Clinical trials: Suicidal Behaviour
Suicidal Ideation, Depression
Brief Cognitive Behavioral Therapy for Reducing Suicidal Ideation in Economically Distressed Migrants
This randomized controlled trial assessed the efficacy of an 8-session, culturally adapted Brief Cognitive Behavioral Therapy (Brief CBT) compared to Treatment as Usual (TAU) in reducing suicidal ideation among economically…
- Conditions
- Suicidal Ideation, Depression, Anxiety, Financial Stress
- Trial name
- Brief CBT (NCT07111377)
- Testing
- Brief Cognitive Behavioral Therapy
- Where
- United Arab Emirates
- Volunteers
- 120 people
- Sponsor
- Bath Spa University Academic Centre RAK
Suicidal Ideation
Suicide Treatment Alternatives for Teens
Quasi-Randomized trial to compare inpatient care versus outpatient crisis intervention clinic. This study plans to enroll up to 1,000 participants across 4 sites in a 5 years period.
- Trial name
- START (NCT04089254)
- Testing
- Inpatient Psychiatry, Outpatient Crisis Intervention Clinic
- Where
- 4 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Depression, Suicidal Ideation
Treatment of Suicidal Ideation With Intravenous Ketamine Infusion
This study is dedicated to achieving better treatments for suicidal thoughts. Specifically, the investigators are studying the effect of a medication called ketamine to quickly treat suicidal thoughts and depression.
- Trial name
- NCT01887990
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Alabama at Birmingham
Bipolar Disorder, Suicidal Ideation
Mentalization-Based Therapy to Prevent Suicidal Behavior in Adolescents With Bipolar Disorder
Children and adolescents with early-onset bipolar disorder (BD) are at high risk for intentionally hurting themselves. Although there are therapies in existence for these youths with BD, they do not address suicide prevention…
- Trial name
- NCT02129790
- Testing
- Mentalization-Based Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
Major Depression
Blood Biomarkers in Suicidal Behaviour
Suicidal behavior (SB) is a major public health problem in France, with more than 10,000 suicides and 220,000 suicide attempts per year.
- Trial name
- 2BSB (NCT02855918)
- Testing
- Blood sample for genetic purpose
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Bipolar Depression, Suicidal Ideas
Sequential Therapy for the Treatment of Severe Bipolar Depression.
NeuroRx is developing NRX-101, a fixed-dose combination oral capsule composed of d-cycloserine (DCS) and lurasidone for the maintenance of remission from Severe Bipolar Depression with Acute Suicidal Ideation (C-SSRS level 4 or…
- Conditions
- Bipolar Depression, Suicidal Ideas, Suicidal Ideation, Suicide, Attempted
- Trial name
- STABIL-B (NCT02974010)
- Testing
- NRX-101 Oral Capsule, Lurasidone Oral Capsule, Ketamine Intravenous Infusion
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- NeuroRx, Inc.
Reintegration Difficulties, Health
National Sponsorship Program for Transitioning Service Members
Background: The United States is undergoing a suicide epidemic for its youngest Veterans (18-to-34-years-old) as their suicide rate has almost doubled since 2001.
- Conditions
- Reintegration Difficulties, Health, Suicidal Ideation and Behaviors, Connectedness
- Trial name
- NCT05224440
- Testing
- Veteran Sponsorship Initiative
- Where
- 2 sites in United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Suicidal Ideation
Ketamine Infusion for Rapid Reduction of Suicidality in Pediatrics
Suicide is a leading cause of death for children and adolescents. Since warning signs of suicide and links to precipitating events differ between age groups, suicide can be difficult to predict.
- Trial name
- Keta4SI (NCT04955470)
- Testing
- Ketamine Injectable Solution, Midazolam Injectable Solution, Normal Saline 0.9% Injectable Solution
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Suicidal Ideation, Suicide, Attempted
Establishing Efficacy of an Inpatient Intervention and Phone App to Reduce Suicidal Risk
In this 2-site study, University of Texas Southwestern Medical Center (UTSW) and Western Psychiatric Institute and Clinic (WPIC), the investigators will conduct a randomized clinical trial (RCT) in 240 psychiatrically…
- Trial name
- ASAP+BRITE (NCT03825588)
- Testing
- ASAP (As Safe As Possible), BRITE smart phone app, TAU (treatment as usual)
- Where
- 2 sites in United States
- Volunteers
- 241 people
- Sponsor
- University of Texas Southwestern Medical Center
Suicidal Ideation, Major Depressive Disorder
The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major Depression
Suicide attempts are a serious concern worldwide. Currently, existing drugs take about three weeks to show effect on suicidal thoughts and drives.
- Conditions
- Suicidal Ideation, Major Depressive Disorder, Healthy Participants
- Trial name
- NCT02037503
- Testing
- Ketamine, Saline
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Major Depressive Disorder With Suicidal Ideation With Intent
Study of Efficacy and Safety of MIJ821 in Addition to Comprehensive Standard of Care on the Rapid Reduction of Symptoms of Major Depressive Disorder in Subjects Who Have Suicidal Ideation With Intent
Study of efficacy and safety of MIJ821 in addition to comprehensive standard of care on the rapid reduction of symptoms of Major Depressive Disorder (MDD) in subjects who have suicidal ideation with intent
- Trial name
- NCT04722666
- Testing
- MIJ821 Intravenous Injection
- Where
- 39 sites in United States, Argentina and 12 more
- Volunteers
- 199 people
- Sponsor
- Novartis Pharmaceuticals
Suicidal Ideation
Online Self-help for Students With Suicidal Ideation
The main goal of this study is to evaluate the effectiveness of an unguided web-based intervention for (college/university) students with suicidal ideation.
- Trial name
- NCT05636722
- Testing
- Unguided web-based intervention
- Where
- Belgium
- Sponsor
- University Ghent
Unipolar Depression, Impulsive Behavior
How to Reduce Suicidal Thoughts and Impulsivity in Depression
The study aims at investigating if tDCS applied to left DLPFC or to right OFC to treatment as usual is effective in reducing severe suicidal ideas in major depressive episode.
- Conditions
- Unipolar Depression, Impulsive Behavior, Suicidal Ideation
- Trial name
- DEPIMPULSE (NCT05894980)
- Testing
- active tDCS stimulating left DLPFC, active tDCS stimulating right OFC
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Unipolar Depression
Response to Social Rejection in Suicidal Behavior
Suicide is a major health problem that causes annually a million death worldwild. In the stress-vulnerability model, suicidal behavior (SB) results from the interaction between an individual's predisposition and stressful…
- Trial name
- SADS-CS (NCT02710279)
- Testing
- Trier Social Stress Test (TSST), smartphone
- Where
- France
- Volunteers
- 79 people
- Sponsor
- University Hospital, Montpellier
Suicide
Alliance With Therapeutic Entourage in Support of Young Suicidal
Regardless of age, the quality of hospital care, the confidence that the young can have in the health care team, joining parents are pivotal elements and influence followed.
- Trial name
- IPSI2 (NCT02524535)
- Testing
- Therapeutic alliance
- Where
- France
- Volunteers
- 292 people
- Sponsor
- University Hospital, Caen
Suicidal Ideation and Behaviors, Suicide Attempt
Video Conference-Based Brief Cognitive Behavioral Therapy for Suicidal High-Risk Outpatients With Mood Disorders
This pilot randomized controlled trial aims to evaluate the feasibility, acceptability, and preliminary effectiveness of videoconference-based brief cognitive behavioral therapy (V-BCBT) for adult outpatients with mood disorders…
- Conditions
- Suicidal Ideation and Behaviors, Suicide Attempt, Cognitive Behavioral Therapy
- Trial name
- V-BCBT (NCT07395817)
- Testing
- Videoconference-Based Brief Cognitive Behavioral Therapy (V-BCBT), Treatment as Usual (TAU)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Hyung Keun Park
Suicide, Attempted, Suicidal Ideation
Motivational Interviewing to Address Suicidal Ideation for Veterans at High Risk for Suicide
The purpose of this project is to conduct a randomized control trial with 470 Veterans to examine the impact of a revised version of Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) on risk for suicide attempts…
- Trial name
- MI-SI (NCT05256940)
- Testing
- Motivational Interviewing to Address Suicidal Ideation- Revised (MI-SI-R), Enhanced usual care (EUC)
- Where
- 3 sites in United States
- Volunteers
- 368 people
- Sponsor
- VA Office of Research and Development
Suicidal Behaviors
Dialectical Behavioral Therapy in Adolescents With Suicidal Behaviors
Suicidal behaviors among adolescents represents a public health problem due to its high prevalence and its low predictability. It is also known that brain development continues during adolescence, therefore, a therapeutic…
- Trial name
- DBT (NCT02406625)
- Testing
- Behavioral Therapy
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Bipolar Depression, Suicidal Ideation
NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Suicidal Ideation
NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. NeuroRx has developed a sequential therapy consisting of IV NRX-100 (ketamine HCL) for rapid stabilization of…
- Trial name
- SBD-ASIB (NCT03396068)
- Testing
- NRX-101, Lurasidone HCl
- Where
- 4 sites in United States
- Volunteers
- 72 people
- Sponsor
- NeuroRx, Inc.
Suicide, Attempted
Youth-Nominated Support Team Intervention for Suicidal Adolescents
This study will attempt to improve treatment adherence and reduce suicide risk among adolescents who are at risk for attempting suicide.
- Trial name
- NCT00071617
- Testing
- Youth-Nominated Support Team
- Where
- United States
- Volunteers
- 448 people
- Sponsor
- University of Michigan