Clinical trials: Sugar; Blood, Low
Hypoglycemia, Obesity, Morbid
The Effect of 'Medical Nutrition Therapy' on Post-bariatric Hypoglycemia 2-4 Years After Gastric Bypass Surgery
This is a pilot study to explore the effect of 'medical nutritional therapy' in patients diagnosed with post-bariatric hypoglycemia (PBH), 2-4 years after gastric bypass surgery.
- Trial name
- NCT05011682
- Testing
- Regular diet, 10-point nutrition plan
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- Helse Nord-Trøndelag HF
Diabetes Mellitus
First Clinical Evaluation of a Novel Glucose Non-invasive Sensor Technology in Patients With Type 1 Diabetes
The primary aim of this clinical study is to find signal characteristics of VOCs detected by Sokru device during fasting, insulin injection and after glucose intake and to find the association with blood glucose variation in…
- Trial name
- VAARA (NCT05771090)
- Testing
- Sokru device
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- DCB Research AG
Hypoglycemia, Complications of Bariatric Procedures
Delivery of G-Pump™ (Glucagon Infusion) From an OmniPod® to Prevent Hypoglycemia in Post-Bariatric Surgery Patients
The primary objective of this study is to test an optimized control system for sensor-guided (physician administered) delivery of glucagon, and test Proof-of-Concept (POC) in a clinical setting in patients with severe…
- Trial name
- NCT02733588
- Testing
- G-Pump™ (glucagon infusion)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Xeris Pharmaceuticals
Hypoglycemia
The Construction and Validation of a Risk Prediction Model for Perioperative Hypoglycemia in Digestive Endoscopy
Digestive endoscopic surgery, including diagnosis and treatment interventions, has become an indispensable means of managing various gastrointestinal diseases in modern gastroenterology practice.
- Trial name
- NCT07132476
- Testing
- No adjuvant therapy
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Ningbo No. 1 Hospital
Type 1 Diabetes, Hypoglycemia
Glycemic Effects of Morning Only, Evening Only or Twice Daily Insulin Glargine in Patients With Type 1 Diabetes
This research is a prospective, randomized, cross-over study that is being done to compare the effect of morning only, evening only and twice daily insulin glargine (Lantus®) on hypoglycemia (blood glucose level <70 mg/dL) as…
- Trial name
- NCT00869414
- Testing
- Evening only administration of insulin glargine, Morning only administration of insulin glargine, split dose insulin glargine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type I
Effect of the Fat Content of the Bedtime Snack on Overnight Hypoglycemia
Low blood sugar at night (called nocturnal hypoglycemia), can often happen without symptoms and can last for a long time. Doctors often suggest that patients take a bedtime snack to try to prevent low blood sugar at night from…
- Trial name
- NCT00493935
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Type 1
Evaluation of the EarEEG System for Detection of Hypoglycaemia-induced Changes in the EEG in Subjects With Type 1 Diabetes
The EarEEG system is a novel non-invasive, unobstructed and discrete method for recording EEG in which the signal is recorded using dry-contact electrodes embedded on a customised ear piece.
- Trial name
- NCT03022058
- Testing
- Ear-EEG system
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Odense University Hospital
Type 1 Diabetes, Hypoglycemia
Islet Allotransplantation With Steroid Free Immunosuppression
The restoration of endogenous insulin secretion carries significant hopes for shifting the paradigm of life long exogenous insulin therapy in selected groups of patients with type 1 diabetes(T1D).
- Conditions
- Type 1 Diabetes, Hypoglycemia, Metabolic Diseases
- Trial name
- NCT00446264
- Testing
- islet transplantation, daclizumab - sirolimus - tacrolimus
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Lille
Blood Glucose Decrease During and After Defined Individual Exercise in T1DM
Exercise in Type 1 Diabetes Mellitus
Background: During and after exercise there is a twofold stimulation of glucose transporter type 4 in type 1 diabetes mellitus (T1DM) caused by an exogenous insulin injection and muscle contraction.
- Trial name
- ExT1DM (NCT02075567)
- Testing
- Experimental
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Type 1 Diabetes Mellitus
Propranolol in Treating Hypoglycemia Unawareness
Impaired awareness of hypoglycemia is common in type 1 diabetes (T1DM) patients. Impaired hypoglycemia awareness increases severe hypoglycemia risk by six-fold.
- Trial name
- NCT03161964
- Testing
- Propranolol 80 Mg Oral Capsule, Extended Release
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Anu Sharma
Hypoglycemia, Diabetes Mellitus, Type 1
Trial to Confirm the Clinical Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in Subjects With T1DM
A randomized, double-blind, parallel-group trial to confirm the clinical efficacy and safety of dasiglucagon in the rescue treatment of hypoglycemia in subjects with type 1 diabetes mellitus (T1DM) compared to placebo
- Trial name
- NCT03688711
- Testing
- Dasiglucagon
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Zealand Pharma
Hypoglycemia
Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide
Idiopathic reactive hypoglycemia (IRH) describes a condition where recurrent episodes of symptomatic hypoglycemia occurs one to four hours after a meal, usually following meals rich in carbohydrates.
- Trial name
- NCT00802971
- Testing
- FOS
- Volunteers
- 12 people
- Sponsor
- Asker & Baerum Hospital
Type 1 Diabetes
Outpatient Pump Shutoff Pilot Feasibility and Efficacy Study
The purpose of this study is to see whether low blood sugar at night can be reduced by using a system that turns off the insulin pump automatically.
- Trial name
- NCT01591681
- Testing
- Pump suspension
- Where
- 3 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- Jaeb Center for Health Research
Brain Neoplasms, Intracranial Aneurysm
Efficiency of Two Glucose Sampling Protocols for Maintenance of Euglycemia
What is the efficacy and safety of q 30 minutes vs. q 1hour glucose sampling and intervention for an intensive insulin protocol to achieve and maintain euglycemia in non-diabetic patients undergoing craniotomy? The investigators…
- Trial name
- NCT00993057
- Testing
- Insulin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Hypoglycemia
Pharmacokinetics (PK) and Pharmacodynamics (PD) of Mayne Glucagon for Injection Compared With Glucagen® (Novo Nordisk) in Healthy Volunteers
The purpose of this study is to evaluate the pharmacokinetics and pharmacodynamic bioequivalence and safety of Hospira Glucagon for Injection and GlucaGen® in healthy volunteers.
- Trial name
- NCT00745186
- Testing
- Glucagen, Mayne Glucagon
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 12 Days in Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02846831
- Testing
- 12-day intervention with sensor-augmented pump therapy, 12-day intervention with single-hormone closed-loop strategy, Insulin pump
- Where
- 2 sites in Canada
- Volunteers
- 36 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 2 Diabetes
Glucose Response, Excursions And Treatment (GREAT) Study
Patients with type 2 diabetes have very variable endogenous insulin secretion. While some patients have relatively preserved endogenous insulin with marked insulin resistance others may develop the very severe insulin deficiency…
- Trial name
- GREAT (NCT02506296)
- Testing
- DPPIV inhibitor -, Continuous glucose monitoring system.
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Diabetes Mellitus, Type I
Study to Determine the Relationship Between Exercise and Hypoglycemia in Children With Type 1 Diabetes
The main purpose of this study is to find out how often low blood sugar (hypoglycemia) happens during the night after exercise in the late afternoon.
- Trial name
- NCT00109434
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus With Hypoglycemia, Diabetes Mellitus, Type 2
Impact of Hypoglycaemia in Patients With Diabetes Mellitus Type 2 on Platelet Activation
This experimental study is planned to investigate the impact of hypoglycaemia on platelet activation parameters (PAP) during a hyperinsulinaemic hypoglycaemic clamp study.
- Conditions
- Diabetes Mellitus With Hypoglycemia, Diabetes Mellitus, Type 2, Hypoglycemia, Hypoglycemic Episode
- Trial name
- Diaplate (NCT03460899)
- Testing
- Euglycaemic Clamp, Hyperinsulinaemic/Hypoglycaemic Clamp
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Graz
Type 1 Diabetes
Prevalence of Post Traumatic Stress Disorder Related to Diabetes Diagnosis or Severe Hypoglycaemia in Adult With Type 1 Diabetes
In France, the adult population living with diabetes in 2016 is estimated at more than 3.3 million patients treated. Type 1 diabetes (T1DM) represents 5.6% of diabetic patients (approximately 185,000 patients).
- Trial name
- NCT05662657
- Testing
- Diagnostic Test: PCL-S Questionnaire
- Where
- 2 sites in France
- Volunteers
- 297 people
- Sponsor
- Hospital St. Joseph, Marseille, France