Clinical trials: Suicidal Behaviour
Depression
Exploration of the Relationship Between Inflammation and Integrity of the Blood-Brain Barrier in Suicidal Behaviour
Recent studies have revealed an association between history of suicide attempt and inflammatory markers in both the cerebrospinal fluid and the plasma.
- Trial name
- IBIS (NCT04137458)
- Testing
- Biological analysis
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Social Isolation, Loneliness
Culture and Well-Being for Latinos
The proposed K23 study is an intervention study using an experimental therapeutics approach. This pilot RCT asks: "Does SOCIAL-ENGAGE increase cultural-social engagement and decrease suicide risk among Spanish-speaking adults?"…
- Conditions
- Social Isolation, Loneliness, Suicidal Ideation
- Trial name
- NCT05244733
- Testing
- Social Engage (S-ENGAGE), The Healthy Lifestyles Education Program
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Rochester
Suicide, Suicide, Attempted
Suicide Prevention Among Recipients of Care
Randomized controlled trial to determine the best brief suicide prevention intervention for adults and adolescents who screen positive for suicidal ideation or behavior in emergency departments or primary care clinics.
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation, Social Support
- Trial name
- SPARC (NCT04893447)
- Testing
- SPI+, SP+CC (Caring Contacts)
- Where
- United States
- Volunteers
- 1,520 people
- Sponsor
- St. Luke's Health System, Boise, Idaho
Suicidal Ideation, Suicide, Attempted
Stepped Approach to Reducing Risk of Suicide in Primary Care
Suicide is the second leading cause of death among young people aged 12-17 years in the United States, yet many youth at risk for suicide are not identified or go untreated.
- Conditions
- Suicidal Ideation, Suicide, Attempted, Suicide Prevention
- Trial name
- STARRS-PC (NCT06018285)
- Testing
- Stepped Approach to Reducing Risk of Suicide in Primary Care
- Where
- 15 sites in United States
- Volunteers
- 2,572 people
- Sponsor
- Cynthia Fontanella
Suicidal Ideation
Improving Our Understanding of Suicidal Ideation in Cancer Survivors
The goal of this project is to assess the feasibility of collecting physiological and psychological data that will allow for preliminary investigation of predictors of suicidal ideation in an ambulatory cancer population already…
- Trial name
- NCT04866758
- Testing
- Survey
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Affect, Wellness, Psychological
The Effects of Walking in Nature (vs. an Urban Setting) on the Wellbeing of Postsecondary Students.
The goal of this randomized controlled trial is to examine the effects of a walking intervention (3 walks per week for a period of 4 weeks) in a nature vs. urban setting on the wellbeing of young adult postsecondary students.
- Conditions
- Affect, Wellness, Psychological, Depressive Symptoms, Anxiety Disorders and Symptoms
- Trial name
- NCT05889078
- Testing
- A 4-week walking intervention
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- McGill University
Non-suicidal Self-injury
Evaluation of the Efficacy of Non-drug Therapy (SMS Intervention) for Adolescents With NSSI
In this proposed study, Text messages are used to intervene in the NSSI behavior of adolescents, and the efficacy of this intervention method is evaluated, as well as the internal mechanism of adolescents' NSSI behavior is…
- Trial name
- NCT04481425
- Testing
- SMS intervention
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Central South University
Reintegration Difficulties, Health
National Sponsorship Program for Transitioning Service Members
Background: The United States is undergoing a suicide epidemic for its youngest Veterans (18-to-34-years-old) as their suicide rate has almost doubled since 2001.
- Conditions
- Reintegration Difficulties, Health, Suicidal Ideation and Behaviors, Connectedness
- Trial name
- NCT05224440
- Testing
- Veteran Sponsorship Initiative
- Where
- 2 sites in United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Suicide, Suicidal
Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth
This randomized comparative effectiveness trial will compare two evidence-based approaches to emergency care for youth ages 13-24 who present to the Emergency Department (ED) with suicidal ideation or behavior.
- Conditions
- Suicide, Suicidal, Self-Harm
- Trial name
- SAFE STEPS (NCT05304065)
- Testing
- SAFETY-A within usual ED Care, Combined SAFETY-A within usual ED Care + CLASP Therapeutic Follow-Up Contacts
- Where
- 5 sites in United States
- Volunteers
- 1,600 people
- Sponsor
- University of California, Los Angeles
Suicidal Ideation
Building Resilience and Attachment in Vulnerable Adolescents
Suicide is the second leading cause of mortality for Canadian adolescents. Mental health complaints are one of the leading reasons for an emergency department visit at the Children's Hospital of Eastern Ontario and 60% of…
- Trial name
- BRAVA (NCT01925807)
- Testing
- Group Intervention
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Allison Kennedy
Suicide, Suicide Ideation
Randomized Suicide Prevention Trial Using ASSIP and ACT in Suicide Attempters
This is a randomized controlled trial that aims to compare the effectiveness of two psychological treatment approaches: the Attempted Suicide Short Intervention Program (ASSIP) and Acceptance and Commitment Therapy (ACT).
- Trial name
- NCT07132099
- Testing
- Attempted Suicide Short Intervention Program (ASSIP), Acceptance and Commitment Therapy (ACT), Treatment as Usual (TAU)
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Ardakan University
Suicidal Ideation, Suicide Attempt
Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part A
This Study will comprehensively evaluate a multi-component suicide prevention technology (Jaspr Health) that facilitates delivery of suicided-related evidence-based practices (EBPs) while replacing wasted waiting time with…
- Conditions
- Suicidal Ideation, Suicide Attempt, Self Harm
- Trial name
- Jaspr-PartA (NCT06223867)
- Testing
- Jaspr App + JAH, ETAU
- Where
- United States
- Volunteers
- 670 people
- Sponsor
- University of Massachusetts, Worcester
Major Depressive Disorder, Suicide
Identifying the Neural Basis of Capability for Suicide
Since capability for suicide involves overriding potential pain, and the opioid system plays a strong role in controlling pain perception, it follows that capability for suicide may be impacted by the opioid system.
- Conditions
- Major Depressive Disorder, Suicide, Suicidal Ideation, Psychiatric Illness
- Trial name
- NCT03327129
- Testing
- fMRI
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Suicidal Ideation, Suicide, Attempted
Establishing Efficacy of an Inpatient Intervention and Phone App to Reduce Suicidal Risk
In this 2-site study, University of Texas Southwestern Medical Center (UTSW) and Western Psychiatric Institute and Clinic (WPIC), the investigators will conduct a randomized clinical trial (RCT) in 240 psychiatrically…
- Trial name
- ASAP+BRITE (NCT03825588)
- Testing
- ASAP (As Safe As Possible), BRITE smart phone app, TAU (treatment as usual)
- Where
- 2 sites in United States
- Volunteers
- 241 people
- Sponsor
- University of Texas Southwestern Medical Center
Non-suicidal Self-injury
Treatment for Non-Suicidal Self-Injury in Young Adults
The purpose of this study is to investigate an intervention specifically for non-suicidal self-injury (NSSI) in young adults. The goal of this 9-session outpatient intervention is to reduce the frequency and severity of NSSI.
- Trial name
- T-SIB (NCT01018433)
- Testing
- T-SIB, Treatment as usual
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fordham University
Suicidal Ideation, Depression
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
This project aims to evaluate the potential rapid and sustained antisuicidal and antidepressant effects of a single intranasal dose of ketamine in inpatients during a mood episode in Major Depressive Disorder (MDD) or Bipolar…
- Conditions
- Suicidal Ideation, Depression, Alcohol Abuse
- Trial name
- NCT03539887
- Testing
- Intranasal ketamine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Non Suicidal Self Injury, Suicidal Ideation
aiTBS for NSSI and Suicide in Adolescent Depression
Repetitive transcranial magnetic stimulation (rTMS) has been successfully used to help patients with treatment resistant depression.
- Conditions
- Non Suicidal Self Injury, Suicidal Ideation, Suicide and Self-harm
- Trial name
- NCT06210100
- Testing
- Active iTBS
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Central South University
Depression, Depression Moderate
Outcomes Associated With Suicidality in Inpatients With Symptoms of Depression (OASIS-D)
This 6-month, naturalistic cohort study examines male and female inpatients aged 18 to 75 years i) with any form of unipolar depressive episode (cohort 1); ii) clinical diagnosis of a moderate or severe unipolar depressive…
- Conditions
- Depression, Depression Moderate, Depression Severe, Suicidal and Self-injurious Behavior
- Trial name
- OASIS-D (NCT04404309)
- Where
- Germany
- Volunteers
- 3,331 people
- Sponsor
- Charite University, Berlin, Germany
Borderline Personality Disorder
Effectiveness of a 24 Hour Phone Line on the Rate of Suicide Attempts in Borderline Patients
This randomized multicentric clinical trial assesses the effectiveness of 24 hour phone line on the rate of suicide attempts and self-injurious behaviors in borderline patients.
- Trial name
- NCT00603421
- Testing
- 24 hour phone line, treatment as usual
- Where
- 2 sites in France
- Volunteers
- 318 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Suicidal Ideation
The Effect of Ketamine on the Length of Hospital Stay of Patients Hospitalized With Suicidal Ideation.
This study will evaluate the effect of ketamine on the treatment of patients hospitalized with suicidal thoughts. Half of the patients will receive one dose of ketamine in the vein. The other half will receive a placebo.
- Trial name
- NCT02997722
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Allen Richert