cardiac Malformations
The QUALIMYORYTHM trial is a multicentre controlled study, aiming to assess health-related quality of life (HRQoL) of 107 children aged 6 to 18 years old with inherited cardiac arrhythmia (long QT syndrome, Brugada syndrome…
- Conditions
- Long QT Syndrome, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Arrhythmogenic Right Ventricular Dysplasia
- Trial name
- QUALIMYORYTHM (NCT04712136)
- Testing
- MRI
- Where
- France
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Arrhythmogenic Right Ventricular Dysplasia, Brugada Syndrome
Distribution of Cell-cell Junction Proteins in Arrhythmic Disorders
Every week in the UK, 12 apparently healthy and fit individuals under the age of 35 die suddenly, a tragic event known as sudden cardiac death (SCD).
- Conditions
- Arrhythmogenic Right Ventricular Dysplasia, Brugada Syndrome, Cardiac Channelopathy
- Trial name
- NCT04257994
- Testing
- obtaining a buccal smear sample
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- St. George's Hospital, London
Ventricular Arrhythmias and Cardiac Arrest
Epicardial Ablation in Brugada Syndrome to Prevent Sudden Death
A total of 150 patients will be randomized to perform catheter ablation or not in a 2:1 fashion in selected patients with Brugada-related symptoms (Ablation+ICD arm 105 patients vs ICD only 45 patients).
- Trial name
- NCT03294278
- Testing
- ablation plus ICD
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Policlinico S. Donato
Brugada Syndrome, Channelopathies
Defining the Electrocardiographic Effect of Propofol on the Ajmaline Provocation Drug Challenge: A Prospective Trial
Background: Brugada Syndrome is an inherited channelopathy associated with risk of ventricular fibrillation and sudden cardiac death in a structurally normal heart.
- Conditions
- Brugada Syndrome, Channelopathies, Ventricular Fibrillation, Cardiac Death
- Trial name
- NCT04580992
- Testing
- Ajmaline
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Universitair Ziekenhuis Brussel
Brugada Syndrome
Right Ventricle Morphology and Hemodynamics in BrS
The study purpose is to evaluate the morphological, functional and electrophysiological characteristics of the right ventricle before and after ajmaline in patients diagnosed with Brugada syndrome as well as to correlate CMR…
- Trial name
- RV-BrS (NCT03524079)
- Testing
- Ajmaline 17-(Chloroacetate) Monohydrochloride
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Brugada Syndrome
Echocardiography During Ajmaline Test
In this study the investigators analyse echocardiographic images before and during Ajmaline test. The purpose is to know if any echocardiographic modifications are present during either negative or positive Ajmaline testing.
- Trial name
- NCT03491475
- Testing
- Ajmaline test
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Brugada Syndrome
Ablation in Brugada Syndrome for the Prevention of VF
This trial aims to develop evidence based curative treatment with optimal net benefit for patients with Brugada syndrome.
- Trial name
- BRAVE (NCT02704416)
- Testing
- Catheter Ablation
- Where
- 6 sites in Netherlands, Thailand
- Volunteers
- 200 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute